Helicobacter pylori in the drinking water in Peru.


BACKGROUND & AIMS:An association between water sources and the prevalence of Helicobacter pylori infection in Peruvian children was shown previously. The aim of this study was to confirm the presence of H. pylori in drinking water in the same community. METHODS:Forty-eight drinking water samples from different locations in pueblo jovenes (new towns) near Lima were collected. Samples were frozen until technology advanced to the point to the point at which H. pylori might be reliably detected. Immunomagnetic beads coated with anti-H. pylori immunoglobulin Gs were used to concentrate H. pylori, and two polymerase chain reaction assays based on different H. pylori genes were used. One was a polymerase chain reaction for the detection of the H. pylori adhesin subunit encoding gene, and the second was a previously validated H. pylori 16S ribosomal RNA reverse transcriptase-polymerase chain reaction. RESULTS:The expected 375-base pair fragment from the adhesin gene was amplified from 24 water samples. The expected 500-base pair fragment of the 16S ribosomal RNA and the 375-base pair fragment of the adhesin gene were amplified from 11 of the samples. CONCLUSIONS:These results confirm the presence of H. pylori in drinking water in Peru and are consistent with conclusions from a previous epidemiological study of the same population. This provides additional evidence for waterborne transmission of H. pylori in some environments.






Hulten K,Han SW,Enroth H,Klein PD,Opekun AR,Gilman RH,Evans DG,Engstrand L,Graham DY,El-Zaatari FA




Has Abstract


1996-04-01 00:00:00














  • Multiple pathways for amino acid transport in brush border membrane vesicles isolated from the human fetal small intestine.

    abstract::The present study was undertaken to identify the different amino acid transport pathways present in the human small intestine during the early gestational period. The uptake time courses of neutral (L-leucine, L-alanine, L-methionine), acidic (L-glutamic and D-aspartic acids), basic (L-lysine), and imino (L-proline) a...


    pub_type: 杂志文章


    authors: Malo C

    更新日期:1991-06-01 00:00:00

  • Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.

    abstract:BACKGROUND & AIMS:Altered gut microbiota is implicated in development of colorectal cancer (CRC). Some intestinal bacteria have been reported to potentiate intestinal carcinogenesis by producing genotoxins, altering the immune response and intestinal microenvironment, and activating oncogenic signaling pathways. We inv...


    pub_type: 杂志文章


    authors: Wong SH,Zhao L,Zhang X,Nakatsu G,Han J,Xu W,Xiao X,Kwong TNY,Tsoi H,Wu WKK,Zeng B,Chan FKL,Sung JJY,Wei H,Yu J

    更新日期:2017-12-01 00:00:00

  • American gastroenterological association institute medical position statement on the use of gastrointestinal medications in pregnancy.

    abstract::This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...


    pub_type: 杂志文章,评审


    authors: Mahadevan U,Kane S

    更新日期:2006-07-01 00:00:00

  • Hepatocytes that express variants of cyclophilin A are resistant to HCV infection and replication.

    abstract:BACKGROUND & AIMS:Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-...


    pub_type: 杂志文章


    authors: von Hahn T,Schiene-Fischer C,Van ND,Pfaender S,Karavul B,Steinmann E,Potthoff A,Strassburg C,Hamdi N,Abdelaziz AI,Sarrazin C,Müller T,Berg T,Trépo E,Wedemeyer H,Manns MP,Pietschmann T,Ciesek S

    更新日期:2012-08-01 00:00:00

  • What remaining questions regarding Helicobacter pylori and associated diseases should be addressed by future research? View from North America.

    abstract::Several areas regarding Helicobacter pylori that need improvement or clarification in the United States include treatment of dyspepsia, physician education on disease associations with H. pylori, and evidence from U.S. studies that 7-day H. pylori eradication regimens are more effective than current regimens. Dyspepsi...


    pub_type: 杂志文章,评审


    authors: Freston JW

    更新日期:1997-12-01 00:00:00

  • Disordered gustatory acuity in liver disease.

    abstract::Disordered gustatory acuity was demonstrated in 22 patients with acute viral hepatitis and in 16 patients with chronic liver disease utilizing subjective responses and objective measurements of detection and recognition thresholds and scaling for NaCl, sucrose, HCl, and urea. In patients with early hepatitis and those...


    pub_type: 杂志文章


    authors: Smith FR,Henkin RI,Dell RB

    更新日期:1976-04-01 00:00:00

  • Macrophage turnover in Crohn's disease and ulcerative colitis.

    abstract::Monocytopoietic proliferation activity was determined in 8 patients during severe attacks of Crohn's disease and in 6 patients with ulcerative colitis. Similar results were obtained in both groups of patients. A moderate but significant hyperproliferation of monocytopoiesis was found to be present in about half of the...


    pub_type: 杂志文章


    authors: Meuret G,Bitzi A,Hammer B

    更新日期:1978-03-01 00:00:00

  • Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia.

    abstract:BACKGROUND & AIMS:This study aimed to determine if hiatal hernia influences vulnerability to reflux and transient lower esophageal sphincter relaxation (tLESR) during gastric distention in patients with gastroesophageal reflux disease (GERD). METHODS:Eight normal subjects and 15 patients with GERD were studied. A meta...


    pub_type: 杂志文章


    authors: Kahrilas PJ,Shi G,Manka M,Joehl RJ

    更新日期:2000-04-01 00:00:00

  • Stimulation of mucosal growth in the rat ileum by bile and pancreatic secretions after jejunal resection.

    abstract::After proximal small bowel resection, the remaining small intestine undergoes adaptive hyperplasia. The role of bile and pancreatic secretions in stimulating ileal mucosal growth after jejunectomy was studied. Male Sprague-Dawley rats were fed either standard rat chow or a liquid elemental diet, and were divided into ...


    pub_type: 杂志文章


    authors: Weser E,Heller R,Tawil T

    更新日期:1977-09-01 00:00:00

  • A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice.

    abstract:BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...


    pub_type: 杂志文章


    authors: Dimagno MJ,Lee SH,Hao Y,Zhou SY,McKenna BJ,Owyang C

    更新日期:2005-08-01 00:00:00

  • Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus.

    abstract:BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...


    pub_type: 杂志文章


    authors: Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

    更新日期:2002-02-01 00:00:00

  • Somatosensory evoked potentials in hepatic encephalopathy.

    abstract::Median nerve somatosensory evoked potentials were recorded from 33 patients with various degrees of hepatic failure and from 10 age-matched controls. Within 20 ms poststimulation, one negative peak (N13) could be recorded from the middle of the back of the patient's neck at the C2 vertebral level. Within 150 ms, three...


    pub_type: 杂志文章


    authors: Yang SS,Chu NS,Liaw YF

    更新日期:1985-09-01 00:00:00

  • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features.

    abstract:BACKGROUND & AIMS:Cancer progression/metastases and embryonic development share many properties including cellular plasticity, dynamic cell motility, and integral interaction with the microenvironment. We hypothesized that the heterogeneous nature of hepatocellular carcinoma (HCC), in part, may be owing to the presence...


    pub_type: 杂志文章


    authors: Yamashita T,Ji J,Budhu A,Forgues M,Yang W,Wang HY,Jia H,Ye Q,Qin LX,Wauthier E,Reid LM,Minato H,Honda M,Kaneko S,Tang ZY,Wang XW

    更新日期:2009-03-01 00:00:00

  • Metabolism, pharmacokinetics, and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters.

    abstract:BACKGROUND/AIMS:The effectiveness of ursodeoxycholic acid in treating biliary liver diseases is limited by low bioavailability and moderate activity. A new analogue of ursodeoxycholic acid was synthesized with a fluorine atom in position 6 because this should have resulted in an analogue more hydrophilic than ursodeoxy...


    pub_type: 杂志文章


    authors: Roda A,Pellicciari R,Polimeni C,Cerrè C,Forti GC,Sadeghpour B,Sapigni E,Gioacchini AM,Natalini B

    更新日期:1995-04-01 00:00:00

  • Incidence and recurrence rates of colorectal adenomas: a prospective study.

    abstract:BACKGROUND/AIMS:The frequency of colorectal adenomas, the precursor lesions for most cases of colorectal carcinoma, has been generally measured as prevalence rates of adenomas at autopsy or colonoscopy. The aim of this study was to estimate the incidence rate of adenomas and compare it with the adenoma recurrence rate....


    pub_type: 杂志文章


    authors: Neugut AI,Jacobson JS,Ahsan H,Santos J,Garbowski GC,Forde KA,Treat MR,Waye J

    更新日期:1995-02-01 00:00:00

  • Rats with gastritis have increased sensitivity to the gastrin stimulatory effects of luminal ammonia.

    abstract:BACKGROUND & AIMS:Persons infected with Helicobacter pylori show an enhanced meal-stimulated gastrin release compared with uninfected controls. The aim of this study was to determine in animal models whether this gastrin release could be related to chronic gastric inflammation, elevated luminal ammonia level, or a comb...


    pub_type: 杂志文章


    authors: Dial EJ,Hall LR,Romero JJ,Lichtenberger LM

    更新日期:1996-03-01 00:00:00

  • Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease.

    abstract:BACKGROUND & AIMS:Infliximab is effective in closing fistulas in patients with Crohn's disease. We examined the effect of infliximab maintenance treatment on hospitalizations, surgeries, and procedures in patients with fistulizing Crohn's disease enrolled in the ACCENT II study. METHODS:After 5 mg/kg infliximab at wee...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Lichtenstein GR,Yan S,Bala M,Blank M,Sands BE

    更新日期:2005-04-01 00:00:00

  • Altered growth and lack of responsiveness to angiotensin II in aortic vascular smooth muscle cells from cirrhotic rats.

    abstract:BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...


    pub_type: 杂志文章


    authors: Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

    更新日期:1997-06-01 00:00:00

  • Lipoxygenase metabolites in the rat gastric microvascular response to intragastric ethanol.

    abstract::The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...


    pub_type: 杂志文章


    authors: Yonei Y,Guth PH

    更新日期:1989-08-01 00:00:00

  • MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach.

    abstract:BACKGROUND & AIMS:Among the human mucin complementary DNAs thus far identified, two (MUC5AC and MUC6) were cloned from stomach libraries. This study examines the distribution of MUC6 in normal tissues and compares it with that of MUC5AC as well as with the expression of Lewis blood group antigens. METHODS:Affinity-pur...


    pub_type: 评论,杂志文章


    authors: De Bolós C,Garrido M,Real FX

    更新日期:1995-09-01 00:00:00

  • Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.

    abstract::Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a sur...


    pub_type: 杂志文章,评审


    authors: di Pietro M,Canto MI,Fitzgerald RC

    更新日期:2018-01-01 00:00:00

  • Development and early prognosis of esophageal varices in severe chronic active liver disease (CALD) treated with prednisone.

    abstract::The prevalence of gastroesophageal varices and gastrointestinal hemorrhage was determined in 124 patients with severe chronic active liver disease (CALD) receiving prednisone and followed regularly for up to 10 yr. Varices were demonstrated by contrast radiography in only 19 patients (15%). Ten had varices before ther...


    pub_type: 杂志文章


    authors: Czaja AJ,Wolf AM,Summerskill WH

    更新日期:1979-10-01 00:00:00

  • Ischemic gastroparesis: resolution after revascularization.

    abstract::Patients with chronic nausea and vomiting frequently present challenging diagnostic and therapeutic problems. In such patients, gastroparesis of unknown cause, or "idiopathic" gastroparesis, may be the only objective finding. Two middle-aged women with nausea, vomiting, and weight loss of 10 and 26 kg over 6 and 18 mo...


    pub_type: 杂志文章


    authors: Liberski SM,Koch KL,Atnip RG,Stern RM

    更新日期:1990-07-01 00:00:00

  • Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases.

    abstract::The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...


    pub_type: 杂志文章


    authors: McFarlane IG,Wojcicka BM,Tsantoulas DC,Portmann BC,Eddleston AL,Williams R

    更新日期:1979-06-01 00:00:00

  • Effect of ethanol on collagen formation in dietary cirrhosis in the rat.

    abstract::Ethanol (10 or 15% in the drinking water) was found to increase the amount of collagen in the livers of rats receiving a cirrhogenic diet. This effect of ethanol was most striking in the animals receiving 10% ethanol. Ethanol lowered the amount of labeled proline incorporated into hydroxyproline and, therefore, into c...


    pub_type: 杂志文章


    authors: Henley KS,Laughrey EG,Appelman HD,Flecker K

    更新日期:1977-03-01 00:00:00

  • NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.

    abstract:BACKGROUND & AIMS:HuR is a RNA-binding factor whose expression is commonly upregulated in some human tumor types. We explored the molecular mechanism underlying HuR elevation and its role in gastric cancer tumorigenesis. METHODS:HuR expression and subcellular localization were determined by polymerase chain reaction, ...


    pub_type: 杂志文章


    authors: Kang MJ,Ryu BK,Lee MG,Han J,Lee JH,Ha TK,Byun DS,Chae KS,Lee BH,Chun HS,Lee KY,Kim HJ,Chi SG

    更新日期:2008-12-01 00:00:00

  • Arginine vasopressin inhibits phasic contractions and stimulates giant contractions in monkey colon.

    abstract::Abdominal cramps and urgent defecation are common side effects of clinical doses of arginine vasopressin, indicating that the drug may have stimulating effects on colonic motor activity. Four strain-gauge transducers were implanted on the colon in six monkeys. A blood flow probe was fixed on the inferior mesenteric ar...


    pub_type: 杂志文章


    authors: Zhu YR,Cowles VE,Herranz ES,Schulte WJ,Condon RE

    更新日期:1992-03-01 00:00:00

  • Regulation of ICAM-1-mediated fibroblast-T cell reciprocal interaction: implications for modulation of gut inflammation.

    abstract:BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...


    pub_type: 杂志文章


    authors: Musso A,Condon TP,West GA,De La Motte C,Strong SA,Levine AD,Bennett CF,Fiocchi C

    更新日期:1999-09-01 00:00:00

  • Enhanced production of endogenous prostaglandin in obstructive jaundiced pancreas in dogs.

    abstract::Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...


    pub_type: 杂志文章


    authors: Kuroda T,Kajikawa S,Hanazaki K,Horigome N,Sodeyama H,Horiuchi A,Iwatsuki K,Chiba S,Homma T,Iida F

    更新日期:1990-05-01 00:00:00

  • Direct evidence for the intact hepatocyte theory in patients with liver cirrhosis.

    abstract::An attempt was made to compare various morphometric parameters, including total hepatocyte number, with the in vivo clearances of aminopyrine and antipyrine in 26 cirrhotic and 14 noncirrhotic patients to evaluate the intact hepatocyte theory. Morphometric analysis was performed with a newly developed method using a c...


    pub_type: 杂志文章


    authors: Kawasaki S,Imamura H,Bandai Y,Sanjo K,Idezuki Y

    更新日期:1992-04-01 00:00:00