Abstract:
:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) of [3H]quinuclidinyl benzilate increased from 196.6 to 346.2 fmol/mg protein without affecting the dissociation constant. This increase of muscarinic acetylcholine receptors was associated with a decrease in the 50% effective dose (ED50) of contractile response to oxotremorine from 3.8 X 10(-7) M to 6.5 X 10(-8) M. In the aganglionic rectum, hexamethonium administration did not change the Bmax (166.4 fmol/mg protein) or dissociation constant value. The ED50 of contractile response to acetylcholine and oxotremorine (4.3 X 10(-8) M, 6.5 X 10(-8) M) was lower than that in the normal rectum (1.9 X 10(-7) M, 2.0 X 10(-7) M), but it was not changed by hexamethonium. It is concluded that cholinergic innervation is congenitally absent in the aganglionic rectum in piebald lethal mice.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai Kdoi
10.1016/0016-5085(85)90008-3subject
Has Abstractpub_date
1985-06-01 00:00:00pages
1834-41issue
6eissn
0016-5085issn
1528-0012pii
S0016508585001822journal_volume
88pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.08.037
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND & AIMS:Apart from its importance as an acid secretogogue, the role of histamine as a downstream target of gastrin has not been fully explored. Previous studies have shown that the combination of hypergastrinemia and Helicobacter infection resulted in accelerated gastric cancer in mice. We used this model to ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.03.027
更新日期:2005-06-01 00:00:00
abstract::The presence of receptors for insulinlike growth factor I and II in human colonic epithelium is demonstrated. Scatchard analysis of binding data obtained with 125I-insulinlike growth factor I showed an insulinlike growth factor I receptor with a dissociation constant of 8.6 nM and a binding capacity of 0.8 pmol/mg mem...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90291-8
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND & AIMS:Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having previously determined that expression of the interferon-sensitive gene (ISG)15 protease USP18 is increased in the liver biopsy specimens of patients who do not respond to inte...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.08.043
更新日期:2006-11-01 00:00:00
abstract::Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia. Significant improvement (P less than 0.002) of both the clinical grade of hepatic encephalopathy and t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90538-v
更新日期:1991-09-01 00:00:00
abstract::Obese subjects are prone to supersaturated bile, which is maintained or increased during weight loss. In this report, two related studies were carried out on obese subjects to investigate effects of bile acid feeding on biliary lipid metabolism before and during weight reduction. In one study, chenodeoxycholic acid (...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-03-01 00:00:00
abstract::The incidence of celiac disease is increasing, partly because of improved recognition of, and testing for, the disease. The rise in incidence is also due to a real increase of this immune-based disorder, independent of disease detection. The reasons for this true rise in recent decades are unknown but may be related t...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.06.098
更新日期:2021-01-01 00:00:00
abstract::In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(92)91720-o
更新日期:1992-05-01 00:00:00
abstract::Upper gut transit and motility among 10 symptomatic and 9 asymptomatic patients with Roux gastrectomy were compared with those among 10 healthy, unoperated controls. Gastric emptying of solids and Roux limb and small intestinal transit of liquids were assessed scintigraphically. Motor patterns in the Roux limb or heal...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91496-q
更新日期:1992-10-01 00:00:00
abstract::Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.10.035
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v112.pm9178700
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND & AIMS:Among the human mucin complementary DNAs thus far identified, two (MUC5AC and MUC6) were cloned from stomach libraries. This study examines the distribution of MUC6 in normal tissues and compares it with that of MUC5AC as well as with the expression of Lewis blood group antigens. METHODS:Affinity-pur...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1016/0016-5085(95)90379-8
更新日期:1995-09-01 00:00:00
abstract::Characteristics of a macroamylase that was considered not to be formed by the binding of normal amylase to immunoglobulins were studied. The macroamylase was reversibly dissociated into apparently normal amylase by treating the macroamylasemic serum with guanidine hydrochloride. Concanavalin A precipitated a large por...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Cholecystokinin (CCK) 58 is the predominant molecular form of CCK in canine and human intestine and circulating blood. There is no report on the metabolism and clearance rate of CCK-58. The aim of this study was to compare the in vivo half-life and metabolism of CCK-58 with that of synthetic CCK-8. METHODS:...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)91070-x
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND & AIMS:Liver X receptors (LXRs) are transcriptional regulators of cholesterol metabolism, controlling cholesterol flow into cells, catabolism, and efflux. Cholesterol controls cell proliferation; disruptions in cholesterol metabolism have been associated with the development of colon cancer. We investigated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.02.005
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND & AIMS:Accurate biomarkers of disease activity and therapeutic response can be valuable for clinical trials. We performed a post hoc analysis of data from a phase 2 trial to assess the relationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes of patients with mod...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2015.09.001
更新日期:2016-01-01 00:00:00
abstract::We investigated the possibility that monocyte suppressor cells play a role in the peripheral lymphocyte hyporesponsiveness of chronic liver disease by utilizing assays of monocyte-mediated suppressor activity in 46 patients with chronic liver disease and 46 controls. The percent change achieved by the addition of indo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.11.003
更新日期:2008-02-01 00:00:00
abstract::Hepatic plasma flow was assessed with sorbitol (hepatic extraction = 0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal sorbitol clearances were calculated, and the extrarenal clearance was obtained by taking the difference between the two. In normal volunteers, the mean (+/- SD) extrarenal so...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(88)80024-6
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70224-1
更新日期:2000-02-01 00:00:00
abstract::Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90004-7
更新日期:1987-03-01 00:00:00
abstract::The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90065-6
更新日期:1989-08-01 00:00:00
abstract::A 44-yr-old woman with non-A, non-B hepatitis developed agranulocytosis and absence of marrow granulocyte precursor cells with only mild involvement of other blood elements. The agranulocytosis was complicated by gram-negative septicemia, successfully treated with antibiotic therapy. Marrow recovery followed 2 wk of s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide localized to primary sensory afferent nerves in the rat stomach. The actions of CGRP in regulating antral neuroendocrine function were examined in vitro through the use of capsaicin, an agent capable of evoking neuropeptide release from periph...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90417-b
更新日期:1993-02-01 00:00:00
abstract::Intestinal handling of water and electrolytes was monitored in 5 conscious dogs with chronic 25-cm Thiry-Vella loops of proximal jejunum using a neutral isosmotic perfusate containing [14C]polyethylene glycol as a recovery marker. Under basal conditions the animals absorbed water, Na+, and Cl-, and there was minimal n...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)91102-9
更新日期:1986-03-01 00:00:00
abstract::To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90862-6
更新日期:1987-01-01 00:00:00
abstract::Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90328-2
更新日期:1985-08-01 00:00:00
abstract::Sphincter of Oddi (SO) manometry was conducted in 48 subjects who had previously undergone cholecystectomy. Ten of these subjects had no detectable biliary or pancreatic disease and served as controls. The other 38 patients were presumed to have SO dysfunction and had presented with episodes of severe biliary-type pai...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80086-x
更新日期:1985-05-01 00:00:00
abstract::The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/0016-5085(88)90512-4
更新日期:1988-08-01 00:00:00