Abstract：
:Three analogues of the carboxyl-terminal tricosapeptide of secretin (S5-27), one with glutamine replacing glutamic acid in position 9 (9-Gln-S5-27), a second with asparagine substituted for aspartic acid in position 15 (15-Asn-S5-27), and a third with both replacements (9-Gln-15-Asn-S5-27) were tested for their ability to interact with hormone receptors on dispersed pancreatic acinar cells. Each of these analogues inhibited binding of 125I-labeled vasoactive intestinal peptide (VIP). None of the analogues increased cellular cyclic AMP but each inhibited the increase in cellular cyclic AMP produced by secretin or VIP. At the high affinity VIP receptor (the low affinity secretin receptor) each analogue had an apparent affinity which was greater than that for S5-27, whereas at he low affinity VIP receptor (the high affinity secretin receptor), each of the analogues had an apparent affinity which was the same as that for S5-27. Thus, in S5-27, substituting glutamine in position 9 or asparagine in position 15 makes the fragment more VIP-like but not less secretin-like. These results also provide additional evidence that the receptor having a low affinity for secretin and a high affinity for VIP is functionally distinct from the receptor having a high affinity for secretin and a low affinity for VIP.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Gardner JD,Conlon TP,Fink ML,Bodanszky Msubject
Has Abstractpub_date
1976-12-01 00:00:00pages
965-70issue
6eissn
0016-5085issn
1528-0012pii
S0016508576003065journal_volume
71pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2005.06.064
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND AND AIMS:It is not clear what induction dose of mesalamine is optimal for treating patients with mildly and moderately active ulcerative colitis (UC). This study was conducted to determine the efficacy and safety of mesalamine 4.8 g/day compared with 2.4 g/day for the treatment of moderately active UC. METH...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2009.08.069
更新日期：2009-12-01 00:00:00
abstract：:This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespectiv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)90437-9
更新日期：1987-10-01 00:00:00
abstract：:Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70311-7
更新日期：1998-05-01 00:00:00
abstract：:This study was conducted to determine whether short-term (1.75 h) luminal glucose perfusion increases the mucosal protein synthesis rate in rat small intestine. A luminal perfusate containing 56 mM glucose was compared with a control perfusate containing mannitol in two jejunal segments constructed in the same animal....
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Using a radioimmunoassay which detect concentrations of alpha-fetoprotein as low as 5 ng per ml, 38% of 176 patients with viral hepatitis compared with health volunteers and patients with chronic diseases not affecting the liver. When separated into two groups based on histological classification of liver biopsy speci...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
abstract：BACKGROUND & AIMS:Prior thermal stress induces heat shock protein 70 (HSP70) expression in the pancreas and protects against secretagogue-induced pancreatitis, but it is not clear that this thermal stress-induced protection is actually mediated by HSP70 since thermal stress may have other, non-HSP related, effects. ME...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.30314
更新日期：2002-01-01 00:00:00
abstract：:Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/0016-5085(95)90033-0
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.10.018
更新日期：2006-02-01 00:00:00
abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91797-8
更新日期：1992-01-01 00:00:00
abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-08-01 00:00:00
abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) can promote or inhibit tumor growth and are therefore being developed as targets for cancer therapies. They are diverse not only in the messenger RNAs (mRNA) they target, but in their production; the same hairpin RNA structure can generate mature products from each strand, termed 5p...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.12.047
更新日期：2012-04-01 00:00:00
abstract：:Canine ileal segments were luminally perfused with known amounts of polyethylene glycol (PEG), and samples obtained were freed of protein by a cold acetone (CA) method and assayed for PEG by trichloroacetic acid in the presence of calcium cations. This procedure was compared to the Barium salt (BaS) protein precipitat...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-04-01 00:00:00
abstract：:Three structurally related peptides, ovine corticotropin-releasing factor, sauvagine, and urotensin I are selective mesenteric vasodilators in dogs. To assess the possible benefit of these peptides in nonocclusive mesenteric ischemia, they were compared with a nonselective vasodilator, sodium nitroprusside, in the ane...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)91122-4
更新日期：1986-03-01 00:00:00
abstract：:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of su...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/s0016-5085(89)80060-5
更新日期：1989-02-01 00:00:00
abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1016/0016-5085(92)90164-t
更新日期：1992-03-01 00:00:00
abstract：:The authors' previous observation that many of the monoclonal antibodies against Helicobacter pylori cross-react with the cells of the human gastric mucosa prompted them to investigate the possibility that gastric self-antigens cross-reacting with H. pylori could be involved in the immune response against this organis...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90023-e
更新日期：1991-08-01 00:00:00
abstract：:Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.12.034
更新日期：2014-04-01 00:00:00
abstract：:Recent reports suggest most solid food enters the duodenum as small particles. Our studies showed that small particles of liver were capable of binding hydrogen ions (H+), but there was slow equilibration of H+ between particulate and aqueous phases. We wondered whether titratable acid as H+ bound to meat particles co...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Fecal recovery of radioactivity after ingestion of a bolus of radiolabeled bile acid is abnormally high in most patients with idiopathic chronic diarrhea. To evaluate the significance of this malabsorption, concurrent fecal excretion of both exogenous radiolabeled bile acid and endogenous (unlabeled) bile acid were me...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)90031-u
更新日期：1990-04-01 00:00:00
abstract：:A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1053/j.gastro.2011.08.036
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND & AIMS:Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo. METHODS:In an in vitro study, liver microsomes from male Wistar rats were preincubated with indomethacin and a r...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.31886
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.08.005
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND/AIMS:Approximately 50% of patients with functional dyspepsia have Helicobacter pylori infection; it remains controversial whether this infection causes chronic symptoms, but rigorously conducted therapeutic trials should establish whether H. pylori plays a role in functional dyspepsia. The aim here was to de...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/0016-5085(94)90007-8
更新日期：1994-05-01 00:00:00
abstract：:Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2012.11.037
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(98)70191-x
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND & AIMS:Photodynamic therapy (PDT) for high-grade dysplasia (HGD) in Barrett's esophagus is a Food and Drug Administration-approved alternative to esophagectomy. Critical information regarding overall survival of patients followed up long-term after these therapies is lacking. Our aim was to compare the long-...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.02.017
更新日期：2007-04-01 00:00:00
abstract：:Insulinlike growth factor I is a potent mitogen with insulinlike metabolic effects. Insulinlike growth factor I is synthesized in the liver, intestine, and other organs. Insulinlike growth factor I receptors are widely distributed and structurally similar to insulin receptors. Frozen sections of rabbit gastrointestina...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91228-x
更新日期：1990-07-01 00:00:00
