Abstract:
:Primary sclerosing cholangitis is a chronic cholestatic liver disease that is commonly associated with chronic ulcerative colitis. We observed the development of varices in the abdominal wall surrounding the ileostomy stoma of patients with primary sclerosing cholangitis who underwent proctocolectomy and ileostomy for chronic ulcerative colitis. In 10 of 19 patients, the development of peristomal varices was documented 12-133 mo after operation. Risk factors for the development of peristomal varices included splenomegaly, esophageal varices, advanced histologic stage at liver biopsy, low serum albumin, thrombocytopenia, and an increased prothrombin time. Recurrent bleeding from peristomal varices was a major problem; 7 of 10 patients required repeated blood transfusions. The only therapy of long-term benefit was surgical decompression of the portal venous system in 1 patient and liver transplantation in a second patient. In contrast, there was no perirectal bleeding in 4 patients with primary sclerosing cholangitis who underwent proctocolectomy with an ileoanal anastomosis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Wiesner RH,LaRusso NF,Dozois RR,Beaver SJdoi
10.1016/0016-5085(86)90926-1subject
Has Abstractpub_date
1986-02-01 00:00:00pages
316-22issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(86)90926-1journal_volume
90pub_type
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