Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.

abstract：:Familial gastrointestinal stromal tumor (GIST) is a rare autosomal dominant genetic disorder associated with KIT germline mutations. In sporadic forms of the disease, somatic mutations target either KIT or PDGFRA genes. In a kindred in which 5 individuals had GIST, no germline mutation in KIT coding sequence has been ...

journal_title：Gastroenterology

authors： Chompret A,Kannengiesser C,Barrois M,Terrier P,Dahan P,Tursz T,Lenoir GM,Bressac-De Paillerets B

更新日期：2004-01-01 00:00:00

abstract：:Antral ulcers were produced in unanesthetized rats in 3 hr by simultaneous intravenous administration of acetylsalicylic acid (ASA) and gastric perfusion with 0.15 M HCl. Intravenous infusion of ASA alone or gastric perfusion with HCl alone produced no antral ulcers. Plasma salicylate levels ranged from 250 to 350 mic...

journal_title：Gastroenterology

authors： Kauffman GL Jr,Grossman MI

更新日期：1978-12-01 00:00:00

abstract：:Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positi...

journal_title：Gastroenterology

authors： Corazza G,Valentini RA,Frisoni M,Volta U,Corrao G,Bianchi FB,Gasbarrini G

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which cholelithiasis increases the risk of acute pancreatitis remains obscure. Because bile acids can enter the pancreas either by luminal diffusion or by interstitial leakage during gallstone impaction and pancreatitis is associated with impaired Ca(2+) signaling, we examined the eff...

journal_title：Gastroenterology

authors： Kim JY,Kim KH,Lee JA,Namkung W,Sun AQ,Ananthanarayanan M,Suchy FJ,Shin DM,Muallem S,Lee MG

更新日期：2002-06-01 00:00:00

abstract：:The case of a 21-yr-old man, who died in cachexia after 2 yr of intermittent abdominal pain, bouts of diarrhea, and anorexia, is reported. Laboratory tests performed shortly before death disclosed signs of malabsorption. Radiologic examination of the gastrointestinal tract showed a coarse mucosal relief in the upper j...

journal_title：Gastroenterology

authors： Jacobs E,Ardichvili D,Perissino A,Gottignies P,Hanssens JF

更新日期：1979-10-01 00:00:00

abstract：:We studied the influence of morphine on intestinal secretion induced by three different secretogogues in an attempt to elucidate the mechanism for its antisecretory activity. In rabbit ileal mucosa in vitro morphine (10(-4) M) did not influence the electrical response to the subsequent administration of prostaglandin ...

journal_title：Gastroenterology

authors： McKay JS,Linaker BD,Higgs NB,Turnberg LA

更新日期：1982-02-01 00:00:00

abstract：:Helicobacter pylori has recently been implicated as an etiologic agent of gastroduodenal disorders. Comparing the antibody to H. pylori in the sera of patients with that of normal controls by Western blot analysis, a unique antibody was detected in the sera of patients, which reacted with the 25-kilodalton antigen of ...

journal_title：Gastroenterology

authors： Sugiyama T,Imai K,Yoshida H,Takayama Y,Yabana T,Yokota K,Oguma K,Yachi A

更新日期：1991-07-01 00:00:00

abstract：:An animal model suitable for in vivo studies of interferon-mediated suppression of hepatic oxidative drug metabolism has been developed. Rats were injected with either recombinant human interferon alpha A, recombinant human interferon gamma, recombinant rat interferon gamma, or vehicle and experiments were performed 2...

journal_title：Gastroenterology

authors： Craig PI,Williams SJ,Cantrill E,Farrell GC

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...

journal_title：Gastroenterology

authors： Fukudo S,Kinoshita Y,Okumura T,Ida M,Akiho H,Nakashima Y,Nishida A,Haruma K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population. METHODS:Adult participants of the Third National Health and Nutrition Examination Survey who did not consume alcohol (n = 8839) were compared w...

journal_title：Gastroenterology

authors： Ioannou GN,Dominitz JA,Weiss NS,Heagerty PJ,Kowdley KV

更新日期：2004-05-01 00:00:00

abstract：:Treatment of eosinophilic esophagitis has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Al...

journal_title：Gastroenterology

authors： Hirano I,Furuta GT

更新日期：2020-03-01 00:00:00

abstract：:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their abilit...

journal_title：Gastroenterology

authors： Gardner JD,Conlon TP,Fink ML,Bodanszky M

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND & AIMS:Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression...

journal_title：Gastroenterology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Sarra M,Stolfi C,Becker C,Macdonald TT,Pallone F,Neurath MF,Monteleone G

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND & AIMS:Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by...

journal_title：Gastroenterology

authors： Bertomeu A,Ros E,Zambón D,Vela M,Pérez-Ayuso RM,Targarona E,Trías M,Sanllehy C,Casals E,Ribó JM

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND & AIMS:There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novo lipogenesis and fatty acid flux between subjects with NAFLD and those without, matched for metabolic factors (controls). METHODS:W...

journal_title：Gastroenterology

authors： Lambert JE,Ramos-Roman MA,Browning JD,Parks EJ

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular mechanisms that contribute to the cholestatic condition in hepatocytes are poorly defined. It has been postulated that a disruption of normal vesicle-based protein trafficking may lead to alterations in hepatocyte polarity. METHODS:To determine if vesicle motility is reduced by cholesta...

journal_title：Gastroenterology

authors： Török NJ,Larusso EM,McNiven MA

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND & AIMS:Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used t...

journal_title：Gastroenterology

authors： Toiyama Y,Okugawa Y,Tanaka K,Araki T,Uchida K,Hishida A,Uchino M,Ikeuchi H,Hirota S,Kusunoki M,Boland CR,Goel A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND & AIMS:The Ki-RAS oncogene is altered in pancreatic ductal neoplasms. Pancreatic ductal cells (PDCs) were purified from cytokeratin 19 (K19)-Ki-RAS(G12V) transgenic mice and control littermates to identify properties of Ki-Ras activation in a cell-type-specific context. Because Ki-RAS mutation has prognostic...

journal_title：Gastroenterology

authors： Schreiber FS,Deramaudt TB,Brunner TB,Boretti MI,Gooch KJ,Stoffers DA,Bernhard EJ,Rustgi AK

更新日期：2004-07-01 00:00:00

abstract：:The clinical case is presented of a 16-yr-old patient with thoracoabdominal duplication that communicated with the main pancreatic duct and the right pleural cavity and resulted in pancreaticopleural fistula. Although abdominal duplications communicating with the pancreas have been described before, to our knowledge, ...

journal_title：Gastroenterology

authors： Fitzgibbons RJ Jr,Nugent FW,Ellis FH Jr,Braasch JW,Scholz FJ

更新日期：1980-08-01 00:00:00

abstract：:Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...

journal_title：Gastroenterology

authors： Meyer JH,Dressman J,Fink A,Amidon G

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND & AIMS:Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel sy...

journal_title：Gastroenterology

authors： Fritscher-Ravens A,Pflaum T,Mösinger M,Ruchay Z,Röcken C,Milla PJ,Das M,Böttner M,Wedel T,Schuppan D

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Oral administration of ursodeoxycholic acid (UDCA) and cholesterol causes bile salt malabsorption; the former by competition for and the latter by down-regulation of ileal bile acid transporters. Because ileectomy in rats induces enterohepatic cycling of bilirubin, the hypothesis that dietary steroids...

journal_title：Gastroenterology

authors： Méndez-Sánchez N,Brink MA,Paigen B,Carey MC

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND & AIMS:In the absence of pathognomonic markers for Crohn's disease (CD) and ulcerative colitis (UC), the diagnosis of inflammatory bowel disease depends on a compendium of clinical, radiographic, endoscopic, and histologic criteria that bears imperfect specificity to the individual disorders. In 10% of cases...

journal_title：Gastroenterology

authors： Joossens S,Reinisch W,Vermeire S,Sendid B,Poulain D,Peeters M,Geboes K,Bossuyt X,Vandewalle P,Oberhuber G,Vogelsang H,Rutgeerts P,Colombel JF

更新日期：2002-05-01 00:00:00

abstract：:Bacterial extracts were prepared from cultures originating in chronic self-filling intestinal blind loops in rats. Their ability to remove active maltase molecules from isolated brush border membranes was studied in vitro. Twelve strains in 51 tested, belonging to one of three species, Bacteroides fragilis, Clostridiu...

journal_title：Gastroenterology

authors： Jonas A,Krishnan C,Forstner G

更新日期：1978-11-01 00:00:00

abstract：:In rats injected with pentagastrin (2-500 micrograms/kg subcutaneously) in saline, peak gastric acid responses occurred after 31 (30-min output) or 63 micrograms/kg (60-min output). Rats were fed or fasted for 48 h and injected every 8 h with 63, 250, or 1000 micrograms/kg pentagastrin. Fasting decreased body weight (...

journal_title：Gastroenterology

authors： Solomon TE

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND & AIMS:Spontaneous hepatitis B surface antigen (HBsAg) seroclearance is a rare event in patients with chronic hepatitis B virus infection. The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients. METHODS:A total o...

journal_title：Gastroenterology

authors： Chen YC,Sheen IS,Chu CM,Liaw YF

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND & AIMS:Body weight (BW) loss and reduction of blood ghrelin level are commonly observed after total gastrectomy (TG). A prospective study was designed to elucidate whether exogenous ghrelin administration prevents postoperative BW loss by improving appetite and oral food intake in patients with gastric cance...

journal_title：Gastroenterology

authors： Adachi S,Takiguchi S,Okada K,Yamamoto K,Yamasaki M,Miyata H,Nakajima K,Fujiwara Y,Hosoda H,Kangawa K,Mori M,Doki Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...

journal_title：Gastroenterology

authors： Ness TJ

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...

journal_title：Gastroenterology

authors： de la Concha EG,Fernandez-Arquero M,Lopez-Nava G,Martin E,Allcock RJ,Conejero L,Paredes JG,Diaz-Rubio M

更新日期：2000-12-01 00:00:00

abstract：:We performed 92 computed tomography-guided percutaneous needle aspirations of pancreatic inflammatory masses in 60 patients suspected of harboring pancreatic infection. Thirty-six patients (60%) were found by Gram stain and culture to have a total of 41 separate episodes of pancreatic infection. Among 42 aspirates jud...

journal_title：Gastroenterology

authors： Gerzof SG,Banks PA,Robbins AH,Johnson WC,Spechler SJ,Wetzner SM,Snider JM,Langevin RE,Jay ME

更新日期：1987-12-01 00:00:00