当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.

Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.

Abstract：

BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver hyperplasia and carcinogenesis. METHODS:Rats were fed hepatocarcinogenic peroxisome proliferator agents for 3 days to 10 months. Livers were examined for proliferation markers, activity and cellular distribution of sex steroid receptors, and key enzymes in sex hormone homeostasis. RESULTS:At all times, liver weight and proliferation markers in treated rats were increased. Early exposure resulted in increased nuclear estrogen and androgen receptor activity in treated rats. Tumors that developed after 9-10 months showed a marked decrease in estrogen receptor activity and, in contrast, an increase in androgen receptor activity, as did liver surrounding the tumors. Both short-term and long-term exposure to the carcinogens resulted in dramatic reductions in steroid metabolism. CONCLUSIONS:This study supports the thesis that, in preneoplastic stages such as hyperplasia, there is an elevation of both receptor activities and that the progression from hyperplasia to cancer results in suppression of estrogen receptor expression but maintenance of androgen receptor.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

doi

10.1053/gast.1996.v110.pm8613010

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

1199-207

issue

4

eissn

0016-5085

issn

1528-0012

pii

S001650859600176X

journal_volume

110

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Early detection of protein depletion in alcoholic cirrhosis: role of body composition analysis.

    abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)91083-t

    authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

    更新日期：1993-12-01 00:00:00

  • Expression of HLA-linked hemochromatosis in subjects homozygous or heterozygous for the C282Y mutation.

    abstract：BACKGROUND & AIMS:In the absence of a genetic test, diagnostic criteria for hereditary hemochromatosis have been imprecise. The identification of the HFE gene and the C282Y mutation allow definition of expression of this disease and reassessment of diagnostic criteria. The aim of this study was to analyze the concordan...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70320-8

    authors： Crawford DH,Jazwinska EC,Cullen LM,Powell LW

    更新日期：1998-05-01 00:00:00

  • Bone disease in cholestatic liver disease.

    abstract：:Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/0016-5085(95)90033-0

    authors： Hay JE

    更新日期：1995-01-01 00:00:00

  • Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study.

    abstract：BACKGROUND & AIMS:Seroclearance of hepatitis B surface antigen (HBsAg) is one of the most important clinical outcomes for chronic hepatitis B treatment trials. Few studies have explored the incidence and determinants of spontaneous seroclearance using a long-term follow-up study. This study aimed to examine the natural...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.04.048

    authors： Liu J,Yang HI,Lee MH,Lu SN,Jen CL,Wang LY,You SL,Iloeje UH,Chen CJ,REVEAL-HBV Study Group.

    更新日期：2010-08-01 00:00:00

  • Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus.

    abstract：BACKGROUND & AIMS:Early growth response gene-1 (Egr-1) is an important inflammatory transcription factor. We hypothesize that leukocyte-derived Egr-1 plays a key inflammatory role in causing postoperative ileus. METHODS:Wild-type, Egr-1 knockout, and chimera mice (constructed by irradiation followed by injection with ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.05.079

    authors： Schmidt J,Stoffels B,Moore BA,Chanthaphavong RS,Mazie AR,Buchholz BM,Bauer AJ

    更新日期：2008-09-01 00:00:00

  • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection.

    abstract：BACKGROUND & AIMS:Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HB...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70289-1

    authors： Maini MK,Boni C,Ogg GS,King AS,Reignat S,Lee CK,Larrubia JR,Webster GJ,McMichael AJ,Ferrari C,Williams R,Vergani D,Bertoletti A

    更新日期：1999-12-01 00:00:00

  • Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients.

    abstract：BACKGROUND & AIMS:Biliary atresia (BA) is a rare disease in infants, with unknown mechanisms of pathogenesis. It is characterized by hepatobiliary inflammatory, progressive destruction of the biliary system leading to liver fibrosis, and deterioration of liver function. Interleukin (IL) 17A promotes inflammatory and au...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2015.09.008

    authors： Klemann C,Schröder A,Dreier A,Möhn N,Dippel S,Winterberg T,Wilde A,Yu Y,Thorenz A,Gueler F,Jörns A,Tolosa E,Leonhardt J,Haas JD,Prinz I,Vieten G,Petersen C,Kuebler JF

    更新日期：2016-01-01 00:00:00

  • Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.

    abstract：:Topical 20% benzocaine (Hurricaine, Beutlich, Inc., Niles, Ill.) spray is frequently used for oral anesthesia before upper endoscopy. Side effects attributed to this agent are exceedingly rare. The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91312-t

    authors： Collins JF

    更新日期：1990-01-01 00:00:00

  • Primary malignant melanoma of the gallbladder, metastatic to the common bile duct.

    abstract：:A primary malignant melanoma of the gallbladder, metastatic to the common bile duct, is reported. Both tumor sites were first visualized by abdominal sonography. The presence of the common bile duct metastasis was confirmed by endoscopic retrograde cholangiopancreatography. Histologic evidence is presented that the pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90461-0

    authors： Verbanck JJ,Rutgeerts LJ,van Aelst FJ,Tytgat JH,Decoster JM,Noyez DN,Theunynck PJ,Geboes KJ

    更新日期：1986-07-01 00:00:00

  • Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

    abstract：BACKGROUND & AIMS:Previous studies have suggested that dietary folic acid (FA) can protect against certain types of cancers. However, the findings have varied, and the mechanisms by which FA exerts chemopreventive effects remain to be clarified. We examined the effects of FA supplementation on DNA methylation, gene exp...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.12.058

    authors： Gonda TA,Kim YI,Salas MC,Gamble MV,Shibata W,Muthupalani S,Sohn KJ,Abrams JA,Fox JG,Wang TC,Tycko B

    更新日期：2012-04-01 00:00:00

  • Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8.

    abstract：BACKGROUND & AIMS:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.09.039

    authors： Ko S,Russell JO,Tian J,Gao C,Kobayashi M,Feng R,Yuan X,Shao C,Ding H,Poddar M,Singh S,Locker J,Weng HL,Monga SP,Shin D

    更新日期：2019-01-01 00:00:00

  • Morphologic and physiologic studies of canine ileal enteroglucagon-containing cells in short-term culture.

    abstract：:Enteroglucagon-containing cells have been maintained in short-term culture, and the morphologic characteristics of these cells and their response to selected agents have been determined. After 48 h in culture the ultrastructural appearance of the enteroglucagon-immunoreactive cells showed evidence of polarization with...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90442-2

    authors： Buchan AM,Barber DL,Gregor M,Soll AH

    更新日期：1987-10-01 00:00:00

  • Lipase and pepsin activity in the gastric mucosa of infants, children, and adults.

    abstract：:The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90467-y

    authors： DiPalma J,Kirk CL,Hamosh M,Colon AR,Benjamin SB,Hamosh P

    更新日期：1991-07-01 00:00:00

  • Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.

    abstract：:Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy s...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Diehl AM,Goodman Z,Ishak KG

    更新日期：1988-10-01 00:00:00

  • Somatostatin inhibits secretin-induced canine pancreatic response via a cholinergic mechanism.

    abstract：BACKGROUND:Somatostatin inhibits pancreatic exocrine secretion in intact animals but not in vitro, suggesting an indirect effect. The present study examined the influence of extrapancreatic nerves and intrapancreatic cholinergic activity on somatostatin-induced inhibition of pancreatic exocrine secretion in conscious d...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90732-r

    authors： Kuvshinoff BW,Brodish RJ,James L,McFadden DW,Fink AS

    更新日期：1993-08-01 00:00:00

  • Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents.

    abstract：BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(00)70214-9

    authors： Kalff JC,Schraut WH,Billiar TR,Simmons RL,Bauer AJ

    更新日期：2000-02-01 00:00:00

  • Intestinal hydrolysis of aspartylphenylalanine--the metabolic product of aspartame.

    abstract：:Aspartame [Nutrasweet, Equal (Searle Consumer Products, Chicago, Ill.)] is the methyl ester of the dipeptide aspartylphenylalanine (Asp-Phe). After hydrolysis of the ester bond in the intestinal lumen, the dipeptide is apparently absorbed and digested in the same manner as dipeptides derived from protein digestion. We...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90697-9

    authors： Tobey NA,Heizer WD

    更新日期：1986-10-01 00:00:00

  • Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome.

    abstract：BACKGROUND/AIMS:The pathways underlying rectal hypersensitivity to balloon distention in patients with irritable bowel syndrome (IBS) are not known. The aim of this study was to characterize the involvement of sacral and thoracolumbar afferents in the perception of rectal distention. METHODS:Rectal balloon distention ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90809-5

    authors： Lembo T,Munakata J,Mertz H,Niazi N,Kodner A,Nikas V,Mayer EA

    更新日期：1994-12-01 00:00:00

  • Gastrin secretion from human antral G cells in culture.

    abstract：:Receptor-dependent and -independent regulation of gastrin secretion from cultured human antral G cells was investigated. Human antral mucosal cell preparations that were enriched for G cells were obtained by sequential incubations with collagenase and ethylenediaminetetraacetic acid, centrifugal elutriation, and short...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91226-v

    authors： Campos RV,Buchan AM,Meloche RM,Pederson RA,Kwok YN,Coy DH

    更新日期：1990-07-01 00:00:00

  • Organoid Models of Human Gastrointestinal Development and Disease.

    abstract：:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2015.12.042

    authors： Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

    更新日期：2016-05-01 00:00:00

  • Abnormal plasma microparticles impair vasoconstrictor responses in patients with cirrhosis.

    abstract：BACKGROUND & AIMS:Circulating membrane-shed microparticles (MPs) participate in regulation of vascular tone. We investigated the cellular origins of MPs in plasma from patients with cirrhosis and assessed the contribution of MPs to arterial vasodilation, a mechanism that contributes to portal hypertension. METHODS:We ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2012.03.040

    authors： Rautou PE,Bresson J,Sainte-Marie Y,Vion AC,Paradis V,Renard JM,Devue C,Heymes C,Letteron P,Elkrief L,Lebrec D,Valla D,Tedgui A,Moreau R,Boulanger CM

    更新日期：2012-07-01 00:00:00

  • Comparison of metronidazole and chloroquine for the treatment of amoebic liver abscess. A controlled trial.

    abstract：:Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Chloroquine was given according to the standard protocol at Los tangeles County-University of Southern California Medical Center, wh...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Cohen HG,Reynolds TB

    更新日期：1975-07-01 00:00:00

  • Basal and calcium-stimulated gastroesophageal sphincter pressure in patients with Zollinger-Ellison syndrome.

    abstract：:Basal lower esophageal sphincter (LES) pressure was measured in 6 patients with the Zollinger-Ellison syndrome (ZES) and hypergastrinemia, and in 6 patients with duodenal ulcer and normogastrinemia. Basal LES pressure in ZES patients, 17.0 +/- 3.7 (mean +/- SE) mm Hg was similar to basal LES pressure in duodenal ulcer...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Snyder N,Hughes W

    更新日期：1977-06-01 00:00:00

  • Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy.

    abstract：:Interleukin 1 (IL-1) has been shown to reduce the severity of experimental gastroduodenal ulceration, but the mechanism of action is unclear. The present study examined the possibility that the mechanism underlying the protective effects of IL-1 in experimental nonsteroidal anti-inflammatory drug (NSAID)-induced gastr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Wallace JL,Keenan CM,Cucala M,Mugridge KG,Parente L

    更新日期：1992-04-01 00:00:00

  • Effect of HCV infection on cause-specific mortality after HIV seroconversion, before and after 1997.

    abstract：BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2012.12.026

    authors： van der Helm J,Geskus R,Sabin C,Meyer L,Del Amo J,Chêne G,Dorrucci M,Muga R,Porter K,Prins M,CASCADE Collaboration in EuroCoord.

    更新日期：2013-04-01 00:00:00

  • Induction of heat-shock gene expression in postischemic pig liver depends on superoxide generation.

    abstract：BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(94)95209-4

    authors： Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

    更新日期：1994-01-01 00:00:00

  • The beta3-adrenoceptor agonist GW427353 (Solabegron) decreases excitability of human enteric neurons via release of somatostatin.

    abstract：BACKGROUND & AIMS:beta3 Adrenoceptor (beta3-AR) is expressed on adipocytes and enteric neurons. GW427353 is a human selective beta3-AR agonist with visceral analgesic effects. Some of its effects may involve release of somatostatin (SST) and actions on enteric neurons. The aim of this study was to investigate the mode ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.09.046

    authors： Schemann M,Hafsi N,Michel K,Kober OI,Wollmann J,Li Q,Zeller F,Langer R,Lee K,Cellek S

    更新日期：2010-01-01 00:00:00

  • Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome.

    abstract：BACKGROUND & AIMS:Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and decreases visceral hypersensitivity in animal studies. In healthy volunteers, linaclotide was safe, well tolerated, increased stool frequency, and decreased stool consistency and time to fir...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2007.06.067

    authors： Andresen V,Camilleri M,Busciglio IA,Grudell A,Burton D,McKinzie S,Foxx-Orenstein A,Kurtz CB,Sharma V,Johnston JM,Currie MG,Zinsmeister AR

    更新日期：2007-09-01 00:00:00

  • Hepatic infarction and diabetic ketoacidosis.

    abstract：:A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Ng RC,Sigmund CJ Jr,Lagos JA,Chernin M

    更新日期：1977-10-01 00:00:00

  • Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients.

    abstract：BACKGROUND & AIMS:Hypercoagulable states may play an important role in the pathogenesis of colon ischemia. Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia. METHODS:We compared the frequency o...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.27227

    authors： Koutroubakis IE,Sfiridaki A,Theodoropoulou A,Kouroumalis EA

    更新日期：2001-09-01 00:00:00