Abstract:
:Hepatic plasma flow was assessed with sorbitol (hepatic extraction = 0.96) at steady state. After infusion of 50 mg/min for 3 h, total and renal sorbitol clearances were calculated, and the extrarenal clearance was obtained by taking the difference between the two. In normal volunteers, the mean (+/- SD) extrarenal sorbitol clearance was 10.6 +/- 2.1 ml/min.kg. In patients with various liver diseases, it was correlated more closely to the fractional clearance of indocyanine green (r = 0.83, n = 57) than the galactose elimination capacity (r = 0.66, n = 55). Hepatic vein catheterization showed that the hepatic extraction of sorbitol was always much higher than the extraction of indocyanine green; there was no evidence for extrahepatic, extrarenal sorbitol elimination. On the basis of these findings, sorbitol is kinetically superior to indocyanine green and, although the noninvasively determined extrarenal sorbitol clearance at steady state may not be equal to total hepatic plasma flow, it may at least be regarded as a measure of parenchymal liver plasma flow.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Zeeh J,Lange H,Bosch J,Pohl S,Loesgen H,Eggers R,Navasa M,Chesta J,Bircher Jdoi
10.1016/s0016-5085(88)80024-6subject
Has Abstractpub_date
1988-09-01 00:00:00pages
749-59issue
3eissn
0016-5085issn
1528-0012pii
S0016-5085(88)80024-6journal_volume
95pub_type
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