The influence of hypercalcemia on basal and cholecystokinin-stimulated pancreatic, gallbladder, and gastric functions in man.

abstract：:Previous epidemiologic studies have suggested a weak association between oral contraceptive use and Crohn's disease, specifically Crohn's colitis. To measure a possible etiologic association, 51 women with Crohn's disease who were 18-50 yr old were studied and compared with peer-nominated age- and sex-matched controls...

journal_title：Gastroenterology

authors： Lashner BA,Kane SV,Hanauer SB

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND & AIMS:The secretion and function of antral histamine are not known. The aims of this study were to characterize the mechanisms of histamine release from the gastric antrum of humans, dogs, and rats and to determine whether histamine can influence the secretion of somatostatin and gastrin. METHODS:Somatosta...

journal_title：Gastroenterology

authors： Vuyyuru L,Schubert ML,Harrington L,Arimura A,Makhlouf GM

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND & AIMS:Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice. METHODS:We analyzed data from 541 patients with CRC in The Cancer Genome Atlas database fo...

journal_title：Gastroenterology

authors： Coleman OI,Lobner EM,Bierwirth S,Sorbie A,Waldschmitt N,Rath E,Berger E,Lagkouvardos I,Clavel T,McCoy KD,Weber A,Heikenwalder M,Janssen KP,Haller D

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

journal_title：Gastroenterology

authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

更新日期：1995-01-01 00:00:00

abstract：:Isolation of a spiral-shaped bacterium closely related to Helicobacter pylori from the cat stomach made it possible to investigate new small animal models of gastric infection. Pure cultures of this bacterium, provisionally named "Helicobacter felis," were fed to germ-free mice. The organism colonized the stomach in l...

journal_title：Gastroenterology

authors： Lee A,Fox JG,Otto G,Murphy J

更新日期：1990-11-01 00:00:00

abstract：:One hundred Chinese patients who received induction cytotoxic therapy for malignant lymphoma were prospectively studied to determine the incidence, morbidity, mortality, and predisposing factors for reactivation of hepatitis B virus replication during cytotoxic therapy. In 18 (67%) hepatitis B surface antigen-positive...

journal_title：Gastroenterology

authors： Lok AS,Liang RH,Chiu EK,Wong KL,Chan TK,Todd D

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...

journal_title：Gastroenterology

authors： Debes JD,van Tilborg M,Groothuismink ZMA,Hansen BE,Schulze Zur Wiesch J,von Felden J,de Knegt RJ,Boonstra A

更新日期：2018-02-01 00:00:00

abstract：:In fed rats, acid production was estimated to be 7 X 10(8) molecules of HCl per cell per sec or 5 X 10(5) molecules per sec per mu2 of secretory surface. In stimulated frog mucosa the corresponding values were 3 X 10(8) molecules of HCl per cell per sec 2 X 10(5) molecules per sec per mu2 or secretory surface. The gen...

journal_title：Gastroenterology

authors： Helander HF

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND/AIMS:Butyrate and factor XIII may improve ulcerative colitis; they also affect tissue and serum transglutaminase levels. We investigated the therapeutic potential of sodium butyrate and factor XIII and the role of transglutaminase during mucosal repair in experimental colitis. METHODS:Rats with induced coli...

journal_title：Gastroenterology

authors： D'Argenio G,Cosenza V,Sorrentini I,De Ritis F,Gatto A,Delle Cave M,D'Armiento FP,Mazzacca G

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR)...

journal_title：Gastroenterology

authors： Poordad F,Lawitz E,Reddy KR,Afdhal NH,Hézode C,Zeuzem S,Lee SS,Calleja JL,Brown RS Jr,Craxi A,Wedemeyer H,Nyberg L,Nelson DR,Rossaro L,Balart L,Morgan TR,Bacon BR,Flamm SL,Kowdley KV,Deng W,Koury KJ,Pedicone LD

更新日期：2013-11-01 00:00:00

abstract：:The role of leukotrienes in the pathogenesis of chronic colitis was investigated using a rat model. Ulceration and inflammation of the distal colon was initiated by the intracolonic administration of the hapten trinitrobenzene sulfonic acid in 50% ethanol. Leukotriene B4 synthesis increased significantly within 4 h af...

journal_title：Gastroenterology

authors： Wallace JL,MacNaughton WK,Morris GP,Beck PL

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Rats fed ethanol at a constant rate through a permanent intragastric cannula have a regular fluctuation in blood alcohol level (BAL) and urine alcohol level (UAL). The level of ethanol peaks every 6-10 days. The question is how the liver differs at the peaks and troughs of the UAL cycle. Hypoxic injur...

journal_title：Gastroenterology

authors： Bardag-Gorce F,French BA,Li J,Riley NE,Yuan QX,Valinluck V,Fu P,Ingelman-Sundberg M,Yoon S,French SW

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with Wilson's disease presenting with liver involvement, the correct diagnosis is often missed or delayed. The aim of this study was to find an algorithm for diagnosis of this difficult patient group. METHODS:Clinical and laboratory findings of 55 patients with Wilson's disease were evalu...

journal_title：Gastroenterology

authors： Steindl P,Ferenci P,Dienes HP,Grimm G,Pabinger I,Madl C,Maier-Dobersberger T,Herneth A,Dragosics B,Meryn S,Knoflach P,Granditsch G,Gangl A

更新日期：1997-07-01 00:00:00

abstract：:The human colon carcinoma cell line CaCo-2, grown in vitro under standard culture conditions and in the absence of differentiation inducers, spontaneously exhibits structural and functional characteristics of mature small bowel enterocytes. Differentiation is complete at late confluency. High activities of ornithine d...

journal_title：Gastroenterology

authors： D'Agostino L,Daniele B,Pignata S,Gentile R,Tagliaferri P,Contegiacomo A,Silvestro G,Polistina C,Bianco AR,Mazzacca G

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investi...

journal_title：Gastroenterology

authors： Choi TY,Ninov N,Stainier DY,Shin D

更新日期：2014-03-01 00:00:00

abstract：:Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...

journal_title：Gastroenterology

authors： Broitman SA,Gottlieb LS,Vitale JJ

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...

journal_title：Gastroenterology

authors： Joosten SPJ,Zeilstra J,van Andel H,Mijnals RC,Zaunbrecher J,Duivenvoorden AAM,van de Wetering M,Clevers H,Spaargaren M,Pals ST

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND & AIMS:Surgical management of pancreatic cancer depends on tumor resectability and staging. This study evaluated a new in vivo technique, fiberoptic confocal fluorescence microscopy (FCFM), for detection and staging of pancreatic tumors in rats. METHODS:FCFM was used with a protease-activated fluorescent ma...

journal_title：Gastroenterology

authors： Ignat M,Aprahamian M,Lindner V,Altmeyer A,Perretta S,Dallemagne B,Mutter D,Marescaux J

更新日期：2009-11-01 00:00:00

abstract：:To determine whether pancreatic polypeptide (PP) is a physiologic inhibitor of pancreatic secretion, we have studied the effects of normal rabbit serum and anti-PP serum on pancreatic secretion during infusion of a physiologic dose of PP or intragastric food instillation in dogs. Infusion of 180 pmol/kg X h of PP, pre...

journal_title：Gastroenterology

authors： de Jong AJ,Singer MV,Lamers CB

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...

journal_title：Gastroenterology

authors： Lai JC,Feng S,Roberts JP

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Newly synthesized apical membrane proteins in hepatocytes go first to the basolateral membrane, from which they are retrieved and delivered to the apical domain. The goal of the present study was to identify the vesicular carriers of these molecules. METHODS:The common bile duct of rats was ligated for 10-7...

journal_title：Gastroenterology

authors： Barr VA,Hubbard AL

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND & AIMS:Biliary epithelial cells are the target of numerous immune-mediated liver diseases, yet their role in pathogenesis remains unclear because of difficulties in obtaining pure preparations. The aim of this study was to establish pure clones of immortalized murine intrahepatic biliary epithelial cells. M...

journal_title：Gastroenterology

authors： Paradis K,Le ON,Russo P,St-Cyr M,Fournier H,Bu D

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND & AIMS:Studies implicating primary sclerosing cholangitis as a risk factor for colorectal neoplasia in patients with ulcerative colitis have been limited by small sample size and referral bias. The aim of this study was to determine the relative risk and cumulative incidence of colorectal neoplasia in a larg...

journal_title：Gastroenterology

authors： Loftus EV Jr,Sandborn WJ,Tremaine WJ,Mahoney DW,Zinsmeister AR,Offord KP,Melton LJ 3rd

更新日期：1996-02-01 00:00:00

abstract：:The 70-kb pYV plasmid of Yersinia enterocolitica directs the synthesis and secretion of several virulence determinants called Yops. These proteins are produced during the invasion of the host tissues and induce a strong antibody response. The yop genes are transcribed from strong promoters activated by a common transc...

journal_title：Gastroenterology

authors： Van Damme M,Sory MP,Biot T,Vaerman JP,Cornelis GR

更新日期：1992-08-01 00:00:00

abstract：:The effect of thyroidectomy on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination was determined in the rat. Thyroidectomy resulted in a marked increase in liver alcohol dehydrogenase activity. Three isoenzymes of alcohol dehydrogenase activity were demonstrated in thyroidectomized anim...

journal_title：Gastroenterology

authors： Mezey E,Potter JJ

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

journal_title：Gastroenterology

authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

更新日期：2009-12-01 00:00:00

abstract：:We have conducted a double-blind controlled trial of colchicine in patients with primary biliary cirrhosis. Fifty-seven patients with biopsy-proven primary biliary cirrhosis were randomized to receive either 0.6 mg of colchicine twice daily or an identically appearing placebo. Patients underwent clinical and laborator...

journal_title：Gastroenterology

authors： Bodenheimer H Jr,Schaffner F,Pezzullo J

更新日期：1988-07-01 00:00:00

abstract：:Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...

journal_title：Gastroenterology

authors： Bitar KN,Zfass AM,Makhlouf GM

更新日期：1978-12-01 00:00:00