Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver.

abstract：:The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...

journal_title：Gastroenterology

authors： Bjarnason I,MacPherson A,Hollander D

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed ...

journal_title：Gastroenterology

authors： Apel R,Cohen Z,Andrews CW Jr,McLeod R,Steinhart H,Odze RD

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND & AIMS:Although bone marrow (BM) is known as a primary lymphoid organ, it also is known to harbor memory T cells, suggesting that this compartment is a preferential site for migration and/or selective retention of memory T cells. We here report the existence and the potential ability to induce colitis of the...

journal_title：Gastroenterology

authors： Nemoto Y,Kanai T,Makita S,Okamoto R,Totsuka T,Takeda K,Watanabe M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with chronic Helicobacter pylori (H pylori) infection, parietal and chief cell atrophy in the gastric corpus, a process known as spasmolytic polypeptide-expressing metaplasia (SPEM), increases the risk for progression to cancer. The relation between H pylori and these metaplastic changes i...

journal_title：Gastroenterology

authors： Sáenz JB,Vargas N,Mills JC

更新日期：2019-01-01 00:00:00

abstract：:The role of adrenal medullary discharge of catecholamines on inhibition of gastric emptying and small intestinal propulsion after laparotomy was examined in rats. The rate of movement of a 51Cr-labeled liquid test meal, which had been introduced by gastric intubation, out of the stomach and through the small intestine...

journal_title：Gastroenterology

authors： Dubois A,Henry DP,Kopin IJ

更新日期：1975-03-01 00:00:00

abstract：:Prior studies confirm the increased incidence of carcinoma of the colon in chronic ulcerative colitis. The authors reviewed clinical and histologic data retrospectively in 23 patients with colon carcinoma and chronic ulcerative colitis. Twenty-two of these patients had dysplasia of colonic epithelium remote from the c...

journal_title：Gastroenterology

authors： Nugent FW,Haggit RC,Colcher H,Kutteruf GC

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND & AIMS:Thyroid hormones are implicated in intestinal development. Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development. METH...

journal_title：Gastroenterology

authors： Plateroti M,Chassande O,Fraichard A,Gauthier K,Freund JN,Samarut J,Kedinger M

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux. METHODS:We compared concordance for reflux in monozygotic (MZ) and dizygotic (DZ) twins. All twins ag...

journal_title：Gastroenterology

authors： Cameron AJ,Lagergren J,Henriksson C,Nyren O,Locke GR 3rd,Pedersen NL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND & AIMS:Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the...

journal_title：Gastroenterology

authors： Wu Y,Berends MJ,Post JG,Mensink RG,Verlind E,Van Der Sluis T,Kempinga C,Sijmons RH,van der Zee AG,Hollema H,Kleibeuker JH,Buys CH,Hofstra RM

更新日期：2001-06-01 00:00:00

abstract：:Propulsion of colonic contents after eating in the whole colon was studied in 15 volunteers by scintigraphy with injection of 111In-diethylenetriamine-pentaacetic acid and 99mTc-sulfur colloid into the colon through a nasogastric tube. The radionuclide was injected into the cecoascending colon (n = 7), the hepatic fle...

journal_title：Gastroenterology

authors： Picon L,Lémann M,Flourié B,Rambaud JC,Rain JD,Jian R

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells. METHODS:Pancreas tissues from Irf2⁺/⁺, Irf2⁺/⁻), and Irf2⁻/⁻ mice were examined by microscopy, immunohistochemical, and immunoblo...

journal_title：Gastroenterology

authors： Mashima H,Sato T,Horie Y,Nakagawa Y,Kojima I,Ohteki T,Ohnishi H

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND & AIMS:Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was to investigate the onset...

journal_title：Gastroenterology

authors： Wang Y,Harvey CB,Hollox EJ,Phillips AD,Poulter M,Clay P,Walker-Smith JA,Swallow DM

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND & AIMS:Anemia is associated commonly with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia associated with inflammation...

journal_title：Gastroenterology

authors： Rivkin M,Simerzin A,Zorde-Khvalevsky E,Chai C,Yuval JB,Rosenberg N,Harari-Steinfeld R,Schneider R,Amir G,Condiotti R,Heikenwalder M,Weber A,Schramm C,Wege H,Kluwe J,Galun E,Giladi H

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are associated with chronic tissue damage and continuous tissue repair. A central, but not well-characterized, event during this process is the migration of activated fibroblasts to the wound. METHODS:Human colonic lamina propria fibroblasts (CLPF) wer...

journal_title：Gastroenterology

authors： Leeb SN,Vogl D,Gunckel M,Kiessling S,Falk W,Göke M,Schölmerich J,Gelbmann CM,Rogler G

更新日期：2003-11-01 00:00:00

abstract：:These studies were designed to better understand the effects of luminal nutrition on intestinal mass and function. Parenterally nourished rats received a midjejunal infusion of either 0.9% saline, 10% glucose, 10% 3-O-methyl glucose, or 30% glucose. A fifth group underwent sham operation. After 7 days, intestinal mass...

journal_title：Gastroenterology

authors： Richter GC,Levine GM,Shiau YF

更新日期：1983-11-01 00:00:00

abstract：:A 20-yr-old man developed recurrent respiratory symptoms and left lower lobe pneumonia 14 yr after long-segment colonic interposition for corrosive esophageal injury. A fistula, from a redundant supradiaphragmatic pouch of colon to a subsegmental bronchus of the lower lobe of the left lung, was discovered and treated ...

journal_title：Gastroenterology

authors： Perlmutter DH,Tapper D,Teele RL,Winter HS

更新日期：1984-06-01 00:00:00

abstract：:Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...

journal_title：Gastroenterology

authors： Corazza G,Valentini RA,Frisoni M,Volta U,Corrao G,Bianchi FB,Gasbarrini G

更新日期：1992-11-01 00:00:00

abstract：:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is rep...

journal_title：Gastroenterology

authors： Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson R

更新日期：1977-02-01 00:00:00

abstract：:The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....

journal_title：Gastroenterology

authors： Schebalin M,Zfass AM,Makhlouf GM

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND & AIMS:The sarcomatoid change in cholangiocarcinoma (CC) contributes to more aggressive intrahepatic spread and widespread metastasis. Therefore, the aim of this study was to identify the molecular mechanisms of CC metastasis during tumor progression and sarcomatoid change. METHODS:Using the subtraction sup...

journal_title：Gastroenterology

authors： Lee MJ,Yu GR,Yoo HJ,Kim JH,Yoon BI,Choi YK,Kim DG

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:No enzyme replacement therapy exists for patients with congenital sucrase-isomaltase deficiency (CSID). A by-product of the manufacture of baker's yeast is a liquid preparation containing high sucrase activity. The aim of the present study was to investigate the activity and stability of this preparation and...

journal_title：Gastroenterology

authors： Treem WR,Ahsan N,Sullivan B,Rossi T,Holmes R,Fitzgerald J,Proujansky R,Hyams J

更新日期：1993-10-01 00:00:00

abstract：:The effects of bile salts on energy metabolism and acid secretion were investigated in the amphibian gastric mucosa in vitro. Serosal exposure to deoxycholate (0.2-2 mM), cholate (2-8 mM), or taurocholate (4-80 mM), at pH 7.4, decreased acid secretion depending on the concentration and time of exposure. Mucosal applic...

journal_title：Gastroenterology

authors： Núñez D,Chacín J

更新日期：1989-01-01 00:00:00

abstract：:The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...

journal_title：Gastroenterology

authors： Coyne MJ,Bonorris GG,Chung A,Winchester R,Schoenfield LJ

更新日期：1978-07-01 00:00:00

abstract：:Colchicine treatment was used in this randomized placebo-controlled trial in patients with severe acute alcoholic hepatitis [serum bilirubin greater than or equal to 5 mg/dL (85.5 mumol/L) mean, 17.5 +/- 7.5 mg/dL (299.25 +/- 128.25 mumol/L)]. Hospitalization mortality and morbidity and the effect on biochemical test ...

journal_title：Gastroenterology

authors： Akriviadis EA,Steindel H,Pinto PC,Fong TL,Kanel G,Reynolds TB,Gupta S

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND & AIMS:Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate cells (HSCs) proliferate and acquire contractile properties. This study investigated the presence of receptors for ANGII and the ef...

journal_title：Gastroenterology

authors： Bataller R,Ginès P,Nicolás JM,Görbig MN,Garcia-Ramallo E,Gasull X,Bosch J,Arroyo V,Rodés J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Cholestasis is one of the principal manifestations of liver disease and often results from disorders involving bile duct epithelia rather than hepatocytes. A range of disorders affects biliary epithelia, and no unifying pathophysiologic event in these cells has been identified as the cause of choles...

journal_title：Gastroenterology

authors： Shibao K,Hirata K,Robert ME,Nathanson MH

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND & AIMS:The duodenum is a cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelium with high bicarbonate secretory capacity. We aimed to define the role of CFTR in human duodenal epithelial bicarbonate secretion in normal (NL) subjects and patients with cystic fibrosis (CF). METHODS:E...

journal_title：Gastroenterology

authors： Pratha VS,Hogan DL,Martensson BA,Bernard J,Zhou R,Isenberg JI

更新日期：2000-06-01 00:00:00

abstract：:In dogs with gastric fistulas, intragastric pressure was measured with a flaccid ballon containing 500 ml of water. Graded doses of dopamine caused graded decreases in intragastric pressure. The effect was blocked by pimozide or by metoclopramide but was not significantly affected by phenoxybenzamine, propranolol, gua...

journal_title：Gastroenterology

authors： Valenzuela JE

更新日期：1976-12-01 00:00:00

abstract：:It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...

journal_title：Gastroenterology

authors： Nasr P,Forsgren MF,Ignatova S,Dahlström N,Cedersund G,Leinhard OD,Norén B,Ekstedt M,Lundberg P,Kechagias S

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...

journal_title：Gastroenterology

authors： Younes M,Lebovitz RM,Lechago LV,Lechago J

更新日期：1993-12-01 00:00:00