当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Selective recognition of mucosal lymphoid high endothelium by gut intraepithelial leukocytes.

Selective recognition of mucosal lymphoid high endothelium by gut intraepithelial leukocytes.

Abstract：

:Circulating precursors of mucosal immunoglobulin A plasma cells and T-cell immunoblasts migrate selectively into mucosal sites from the blood, but the mechanisms controlling this selective trafficking have not been determined. One possibility is that the site-specific extravasation of circulating effector cell populations is determined by organ-specific endothelial cell recognition mechanisms. Here we have assessed the ability of isolated mouse gut intraepithelial lymphocytes to recognize and bind to mucosal versus nonmucosal lymphoid organ high endothelial venules, vessels that support high levels of lymphocyte traffic in vivo. In an in vitro assay of lymphocyte interaction with high endothelial venules in frozen sections, intraepithelial leukocytes bind well to high endothelial venules in Peyer's patches but, unlike most circulating B and T lymphocytes, are unable to interact with peripheral lymph node high endothelial venules. Furthermore, we show by in situ immunohistology and in cell suspension immunofluorescence studies that intraepithelial leukocytes fail to stain with a monoclonal antibody, MEL-14, against putative lymphocyte receptors for lymph node high endothelial venules. Thus, they lack a cell surface glycoprotein required for homing to peripheral nodes. The demonstration of organ-specific recognition of endothelial cells by a normal mucosal effector lymphocyte population suggests that selective interactions with endothelium may play an important role in controlling the distribution of effector cells in vivo. The utilization of organ-specific endothelial cell recognition mechanisms by circulating precursors of mucosal effector cells could explain both the unification of immune responses in diverse mucosal sites and the physiologic segregation of mucosal from nonmucosal immune mechanisms.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Schmitz M,Nunez D,Butcher EC

doi

10.1016/0016-5085(88)90226-0

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

576-81

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(88)90226-0

journal_volume

94

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Crohn's disease: influence of age at diagnosis on site and clinical type of disease.

    abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v111.pm8780560

    authors： Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

    更新日期：1996-09-01 00:00:00

  • Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis.

    abstract：BACKGROUND & AIMS:AJM300 is an orally active small-molecule antagonist of the α4 integrin subunit. We performed a randomized trial to investigate the efficacy and safety of AJM300 in patients with active ulcerative colitis (UC). METHODS:In a double-blind, placebo-controlled, phase 2a study, 102 patients with moderatel...

    journal_title：Gastroenterology

    pub_type： 评论,杂志文章

    doi：10.1053/j.gastro.2015.08.044

    authors： Yoshimura N,Watanabe M,Motoya S,Tominaga K,Matsuoka K,Iwakiri R,Watanabe K,Hibi T,AJM300 Study Group.

    更新日期：2015-12-01 00:00:00

  • Reduced mortality rates following elective percutaneous liver biopsies.

    abstract：BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.06.015

    authors： West J,Card TR

    更新日期：2010-10-01 00:00:00

  • Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress.

    abstract：BACKGROUND & AIMS:Ethanol impairs the mitochondrial transport of reduced glutathione (GSH), resulting in lower mitochondrial GSH (mGSH) levels. Our purpose was to evaluate the role of acetaldehyde on the regulation of mGSH in HepG2 cells. METHODS:mGSH levels and transport, mitochondrial membrane microviscosity, and li...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2003.50089

    authors： Lluis JM,Colell A,García-Ruiz C,Kaplowitz N,Fernández-Checa JC

    更新日期：2003-03-01 00:00:00

  • Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.

    abstract：BACKGROUND & AIMS:Lynch syndrome, a nonpolyposis form of hereditary colorectal cancer, is caused by inherited defects in DNA mismatch repair (MMR) genes. Most patients carry a germline mutation in 1 allele of the MMR genes MSH2 or MLH1. With spontaneous loss of the wild-type allele, cells with defects in MMR exist amon...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.07.052

    authors： Wojciechowicz K,Cantelli E,Van Gerwen B,Plug M,Van Der Wal A,Delzenne-Goette E,Song JY,De Vries S,Dekker M,Te Riele H

    更新日期：2014-11-01 00:00:00

  • Direct-Acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-Induced Cryoglobulinemia Vasculitis.

    abstract：BACKGROUND & AIMS:Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.02.037

    authors： Comarmond C,Garrido M,Pol S,Desbois AC,Costopoulos M,Le Garff-Tavernier M,Si Ahmed SN,Alric L,Fontaine H,Bellier B,Maciejewski A,Rosenzwajg M,Klatzmann D,Musset L,Poynard T,Cacoub P,Saadoun D

    更新日期：2017-06-01 00:00:00

  • Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers.

    abstract：BACKGROUND & AIMS:The accurate identification of inactive (serum HBV-DNA persistently

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.04.052

    authors： Brunetto MR,Oliveri F,Colombatto P,Moriconi F,Ciccorossi P,Coco B,Romagnoli V,Cherubini B,Moscato G,Maina AM,Cavallone D,Bonino F

    更新日期：2010-08-01 00:00:00

  • Gastric epithelial restitution at low luminal pH during influence of pentagastrin or cimetidine in the cat.

    abstract：:This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespectiv...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90437-9

    authors： Grönbech JE,Grong K,Varhaug JE,Lekven J,Svanes K

    更新日期：1987-10-01 00:00:00

  • Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants.

    abstract：BACKGROUND & AIMS:Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood. We performed a retrospective analysis of data from 17 centers from Europe an...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2011.02.050

    authors： Kamar N,Garrouste C,Haagsma EB,Garrigue V,Pischke S,Chauvet C,Dumortier J,Cannesson A,Cassuto-Viguier E,Thervet E,Conti F,Lebray P,Dalton HR,Santella R,Kanaan N,Essig M,Mousson C,Radenne S,Roque-Afonso AM,Izopet J,

    更新日期：2011-05-01 00:00:00

  • Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms.

    abstract：BACKGROUND & AIMS:Pancreatic mucinous cystic neoplasm (MCN), a cystic tumor of the pancreas that develops most frequently in women, is a potential precursor to pancreatic ductal adenocarcinoma. MCNs develop primarily in the body and tail of the pancreas and are characterized by the presence of a mucinous epithelium and...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.09.044

    authors： Sano M,Driscoll DR,De Jesus-Monge WE,Klimstra DS,Lewis BC

    更新日期：2014-01-01 00:00:00

  • CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor alpha chain-deficient mice.

    abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9178680

    authors： Takahashi I,Kiyono H,Hamada S

    更新日期：1997-06-01 00:00:00

  • Acetazolamide inhibits basal and stimulated HCO3- secretion in the human proximal duodenum.

    abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0016-5085(95)90013-6

    authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

    更新日期：1995-01-01 00:00:00

  • Effects of short-term pancreatic duct obstruction in rats.

    abstract：:The short-term effects of rat pancreatic duct obstruction were evaluated and compared with those recently reported to follow obstruction of the rabbit pancreatic duct. In both species pancreatic edema and hyperamylasemia are noted, and the lysosomal hydrolase cathepsin B is redistributed from the lysosome-enriched to ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90601-g

    authors： Ohshio G,Saluja A,Steer ML

    更新日期：1991-01-01 00:00:00

  • An examination of liver offers to candidates on the liver transplant wait-list.

    abstract：BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.07.105

    authors： Lai JC,Feng S,Roberts JP

    更新日期：2012-11-01 00:00:00

  • Efficacy of Glecaprevir and Pibrentasvir in Patients With Genotype 1 Hepatitis C Virus Infection With Treatment Failure After NS5A Inhibitor Plus Sofosbuvir Therapy.

    abstract：BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2019.08.008

    authors： Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

    更新日期：2019-12-01 00:00:00

  • Autophagy, microbial sensing, endoplasmic reticulum stress, and epithelial function in inflammatory bowel disease.

    abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2011.02.048

    authors： Kaser A,Blumberg RS

    更新日期：2011-05-01 00:00:00

  • Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line.

    abstract：:To gain further insight on the mosaic expression of specific functional intestinal markers (such as sucrase-isomaltase) in postconfluent Caco-2 cells, a human colon cancer cell line unique in its property to differentiate in vitro into a mature enterocyte-like cell type, a comparative study was undertaken to examine t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90829-n

    authors： Vachon PH,Beaulieu JF

    更新日期：1992-08-01 00:00:00

  • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.

    abstract：BACKGROUND & AIMS:Cancer progression/metastases and embryonic development share many properties including cellular plasticity, dynamic cell motility, and integral interaction with the microenvironment. We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.12.004

    authors： Yamashita T,Ji J,Budhu A,Forgues M,Yang W,Wang HY,Jia H,Ye Q,Qin LX,Wauthier E,Reid LM,Minato H,Honda M,Kaneko S,Tang ZY,Wang XW

    更新日期：2009-03-01 00:00:00

  • Rectal sparing in antibiotic-associated pseudomembranous colitis: a prospective study.

    abstract：:A prospective study of 22 patients with antibiotic-associated pseudomembranous colitis demonstrated that the most distal location of the pseudomembranes was noted from 0 to 25 cm from the anus in 17 patients, from 25 to 60 cm from the anus in 3 patients, and greater than 60 cm from the anus in only 2 patients. These d...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Tedesco FJ,Corless JK,Brownstein RE

    更新日期：1982-12-01 00:00:00

  • Causes of Post-Colonoscopy Colorectal Cancers Based on World Endoscopy Organization System of Analysis.

    abstract：BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.12.031

    authors： Anderson R,Burr NE,Valori R

    更新日期：2020-04-01 00:00:00

  • Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial.

    abstract：:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2017.06.006

    authors： Vanclooster A,van Deursen C,Jaspers R,Cassiman D,Koek G

    更新日期：2017-09-01 00:00:00

  • Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group.

    abstract：BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or unt...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0016-5085(98)70419-6

    authors： Timmer A,Sutherland LR,Martin F

    更新日期：1998-06-01 00:00:00

  • Tetracycline-induced bile duct paucity and prolonged cholestasis.

    abstract：:Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred w...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90830-3

    authors： Hunt CM,Washington K

    更新日期：1994-12-01 00:00:00

  • Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice.

    abstract：BACKGROUND & AIMS:The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and re...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.01.040

    authors： Popov Y,Sverdlov DY,Sharma AK,Bhaskar KR,Li S,Freitag TL,Lee J,Dieterich W,Melino G,Schuppan D

    更新日期：2011-05-01 00:00:00

  • Prevalence of high-grade dysplasia and cancer in the anal canal in human papillomavirus-infected individuals.

    abstract：BACKGROUND & AIMS:The incidence of anal cancer is higher in patients with anal canal condyloma, a sexually transmitted disease, than in the general population. We determined the prevalence of anal dysplasia and cancer in patients with anal canal condyloma with respect to human immunodeficiency virus (HIV) status, immun...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.22446

    authors： Sobhani I,Vuagnat A,Walker F,Vissuzaine C,Mirin B,Hervatin F,Marmuse JP,Crémieux AC,Carbon C,Henin D,Lehy T,Mignon M

    更新日期：2001-03-01 00:00:00

  • Functions of autophagy in hepatic and pancreatic physiology and disease.

    abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2011.04.038

    authors： Czaja MJ

    更新日期：2011-06-01 00:00:00

  • Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.

    abstract：BACKGROUND & AIMS:Agents designed to block or alter cytokinesis can kill or stop proliferation of cancer cells. We aimed to identify cytokinesis-related proteins that are overexpressed in hepatocellular carcinoma (HCC) cells and might be targeted to slow liver tumor growth. METHODS:Using the Oncomine database, we comp...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.07.010

    authors： Yang XM,Cao XY,He P,Li J,Feng MX,Zhang YL,Zhang XL,Wang YH,Yang Q,Zhu L,Nie HZ,Jiang SH,Tian GA,Zhang XX,Liu Q,Ji J,Zhu X,Xia Q,Zhang ZG

    更新日期：2018-10-01 00:00:00

  • High-resolution manometry and impedance-pH/manometry: valuable tools in clinical and investigational esophagology.

    abstract：:Both high-resolution manometry (HRM) and impedance-pH/manometry monitoring have established themselves as research tools and both are now emerging in the clinical arena. Solid-state HRM capable of simultaneously monitoring the entire pressure profile from the pharynx to the stomach along with pressure topography plott...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2008.05.048

    authors： Kahrilas PJ,Sifrim D

    更新日期：2008-09-01 00:00:00

  • Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.

    abstract：BACKGROUND & AIMS:Drug-induced cholestasis is a frequent form of acquired liver disease. To elucidate the molecular pathogenesis of drug-induced cholestasis, we investigated the effects of prototypic cholestatic drugs on the canalicular bile salt export pump (Bsep) of rat liver. METHODS:Vesicles were isolated from Bse...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(00)70224-1

    authors： Stieger B,Fattinger K,Madon J,Kullak-Ublick GA,Meier PJ

    更新日期：2000-02-01 00:00:00

  • Reconciliation of Recent Helicobacter pylori Treatment Guidelines in a Time of Increasing Resistance to Antibiotics.

    abstract：:Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of H pylori infection. We compared the recommendations o...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2019.04.011

    authors： Fallone CA,Moss SF,Malfertheiner P

    更新日期：2019-07-01 00:00:00