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Endogenous nitric oxide as a mediator of gastric mucosal vasodilatation during acid secretion.

Abstract：

:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide synthesis, NG-monomethyl-L-arginine (12.5 and 50 mg/kg), which dose-dependently increased systemic arterial blood pressure, did not affect resting acid output. However, NG-monomethyl-L-arginine significantly reduced resting gastric mucosal blood flow at the higher dose, as determined by hydrogen gas clearance. Infusion of pentagastrin (80 micrograms kg-1.h-1) stimulated gastric acid secretion and elevated gastric mucosal blood flow. Pretreatment with NG-monomethyl-L-arginine (12.5 mg/kg IV) did not affect this stimulation of acid output but substantially attenuated (by 65% +/- 10%; P less than 0.01) the associated increase in gastric mucosal blood flow. Pretreatment with NG-monomethyl-L-arginine (50 mg/kg IV) induced a minor inhibition of pentagastrin-stimulated acid secretion but abolished the increase in gastric mucosal blood flow. When administered during pentagastrin infusion, NG-monomethyl-L-arginine (50 mg/kg IV) did not affect the acid secretory response but induced a 76% +/- 8% inhibition (P less than 0.05) of the elevated gastric mucosal blood flow. The effects of NG-monomethyl-L-arginine on blood pressure, acid secretion, and gastric mucosal blood flow were abolished by pretreatment with the precursor for nitric oxide synthesis, L-arginine (300 mg/kg IV). These findings in the rat suggest that endogenous nitric oxide, synthesized from L-arginine, does not directly modulate the acid secretory response induced by pentagastrin but makes a substantial contribution to the mucosal vasodilatation associated with the stimulation of gastric acid secretion.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Pique JM,Esplugues JV,Whittle BJ

doi

10.1016/0016-5085(92)91797-8

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

168-74

issue

1

eissn

0016-5085

issn

1528-0012

pii

0016-5085(92)91797-8

journal_volume

102

pub_type

杂志文章

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