Abstract:
:Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-induced cirrhosis and recurrent variceal hemorrhage. She underwent successful orthotopic liver transplant. Her postoperative course was uncomplicated, with no evidence of rejection or recurrence of graft-vs.-host disease. As bone marrow transplantation is more widely used and survival improves, the number of patients with graft-vs.-host disease or venoocclusive disease resulting in cirrhosis is likely to increase. Hepatic transplantation should be considered for bone marrow transplant patients who develop end-stage liver disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RSdoi
10.1016/0016-5085(90)91039-9subject
Has Abstractpub_date
1990-08-01 00:00:00pages
536-8issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(90)91039-9journal_volume
99pub_type
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