p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: a follow-up study.

abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...

journal_title：Gastroenterology

authors： Schreiber S,Rutgeerts P,Fedorak RN,Khaliq-Kareemi M,Kamm MA,Boivin M,Bernstein CN,Staun M,Thomsen OØ,Innes A,CDP870 Crohn's Disease Study Group.

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

journal_title：Gastroenterology

authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

更新日期：1999-12-01 00:00:00

abstract：:Eight homosexual men presented with odynophagia. Five had a maculopapular rash and 2 had oral ulcers. Upper panendoscopy revealed the presence of multiple discrete ulcers measuring 3 mm-1.5 cm in diameter in the esophagus of each patient. The intervening mucosa appeared normal. Endoscopic brushings and biopsy specimen...

journal_title：Gastroenterology

authors： Rabeneck L,Boyko WJ,McLean DM,McLeod WA,Wong KK

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...

journal_title：Gastroenterology

authors： Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND & AIMS:Long-term data on the risk of colorectal cancer according to dose, duration, and consistency of aspirin therapy are limited. METHODS:We conducted a prospective study of 47,363 male health professionals who were ages 40-75 years at enrollment in 1986. Biennially, we collected data on aspirin use, othe...

journal_title：Gastroenterology

authors： Chan AT,Giovannucci EL,Meyerhardt JA,Schernhammer ES,Wu K,Fuchs CS

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis E virus (HEV) infection can cause chronic hepatitis in recipients of solid organ transplants. However, the factors that contribute to chronic infection and the outcomes of these patients are incompletely understood. We performed a retrospective analysis of data from 17 centers from Europe an...

journal_title：Gastroenterology

authors： Kamar N,Garrouste C,Haagsma EB,Garrigue V,Pischke S,Chauvet C,Dumortier J,Cannesson A,Cassuto-Viguier E,Thervet E,Conti F,Lebray P,Dalton HR,Santella R,Kanaan N,Essig M,Mousson C,Radenne S,Roque-Afonso AM,Izopet J,

更新日期：2011-05-01 00:00:00

abstract：:To examine the premise that exercise reduces the gastrointestinal transit time, we evaluated the effect of walking 4.5 km in an hour on mouth-to-cecum transit time. Twenty-three healthy volunteers, 9 men and 14 women, with an age range of 19-28 yr, were studied. After an overnight fast, the subjects ingested 10 g of l...

journal_title：Gastroenterology

authors： Meshkinpour H,Kemp C,Fairshter R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

更新日期：2000-09-01 00:00:00

abstract：:Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagonized by bilateral cervical vagoto...

journal_title：Gastroenterology

authors： Rattan S,Goyal RK

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...

journal_title：Gastroenterology

authors： Miyanishi K,Takayama T,Ohi M,Hayashi T,Nobuoka A,Nakajima T,Takimoto R,Kogawa K,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-10-01 00:00:00

abstract：:Primary sclerosing cholangitis is a chronic cholestatic liver disease that is commonly associated with chronic ulcerative colitis. We observed the development of varices in the abdominal wall surrounding the ileostomy stoma of patients with primary sclerosing cholangitis who underwent proctocolectomy and ileostomy for...

journal_title：Gastroenterology

authors： Wiesner RH,LaRusso NF,Dozois RR,Beaver SJ

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...

journal_title：Gastroenterology

authors： McDonald-Haile J,Bradley LA,Bailey MA,Schan CA,Richter JE

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...

journal_title：Gastroenterology

authors： Campbell PT,Deka A,Jacobs EJ,Newton CC,Hildebrand JS,McCullough ML,Limburg PJ,Gapstur SM

更新日期：2010-10-01 00:00:00

abstract：:The effect of aging on gastric and duodenal mucosal prostaglandins has not been reported. Gastric and duodenal mucosal prostaglandin concentrations were measured in 46 healthy adults, 35 of whom were relatively young (21-40 years old) and 11 of whom were considerably more elderly (aged 52-72 years). Mucosal biopsy spe...

journal_title：Gastroenterology

authors： Cryer B,Redfern JS,Goldschmiedt M,Lee E,Feldman M

更新日期：1992-04-01 00:00:00

abstract：:Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...

journal_title：Gastroenterology

authors： Burk RJ,Ludden TM,Lane JM

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...

journal_title：Gastroenterology

authors： Yin J,Harpaz N,Tong Y,Huang Y,Laurin J,Greenwald BD,Hontanosas M,Newkirk C,Meltzer SJ

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND & AIMS:Proinflammatory cytokines alter function in enteric nerves, but little is known about underlying mechanisms. This study was designed to investigate the roles of prostanoids and of macrophage-like cells in cytokine-induced suppression of [3H]norepinephrine release from rat myenteric plexus. METHODS:Th...

journal_title：Gastroenterology

authors： Rühl A,Berezin I,Collins SM

更新日期：1995-12-01 00:00:00

abstract：:Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves interactions among the neural components, including (1) the autonomic nervous system, (2) the central nervous system, (3) the stress system (hyp...

journal_title：Gastroenterology

authors： Bonaz BL,Bernstein CN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...

journal_title：Gastroenterology

authors： Luo Y,Wong CJ,Kaz AM,Dzieciatkowski S,Carter KT,Morris SM,Wang J,Willis JE,Makar KW,Ulrich CM,Lutterbaugh JD,Shrubsole MJ,Zheng W,Markowitz SD,Grady WM

更新日期：2014-08-01 00:00:00

abstract：:The assessment of disease activity in Crohn's disease involves determination of either clinical indexes (e.g., Crohn's disease activity index) or laboratory measurements (e.g., C-reactive protein and erythrocyte sedimentation rate). These have the disadvantage of being indirect and nonspecific correlates of gut inflam...

journal_title：Gastroenterology

authors： Saverymuttu SH,Peters AM,Lavender JP,Pepys MB,Hodgson HJ,Chadwick VS

更新日期：1983-12-01 00:00:00

abstract：:A randomized, double-blind comparison of lactose enemas plus placebo tablets vs. starch enemas plus neomycin tablets was performed on 18 patients with acute portal systemic encephalopathy. Ten patients received starch enemas (10%; 1000 ml t.i.d.) plus neomycin tablets and 8 patients received lactose enemas (20%; 1000 ...

journal_title：Gastroenterology

authors： Uribe M,Berthier JM,Lewis H,Mata JM,Sierra JG,García-Ramos G,Ramírez Acosta J,Dehesa M

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...

journal_title：Gastroenterology

authors： Hwang SJ,Lu RH,Chan CY,Wang YJ,Wu JC,Lee SD

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular features of colorectal tumors differ with their anatomic location. Colorectal tumors are usually classified as proximal or distal. We collected data from 3 cohorts to identify demographic, clinical, anthropometric, lifestyle, and dietary risk factors for colorectal cancer (CRC) at 7 anat...

journal_title：Gastroenterology

authors： Wang L,Lo CH,He X,Hang D,Wang M,Wu K,Chan AT,Ogino S,Giovannucci EL,Song M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND & AIMS:Recent studies indicate that kringle 1-5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1-5 gene transfer on hepatocellular carcinoma in mice. METHODS:The inhibitory effect of kringle 1-5 protein on proliferation of bovine capillary endothelia...

journal_title：Gastroenterology

authors： Torimura T,Ueno T,Kin M,Taniguchi E,Nakamura T,Inoue K,Sakata R,Hashimoto O,Sakamoto M,Ohira H,Kumashiro R,Sata M,Yano H,Kojiro M,Veitonmaki N,Cao Y

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:Histamine-producing enterochromaffin-like (ECL) cells play an integrative role in the regulation of acid secretion. Decreased mucosal histamine concentrations and increased levels of interleukin (IL) 1 beta, IL-6, and IL-8 have been detected in the gastric mucosa inflamed with Helicobacter pylori. The...

journal_title：Gastroenterology

authors： Prinz C,Neumayer N,Mahr S,Classen M,Schepp W

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...

journal_title：Gastroenterology

authors： Anderson R,Burr NE,Valori R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Corticofugal pathways to the human esophagus have been recently identified in humans using transcranial magnetic stimulation. The aim of this study was to determine the topographic representation of the esophagus on the cerebral cortex. METHODS:Focal magnetic stimulation of 1-cm areas was performed o...

journal_title：Gastroenterology

authors： Aziz Q,Rothwell JC,Hamdy S,Barlow J,Thompson DG

更新日期：1996-10-01 00:00:00

abstract：:Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

journal_title：Gastroenterology

authors： Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhosis and portal hypertension due to chronic common bile duct ligation reproduce the features of human hepatopulmonary syndrome, whereas portal hypertension alone due to partial portal vein ligation does not. Nitric oxide contributes to experimental hepatopulmonary syndrome, but the nitric oxide s...

journal_title：Gastroenterology

authors： Zhang J,Ling Y,Luo B,Tang L,Ryter SW,Stockard CR,Grizzle WE,Fallon MB

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Prolonged lamivudine therapy is associated with treatment-resistant YMDD mutant hepatitis B virus (HBV). We evaluated the efficacy and safety of adding adefovir dipivoxil to lamivudine in 135 patients with chronic hepatitis B (CHB) and YMDD mutant HBV. METHODS:Ninety-five patients with compensated ...

journal_title：Gastroenterology

authors： Perrillo R,Hann HW,Mutimer D,Willems B,Leung N,Lee WM,Moorat A,Gardner S,Woessner M,Bourne E,Brosgart CL,Schiff E

更新日期：2004-01-01 00:00:00