Abstract:
:To determine the effect of intraduodenal calcium on pancreatic, gallbladder, and gastric functions in healthy man, a validated perfusion method was employed to quantify total pancreatic, biliary, and gastric outputs during duodenal perfusion of either 6 mM, 12 mM,or 25 mM of elemental calcium (as isotonic calcium chloride solutions). Intraluminal calcium stimulated pancreatic enzyme secretion and gallbladder contraction in a dose-related fashion, achieving comparable responses to those produced by intravenous cholecystokinin-pancreozymin (CCK-z). Responses to calcium were reproducible when repeated in the same individual. Gastric acid outputs and serum gastrin levels increased significantly only with higher calcium perfusions (25 mM). Although duodenal calcium perfusion (25 mM) slightly increased serum calcium concentrations, induced hypercalcemia (by intravenous calcium infusion) of similar magnitude had no effect on pancreatic or gallbladder function. It is suggested that intraduodenal calcium may induce release of CCK-PZ (and/or other neurohormonal factors) from the gut, causing stimulation of these digestive organs.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Holtermuller KH,Mallagelada JR,McCall JT,Go VLkeywords:
subject
Has Abstractpub_date
1976-05-01 00:00:00pages
693-6issue
5 PT.1eissn
0016-5085issn
1528-0012pii
S0016508576001030journal_volume
70pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Gastric histology is not well studied in patients with Crohn's disease. The aim of this study was to analyze the histological appearance of gastric mucosa in patients with Crohn's disease. METHODS:In a prospective study, biopsy specimens taken from the antrum and body of 75 patients with known Crohn'...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/gast.1997.v112.pm9041230
更新日期:1997-03-01 00:00:00
abstract::We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90303-4
更新日期:1988-07-01 00:00:00
abstract::The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract::This study was performed to ascertain whether testosterone metabolism is altered in male rats with portal bypass, and whether such changes could contribute to the reduction in serum testosterone concentration and raised serum estrogen levels that are observed in this situation. The metabolic clearance rate of testoste...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90500-8
更新日期:1988-08-01 00:00:00
abstract::Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND & AIMS:There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigeneti...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.08.001
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND & AIMS:Viral genotypes have been associated with different severity and outcome of hepatitis C virus (HCV)-related liver disease. The aim of this study was to determine whether HCV genotypes may influence the cirrhosis-related risk of the development of hepatocellular carcinoma (HCC). METHODS:Three groups o...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8698200
更新日期:1996-07-01 00:00:00
abstract::We investigated the ability of isolated human colonic epithelial cells to express the common acute lymphoblastic leukemia antigen (CALLA), the transferrin receptor, and the 4F2 antigen in response to different types of stimuli. The expression of these markers was assessed by immunofluorescence using monoclonal antibod...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)90387-9
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND & AIMS:Prophylactic administration of interleukin (IL)-10 decreases the severity of experimental pancreatitis. Prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in humans is a unique model to study the potential role of IL-10 in this setting. METHODS:In a single-center, d...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.2001.21172
更新日期:2001-02-01 00:00:00
abstract::Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2017.06.006
更新日期:2017-09-01 00:00:00
abstract::The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.03.116
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND & AIMS:High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear. METHODS:We examined the associations between high-carbohydrate diets with a high glycemic response and the...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.05.016
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.07.061
更新日期:2005-11-01 00:00:00
abstract::The effect of atropine (100 micrograms/kg/h, i.v.) on plasma cholecystokinin and pancreatic secretion during diversion of bile and pancreatic juice from the intestine was studied in 8 conscious rats equipped with jugular vein, pancreatic, biliary, and duodenal cannulas, and with pyloric ligation and gastric drainage. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90836-p
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.11.041
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.07.046
更新日期:2011-11-01 00:00:00
abstract::Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90676-2
更新日期:1988-06-01 00:00:00
abstract::The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract:BACKGROUND & AIMS:We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. METHODS:The Ontario Pancreas Cancer Study enrolls consenting participants with pancreatic cancer from a province-wide elect...
journal_title:Gastroenterology
pub_type: 评论,杂志文章
doi:10.1053/j.gastro.2014.11.042
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2018.09.037
更新日期:2019-01-01 00:00:00
abstract::Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(86)90079-x
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2016.09.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND & AIMS:Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)01066-7
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND & AIMS:Intestinal fibrosis and stricture formation are serious complications of Crohn's disease, often requiring surgical intervention. Unfortunately, the mechanisms underlying intestinal fibrosis development are poorly understood, in part because of the lack of relevant animal models. Here, we present a nov...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.12.043
更新日期:2008-03-01 00:00:00
abstract::Exposure of isolated gastric mucosal surface cells to NH4+ results in acidification of cells as determined by a fluorescent dye technique using acridine orange. The resulting intracellular pH gradient is maintained when cells are suspended in either buffered HCO3- -free Ringer's or choline chloride solution. Cells sus...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND AND AIMS:CD4+CD25+Foxp3+ T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.11.277
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND & AIMS:The study and management of reflux esophagitis require an endoscopic classification system founded on esophageal lesions that can be reproducibly identified. The aim of this study was to investigate interobserver agreement for the identification of endoscopic lesions typical of reflux esophagitis. ME...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8698230
更新日期:1996-07-01 00:00:00
abstract::A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND/AIMS:The survival rate for hepatocellular carcinoma after hepatectomy remains unsatisfactorily low because of the high recurrence rate. The purpose of this study was to elucidate predictive factors for postoperative recurrence of hepatocellular carcinoma. METHODS:Univariate analysis and a multiple regressio...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90419-7
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND & AIMS:People infected with human immunodeficiency virus (HIV) have an increased risk of some malignancies, but little is known about the effects of infection on risk of cancers of the upper gastrointestinal tract. We evaluated the risks of different histologic and anatomic subtypes of carcinomas and non-Hod...
journal_title:Gastroenterology
pub_type: 杂志文章,收录出版
doi:10.1053/j.gastro.2012.07.013
更新日期:2012-10-01 00:00:00