An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer.

Abstract:

:Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Burnett-Hartman AN,Lee JK,Demb J,Gupta S

doi

10.1053/j.gastro.2020.12.068

subject

Has Abstract

pub_date

2021-01-05 00:00:00

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(21)00008-1

pub_type

杂志文章,评审
  • Food, immunity, and the microbiome.

    abstract::There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2014.12.036

    authors: Tilg H,Moschen AR

    更新日期:2015-05-01 00:00:00

  • Monensin action on the Golgi complex in perfused rat liver: evidence against bile salt vesicular transport.

    abstract::Several studies suggest that bile salts are transported from the basolateral to the canalicular membrane of hepatocytes by a vesicular pathway, possibly in part via the Golgi complex. To test this hypothesis, the present study examined, in the perfused rat liver, the influence of the Na+ ionophore monensin on the bili...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(92)90328-v

    authors: Reynier MO,Abou Hashieh I,Crotte C,Carbuccia N,Richard B,Gérolami A

    更新日期:1992-06-01 00:00:00

  • Chronic Helicobacter pylori infections induce gastric mutations in mice.

    abstract:BACKGROUND & AIMS:Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the induction of mutagenic events in gastric epithelial cells. The effect of a high-salt diet as a genotoxic risk factor was also investig...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(03)00266-x

    authors: Touati E,Michel V,Thiberge JM,Wuscher N,Huerre M,Labigne A

    更新日期:2003-05-01 00:00:00

  • Amitriptyline-induced prolonged cholestasis.

    abstract::We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis. Jaundice and pruritus lasted 19 and 20 mo, respectively. Three liver biopsies were performed at different stages of the disease showing the course of liver lesions. Cholestasis initially located in the ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(88)90631-2

    authors: Larrey D,Amouyal G,Pessayre D,Degott C,Danne O,Machayekhi JP,Feldmann G,Benhamou JP

    更新日期:1988-01-01 00:00:00

  • Neurohumoral pathways mediating stress-induced changes in rat gastrointestinal transit.

    abstract::Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)91439-x

    authors: Lenz HJ

    更新日期:1989-07-01 00:00:00

  • Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural, and functional time sequence analysis.

    abstract::Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(85)80191-8

    authors: Hollander D,Tarnawski A,Krause WJ,Gergely H

    更新日期:1985-01-01 00:00:00

  • Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.

    abstract:BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2013.03.013

    authors: Holczbauer Á,Factor VM,Andersen JB,Marquardt JU,Kleiner DE,Raggi C,Kitade M,Seo D,Akita H,Durkin ME,Thorgeirsson SS

    更新日期:2013-07-01 00:00:00

  • Induction of heat-shock gene expression in postischemic pig liver depends on superoxide generation.

    abstract:BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(94)95209-4

    authors: Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

    更新日期:1994-01-01 00:00:00

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

    abstract:BACKGROUND:The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients. We aimed to update the original STRIDE statements for incorporating treatme...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.12.031

    authors: Turner D,Ricciuto A,Lewis A,D'Amico F,Dhaliwal J,Griffiths AM,Bettenworth D,Sandborn WJ,Sands BE,Reinisch W,Schölmerich J,Bemelman W,Danese S,Mary JY,Rubin D,Colombel JF,Peyrin-Biroulet L,Dotan I,Abreu MT,Dignass A

    更新日期:2020-12-21 00:00:00

  • Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation.

    abstract:BACKGROUND & AIMS:The effects of aging on pancreatic acinar cell proliferation have not been clearly defined. Phosphatidylinositol 3-kinase (PI3K)-mediated phosphorylation of Akt is a critical step for proliferation of various cell types and insulin secretion from pancreatic endocrine cells; however, its role in acinar...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.03.016

    authors: Watanabe H,Saito H,Rychahou PG,Uchida T,Evers BM

    更新日期:2005-05-01 00:00:00

  • Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver.

    abstract:BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(96)70073-2

    authors: Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

    更新日期:1996-10-01 00:00:00

  • Platelets circulate in an activated state in inflammatory bowel disease.

    abstract:BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90741-2

    authors: Collins CE,Cahill MR,Newland AC,Rampton DS

    更新日期:1994-04-01 00:00:00

  • Severe cholestatic jaundice associated with piroxicam.

    abstract::A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1016/0016-5085(91)90417-j

    authors: Hepps KS,Maliha GM,Estrada R,Goodgame RW

    更新日期:1991-12-01 00:00:00

  • JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection.

    abstract:BACKGROUND & AIMS:JNJ-56136379 (JNJ-6379), a capsid assembly modulator that blocks hepatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional pharmacokinetics in healthy participants in part 1 of its first clinical trial. In part 2, we have evaluated the safety, pharmacokinetics, and ant...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.04.036

    authors: Zoulim F,Lenz O,Vandenbossche JJ,Talloen W,Verbinnen T,Moscalu I,Streinu-Cercel A,Bourgeois S,Buti M,Crespo J,Manuel Pascasio J,Sarrazin C,Vanwolleghem T,Shukla U,Fry J,Yogaratnam JZ

    更新日期:2020-08-01 00:00:00

  • Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine.

    abstract:BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.36581

    authors: Gao C,Liu S,Hu HZ,Gao N,Kim GY,Xia Y,Wood JD

    更新日期:2002-11-01 00:00:00

  • Enhanced hyperplasia of gastric enterochromaffinlike cells in response to omeprazole-evoked hypergastrinemia in rats with portacaval shunts. An immunocytochemical and chemical study.

    abstract::The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)90948-z

    authors: Axelson J,Ekelund M,Sundler F,Håkanson R

    更新日期:1990-09-01 00:00:00

  • Effects of alcohols on the actions of VIP and secretin on acinar cells from guinea pig pancreas.

    abstract::In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Uhlemann ER,Robberecht P,Gardner JD

    更新日期:1979-05-01 00:00:00

  • Radioembolization results in longer time-to-progression and reduced toxicity compared with chemoembolization in patients with hepatocellular carcinoma.

    abstract:BACKGROUND & AIMS:Chemoembolization is one of several standards of care treatment for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a novel, transarterial approach to radiation therapy. We performed a comparative effectiveness analysis of these therapies in patients with HCC. METHOD...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2010.10.049

    authors: Salem R,Lewandowski RJ,Kulik L,Wang E,Riaz A,Ryu RK,Sato KT,Gupta R,Nikolaidis P,Miller FH,Yaghmai V,Ibrahim SM,Senthilnathan S,Baker T,Gates VL,Atassi B,Newman S,Memon K,Chen R,Vogelzang RL,Nemcek AA,Resnick SA

    更新日期:2011-02-01 00:00:00

  • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.

    abstract:BACKGROUND & AIMS:Host genetic factors are likely to contribute to the variable course of hepatic fibrosis in response to chronic liver injury. Similarly, the fibrotic response differs among inbred mouse strains after challenge with CCl(4). Our aim was to identify unknown susceptibility loci for hepatic fibrosis in a c...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.37069

    authors: Hillebrandt S,Goos C,Matern S,Lammert F

    更新日期:2002-12-01 00:00:00

  • Colonoscopic polypectomy: silent perforation.

    abstract::The management of colon polyps has been completely revolutionized since the introduction of colonoscopic polypectomy. The reductions in patient time, cost, morbidity, and mortality are major advantages. Reported complications include primarily hemorrhage (1.7%) and frank clinical perforation (0.32%). This report descr...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Overholt BF,Hargrove RL,Farris RK,Wilson BM

    更新日期:1976-01-01 00:00:00

  • The microRNA-30 family is required for vertebrate hepatobiliary development.

    abstract:BACKGROUND & AIMS:The function of microRNA (miRNA) in liver development is unknown. To address this issue, we characterized miRNA expression in the embryonic mouse liver, performed functional miRNA analysis in zebrafish larvae, and identified novel hepatic miRNA targets. METHODS:Hepatic RNA isolated from mice at embry...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2008.12.006

    authors: Hand NJ,Master ZR,Eauclaire SF,Weinblatt DE,Matthews RP,Friedman JR

    更新日期:2009-03-01 00:00:00

  • Correlation Between Concentrations of Fecal Calprotectin and Outcomes of Patients With Ulcerative Colitis in a Phase 2 Trial.

    abstract:BACKGROUND & AIMS:Accurate biomarkers of disease activity and therapeutic response can be valuable for clinical trials. We performed a post hoc analysis of data from a phase 2 trial to assess the relationship between the concentration of fecal calprotectin (FCP) and clinical and endoscopic outcomes of patients with mod...

    journal_title:Gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.gastro.2015.09.001

    authors: Sandborn WJ,Panés J,Zhang H,Yu D,Niezychowski W,Su C

    更新日期:2016-01-01 00:00:00

  • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.

    abstract:BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.10.005

    authors: Imamura M,Ogawa T,Sasaguri Y,Chayama K,Ueno H

    更新日期:2005-01-01 00:00:00

  • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.

    abstract:BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...

    journal_title:Gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1053/j.gastro.2011.06.054

    authors: Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

    更新日期:2011-10-01 00:00:00

  • Role of prostaglandins in the formation of aspirin-induced gastric ulcers.

    abstract::Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

    更新日期:1981-01-01 00:00:00

  • Hepatic failure and death from erythropoietic protoporphyria.

    abstract::A 60-year-old white male presenting with a clinical picture of obstructive jaundice was subsequently found to have erythropoietic protoporphyria. The diagnosis was suspected because of a history of life-long photosensitivity and was confirmed by finding high levels of erythrocyte protoporphyrin. Liver biopsy revealed ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Singer JA,Plaut AG,Kaplan MM

    更新日期:1978-03-01 00:00:00

  • Bacterial translocation to mesenteric lymph nodes is increased in cirrhotic rats with ascites.

    abstract:BACKGROUND/AIMS:Cirrhotic patients are predisposed to develop spontaneous bacteremias and/or peritonitis, mainly caused by enteric bacteria. The aim of this study was to investigate if bacterial translocation, which is the passage of bacteria from the intestinal lumen to regional lymph nodes and/or the systemic circula...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90147-7

    authors: Garcia-Tsao G,Lee FY,Barden GE,Cartun R,West AB

    更新日期:1995-06-01 00:00:00

  • Reduction in colorectal cancer mortality by fecal occult blood screening in a French controlled study.

    abstract:BACKGROUND & AIMS:Several randomized population-based studies have shown that screening for colorectal cancer (CRC) by fecal occult blood tests (FOBTs) can reduce CRC mortality. The aim of this French population-based study was to assess whether a similar benefit could be obtained in countries characterized by high per...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1053/j.gastro.2004.02.018

    authors: Faivre J,Dancourt V,Lejeune C,Tazi MA,Lamour J,Gerard D,Dassonville F,Bonithon-Kopp C

    更新日期:2004-06-01 00:00:00

  • Sulfate-sodium cotransport by brush-border membrane vesicles isolated from rat ileum.

    abstract::Uptake of inorganic sulfate into brush-border membrane vesicles isolated by a calcium precipitation method from rat small intestine was investigated using a rapid filtration technique and 35Sulfur acid as tracer. Sulfate uptake by membrane vesicles was osmotically sensitive, suggesting transport into an intravesicular...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Lücke H,Stange G,Murer H

    更新日期:1981-01-01 00:00:00

  • Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.

    abstract:BACKGROUND & AIMS:We assessed the influence of genetic variants in the hepatitis B virus (HBV) core, which is a principal immunologic target, on the progression to hepatocellular carcinoma (HCC) in a cohort of 4841 male HBV carriers followed up for 16 years. METHODS:First, baseline sera from 116 HCC cases and 154 cont...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2009.07.063

    authors: Sung FY,Jung CM,Wu CF,Lin CL,Liu CJ,Liaw YF,Tsai KS,Yu MW

    更新日期:2009-11-01 00:00:00