当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish.

Extensive conversion of hepatic biliary epithelial cells to hepatocytes after near total loss of hepatocytes in zebrafish.

Abstract：

BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investigate this issue, we established a zebrafish model of liver regeneration in which the extent of hepatocyte ablation can be controlled. METHODS:Hepatocytes were depleted by administration of metronidazole to Tg(fabp10a:CFP-NTR) animals. We traced the origin of regenerating hepatocytes using short-term lineage-tracing experiments, as well as the inducible Cre/loxP system; specifically, we utilized both a BEC tracer line Tg(Tp1:CreER(T2)) and a hepatocyte tracer line Tg(fabp10a:CreER(T2)). We also examined BEC and hepatocyte proliferation and liver marker gene expression during liver regeneration. RESULTS:BECs gave rise to most of the regenerating hepatocytes in larval and adult zebrafish after severe hepatocyte depletion. After hepatocyte loss, BECs proliferated as they dedifferentiated into hepatoblast-like cells; they subsequently differentiated into highly proliferative hepatocytes that restored the liver mass. This process was impaired in zebrafish wnt2bb mutants; in these animals, hepatocytes regenerated but their proliferation was greatly reduced. CONCLUSIONS:BECs contribute to regenerating hepatocytes after substantial hepatocyte depletion in zebrafish, thereby leading to recovery from severe liver damage.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Choi TY,Ninov N,Stainier DY,Shin D

doi

10.1053/j.gastro.2013.10.019

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

776-88

issue

3

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(13)01493-5

journal_volume

146

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

    abstract：BACKGROUND & AIMS:Keratins 8 and 18 (K8/K18) provide anti-apoptotic functions upon liver injury. The cytoprotective function of keratins explains the overrepresentation of K8/K18 variants in patients with cirrhosis. However, K8/K18 variant-associated susceptibility to acute liver injury, which is well-described in anim...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2010.06.007

    authors： Strnad P,Zhou Q,Hanada S,Lazzeroni LC,Zhong BH,So P,Davern TJ,Lee WM,Acute Liver Failure Study Group.,Omary MB

    更新日期：2010-09-01 00:00:00

  • Favorable response to parenteral nutrition and medical therapy in Crohn's colitis. A report of 38 patients comparing severe Crohn's and ulcerative colitis.

    abstract：:The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90470-l

    authors： Sitzmann JV,Converse RL Jr,Bayless TM

    更新日期：1990-12-01 00:00:00

  • Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol.

    abstract：BACKGROUND & AIMS:Alterations of hepatic cholesterol metabolism in patients with cholesterol gallstones are still controversial. This study investigated whether hepatic cholesterol metabolism is altered in Japanese patients with cholesterol gallstones. METHODS:In this systematic study of 24 middle-aged nonobese and no...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v110.pm8613070

    authors： Ito T,Kawata S,Imai Y,Kakimoto H,Trzaskos JM,Matsuzawa Y

    更新日期：1996-05-01 00:00:00

  • Cytomegalovirus DNA level on biopsy specimens during treatment of cytomegalovirus gastrointestinal disease.

    abstract：BACKGROUND & AIMS:There is no clear and point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AI...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v111.pm8690210

    authors： Cotte L,Drouet E,Bailly F,Vitozzi S,Denoyel G,Trepo C

    更新日期：1996-08-01 00:00:00

  • Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study.

    abstract：BACKGROUND & AIMS:Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy are associated with occurrence of gastrointestinal and nongastrointestinal cancers. METHODS:We pe...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.02.013

    authors： Shabanzadeh DM,Sørensen LT,Jørgensen T

    更新日期：2017-06-01 00:00:00

  • Human intestinal brush border peptidases.

    abstract：:Hydrolysis of small peptides, like disaccharide hydrolysis, is an important function of the intestinal brush border, but little is known of the individual human peptidases. The purposes of this study were to detect all human brush border enzymes hydrolyzing dipeptides and tripeptides, identify the most discriminating ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(85)80008-1

    authors： Tobey N,Heizer W,Yeh R,Huang TI,Hoffner C

    更新日期：1985-04-01 00:00:00

  • JNJ-56136379, an HBV Capsid Assembly Modulator, Is Well-Tolerated and Has Antiviral Activity in a Phase 1 Study of Patients With Chronic Infection.

    abstract：BACKGROUND & AIMS:JNJ-56136379 (JNJ-6379), a capsid assembly modulator that blocks hepatitis B virus (HBV) replication, was well tolerated and demonstrated dose-proportional pharmacokinetics in healthy participants in part 1 of its first clinical trial. In part 2, we have evaluated the safety, pharmacokinetics, and ant...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.04.036

    authors： Zoulim F,Lenz O,Vandenbossche JJ,Talloen W,Verbinnen T,Moscalu I,Streinu-Cercel A,Bourgeois S,Buti M,Crespo J,Manuel Pascasio J,Sarrazin C,Vanwolleghem T,Shukla U,Fry J,Yogaratnam JZ

    更新日期：2020-08-01 00:00:00

  • Multicenter trial of octreotide in patients with refractory acquired immunodeficiency syndrome-associated diarrhea.

    abstract：BACKGROUND/AIMS:Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea. METHODS:In a 3-week protocol, 129 patients with a stool weight of > 500 g/day despite standard antidiarrh...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/0016-5085(95)90137-x

    authors： Simon DM,Cello JP,Valenzuela J,Levy R,Dickerson G,Goodgame R,Brown M,Lyche K,Fessel WJ,Grendell J

    更新日期：1995-06-01 00:00:00

  • Biliary symptoms and complications more than 8 years after endoscopic sphincterotomy for choledocholithiasis.

    abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v110.pm8608900

    authors： Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

    更新日期：1996-03-01 00:00:00

  • Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.

    abstract：BACKGROUND & AIMS:Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. METHODS:...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2019.05.056

    authors： Moayyedi P,Eikelboom JW,Bosch J,Connolly SJ,Dyal L,Shestakovska O,Leong D,Anand SS,Störk S,Branch KRH,Bhatt DL,Verhamme PB,O'Donnell M,Maggioni AP,Lonn EM,Piegas LS,Ertl G,Keltai M,Bruns NC,Muehlhofer E,Dagenais G

    更新日期：2019-09-01 00:00:00

  • Expression of two types of receptor for insulinlike growth factors in human colonic epithelium.

    abstract：:The presence of receptors for insulinlike growth factor I and II in human colonic epithelium is demonstrated. Scatchard analysis of binding data obtained with 125I-insulinlike growth factor I showed an insulinlike growth factor I receptor with a dissociation constant of 8.6 nM and a binding capacity of 0.8 pmol/mg mem...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90291-8

    authors： Rouyer-Fessard C,Gammeltoft S,Laburthe M

    更新日期：1990-03-01 00:00:00

  • Gum arabic promotes rat jejunal sodium and water absorption from oral rehydration solutions in two models of diarrhea.

    abstract：BACKGROUND & AIMS:We have shown that addition of gum arabic (GA) to a 90 mmol/L sodium-111 mmol/L glucose oral rehydration solution (ORS) enhances its effectiveness for water and electrolyte absorption in normal rats. The present study extends these observations on GA in ORS to two rat models of diarrheal disease. MET...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9178690

    authors： Wapnir RA,Wingertzahn MA,Moyse J,Teichberg S

    更新日期：1997-06-01 00:00:00

  • Fibrosing cytolytic liver failure secondary to recurrent hepatitis B after liver transplantation.

    abstract：:Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)91521-5

    authors： Benner KG,Lee RG,Keeffe EB,Lopez RR,Sasaki AW,Pinson CW

    更新日期：1992-10-01 00:00:00

  • Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury.

    abstract：BACKGROUND & AIMS:Regulation of blood flow and oxygen supply are important pathogenetic factors in alcoholic liver disease. Because nitric oxide may have an important role, its effects on alcoholic liver injury were investigated. METHODS:Rats were fed ethanol intragastrically with either saturated fat or corn oil. Spo...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90400-x

    authors： Nanji AA,Greenberg SS,Tahan SR,Fogt F,Loscalzo J,Sadrzadeh SM,Xie J,Stamler JS

    更新日期：1995-09-01 00:00:00

  • Pancreatic cystic neoplasms: management and unanswered questions.

    abstract：:Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care doctors rely on gastroenterologists for direction because no one wants to miss a diagnosis of pancreatic cancer, but meanwhil...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2013.01.073

    authors： Farrell JJ,Fernández-del Castillo C

    更新日期：2013-06-01 00:00:00

  • Mediation of guinea pig gastric secretion in vitro by cyclic nucleotides.

    abstract：:The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Schebalin M,Zfass AM,Makhlouf GM

    更新日期：1977-07-01 00:00:00

  • Immune activation in patients with irritable bowel syndrome.

    abstract：BACKGROUND AND AIMS:We set out to test the hypothesis that irritable bowel syndrome (IBS) is characterized by an augmented cellular immune response with enhanced production of proinflammatory cytokines. We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinfla...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2007.01.046

    authors： Liebregts T,Adam B,Bredack C,Röth A,Heinzel S,Lester S,Downie-Doyle S,Smith E,Drew P,Talley NJ,Holtmann G

    更新日期：2007-03-01 00:00:00

  • Up-regulation of insulinlike growth factor I binding sites in experimental colitis in rats.

    abstract：BACKGROUND/AIMS:The gastrointestinal tract is a major target of insulinlike growth factor (IGF) I. IGF-I binds to two different receptors and to binding proteins (IGFBPs), which act as carriers and mediators. This study investigated the regulation of IGF-I binding sites in rat colitis. METHODS:Colitis was induced by c...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90435-2

    authors： Zeeh JM,Hoffmann P,Sottili M,Eysselein VE,McRoberts JA

    更新日期：1995-03-01 00:00:00

  • Cholinergic effects on esophageal transit and clearance.

    abstract：:Modern manometric and scintigraphic techniques were employed in an effort to determine the relationships between esophageal contractions and esophageal transit and clearance. The effects of direct cholinergic stimulation with bethanechol and blockade with atropine were evaluated in a total of 20 normal subjects and 13...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Phaosawasdi K,Malmud LS,Tolin RD,Stelzer F,Applegate G,Fisher RS

    更新日期：1981-11-01 00:00:00

  • Hypertrophic smooth muscle in the partially obstructed opossum esophagus. Excitability and electrophysiological properties.

    abstract：:Partial obstruction of the opossum esophagus leads to thickening of the circular muscle, hypertrophy of smooth muscle cells, and diminution of the extracellular space. The pharmacological and electrophysiological properties of this hypertrophied muscle were studied. Carbachol produced phasic and tonic contractions of ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90522-m

    authors： Conklin JL,Du CA,Schulze-Delrieu K,Shirazi S

    更新日期：1991-09-01 00:00:00

  • Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.

    abstract：BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.12.004

    authors： Galandiuk S,Rodriguez-Justo M,Jeffery R,Nicholson AM,Cheng Y,Oukrif D,Elia G,Leedham SJ,McDonald SA,Wright NA,Graham TA

    更新日期：2012-04-01 00:00:00

  • Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.

    abstract：:Acute liver injury was induced experimentally in rats by a single injection of a large amount of D-galactosamine. Hepatocellular damage was apparent from decrease of total serum proteins, marked release of transaminases into the circulation, precipitous decrease of total microsomal proteins, and intracellular enzymes ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Sawamura T,Kawasato S,Shiozaki Y,Sameshima Y,Nakada H,Tashiro Y

    更新日期：1981-09-01 00:00:00

  • Precore mutations and core clustering mutations in chronic hepatitis B virus infection.

    abstract：BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90861-6

    authors： Chuang WL,Omata M,Ehata T,Yokosuka O,Ito Y,Imazeki F,Lu SN,Chang WY,Ohto M

    更新日期：1993-01-01 00:00:00

  • Effect of psyllium, calcium polycarbophil, and wheat bran on secretory diarrhea induced by phenolphthalein.

    abstract：BACKGROUND:Fiber and water-holding agents are used for the treatment of constipation. In what may appear to be a paradox, they are sometimes also used for the treatment of diarrhea; it has been proposed that they sequester water from liquid stools and/or increase the ratio of fecal solids to fecal water and thereby imp...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0016-5085(93)90267-g

    authors： Eherer AJ,Santa Ana CA,Porter J,Fordtran JS

    更新日期：1993-04-01 00:00:00

  • Superficial thrombophlebitis, dysplasia, and cholangiocarcinoma in primary sclerosing cholangitis.

    abstract：:Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed chol...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90182-1

    authors： Martins EB,Fleming KA,Garrido MC,Hine KR,Chapman RW

    更新日期：1994-08-01 00:00:00

  • Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression.

    abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.09.002

    authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

    更新日期：2009-12-01 00:00:00

  • Kinetics of cholesterol and bile acids in patients with cholesterol cholelithiasis.

    abstract：:The kinetics of cholesterol and bile acid was determined from a 10-week analysis of the biliary lipids after a single injection of labeled cholesterol in parallel with a conventional 1-week study of primary bile acid kinetics. Six healthy controls and 6 patients with cholesterol cholelithiasis were studied. Two of the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Hepner GW,Quarfordt SH

    更新日期：1975-08-01 00:00:00

  • Na+/H+ exchange in isolated hamster enterocytes. Its major role in intracellular pH regulation.

    abstract：:The intracellular pH (pHi) of isolated hamster intestinal cells was determined with three techniques: the null-point method with digitonin, the distribution of the weak acid 5,5-dimethyloxazolidine-2,4-dione, and the trapped fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In physiologic saline, ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91492-3

    authors： Goré J,Hoinard C

    更新日期：1989-10-01 00:00:00

  • Relaxation training reduces symptom reports and acid exposure in patients with gastroesophageal reflux disease.

    abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0016-5085(94)90061-2

    authors： McDonald-Haile J,Bradley LA,Bailey MA,Schan CA,Richter JE

    更新日期：1994-07-01 00:00:00

  • Verapamil reversal of serotonin-induced jejunal secretion of water and electrolytes in awake dogs.

    abstract：:Intestinal handling of water and electrolytes was monitored in 5 conscious dogs with chronic 25-cm Thiry-Vella loops of proximal jejunum using a neutral isosmotic perfusate containing [14C]polyethylene glycol as a recovery marker. Under basal conditions the animals absorbed water, Na+, and Cl-, and there was minimal n...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)91102-9

    authors： Zinner MJ,McFadden D,Sherlock D,Jaffe BM

    更新日期：1986-03-01 00:00:00