Hepatic cholesterol metabolism in patients with cholesterol gallstones: enhanced intracellular transport of cholesterol.


BACKGROUND & AIMS:Alterations of hepatic cholesterol metabolism in patients with cholesterol gallstones are still controversial. This study investigated whether hepatic cholesterol metabolism is altered in Japanese patients with cholesterol gallstones. METHODS:In this systematic study of 24 middle-aged nonobese and nondiabetic Japanese patients who had cholesterol gallstones and were undergoing elective cholecystectomy, an analysis of three regulatory enzymes in the cholesterol metabolism, as well as cytosolic total and free cholesterol levels and sterol carrier protein 2/nonspecific lipid transfer protein (SCP2/nsLTP) levels, was conducted using liver biopsy samples obtained during surgery. RESULTS:The activities of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, cholesterol 7 alpha-hydroxylase, and acyl-CoA/cholesterol acyltransferase were not significantly different between patients and controls. Nevertheless, patients with gallstones showed tendencies for elevated HMG-CoA reductase activity and protein content and decreased cholesterol 7 alpha-hydroxylase activities. As anticipated, serum levels of 7 alpha-hydroxycholesterol and squalene paralleled these findings. The patients with gallstones also had significantly increased cytosolic total and free cholesterol levels (P < 0.001), which correlated strongly with increased cytosolic levels of SCP2/nsLTP (r = 0.80, P < 0.001 and r = 0.81, P < 0.001, respectively). CONCLUSIONS:The results suggest that intracellular cholesterol transport is enhanced in patients with cholesterol gallstones.






Ito T,Kawata S,Imai Y,Kakimoto H,Trzaskos JM,Matsuzawa Y




Has Abstract


1996-05-01 00:00:00














  • Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus.

    abstract:BACKGROUND AND AIMS:Prolonged lamivudine therapy is associated with treatment-resistant YMDD mutant hepatitis B virus (HBV). We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV. METHODS:Ninety-five patients with compensated ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Perrillo R,Hann HW,Mutimer D,Willems B,Leung N,Lee WM,Moorat A,Gardner S,Woessner M,Bourne E,Brosgart CL,Schiff E

    更新日期:2004-01-01 00:00:00

  • Spontaneous bacterial empyema in cirrhosis.

    abstract::Spontaneous bacterial peritonitis in decompensated cirrhotic patients develops when bacteria invade preexising ascites. It is probable that other transudates such as pleural effusions can be afected in a similar manner. This paper describes a cirrhotic patient with long-standing pleural effusion in whom Escherichia co...


    pub_type: 杂志文章


    authors: Flaum MA

    更新日期:1976-03-01 00:00:00

  • Chemoprevention of colorectal neoplasia: the potential for personalized medicine.

    abstract::CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...


    pub_type: 杂志文章,评审


    authors: Arber N,Levin B

    更新日期:2008-04-01 00:00:00

  • Organoid Models of Human Gastrointestinal Development and Disease.

    abstract::We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...


    pub_type: 杂志文章,评审


    authors: Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

    更新日期:2016-05-01 00:00:00

  • A starring role for stellate cells in the pancreatic cancer microenvironment.

    abstract::Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...


    pub_type: 杂志文章,评审


    authors: Apte MV,Wilson JS,Lugea A,Pandol SJ

    更新日期:2013-06-01 00:00:00

  • Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice.

    abstract:BACKGROUND & AIMS:Tumor necrosis factor alpha (TNF-alpha) release plays a pivotal role in the pathogenesis of liver injury induced by lipopolysaccharide (LPS) administration in D-galactosamine (GalN)-sensitized mice. Interleukin (IL) 10 is an anti-inflammatory cytokine that inhibits TNF-alpha synthesis and release both...


    pub_type: 杂志文章


    authors: Santucci L,Fiorucci S,Chiorean M,Brunori PM,Di Matteo FM,Sidoni A,Migliorati G,Morelli A

    更新日期:1996-09-01 00:00:00

  • A critique of therapeutic trials in Helicobacter pylori-positive functional dyspepsia.

    abstract:BACKGROUND/AIMS:Approximately 50% of patients with functional dyspepsia have Helicobacter pylori infection; it remains controversial whether this infection causes chronic symptoms, but rigorously conducted therapeutic trials should establish whether H. pylori plays a role in functional dyspepsia. The aim here was to de...


    pub_type: 杂志文章,评审


    authors: Talley NJ

    更新日期:1994-05-01 00:00:00

  • Involvement of 5-hydroxytryptamine 3 receptors in regulation of interdigestive gastric contractions by motilin in the dog.

    abstract::The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouch in the conscious state by means of chronically implanted force transducers in the gastrointestinal tract and the pouch. I...


    pub_type: 杂志文章


    authors: Itoh Z,Mizumoto A,Iwanaga Y,Yoshida N,Torii K,Wakabayashi K

    更新日期:1991-04-01 00:00:00

  • Involvement of tumor necrosis factor-alpha in the pathogenesis of activated macrophage-mediated hepatitis in mice.

    abstract::The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuc...


    pub_type: 杂志文章


    authors: Nagakawa J,Hishinuma I,Hirota K,Miyamoto K,Yamanaka T,Tsukidate K,Katayama K,Yamatsu I

    更新日期:1990-09-01 00:00:00

  • Hepatocellular carcinoma: an unusual course with hyperthyroidism and inappropriate thyroid-stimulating hormone production.

    abstract::A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...


    pub_type: 杂志文章


    authors: Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

    更新日期:1985-01-01 00:00:00

  • Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

    abstract:BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...


    pub_type: 杂志文章


    authors: Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

    更新日期:2019-05-01 00:00:00

  • Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.

    abstract:BACKGROUND & AIMS:Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice. METHODS:We analyzed data from 541 patients with CRC in The Cancer Genome Atlas database fo...


    pub_type: 杂志文章


    authors: Coleman OI,Lobner EM,Bierwirth S,Sorbie A,Waldschmitt N,Rath E,Berger E,Lagkouvardos I,Clavel T,McCoy KD,Weber A,Heikenwalder M,Janssen KP,Haller D

    更新日期:2018-11-01 00:00:00

  • Increased prevalence of precancerous changes in relatives of gastric cancer patients: critical role of H. pylori.

    abstract:BACKGROUND & AIMS:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhyd...


    pub_type: 杂志文章


    authors: El-Omar EM,Oien K,Murray LS,El-Nujumi A,Wirz A,Gillen D,Williams C,Fullarton G,McColl KE

    更新日期:2000-01-01 00:00:00

  • Primary hepatic actinomycosis.

    abstract::Fever of 10 mo duration in a man of 35 yr was discovered at the time of a second laparatomy to be caused by actinomycotic infection of the liver. Actinomycosis of the liver usually presents as large single or as multiple abscesses. In this patient only nonspecific cellular infiltrates of the liver were found in liver ...


    pub_type: 杂志文章


    authors: Meade RH 3rd

    更新日期:1980-02-01 00:00:00

  • Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice.

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    pub_type: 杂志文章


    authors: Manieri NA,Drylewicz MR,Miyoshi H,Stappenbeck TS

    更新日期:2012-07-01 00:00:00

  • Wilson's disease in patients presenting with liver disease: a diagnostic challenge.

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    pub_type: 杂志文章


    authors: Steindl P,Ferenci P,Dienes HP,Grimm G,Pabinger I,Madl C,Maier-Dobersberger T,Herneth A,Dragosics B,Meryn S,Knoflach P,Granditsch G,Gangl A

    更新日期:1997-07-01 00:00:00

  • Recurrent familial prolonged intrahepatic cholestasis of pregnancy associated with chronic liver disease.

    abstract::Four Puerto Rican sisters had recurrent prolonged cholestasis of pregnancy without preexisting or intercurrent hepatic disorders. Available information was reviewed on the course, mechanism, and sequelae of prolonged recurrent cholestasis after 14 pregnancies in the 4 sisters. Etiologic, clinical, laboratory, radiolog...


    pub_type: 杂志文章


    authors: Leevy CB,Koneru B,Klein KM

    更新日期:1997-09-01 00:00:00

  • Germline mutations of EXO1 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms.

    abstract:BACKGROUND & AIMS:Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the...


    pub_type: 杂志文章


    authors: Wu Y,Berends MJ,Post JG,Mensink RG,Verlind E,Van Der Sluis T,Kempinga C,Sijmons RH,van der Zee AG,Hollema H,Kleibeuker JH,Buys CH,Hofstra RM

    更新日期:2001-06-01 00:00:00

  • Verapamil reversal of serotonin-induced jejunal secretion of water and electrolytes in awake dogs.

    abstract::Intestinal handling of water and electrolytes was monitored in 5 conscious dogs with chronic 25-cm Thiry-Vella loops of proximal jejunum using a neutral isosmotic perfusate containing [14C]polyethylene glycol as a recovery marker. Under basal conditions the animals absorbed water, Na+, and Cl-, and there was minimal n...


    pub_type: 杂志文章


    authors: Zinner MJ,McFadden D,Sherlock D,Jaffe BM

    更新日期:1986-03-01 00:00:00

  • Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus.

    abstract:BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...


    pub_type: 杂志文章


    authors: Thompson AJ,Muir AJ,Sulkowski MS,Ge D,Fellay J,Shianna KV,Urban T,Afdhal NH,Jacobson IM,Esteban R,Poordad F,Lawitz EJ,McCone J,Shiffman ML,Galler GW,Lee WM,Reindollar R,King JW,Kwo PY,Ghalib RH,Freilich B,Nyberg

    更新日期:2010-07-01 00:00:00

  • Effect of peptic digestion on emptying of cooked liver in dogs.

    abstract::By speeding the fragmentation of meat, peptic digestion might accelerate gastric emptying. To examine this possibility, mongrel dogs prepared with chronic duodenal fistulas were fed steak and 99mTc-labeled chicken liver, measuring 99mTc in all chyme exiting from the stomach out the duodenal fistula allowed quantitatio...


    pub_type: 杂志文章


    authors: Ohashi H,Meyer JH

    更新日期:1980-08-01 00:00:00

  • Effect of glucagon infusion on the renal clearance of amylase relative to creatinine.

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    pub_type: 临床试验,杂志文章


    authors: Tedesco FJ,Davila E,Gardner LB

    更新日期:1978-10-01 00:00:00

  • Factors Associated With Shorter Colonoscopy Surveillance Intervals for Patients With Low-Risk Colorectal Adenomas and Effects on Outcome.

    abstract:BACKGROUND & AIMS:Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs; 1-2 small tubular adenomas, < 1 cm) every 5-10 years for colorectal cancer; many recommend shorter surveillance intervals for these individuals. We aimed to identify the reasons that endoscopists recomm...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Anderson JC,Baron JA,Ahnen DJ,Barry EL,Bostick RM,Burke CA,Bresalier RS,Church TR,Cole BF,Cruz-Correa M,Kim AS,Mott LA,Sandler RS,Robertson DJ

    更新日期:2017-06-01 00:00:00

  • Hypervitaminosis A unmasked by acute viral hepatitis.

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    pub_type: 杂志文章


    authors: Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JB

    更新日期:1982-01-01 00:00:00

  • Estrogen enhances dietary cholesterol induction of saturated bile in the hamster.

    abstract::The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...


    pub_type: 杂志文章


    authors: Coyne MJ,Bonorris GG,Chung A,Winchester R,Schoenfield LJ

    更新日期:1978-07-01 00:00:00

  • Relapsing ulcerative colitis associated with spinal cord stimulation.

    abstract::Spinal cord stimulation is an increasingly popular form of pain treatment. An electrode positioned on the dorsal aspect of the spinal cord at the level of the nerve roots from the painful area stimulates the spinal cord. Current from the electrode is supplied by a pulse generator in the lower anterior abdominal wall. ...


    pub_type: 杂志文章


    authors: Kemler MA,Barendse GA,Van Kleef M

    更新日期:1999-07-01 00:00:00

  • Effects of nonsteroidal anti-inflammatory drugs and misoprostol on gastroduodenal epithelial proliferation in arthritis.

    abstract::In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...


    pub_type: 临床试验,杂志文章


    authors: Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

    更新日期:1992-05-01 00:00:00

  • Long-term antigen challenge results in progressively diminished mucosal mast cell degranulation in rats.

    abstract:BACKGROUND & AIMS:The effects of short-term antigenic activation of mast cells on the gastrointestinal tract have been well characterized, but little is known about the effects of long-term exposure to antigen on mucosal mast cell reactivity. The aim of this study was to determine the effects of long-term antigen expos...


    pub_type: 杂志文章


    authors: Rioux KP,Wallace JL

    更新日期:1996-12-01 00:00:00

  • Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation.

    abstract::Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...


    pub_type: 杂志文章


    authors: Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

    更新日期:1990-08-01 00:00:00

  • Effects of bile salts on energy metabolism and acid secretion by the isolated toad gastric mucosa.

    abstract::The effects of bile salts on energy metabolism and acid secretion were investigated in the amphibian gastric mucosa in vitro. Serosal exposure to deoxycholate (0.2-2 mM), cholate (2-8 mM), or taurocholate (4-80 mM), at pH 7.4, decreased acid secretion depending on the concentration and time of exposure. Mucosal applic...


    pub_type: 杂志文章


    authors: Núñez D,Chacín J

    更新日期:1989-01-01 00:00:00