Abstract：
BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at diagnosis of Crohn's disease on disease site, type, and course. METHODS:Records of 552 consecutive patients with Crohn's disease were reviewed retrospectively. RESULTS:Younger age at diagnosis (younger than 20 years), compared with an older age (40 years or older), was associated with a greater prevalence of a family history of Crohn's disease (29.9% vs. 13.6%), greater small bowel involvement (88.7% vs. 57.5%), more stricturing disease (45.8% vs. 28.8%), and a higher frequency of surgery (70.6% vs. 55.3%). Older age at diagnosis was associated with a greater prevalence of colonic disease (84.8% vs. 71.2%) and the inflammatory subtype (54.5% vs. 34.4%). A conditional logistic regression analysis confirmed an independent effect of age at diagnosis on ileal disease and surgery for intractable disease. CONCLUSIONS:In Crohn's disease, early age at diagnosis is associated with more complicated disease and a greater likelihood of having affected relatives. Stratification of Crohn's disease by age at diagnosis provides support for the concept of genetic heterogeneity.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TMdoi
10.1053/gast.1996.v111.pm8780560subject
Has Abstractpub_date
1996-09-01 00:00:00pages
580-6issue
3eissn
0016-5085issn
1528-0012pii
S0016508596003873journal_volume
111pub_type
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