The many faces of celiac disease: clinical presentation of celiac disease in the adult population.

abstract：BACKGROUND & AIMS:Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy are associated with occurrence of gastrointestinal and nongastrointestinal cancers. METHODS:We pe...

journal_title：Gastroenterology

authors： Shabanzadeh DM,Sørensen LT,Jørgensen T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:The basic mechanisms of food allergies are still unknown. The aims of this study were to investigate whether endothelins (ETs) in the intestinal mucosa are involved in the pathogenesis of intestinal anaphylaxis. METHODS:Sprague-Dawley rats were sensitized to chicken egg albumin (EA) by intraperitonea...

journal_title：Gastroenterology

authors： Shigematsu T,Miura S,Hirokawa M,Hokari R,Higuchi H,Tsuzuki Y,Kimura H,Nakatsumi RC,Serizawa H,Saito H,Ishii H

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited. METHODS:We conducted a prospective study of 47,363 male health professionals who were ages 40-75 years at enrollment in 1986. Biennially, we collected data on aspirin use, othe...

journal_title：Gastroenterology

authors： Chan AT,Giovannucci EL,Meyerhardt JA,Schernhammer ES,Wu K,Fuchs CS

更新日期：2008-01-01 00:00:00

abstract：:To find a possible explanation for the selective hepatic conjugation of bile acids with glycine or taurine, the N-acyl amidates of cholic acid and a number of amino acids and amino acid analogues were synthesized, and their susceptibility to hydrolysis by pancreatic juice, gastric juice, serum, or small intestinal muc...

journal_title：Gastroenterology

authors： Huijghebaert SM,Hofmann AF

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Endogenous nitric oxide has been implicated in the control of mesenteric circulation, but its role in the control of pancreatic blood flow and exocrine pancreatic secretion has not been studied. METHODS:Secretory studies were performed on conscious dogs with chronic pancreatic fistulas, and changes in pancr...

journal_title：Gastroenterology

authors： Konturek SJ,Bilski J,Konturek PK,Cieszkowski M,Pawlik W

更新日期：1993-03-01 00:00:00

abstract：:A pancreatic somatostatinoma metastatized to the liver was detected in a 70-yr-old woman presenting with chronic diarrhea, steatorrhea, pancreatic insufficiency, diabetes mellitus, and achlorhydria. At immunocytochemistry, most tumor cells stored both somatostatin and calcitoninlike substances. Chromatography of acid ...

journal_title：Gastroenterology

authors： Galmiche JP,Chayvialle JA,Dubois PM,David L,Descos F,Paulin C,Ducastelle T,Colin R,Geffroy Y

更新日期：1980-06-01 00:00:00

abstract：:Phenobarbital response, bile pigment composition, and the fractional biliary excretion ratio of bilirubin were studied in nine children with Crigler-Najjar disease. In five children, serum bilirubin levels decreased during phenobarbital treatment by 26% or more and the pigment composition in bile changed with a decrea...

journal_title：Gastroenterology

authors： Sinaasappel M,Jansen PL

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of Hirschsprung disease (total colonic aganglionosis). However, 80% o...

journal_title：Gastroenterology

authors： Lai FP,Lau ST,Wong JK,Gui H,Wang RX,Zhou T,Lai WH,Tse HF,Tam PK,Garcia-Barcelo MM,Ngan ES

更新日期：2017-07-01 00:00:00

abstract：:Human intrinsic factor (IF) is found on the surface of parietal cells at the light microscopic level by immunofluorescence, but there is no direct evidence that IF is synthesized in and secreted from this cell. In order to provide this evidence, IF was localized at the ultrastructural level in human stomach, using an ...

journal_title：Gastroenterology

authors： Levine JS,Nakane PK,Allen RH

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND & AIMS:Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells a...

journal_title：Gastroenterology

authors： Morey P,Pfannkuch L,Pang E,Boccellato F,Sigal M,Imai-Matsushima A,Dyer V,Koch M,Mollenkopf HJ,Schlaermann P,Meyer TF

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND/AIMS:Platelet-activating factor (PAF) is involved in the pathophysiology of motility changes induced by intestinal inflammation. The aim of this study was to evaluate a possible desensitization of PAF receptors in guinea pig intestinal smooth muscle cells after experimental inflammation induced by trinitrobe...

journal_title：Gastroenterology

authors： Jeanneton O,Delvaux M,Frexinos J,Bueno L

更新日期：1995-06-01 00:00:00

abstract：:The published world literature on the efficacy of cimetidine, a histamine H2-receptor antagonist, in the treatment of duodenal ulcer is reviewed. In eight prospective randomized double blind placebo-controlled studies, cimetidine was administered to 348 duodenal ulcer patients with an incidence of endoscopically verif...

journal_title：Gastroenterology

authors： Winship DH

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

journal_title：Gastroenterology

authors： Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND AND AIMS:It is not clear what induction dose of mesalamine is optimal for treating patients with mildly and moderately active ulcerative colitis (UC). This study was conducted to determine the efficacy and safety of mesalamine 4.8 g/day compared with 2.4 g/day for the treatment of moderately active UC. METH...

journal_title：Gastroenterology

authors： Sandborn WJ,Regula J,Feagan BG,Belousova E,Jojic N,Lukas M,Yacyshyn B,Krzeski P,Yeh CH,Messer CA,Hanauer SB

更新日期：2009-12-01 00:00:00

abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...

journal_title：Gastroenterology

authors： Debes JD,van Tilborg M,Groothuismink ZMA,Hansen BE,Schulze Zur Wiesch J,von Felden J,de Knegt RJ,Boonstra A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...

journal_title：Gastroenterology

authors： Maaser C,Eckmann L,Paesold G,Kim HS,Kagnoff MF

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND & AIMS:The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional diarrhea and diarrhea-predominant irritable bowel sy...

journal_title：Gastroenterology

authors： Carrasco-Labra A,Lytvyn L,Falck-Ytter Y,Surawicz CM,Chey WD

更新日期：2019-09-01 00:00:00

abstract：:Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...

journal_title：Gastroenterology

authors： Whitehead WE,Cheskin LJ,Heller BR,Robinson JC,Crowell MD,Benjamin C,Schuster MM

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptor (TLR)-dependent signaling was proposed as immunotherapeutic targets against invading pathogens and tumorigenesis. Here, we investigated whether TLR5-dependent signaling modulates colonic tumor development in mouse xenograft model of human colon cancer. METHODS:The expression of mye...

journal_title：Gastroenterology

authors： Rhee SH,Im E,Pothoulakis C

更新日期：2008-08-01 00:00:00

abstract：:Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...

journal_title：Gastroenterology

authors： Surawicz CM,Levine DS,Saunders DR,Rubin CE

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

journal_title：Gastroenterology

authors： Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...

journal_title：Gastroenterology

authors： Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

更新日期：2011-07-01 00:00:00

abstract：:Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hyp...

journal_title：Gastroenterology

authors： Bonaz BL,Bernstein CN

更新日期：2013-01-01 00:00:00

abstract：:A 36-year-old woman was admitted to hospital with a first attack of acute intermittent porphyria. At the same time increased serum levels of amylase and lipase as well as an increased amylase clearance to creatinine clearance ratio were observed, permitting the diagnosis of acute pancreatitis. The etiology of the latt...

journal_title：Gastroenterology

authors： Kobza K,Gyr K,Neuhaus K,Gudat F

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND & AIMS:In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways t...

journal_title：Gastroenterology

authors： Gougelet A,Sartor C,Senni N,Calderaro J,Fartoux L,Lequoy M,Wendum D,Talbot JN,Prignon A,Chalaye J,Imbeaud S,Zucman-Rossi J,Tordjmann T,Godard C,Bossard P,Rosmorduc O,Amaddeo G,Colnot S

更新日期：2019-09-01 00:00:00

abstract：:We have previously shown that in pregnancy fasting gallbladder volume is increased and emptying after a small volume liquid meal is incomplete. In this study we measured gallbladder volume throughout day and night in healthy women ingesting regular meals. Pregnant women, postpartum women, contraceptive-steroid users, ...

journal_title：Gastroenterology

authors： Everson GT,McKinley C,Lawson M,Johnson M,Kern F Jr

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with irritable bowel syndrome with diarrhea (IBS-D) have increased mucosal serotonin (5-hydroxytryptamine [5-HT]) availability, possibly because immune activation reduces activity of the 5-HT transporter (SERT). We investigated the relationship between mucosal and platelet SERT and immune act...

journal_title：Gastroenterology

authors： Foley S,Garsed K,Singh G,Duroudier NP,Swan C,Hall IP,Zaitoun A,Bennett A,Marsden C,Holmes G,Walls A,Spiller RC

更新日期：2011-05-01 00:00:00

abstract：:Sphincter of Oddi (SO) manometry was conducted in 48 subjects who had previously undergone cholecystectomy. Ten of these subjects had no detectable biliary or pancreatic disease and served as controls. The other 38 patients were presumed to have SO dysfunction and had presented with episodes of severe biliary-type pai...

journal_title：Gastroenterology

authors： Toouli J,Roberts-Thomson IC,Dent J,Lee J

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...

journal_title：Gastroenterology

authors： Thompson AJ,Muir AJ,Sulkowski MS,Ge D,Fellay J,Shianna KV,Urban T,Afdhal NH,Jacobson IM,Esteban R,Poordad F,Lawitz EJ,McCone J,Shiffman ML,Galler GW,Lee WM,Reindollar R,King JW,Kwo PY,Ghalib RH,Freilich B,Nyberg

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The chemokines CCL19 and CCL21 bind CCR7, which is involved in the organization of secondary lymphoid tissue and is expressed during chronic tissue inflammation. We investigated the expression of CCL21 and CCR7 in chronic hepatitis C. The effects of CCL21 on hepatic stellate cells (HSCs) were also s...

journal_title：Gastroenterology

authors： Bonacchi A,Petrai I,Defranco RM,Lazzeri E,Annunziato F,Efsen E,Cosmi L,Romagnani P,Milani S,Failli P,Batignani G,Liotta F,Laffi G,Pinzani M,Gentilini P,Marra F

更新日期：2003-10-01 00:00:00