Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.


BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver hyperplasia and carcinogenesis. METHODS:Rats were fed hepatocarcinogenic peroxisome proliferator agents for 3 days to 10 months. Livers were examined for proliferation markers, activity and cellular distribution of sex steroid receptors, and key enzymes in sex hormone homeostasis. RESULTS:At all times, liver weight and proliferation markers in treated rats were increased. Early exposure resulted in increased nuclear estrogen and androgen receptor activity in treated rats. Tumors that developed after 9-10 months showed a marked decrease in estrogen receptor activity and, in contrast, an increase in androgen receptor activity, as did liver surrounding the tumors. Both short-term and long-term exposure to the carcinogens resulted in dramatic reductions in steroid metabolism. CONCLUSIONS:This study supports the thesis that, in preneoplastic stages such as hyperplasia, there is an elevation of both receptor activities and that the progression from hyperplasia to cancer results in suppression of estrogen receptor expression but maintenance of androgen receptor.






Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN




Has Abstract


1996-04-01 00:00:00














  • Behavioral management of fecal incontinence in adults.

    abstract::Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...


    pub_type: 杂志文章,评审


    authors: Norton C

    更新日期:2004-01-01 00:00:00

  • Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility.

    abstract::Ceftriaxone, a semisynthetic third-generation cephalosporin, has recently been associated with biliary sludge formation. Analysis of the biliary concretions induced by this agent shows a calcium salt of ceftriaxone. The present in vitro studies were undertaken to provide insight into the pathogenesis of ceftriaxone-as...


    pub_type: 杂志文章


    authors: Shiffman ML,Keith FB,Moore EW

    更新日期:1990-12-01 00:00:00

  • Orthotopic liver transplantation for graft-versus-host disease following bone marrow transplantation.

    abstract::Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...


    pub_type: 杂志文章


    authors: Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

    更新日期:1990-08-01 00:00:00

  • Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication.

    abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-...


    pub_type: 杂志文章


    authors: von Hahn T,Schiene-Fischer C,Van ND,Pfaender S,Karavul B,Steinmann E,Potthoff A,Strassburg C,Hamdi N,Abdelaziz AI,Sarrazin C,Müller T,Berg T,Trépo E,Wedemeyer H,Manns MP,Pietschmann T,Ciesek S

    更新日期:2012-08-01 00:00:00

  • Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B.

    abstract:BACKGROUND & AIMS:Predictors of reactivation of hepatitis B following hepatitis B e antigen (HBeAg) seroconversion in chronic hepatitis B have rarely been reported before and deserve further study. METHODS:A total of 133 HBeAg-positive asymptomatic carriers who have undergone HBeAg seroconversion were studied. Reactiv...


    pub_type: 杂志文章


    authors: Chu CM,Liaw YF

    更新日期:2007-11-01 00:00:00

  • Intestinal myofibroblasts in innate immune responses of the intestine.

    abstract:BACKGROUND & AIMS:Intestinal myofibroblasts are known to respond to inflammatory signals and may play a role in Crohn's disease-associated fibrosis. However, putative involvement by myofibroblasts in innate immune responses as part of intestinal host defense has not been characterized. We therefore analyzed expression ...


    pub_type: 杂志文章


    authors: Otte JM,Rosenberg IM,Podolsky DK

    更新日期:2003-06-01 00:00:00

  • Restricted V(H) gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis.

    abstract:BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...


    pub_type: 杂志文章


    authors: Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

    更新日期:2001-07-01 00:00:00

  • Enterohepatic circulation of bacterial chemotactic peptide in rats with experimental colitis.

    abstract::The association of hepatobiliary disorders with colonic inflammation is well recognized. Although the pathophysiology is obscure, increased permeation of toxic bacterial products across the inflamed gut to the portal circulation might be one mechanism. Potentially toxic metabolites include N-formylated chemotactic pep...


    pub_type: 杂志文章


    authors: Hobson CH,Butt TJ,Ferry DM,Hunter J,Chadwick VS,Broom MF

    更新日期:1988-04-01 00:00:00

  • STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD.

    abstract:BACKGROUND:The Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) initiative of the International Organization for the Study of Inflammatory Bowel Diseases (IOIBD) has proposed treatment-targets in 2015 for adult IBD patients. We aimed to update the original STRIDE statements for incorporating treatme...


    pub_type: 杂志文章


    authors: Turner D,Ricciuto A,Lewis A,D'Amico F,Dhaliwal J,Griffiths AM,Bettenworth D,Sandborn WJ,Sands BE,Reinisch W,Schölmerich J,Bemelman W,Danese S,Mary JY,Rubin D,Colombel JF,Peyrin-Biroulet L,Dotan I,Abreu MT,Dignass A

    更新日期:2020-12-21 00:00:00

  • In vitro degradation of gastric mucin. Carbohydrate side chains protect polypeptide core from pancreatic proteases.

    abstract::The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbo...


    pub_type: 杂志文章


    authors: Variyam EP,Hoskins LC

    更新日期:1983-03-01 00:00:00

  • Hepatic vasculature: a conceptual review.

    abstract::The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...


    pub_type: 杂志文章,评审


    authors: Lautt WW

    更新日期:1977-11-01 00:00:00

  • Rapid mitogen-activated protein kinase activation by transforming growth factor alpha in wounded rat intestinal epithelial cells.

    abstract:BACKGROUND & AIMS:To define signaling events initiating healing after intestinal epithelial injury, activation of mitogen-activated protein kinase (MAPK) pathways was assessed after wounding using an in vitro model. METHODS:Proteins isolated from wounded monolayers of nontransformed intestinal epithelial cells (IEC-6)...


    pub_type: 杂志文章


    authors: Göke M,Kanai M,Lynch-Devaney K,Podolsky DK

    更新日期:1998-04-01 00:00:00

  • AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D).

    abstract:BACKGROUND & AIMS:The evaluation of patients with chronic watery diarrhea represents a diagnostic challenge for clinicians because organic causes, including inflammatory bowel disease, microscopic colitis, and chronic infection, must be differentiated from functional diarrhea and diarrhea-predominant irritable bowel sy...


    pub_type: 杂志文章,实务指引,评审


    authors: Carrasco-Labra A,Lytvyn L,Falck-Ytter Y,Surawicz CM,Chey WD

    更新日期:2019-09-01 00:00:00

  • Interferon-induced gene expression is a stronger predictor of treatment response than IL28B genotype in patients with hepatitis C.

    abstract:BACKGROUND & AIMS:The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with ...


    pub_type: 杂志文章


    authors: Dill MT,Duong FH,Vogt JE,Bibert S,Bochud PY,Terracciano L,Papassotiropoulos A,Roth V,Heim MH

    更新日期:2011-03-01 00:00:00

  • Adenocarcinomas of the colon and rectum in persons under 40 years old. A population-based study.

    abstract::Data collected by nine population-based tumor registries participating in the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute were analyzed to characterize the epidemiology of noncarcinoid adenocarcinomas of the colon and rectum in young adults. Tumors diagnosed in persons under 40...


    pub_type: 杂志文章


    authors: Griffin PM,Liff JM,Greenberg RS,Clark WS

    更新日期:1991-04-01 00:00:00

  • Isotretinoin-associated proctosigmoiditis.

    abstract::A 17-yr-old boy developed acute proctosigmoiditis after the institution of isotretinoin for the treatment of cystic acne vulgaris. Painless diarrhea, accompanied by mucus and eventually blood, began within days of commencing treatment and persisted while the drug was administered. At sigmoidoscopy patchy mucosal infla...


    pub_type: 杂志文章


    authors: Martin P,Manley PN,Depew WT,Blakeman JM

    更新日期:1987-09-01 00:00:00

  • Ritanserin decreases portal pressure in conscious and unrestrained cirrhotic rats.

    abstract::We have recently demonstrated that ritanserin, a serotonin 5-hydroxytryptamine receptor antagonist void of systemic effects, caused a significant reduction of portal pressure in conscious cirrhotic dogs. The mechanism by which ritanserin lowers portal pressure is poorly defined. We investigated the splanchnic and syst...


    pub_type: 杂志文章


    authors: Mastai R,Giroux L,Semret M,Huet PM

    更新日期:1990-01-01 00:00:00

  • Effects of 2-camphanone on canine portal vein blood flow and rat smooth muscle.

    abstract::2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...


    pub_type: 杂志文章


    authors: Xie JM,Greenberg SS,Longenecker G

    更新日期:1992-02-01 00:00:00

  • Delayed-release oral mesalamine 4.8 g/day (800-mg tablet) is effective for patients with moderately active ulcerative colitis.

    abstract:BACKGROUND AND AIMS:It is not clear what induction dose of mesalamine is optimal for treating patients with mildly and moderately active ulcerative colitis (UC). This study was conducted to determine the efficacy and safety of mesalamine 4.8 g/day compared with 2.4 g/day for the treatment of moderately active UC. METH...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Sandborn WJ,Regula J,Feagan BG,Belousova E,Jojic N,Lukas M,Yacyshyn B,Krzeski P,Yeh CH,Messer CA,Hanauer SB

    更新日期:2009-12-01 00:00:00

  • Effects of experimental cirrhosis on splanchnic microvascular fluid and solute exchange in the rat.

    abstract::In human cirrhosis, there is evidence that there are considerable alterations in fluid and solute exchange in the hepatic and intestinal microcirculations . Experimental cirrhosis was induced in rats by using oral phenobarbitone and carbon tetrachloride inhalation over an 8-wk period. Portal venous pressure, hepatic a...


    pub_type: 杂志文章


    authors: Barrowman JA,Granger DN

    更新日期:1984-07-01 00:00:00

  • Malignant potential of chronic ulcerative colitis. Preliminary report.

    abstract::Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the c...


    pub_type: 杂志文章


    authors: Nugent FW,Haggit RC,Colcher H,Kutteruf GC

    更新日期:1979-01-01 00:00:00

  • Involvement of 5-hydroxytryptamine 3 receptors in regulation of interdigestive gastric contractions by motilin in the dog.

    abstract::The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouch in the conscious state by means of chronically implanted force transducers in the gastrointestinal tract and the pouch. I...


    pub_type: 杂志文章


    authors: Itoh Z,Mizumoto A,Iwanaga Y,Yoshida N,Torii K,Wakabayashi K

    更新日期:1991-04-01 00:00:00

  • Benign recurrent intrahepatic cholestasis: treatment with S-adenosylmethionine.

    abstract::S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...


    pub_type: 杂志文章


    authors: Everson GT,Ahnen D,Harper PC,Krawitt EL

    更新日期:1989-05-01 00:00:00

  • Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

    abstract:BACKGROUND & AIMS:Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and...


    pub_type: 杂志文章


    authors: Marí M,Colell A,Morales A,Caballero F,Moles A,Fernández A,Terrones O,Basañez G,Antonsson B,García-Ruiz C,Fernández-Checa JC

    更新日期:2008-05-01 00:00:00

  • A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease.

    abstract:BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...


    pub_type: 临床试验,杂志文章


    authors: Costamagna G,Shah SK,Riccioni ME,Foschia F,Mutignani M,Perri V,Vecchioli A,Brizi MG,Picciocchi A,Marano P

    更新日期:2002-10-01 00:00:00

  • Severe TNF receptor-associated periodic syndrome due to 2 TNFRSF1A mutations including a new F60V substitution.

    abstract::Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is typically characterized by episodic fever, myalgia, skin rash, conjunctivitis, and abdominal cramps. Recently, mutations in the TNFRSF1A gene on chromosome 12p13 encoding tumor necrosis factor receptor type 1 have been linked to this autoinflammato...


    pub_type: 杂志文章


    authors: Haas SL,Lohse P,Schmitt WH,Hildenbrand R,Karaorman M,Singer MV,Böcker U

    更新日期:2006-01-01 00:00:00

  • Genetic variants in cyclooxygenase-2: Expression and risk of gastric cancer and its precursors in a Chinese population.

    abstract:BACKGROUND & AIMS:To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects on COX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. METHODS:Genotypes were d...


    pub_type: 杂志文章


    authors: Liu F,Pan K,Zhang X,Zhang Y,Zhang L,Ma J,Dong C,Shen L,Li J,Deng D,Lin D,You W

    更新日期:2006-06-01 00:00:00

  • Signal transduction pathways associated with contraction during development of the feline gastric antrum.

    abstract:BACKGROUND & AIMS:Unlike adult antral cells, feline newborn antral cells are unable to contract in response to agonists in the absence of extracellular calcium or in response to exogenous inositol 1,4,5-triphosphate (IP3) after permeabilization. Changes in intracellular pathways that are associated with these differenc...


    pub_type: 杂志文章


    authors: Hillemeier AC,Deutsch DE,Bitar KN

    更新日期:1997-08-01 00:00:00

  • C-kit inhibition by imatinib mesylate attenuates progenitor cell expansion and inhibits liver tumor formation in mice.

    abstract:BACKGROUND & AIMS:Numerous studies have linked the proliferation of liver progenitor cells (LPCs) during chronic liver disease to the risk for development of hepatocellular carcinoma. Thus, selective inhibition of LPC growth during preneoplastic injury may prevent or delay the onset of liver cancer. Rats carrying a ger...


    pub_type: 杂志文章


    authors: Knight B,Tirnitz-Parker JE,Olynyk JK

    更新日期:2008-09-01 00:00:00

  • Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes.

    abstract:BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is associated with increased risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce liver fat, but can induce insulin resistance. We investigated the effects of d...


    pub_type: 杂志文章,随机对照试验


    authors: Markova M,Pivovarova O,Hornemann S,Sucher S,Frahnow T,Wegner K,Machann J,Petzke KJ,Hierholzer J,Lichtinghagen R,Herder C,Carstensen-Kirberg M,Roden M,Rudovich N,Klaus S,Thomann R,Schneeweiss R,Rohn S,Pfeiffer AF

    更新日期:2017-02-01 00:00:00