H+ disposal by rabbit gastric mucosal surface cells.

abstract：BACKGROUND & AIMS:Crohn's disease (CD) usually recurs after intestinal resection; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence. We investigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis of the mucosa. METHODS:We analyze...

journal_title：Gastroenterology

authors： Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Krejany EO,Leach S,Gorelik A,Liew D,Prideaux L,Lawrance IC,Andrews JM,Bampton PA,Jakobovits SL,Florin TH,Gibson PR,Debinski H,Macrae FA,Samuel D,Kronborg I,Radfor

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Point mutations of the Ki-ras gene at codon 12 have been frequently identified in pure pancreatic juice of patients with pancreatic cancer in studies examining pancreatic cancer tissues. The aim of this study was to examine mutations of the Ki-ras codon 12 in the duodenal juice collected from patients...

journal_title：Gastroenterology

authors： Iguchi H,Sugano K,Fukayama N,Ohkura H,Sadamoto K,Ohkoshi K,Seo Y,Tomoda H,Funakoshi A,Wakasugi H

更新日期：1996-01-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients with hepatitis C were studied to make these assessments. METHODS:Hepatitis...

journal_title：Gastroenterology

authors： Di Bisceglie AM,Hoofnagle JH,Krawczynski K

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND & AIMS:Exposure to biologic and immunosuppressant agents during breastfeeding is controversial, and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBDs) and whether breastfeeding while receiving...

journal_title：Gastroenterology

authors： Matro R,Martin CF,Wolf D,Shah SA,Mahadevan U

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori is an important etiologic factor in the development of gastric cancer. The aim of this study was to analyze the role of H. pylori infections in the induction of mutagenic events in gastric epithelial cells. The effect of a high-salt diet as a genotoxic risk factor was also investig...

journal_title：Gastroenterology

authors： Touati E,Michel V,Thiberge JM,Wuscher N,Huerre M,Labigne A

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：:Endoscopic screening in 123 patients with pernicious anemia (PA) yielded 4 patients with solitary and 1 patient with multiple gastric carcinoid tumors. Quantitative histologic studies of multiple standardized biopsy specimens showed a significantly increased number of fundic mucosal argyrophil endocrine cells in 40 pa...

journal_title：Gastroenterology

authors： Borch K,Renvall H,Liedberg G

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND & AIMS:This study examined the possible role of endotoxinemia (from increased gut permeability) as an additional trigger factor for overt pancreatic disease and as a promoter of chronic pancreatic injury in alcoholics by using a rat model of chronic alcohol feeding and in vitro experiments with cultured panc...

journal_title：Gastroenterology

authors： Vonlaufen A,Xu Z,Daniel B,Kumar RK,Pirola R,Wilson J,Apte MV

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND/AIMS:A double-blind, placebo-controlled trial of ursodeoxycholic acid (UDCA) was conducted in 180 patients with primary biliary cirrhosis (PBC) to define the efficacy and safety of UDCA. Efficacy was assessed by time to treatment failure defined as death; liver transplantation; histological progression; deve...

journal_title：Gastroenterology

authors： Lindor KD,Dickson ER,Baldus WP,Jorgensen RA,Ludwig J,Murtaugh PA,Harrison JM,Wiesner RH,Anderson ML,Lange SM

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND & AIMS:Regulatory cytokines mediate intestinal epithelial cell (IEC) participation in mucosal immune responses. The aim of this study was to investigate the expression of secretory and intracellular isoforms of interleukin 1 receptor antagonist (IL-1Ra) in human primary IECs and carcinoma-derived cell lines....

journal_title：Gastroenterology

authors： Böcker U,Damião A,Holt L,Han DS,Jobin C,Panja A,Mayer L,Sartor RB

更新日期：1998-12-01 00:00:00

abstract：:Endoscopic sphincterotomy has proven to be a safe alternative to surgery for selected types of biliary disease. Despite a relatively low morbidity, postprocedure complications are well described. This report presents an experience with three patients in whom acute relapsing pancreatitis developed as a possible complic...

journal_title：Gastroenterology

authors： Asbun HJ,Rossi RL,Heiss FW,Shea JA

更新日期：1993-06-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND & AIMS:Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended si...

journal_title：Gastroenterology

authors： Vasen HF,Abdirahman M,Brohet R,Langers AM,Kleibeuker JH,van Kouwen M,Koornstra JJ,Boot H,Cats A,Dekker E,Sanduleanu S,Poley JW,Hardwick JC,de Vos Tot Nederveen Cappel WH,van der Meulen-de Jong AE,Tan TG,Jacobs MA,Mohame

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Few data are available concerning the long-term prognosis of chronic liver disease associated with hepatitis C virus infection. This study examined the morbidity and survival of patients with compensated cirrhosis type C. METHODS:A cohort of 384 European cirrhotic patients was enrolled at seven terti...

journal_title：Gastroenterology

authors： Fattovich G,Giustina G,Degos F,Tremolada F,Diodati G,Almasio P,Nevens F,Solinas A,Mura D,Brouwer JT,Thomas H,Njapoum C,Casarin C,Bonetti P,Fuschi P,Basho J,Tocco A,Bhalla A,Galassini R,Noventa F,Schalm SW,Realdi

更新日期：1997-02-01 00:00:00

abstract：DESCRIPTION:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update is to review the available evidence and best practice advice statements regarding the use of endoscopic therapies in treating patients with non-variceal upper gastrointestinal bleeding. METHODS:This expert...

journal_title：Gastroenterology

authors： Mullady DK,Wang AY,Waschke KA

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND & AIMS:Proliferating cholangiocytes secrete and respond to neuroendocrine hormones, including secretin. We investigated whether secretin secreted by S cells and cholangiocytes stimulates biliary proliferation in mice. METHODS:Cholestasis was induced in secretin knockout (Sct(-/-)) and wild-type (control) mi...

journal_title：Gastroenterology

authors： Glaser S,Meng F,Han Y,Onori P,Chow BK,Francis H,Venter J,McDaniel K,Marzioni M,Invernizzi P,Ueno Y,Lai JM,Huang L,Standeford H,Alvaro D,Gaudio E,Franchitto A,Alpini G

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND & AIMS:Most colon cancers arise from polypoid adenomas, but how these benign lesions develop into malignant neoplasms is not understood. This study examined the migration of epithelial cells within human adenomatous polyps by determining the distribution of proliferating and apoptotic cells and immunoreactiv...

journal_title：Gastroenterology

authors： Moss SF,Liu TC,Petrotos A,Hsu TM,Gold LI,Holt PR

更新日期：1996-12-01 00:00:00

abstract：:This paper describes the clinical management of 204 patients with Crohn's disease involving the colon who have been reviewed regularly for many years. The results have been analyzed to define the morbidity, mortality, and long term prognosis of the disorder. Despite a high morbidity, the long term prognosis is good. A...

journal_title：Gastroenterology

authors： Allan R,Steinberg DM,Williams JA,Cooke WT

更新日期：1977-10-01 00:00:00

abstract：:Transient relaxation of the lower esophageal sphincter (LES) is observed fairly frequently during prolonged continuous monitoring of the LES. The aim of this study was to test whether the presence of a catheter in the pharynx through the stimulation of mechanoreceptors may induce transient LES relaxation. LES and esop...

journal_title：Gastroenterology

authors： Mittal RK,Stewart WR,Schirmer BD

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND & AIMS:Incidence of and mortality from pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer, are almost equivalent, so better treatments are needed. We studied gene expression profiles of PDACs and the functions of genes with altered expression to identify new therapeutic target...

journal_title：Gastroenterology

authors： Jandaghi P,Najafabadi HS,Bauer AS,Papadakis AI,Fassan M,Hall A,Monast A,von Knebel Doeberitz M,Neoptolemos JP,Costello E,Greenhalf W,Scarpa A,Sipos B,Auld D,Lathrop M,Park M,Büchler MW,Strobel O,Hackert T,Giese NA,

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation. METHODS:To cause experimental pancreatitis, rats and mice were treated with ...

journal_title：Gastroenterology

authors： Gukovskaya AS,Vaquero E,Zaninovic V,Gorelick FS,Lusis AJ,Brennan ML,Holland S,Pandol SJ

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：:The effects of corticosteroid treatment on mucosal mast cells in rat jejunal mucosa were examined. Rats previously infected with Nippostrongylus brasiliensis received a single IP injection of 1 mg dexamethasone. Three hours later, one third of mucosal mast cells demonstrated minor granular changes (fusion or periphera...

journal_title：Gastroenterology

authors： Soda K,Kawabori S,Perdue MH,Bienenstock J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND & AIMS:Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by...

journal_title：Gastroenterology

authors： Sun X,Wu Y,Gao W,Enjyoji K,Csizmadia E,Müller CE,Murakami T,Robson SC

更新日期：2010-09-01 00:00:00

abstract：:We have been able to isolate mycobacteria from intestinal specimens obtained by surgical resection or endoscopic biopsy from patients with Crohn's disease, ulcerative colitis, and noninflammatory bowel diseases. Nineteen slow-growing (Runyon groups I and III) and 17 rapid-growing (Runyon group IV) mycobacterial isolat...

journal_title：Gastroenterology

authors： Graham DY,Markesich DC,Yoshimura HH

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:Simvastatin improves liver generation of nitric oxide and hepatic endothelial dysfunction in patients with cirrhosis, so it could be an effective therapy for portal hypertension. This randomized controlled trial evaluated the effects of continuous simvastatin administration on the hepatic venous press...

journal_title：Gastroenterology

authors： Abraldes JG,Albillos A,Bañares R,Turnes J,González R,García-Pagán JC,Bosch J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND AND AIMS:To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. We therefore aimed to characterize the genetic potential of the gut microbiome in PSC compared to ...

journal_title：Gastroenterology

authors： Kummen M,Thingholm LB,Rühlemann MC,Holm K,Hansen SH,Moitinho-Silva L,Liwinski T,Zenouzi R,Storm-Larsen C,Midttun Ø,McCann A,Ueland PM,Høivik ML,Vesterhus M,Trøseid M,Laudes M,Lieb W,Karlsen TH,Bang C,Schramm C,Fra

更新日期：2020-12-30 00:00:00

abstract：:Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...

journal_title：Gastroenterology

authors： Francis BH,Baskin DG,Saunders DR,Ensinck JW

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...

journal_title：Gastroenterology

authors： Halfvarson J,Bodin L,Tysk C,Lindberg E,Järnerot G

更新日期：2003-06-01 00:00:00