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Effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase II study.

Abstract：

BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cancer after undergoing TG. METHODS:In this randomized phase II study, 21 patients undergoing TG were assigned to a ghrelin (11 patients) or placebo group (10 patients). They received intravenous infusion of synthetic human ghrelin (3 microg/kg) or saline twice daily for 10 days after starting oral food intake following surgery. Changes in BW, appetite visual analog scale score, food intake calories, body composition, basal metabolic rate, and various blood test results were evaluated. RESULTS:Excluding one patient who developed profound diaphoresis during ghrelin infusion, 20 patients completed the study. Food intake and appetite were significantly higher with ghrelin compared with placebo (average, 13.8 vs 10.4 kcal/kg/day [P = .030] and 5.7 vs 3.9 cm [P = .032], respectively). BW loss was significantly lower in the ghrelin than in the placebo group (-1.4% vs -3.7%; P = .044). Fat mass, lean body mass, and basal metabolic rate decreased significantly in the placebo group; however, the reductions in lean body mass and basal metabolic rate were not significant in the ghrelin group, although that of fat mass was significant. CONCLUSIONS:Short-term administration of synthetic ghrelin was safe and successfully lessened postoperative BW loss and improved appetite and food intake after TG.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

doi

10.1053/j.gastro.2009.12.058

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

1312-20

issue

4

eissn

0016-5085

issn

1528-0012

pii

S0016-5085(10)00010-7

journal_volume

138

pub_type

杂志文章,随机对照试验

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