Abstract:
BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosis. Evidence for these associations is poor. We sought to determine whether low-fiber or high-fat diets, diets that include large quantities of red meat, constipation, or physical inactivity increase risk for asymptomatic diverticulosis. METHODS:We performed a cross-sectional study of 2104 participants, 30-80 years old, who underwent outpatient colonoscopy from 1998 to 2010. Diet and physical activity were assessed in interviews using validated instruments. RESULTS:The prevalence of diverticulosis increased with age, as expected. High intake of fiber did not reduce the prevalence of diverticulosis. Instead, the quartile with the highest fiber intake had a greater prevalence of diverticulosis than the lowest (prevalence ratio = 1.30; 95% confidence interval, 1.13-1.50). Risk increased when calculated based on intake of total fiber, fiber from grains, soluble fiber, and insoluble fiber. Constipation was not a risk factor. Compared to individuals with <7 bowel movements per week, individuals with >15 bowel movements per week had a 70% greater risk for diverticulosis (prevalence ratio = 1.70; 95% confidence interval, 1.24-2.34). Neither physical inactivity nor intake of fat or red meat was associated with diverticulosis. CONCLUSIONS:A high-fiber diet and increased frequency of bowel movements are associated with greater, rather than lower, prevalence of diverticulosis. Hypotheses regarding risk factors for asymptomatic diverticulosis should be reconsidered.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Peery AF,Barrett PR,Park D,Rogers AJ,Galanko JA,Martin CF,Sandler RSdoi
10.1053/j.gastro.2011.10.035subject
Has Abstractpub_date
2012-02-01 00:00:00pages
266-72.e1issue
2eissn
0016-5085issn
1528-0012pii
S0016-5085(11)01509-5journal_volume
142pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90132-5
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.12.036
更新日期:2006-04-01 00:00:00
abstract::We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90187-3
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.07.008
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND & AIMS:The mechanisms by which hepatitis C virus (HCV) induces liver fibrosis are unknown. Hepatocytes secrete HCV proteins, which may interact with hepatic stellate cells (HSCs). Our aims were to investigate whether HCV proteins induce fibrogenic effects on HSCs. METHODS & RESULTS:Human-activated HSCs expr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2003.11.018
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND/AIMS:Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis. However, new imaging techniques allow for the diagnosis of hepatic vein thrombosis in asymptomatic cases. The aim of our study was to re-evaluate symptoms and prognosis in p...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90765-x
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70138-0
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2004.06.017
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31891
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2016.09.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.10.014
更新日期:2006-01-01 00:00:00
abstract::The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complicatio...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2017.01.046
更新日期:2017-05-01 00:00:00
abstract::We have previously demonstrated circulating and tissue-fixed immune complexes containing the small cytoplasmic ribonucleoprotein antigen Ro and immunoglobulin G (IgG) in a case of sicca syndrome associated with primary biliary cirrhosis. To establish the overall prevalence of such complexes in liver disease, we perfor...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)91129-7
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.11.028
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND/AIMS:Conventional flow-cytometric analysis of colorectal tumor DNA content includes both tumor and stromal cell DNA. To improve the method, we evaluated the DNA content of purified epithelial cells using the crypt-isolation technique. METHODS:Normal and neoplastic crypts were isolated from fresh resected co...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(94)94651-5
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND & AIMS:Barrett's esophagus-associated high-grade dysplasia is commonly treated by endoscopy. However, most guidelines offer no recommendations for endoscopic treatment of mucosal adenocarcinoma of the esophagus (mAC). We investigated the efficacy and safety of endoscopic resection in a large series of patien...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.11.006
更新日期:2014-03-01 00:00:00
abstract::Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-01-01 00:00:00
abstract::Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is influenced by the local colonic environment and the patient's genetic background. Consolidating the knowledge of genetic and epigenetic events that occur with initiation, progression, and metastasis of sporadic CRC has identified so...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2015.06.047
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND & AIMS:Anemia is associated commonly with acute and chronic inflammation, but the mechanisms of their interaction are not clear. We investigated whether microRNA 122 (MIR122), which is generated in the liver and is secreted into the blood, is involved in the development of anemia associated with inflammation...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.07.031
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND & AIMS:Guidelines recommend a 10-year interval between screening colonoscopies with negative results for average-risk individuals. However, many patients are examined at shorter intervals. We investigated outcomes of individuals with no polyps who had repeat colonoscopy in <10 years. METHODS:Data were colle...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.04.020
更新日期:2014-08-01 00:00:00
abstract::Vascular casts of human oxyntic mucosa, examined by scanning electron microscopy, revealed that (a) arterial breakup occurs only at the submucosal aspect of the mucosa, there being no arterial vessels further into the mucosa and (b) mucosal capillaries drain into the infrequent mucosal venules only in the most luminal...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v112.pm9178670
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2013.05.014
更新日期:2013-09-01 00:00:00
abstract::A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2010.01.055
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00385-8
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND & AIMS:Reduced generation of all-trans retinoic acid (RA) by CD103(+) intestinal dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in intestinal inflammation in humans is unclear. We investigated which antigen-presenting cells (APCs) produce RA in the human intestine...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.01.057
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Calretinin and calbindin-D28k are similar Ca(2+)-binding proteins previously described in specific central neurons and other cells. METHODS:The immunocytochemical distribution of these two proteins was studied in the human gastrointestinal tract. RESULTS:In gastric and small intestinal endocrine cells, cal...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90346-e
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatopulmonary syndrome (HPS) affects 10%-30% of patients with cirrhosis and portal hypertension and significantly increases mortality. Studies in experimental models indicate that pulmonary angiogenesis contributes to the development of HPS, but pathogenesis in humans is poorly understood. We invest...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2010.03.044
更新日期:2010-07-01 00:00:00
abstract::Sixty-six outpatients with active ulcerative colitis who were intolerant of sulfasalazine were treated in a double-blind randomized trial. They received placebo or olsalazine sodium in daily doses of 0.75, 1.5, or 3 g. Overall, 35% of patients receiving olsalazine improved clinically, compared to 16% of patients recei...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0016-5085(87)90253-8
更新日期:1987-12-01 00:00:00
abstract::In rats, hypergastrinemia due to achlorhydria produced by antisecretory drugs or resection of the gastric fundus leads to enterochromaffinlike (ECL) cell hyperplasia and gastric carcinoids. In humans, achlorhydria due to pernicious anemia may also lead to ECL cell hyperplasia and multicentric gastric carcinoids in as ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00