Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.


BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver hyperplasia and carcinogenesis. METHODS:Rats were fed hepatocarcinogenic peroxisome proliferator agents for 3 days to 10 months. Livers were examined for proliferation markers, activity and cellular distribution of sex steroid receptors, and key enzymes in sex hormone homeostasis. RESULTS:At all times, liver weight and proliferation markers in treated rats were increased. Early exposure resulted in increased nuclear estrogen and androgen receptor activity in treated rats. Tumors that developed after 9-10 months showed a marked decrease in estrogen receptor activity and, in contrast, an increase in androgen receptor activity, as did liver surrounding the tumors. Both short-term and long-term exposure to the carcinogens resulted in dramatic reductions in steroid metabolism. CONCLUSIONS:This study supports the thesis that, in preneoplastic stages such as hyperplasia, there is an elevation of both receptor activities and that the progression from hyperplasia to cancer results in suppression of estrogen receptor expression but maintenance of androgen receptor.






Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN




Has Abstract


1996-04-01 00:00:00














  • Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats.

    abstract:BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tiss...


    pub_type: 杂志文章


    authors: Romano M,Lesch CA,Meise KS,Veljaca M,Sanchez B,Kraus ER,Boland CR,Guglietta A,Coffey RJ

    更新日期:1996-05-01 00:00:00

  • Impairment of aminopyrine clearance in aspirin-damaged canine gastric mucosa.

    abstract::Using an in vivo canine chambered stomach preparation, the clearance of [14C]aminopyrine across mucosa when intravenously infused and the back-diffusion of this substance from gastric lumen to mucosa when topically applied to gastric epithelium were evaluated in aspirin-damaged gastric epithelium. In mucosa damaged by...


    pub_type: 杂志文章


    authors: Miller TA,Henagan JM,Loy TM

    更新日期:1983-09-01 00:00:00

  • A Novel Role of SLC26A3 in the Maintenance of Intestinal Epithelial Barrier Integrity.

    abstract:BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...


    pub_type: 杂志文章


    authors: Kumar A,Priyamvada S,Ge Y,Jayawardena D,Singhal M,Anbazhagan AN,Chatterjee I,Dayal A,Patel M,Zadeh K,Saksena S,Alrefai WA,Gill RK,Zadeh M,Zhao N,Mohamadzadeh M,Dudeja PK

    更新日期:2020-11-13 00:00:00

  • Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...


    pub_type: 杂志文章


    authors: Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

    更新日期:2014-03-01 00:00:00

  • Medications (NSAIDs, statins, proton pump inhibitors) and the risk of esophageal adenocarcinoma in patients with Barrett's esophagus.

    abstract:BACKGROUND & AIMS:Limited evidence suggests that proton pump inhibitors (PPI), nonsteroidal anti-inflammatory drugs (NSAID)/aspirin, and statins may be associated with a low risk of esophageal neoplasia. However, the possible effect these medications may have on the risk of esophageal adenocarcinoma (EAC) in patients w...


    pub_type: 杂志文章


    authors: Nguyen DM,Richardson P,El-Serag HB

    更新日期:2010-06-01 00:00:00

  • Plasma amino acid abnormalities in the alcoholic: respective role of alcohol, nutrition, and liver injury.

    abstract::Plasma amino acid abnormalities are common in alcoholics, but the respective role of alcoholism, nutrition, and liver injury in producing these abnormalities is unknown. To elucidate this question, amino acids were measured in 56 alcoholics and 32 nonalcoholics with liver disease, and in an experimental model of alcoh...


    pub_type: 杂志文章


    authors: Shaw S,Lieber CS

    更新日期:1978-04-01 00:00:00

  • An examination of liver offers to candidates on the liver transplant wait-list.

    abstract:BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...


    pub_type: 杂志文章


    authors: Lai JC,Feng S,Roberts JP

    更新日期:2012-11-01 00:00:00

  • Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RAS(G12V) oncogene.

    abstract:BACKGROUND & AIMS:The Ki-RAS oncogene is altered in pancreatic ductal neoplasms. Pancreatic ductal cells (PDCs) were purified from cytokeratin 19 (K19)-Ki-RAS(G12V) transgenic mice and control littermates to identify properties of Ki-Ras activation in a cell-type-specific context. Because Ki-RAS mutation has prognostic...


    pub_type: 杂志文章


    authors: Schreiber FS,Deramaudt TB,Brunner TB,Boretti MI,Gooch KJ,Stoffers DA,Bernhard EJ,Rustgi AK

    更新日期:2004-07-01 00:00:00

  • Using a 3% Proton Density Fat Fraction as a Cut-Off Value Increases Sensitivity of Detection of Hepatic Steatosis, Based on Results From Histopathology Analysis.

    abstract::It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...


    pub_type: 杂志文章


    authors: Nasr P,Forsgren MF,Ignatova S,Dahlström N,Cedersund G,Leinhard OD,Norén B,Ekstedt M,Lundberg P,Kechagias S

    更新日期:2017-07-01 00:00:00

  • Caloric intake and unconjugated hyperbilirubinemia.

    abstract::Reduction in caloric intake was associated with a greater absolute rise in the serum bilirubin concentration in patients with Gilbert's syndrome and partial hepatic bilirubin uridine diphosphate glucuronyltransferase (UDPG-T) dysfunction compared to patients with hemolytic unconjugated hyperbilirubinemia and normal su...


    pub_type: 杂志文章


    authors: Felsher BF,Carpio NM

    更新日期:1975-07-01 00:00:00

  • A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.

    abstract:BACKGROUND & AIMS:Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection. METHODS:We collected 314 HCC samples from patients at Bordeaux (1998-200...


    pub_type: 杂志文章


    authors: Nault JC,De Reyniès A,Villanueva A,Calderaro J,Rebouissou S,Couchy G,Decaens T,Franco D,Imbeaud S,Rousseau F,Azoulay D,Saric J,Blanc JF,Balabaud C,Bioulac-Sage P,Laurent A,Laurent-Puig P,Llovet JM,Zucman-Rossi J

    更新日期:2013-07-01 00:00:00

  • Effect of age on tests of intestinal and hepatic function in healthy humans.

    abstract::We studied intestinal function and hepatic microsomal phase I monooxygenase function in healthy, free-living subjects, aged 19-91 yr. In subjects (n = 114) given a diet including 100 g/day of fat, fecal fat in a 72-h collection did not increase with advancing age. D-Xylose excretion (n = 54) following a 25-g oral load...


    pub_type: 杂志文章


    authors: Arora S,Kassarjian Z,Krasinski SD,Croffey B,Kaplan MM,Russell RM

    更新日期:1989-06-01 00:00:00

  • Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells.

    abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...


    pub_type: 杂志文章


    authors: Almeida MI,Nicoloso MS,Zeng L,Ivan C,Spizzo R,Gafà R,Xiao L,Zhang X,Vannini I,Fanini F,Fabbri M,Lanza G,Reis RM,Zweidler-McKay PA,Calin GA

    更新日期:2012-04-01 00:00:00

  • Mucosal microvascular architecture of the fundus and body of human stomach.

    abstract::Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...


    pub_type: 杂志文章


    authors: Gannon B,Browning J,O'Brien P,Rogers P

    更新日期:1984-05-01 00:00:00

  • Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression.

    abstract:BACKGROUND & AIMS:Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression...


    pub_type: 杂志文章


    authors: Fantini MC,Rizzo A,Fina D,Caruso R,Sarra M,Stolfi C,Becker C,Macdonald TT,Pallone F,Neurath MF,Monteleone G

    更新日期:2009-04-01 00:00:00

  • Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis.

    abstract:BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...


    pub_type: 杂志文章


    authors: Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

    更新日期:1996-05-01 00:00:00

  • High-dose oral erythromycin decreased the incidence of parenteral nutrition-associated cholestasis in preterm infants.

    abstract:BACKGROUND & AIMS:Feeding intolerance because of functional gastrointestinal dysmotility and parenteral nutrition-associated cholestasis (PNAC) are common problems in preterm, very-low-birth-weight (VLBW) infants. This double-blind, randomized, placebo-controlled study aimed to assess the effectiveness of "high-dose" o...


    pub_type: 杂志文章,随机对照试验


    authors: Ng PC,Lee CH,Wong SP,Lam HS,Liu FY,So KW,Lee CY,Fok TF

    更新日期:2007-05-01 00:00:00

  • Jejunal manometry patterns in health, partial intestinal obstruction, and pseudoobstruction.

    abstract::The purpose of this study was to determine the utility of jejunal manometry in evaluating patients having partial small intestinal obstruction or the pseudoobstruction syndrome. We studied 10 healthy volunteers, 9 patients with documented mechanical obstruction, and 3 patients with chronic intestinal pseudoobstruction...


    pub_type: 杂志文章


    authors: Summers RW,Anuras S,Green J

    更新日期:1983-12-01 00:00:00

  • Multigenic control of hepatic iron loading in a murine model of hemochromatosis.

    abstract:BACKGROUND & AIMS:Hereditary hemochromatosis is a common disorder of iron homeostasis characterized by increased dietary iron absorption and progressive iron accumulation, mainly in the liver. Most patients are homozygous for the C282Y mutation in the HFE gene. However, not all individuals carrying the hemochromatosis-...


    pub_type: 杂志文章


    authors: Bensaid M,Fruchon S,Mazères C,Bahram S,Roth MP,Coppin H

    更新日期:2004-05-01 00:00:00

  • Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat.

    abstract:BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...


    pub_type: 杂志文章


    authors: Nanji AA,Khwaja S,Rahemtulla A,Miao L,Zhao S,Tahan SR

    更新日期:1997-01-01 00:00:00

  • Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virus.

    abstract:BACKGROUND & AIMS:Several small molecule inhibitors of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease have advanced successfully to clinical trials. However, the selection of drug-resistant mutants is a significant issue with protease inhibitors (PIs). A variety of amino acid substitutions in the ...


    pub_type: 杂志文章


    authors: Shimakami T,Welsch C,Yamane D,McGivern DR,Yi M,Zeuzem S,Lemon SM

    更新日期:2011-02-01 00:00:00

  • Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium.

    abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...


    pub_type: 杂志文章


    authors: Maaser C,Eckmann L,Paesold G,Kim HS,Kagnoff MF

    更新日期:2002-03-01 00:00:00

  • Involvement of eicosanoids and macrophage-like cells in cytokine-mediated changes in rat myenteric nerves.

    abstract:BACKGROUND & AIMS:Proinflammatory cytokines alter function in enteric nerves, but little is known about underlying mechanisms. This study was designed to investigate the roles of prostanoids and of macrophage-like cells in cytokine-induced suppression of [3H]norepinephrine release from rat myenteric plexus. METHODS:Th...


    pub_type: 杂志文章


    authors: Rühl A,Berezin I,Collins SM

    更新日期:1995-12-01 00:00:00

  • Role of endogenous nitric oxide in the control of canine pancreatic secretion and blood flow.

    abstract:BACKGROUND:Endogenous nitric oxide has been implicated in the control of mesenteric circulation, but its role in the control of pancreatic blood flow and exocrine pancreatic secretion has not been studied. METHODS:Secretory studies were performed on conscious dogs with chronic pancreatic fistulas, and changes in pancr...


    pub_type: 杂志文章


    authors: Konturek SJ,Bilski J,Konturek PK,Cieszkowski M,Pawlik W

    更新日期:1993-03-01 00:00:00

  • Colorectal cancer after cholecystectomy: absence of risk increase within 11-14 years.

    abstract::The importance of cholecystectomy as a risk factor for colorectal cancer was analyzed in an historical cohort study covering 16,773 cases during 11-14 years completed after operation. The observed number of colorectal cancers (130) was lower than the expected 153.5 [relative risk (RR) = 0.85]. For cancer of the colon,...


    pub_type: 杂志文章


    authors: Adami HO,Meirik O,Gustavsson S,Nyrén O,Krusemo UB

    更新日期:1983-10-01 00:00:00

  • Alcohollike liver disease in nonalcoholics. A clinical and histologic comparison with alcohol-induced liver injury.

    abstract::Individuals who deny alcohol consumption may develop liver injury that histologically resembles the liver injury found in alcoholic patients. To determine whether any clinical or histologic features distinguish alcoholic and nonalcoholic subjects with "alcohollike" liver injury, the clinical records and liver biopsy s...


    pub_type: 杂志文章


    authors: Diehl AM,Goodman Z,Ishak KG

    更新日期:1988-10-01 00:00:00

  • The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

    abstract:BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...


    pub_type: 杂志文章


    authors: Nanda SK,Herion D,Liang TJ

    更新日期:2006-03-01 00:00:00

  • Colostomy closure promotes cell proliferation and dimethylhydrazine-induced carcinogenesis in rat distal colon.

    abstract::The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...


    pub_type: 杂志文章


    authors: Terpstra OT,Dahl EP,Williamson RC,Ross JS,Malt RA

    更新日期:1981-09-01 00:00:00

  • Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice.

    abstract:BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...


    pub_type: 评论,杂志文章


    authors: Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

    更新日期:2005-12-01 00:00:00

  • Consensus statements on the risk, prevention, and treatment of venous thromboembolism in inflammatory bowel disease: Canadian Association of Gastroenterology.

    abstract:BACKGROUND & AIMS:Guidelines for the management of venous thromboembolism (VTE) from the American College of Chest Physicians do not address patients with inflammatory bowel disease (IBD), a group with a high risk of both VTE and gastrointestinal bleeding. We present recommendations for the prevention and treatment of ...


    pub_type: 共识发展会议,杂志文章,评审


    authors: Nguyen GC,Bernstein CN,Bitton A,Chan AK,Griffiths AM,Leontiadis GI,Geerts W,Bressler B,Butzner JD,Carrier M,Chande N,Marshall JK,Williams C,Kearon C

    更新日期:2014-03-01 00:00:00