Mediation of guinea pig gastric secretion in vitro by cyclic nucleotides.

abstract：BACKGROUND & AIMS:Conflicting results have been published concerning the effects of different opioid-receptor agonists against visceral noxious stimulation. The introduction of colorectal distention facilitates research in this field. The aim of this study was to examine intrathecally administered opioid agonists again...

journal_title：Gastroenterology

authors： Borgbjerg FM,Frigast C,Madsen JB,Mikkelsen LF

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND & AIMS:Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci ...

journal_title：Gastroenterology

authors： Dong J,Maj C,Tsavachidis S,Ostrom QT,Gharahkhani P,Anderson LA,Wu AH,Ye W,Bernstein L,Borisov O,Schröder J,Chow WH,Gammon MD,Liu G,Caldas C,Pharoah PD,Risch HA,May A,Gerges C,Anders M,Venerito M,Schmidt T,Izbi

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatopulmonary syndrome (HPS) affects 10%-30% of patients with cirrhosis and portal hypertension and significantly increases mortality. Studies in experimental models indicate that pulmonary angiogenesis contributes to the development of HPS, but pathogenesis in humans is poorly understood. We invest...

journal_title：Gastroenterology

authors： Roberts KE,Kawut SM,Krowka MJ,Brown RS Jr,Trotter JF,Shah V,Peter I,Tighiouart H,Mitra N,Handorf E,Knowles JA,Zacks S,Fallon MB,Pulmonary Vascular Complications of Liver Disease Study Group.

更新日期：2010-07-01 00:00:00

abstract：:The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbo...

journal_title：Gastroenterology

authors： Variyam EP,Hoskins LC

更新日期：1983-03-01 00:00:00

abstract：:The reason why hepatocellular carcinoma occurs less frequently in women than in men is unknown. The possibility that differences in the hepatitis B virus status between men and women with this tumor might be important in this regard was investigated in 75 black women and 75 age- and ethnically-matched men with hepatoc...

journal_title：Gastroenterology

authors： Kew MC,Rossouw E,Paterson A,Hodkinson J,Whitcutt M,Dusheiko G

更新日期：1983-04-01 00:00:00

abstract：:The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuc...

journal_title：Gastroenterology

authors： Nagakawa J,Hishinuma I,Hirota K,Miyamoto K,Yamanaka T,Tsukidate K,Katayama K,Yamatsu I

更新日期：1990-09-01 00:00:00

abstract：:The major modes of presentation of patients with celiac disease are the classic diarrhea-predominant form and silent celiac disease. Those with silent celiac disease lack diarrhea, although they may present with manifestations of celiac disease that include an irritable bowel syndrome, anemia, osteoporosis, neurologic...

journal_title：Gastroenterology

authors： Green PH

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND & AIMS:Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver inj...

journal_title：Gastroenterology

authors： Pradhan-Sundd T,Vats R,Russell JO,Singh S,Michael AA,Molina L,Kakar S,Cornuet P,Poddar M,Watkins SC,Nejak-Bowen KN,Monga SP,Sundd P

更新日期：2018-10-01 00:00:00

abstract：:Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the c...

journal_title：Gastroenterology

authors： Nugent FW,Haggit RC,Colcher H,Kutteruf GC

更新日期：1979-01-01 00:00:00

abstract：:The genes associated with each of the inherited syndromes of colon cancer have now been identified, and genetic testing is available for diagnosis. These syndromes include familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and, possibly, Cowd...

journal_title：Gastroenterology

authors： Burt R,Neklason DW

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND & AIMS:An association between water sources and the prevalence of Helicobacter pylori infection in Peruvian children was shown previously. The aim of this study was to confirm the presence of H. pylori in drinking water in the same community. METHODS:Forty-eight drinking water samples from different locatio...

journal_title：Gastroenterology

authors： Hulten K,Han SW,Enroth H,Klein PD,Opekun AR,Gilman RH,Evans DG,Engstrand L,Graham DY,El-Zaatari FA

更新日期：1996-04-01 00:00:00

abstract：:The human colon carcinoma cell line CaCo-2, grown in vitro under standard culture conditions and in the absence of differentiation inducers, spontaneously exhibits structural and functional characteristics of mature small bowel enterocytes. Differentiation is complete at late confluency. High activities of ornithine d...

journal_title：Gastroenterology

authors： D'Agostino L,Daniele B,Pignata S,Gentile R,Tagliaferri P,Contegiacomo A,Silvestro G,Polistina C,Bianco AR,Mazzacca G

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...

journal_title：Gastroenterology

authors： Bruix J,Poynard T,Colombo M,Schiff E,Burak K,Heathcote EJ,Berg T,Poo JL,Mello CB,Guenther R,Niederau C,Terg R,Bedossa P,Boparai N,Griffel LH,Burroughs M,Brass CA,Albrecht JK,EPIC3 Study Group.

更新日期：2011-06-01 00:00:00

abstract：:Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...

journal_title：Gastroenterology

authors： Buts JP,Vaerman JP,Lescoat G

更新日期：1992-03-01 00:00:00

abstract：:In rats, hypergastrinemia due to achlorhydria produced by antisecretory drugs or resection of the gastric fundus leads to enterochromaffinlike (ECL) cell hyperplasia and gastric carcinoids. In humans, achlorhydria due to pernicious anemia may also lead to ECL cell hyperplasia and multicentric gastric carcinoids in as ...

journal_title：Gastroenterology

authors： Hirschowitz BI,Griffith J,Pellegrin D,Cummings OW

更新日期：1992-04-01 00:00:00

abstract：:A case of acute bacterial endocarditis is presented in which gallbladder infarction and areas of hepatic infarction were documented. Selective angiography showed findings consistent with emboli to the gallbladder and hepatic circulations. ...

journal_title：Gastroenterology

authors： Henrich WL,Huehnegarth RJ,Rösch J,Melnyk CS

更新日期：1975-06-01 00:00:00

abstract：:Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagonized by bilateral cervical vagoto...

journal_title：Gastroenterology

authors： Rattan S,Goyal RK

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND & AIMS:Several studies have shown that signaling via the interleukin 23 (IL23) receptor is required for development of colitis. We studied the roles of IL23, dietary factors, alterations to the microbiota, and T cells in the development and progression of colitis in mice. METHODS:All mice were maintained on...

journal_title：Gastroenterology

authors： Chen L,He Z,Iuga AC,Martins Filho SN,Faith JJ,Clemente JC,Deshpande M,Jayaprakash A,Colombel JF,Lafaille JJ,Sachidanandam R,Furtado GC,Lira SA

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND & AIMS:Risk factors for cardiovascular disease, such as obesity and hypertension, have been associated with nonalcoholic fatty liver disease. Psychological distress (symptoms of anxiety and depression) is a risk factor for cardiovascular disease, so it might also be associated, directly or indirectly, with l...

journal_title：Gastroenterology

authors： Russ TC,Kivimäki M,Morling JR,Starr JM,Stamatakis E,Batty GD

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy. METHODS:Two hundred forty-four consecutive hepatitis B surface antigen (HBsAg)-negative lymphoma patients ...

journal_title：Gastroenterology

authors： Hui CK,Cheung WW,Zhang HY,Au WY,Yueng YH,Leung AY,Leung N,Luk JM,Lie AK,Kwong YL,Liang R,Lau GK

更新日期：2006-07-01 00:00:00

abstract：:Hepatic plasma flow was assessed with sorbitol (hepatic extraction = 0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal sorbitol clearances were calculated, and the extrarenal clearance was obtained by taking the difference between the two. In normal volunteers, the mean (+/- SD) extrarenal so...

journal_title：Gastroenterology

authors： Zeeh J,Lange H,Bosch J,Pohl S,Loesgen H,Eggers R,Navasa M,Chesta J,Bircher J

更新日期：1988-09-01 00:00:00

abstract：:Insulinlike growth factor I is a potent mitogen with insulinlike metabolic effects. Insulinlike growth factor I is synthesized in the liver, intestine, and other organs. Insulinlike growth factor I receptors are widely distributed and structurally similar to insulin receptors. Frozen sections of rabbit gastrointestina...

journal_title：Gastroenterology

authors： Termanini B,Nardi RV,Finan TM,Parikh I,Korman LY

更新日期：1990-07-01 00:00:00

abstract：:Aminopeptidase M (APM) was localized in the kidney and alimentary tract of guinea pigs and rats by indirect immunohistochemistry. APM was detected in the brush border of the epithelium of the proximal convoluted tubule of the kidney and of the small intestine, and it was localized to cells scattered throughout lymphoi...

journal_title：Gastroenterology

authors： Terashima H,Wong H,Kobayashi R,Bunnett NW

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

journal_title：Gastroenterology

authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...

journal_title：Gastroenterology

authors： van der Helm J,Geskus R,Sabin C,Meyer L,Del Amo J,Chêne G,Dorrucci M,Muga R,Porter K,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND & AIMS:Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemo...

journal_title：Gastroenterology

authors： Jeffers L,Chalasani N,Balart L,Pyrsopoulos N,Erhardtsen E

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...

journal_title：Gastroenterology

authors： Fukudo S,Kinoshita Y,Okumura T,Ida M,Akiho H,Nakashima Y,Nishida A,Haruma K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...

journal_title：Gastroenterology

authors： Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...

journal_title：Gastroenterology

authors： Andersson J,Bümming P,Meis-Kindblom JM,Sihto H,Nupponen N,Joensuu H,Odén A,Gustavsson B,Kindblom LG,Nilsson B

更新日期：2006-05-01 00:00:00

abstract：:Using flowing isotonic NaCl or flowing molar KCl electrodes, the magnitude of liquid junction potentials between the electrode tip and gastric juice was measured directly, and calculated from electrolyte concentrations in gastric juice according to standard formulas. Gastric transepithelial potential difference was ob...

journal_title：Gastroenterology

authors： Read NW,Fordtran JS

更新日期：1979-05-01 00:00:00