Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts.

abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

journal_title：Gastroenterology

authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

更新日期：2000-07-01 00:00:00

abstract：:The genes associated with each of the inherited syndromes of colon cancer have now been identified, and genetic testing is available for diagnosis. These syndromes include familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, Peutz-Jeghers syndrome, juvenile polyposis syndrome, and, possibly, Cowd...

journal_title：Gastroenterology

authors： Burt R,Neklason DW

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：:From 1979 to 1984, we followed the cases of 3 men (aged 13, 31, and 75 yr) and 2 women (aged 38 and 45 yr who had never used oral contraceptives) suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma. During the same period, we observed 2...

journal_title：Gastroenterology

authors： Flejou JF,Barge J,Menu Y,Degott C,Bismuth H,Potet F,Benhamou JP

更新日期：1985-11-01 00:00:00

abstract：:Sixty chronically alcoholic men who were impotent and known to have abstained from alcohol were followed prospectively to determine (a) the frequency of spontaneous recovery of normal sexual functioning, (b) indicators of spontaneous recovery, and (c) the response of those who did not achieve a spontaneous recovery to...

journal_title：Gastroenterology

authors： Van Thiel DH,Gavaler JS,Sanghvi A

更新日期：1983-04-01 00:00:00

abstract：:We describe a 47-year-old patient who developed cholelithiasis in adolescence, followed by recurrent intrahepatic cholestasis of pregnancy, and finally biliary cirrhosis in adulthood. In our patient, the consecutive presentation of the 3 mentioned disorders raised the suspicion of a defect of MDR3, the canalicular pro...

journal_title：Gastroenterology

authors： Lucena JF,Herrero JI,Quiroga J,Sangro B,Garcia-Foncillas J,Zabalegui N,Sola J,Herraiz M,Medina JF,Prieto J

更新日期：2003-04-01 00:00:00

abstract：:Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other me...

journal_title：Gastroenterology

authors： Nieuwdorp M,Gilijamse PW,Pai N,Kaplan LM

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND & AIMS:The cyclic adenosine monophosphate (cAMP) and Ca(2+) signaling pathways synergize to regulate many physiological functions. However, little is known about the mechanisms by which these pathways interact. We investigated the synergy between these signaling pathways in mouse pancreatic and salivary glan...

journal_title：Gastroenterology

authors： Park S,Shcheynikov N,Hong JH,Zheng C,Suh SH,Kawaai K,Ando H,Mizutani A,Abe T,Kiyonari H,Seki G,Yule D,Mikoshiba K,Muallem S

更新日期：2013-07-01 00:00:00

abstract：:To study the relationship between gallstone disease (cholelithiasis and cholecystectomy) and cancer, a case-control study was performed in two Swedish hospitals comparing the prevalence of gallstone disease discovered at necropsy in 1422 subjects who died of cancer and 1205 subjects who did not die of cancer. Gallston...

journal_title：Gastroenterology

authors： Lowenfels AB,Domellöf L,Lindström CG,Bergman F,Monk MA,Sternby NH

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND/AIMS:Clinical and experimental studies suggest a link between nutritional status and the recovery of hepatic function after hypoxic and hypothermic insults. This study aimed at determining the metabolic pathways involved in such recovery as a function of nutrition. METHODS:Livers from fed and fasted mice we...

journal_title：Gastroenterology

authors： Dimicoli JL,Patry J,Adam R,Dennison A,Nedelec JF,Bismuth H

更新日期：1994-12-01 00:00:00

abstract：:Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...

journal_title：Gastroenterology

authors： Lenz HJ

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:Sjögren's syndrome and autoimmune pancreatitis are disorders with decreased function of salivary, lacrimal glands, and the exocrine pancreas. Nonobese diabetic/ShiLTJ mice and mice transduced with the cytokine BMP6 develop Sjögren's syndrome and chronic pancreatitis and MRL/Mp mice are models of autoi...

journal_title：Gastroenterology

authors： Zeng M,Szymczak M,Ahuja M,Zheng C,Yin H,Swaim W,Chiorini JA,Bridges RJ,Muallem S

更新日期：2017-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is the agent responsible for posttransfusion hepatitis. The incidence, timing, and clinical course of HCV positive hepatitis in liver transplant recipients are unknown. Three hundred and seventeen donor-recipient liver transplant pairs were grouped on the basis of their pretransplant HCV antibo...

journal_title：Gastroenterology

authors： Shah G,Demetris AJ,Gavaler JS,Lewis JH,Todo S,Starzl TE,Van Thiel DH

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...

journal_title：Gastroenterology

authors： Chan FK,Kyaw M,Tanigawa T,Higuchi K,Fujimoto K,Cheong PK,Lee V,Kinoshita Y,Naito Y,Watanabe T,Ching JY,Lam K,Lo A,Chan H,Lui R,Tang RS,Sakata Y,Tse YK,Takeuchi T,Handa O,Nebiki H,Wu JC,Abe T,Mishiro T,Ng S

更新日期：2017-01-01 00:00:00

abstract：:One hundred symptomatic patients with radiolucent gallbladder stones were treated with a new piezoelectric lithotripter and oral chemolitholytic agents. Stone disintegration was achieved in 99 of these patients (99%) with a mean (+/- SD) maximum fragment size of 5.1 +/- 4.1 mm. Significant differences were found when ...

journal_title：Gastroenterology

authors： Ell C,Kerzel W,Schneider HT,Benninger J,Wirtz P,Domschke W,Hahn EG

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND & AIMS:Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs; 1-2 small tubular adenomas, < 1 cm) every 5-10 years for colorectal cancer; many recommend shorter surveillance intervals for these individuals. We aimed to identify the reasons that endoscopists recomm...

journal_title：Gastroenterology

authors： Anderson JC,Baron JA,Ahnen DJ,Barry EL,Bostick RM,Burke CA,Bresalier RS,Church TR,Cole BF,Cruz-Correa M,Kim AS,Mott LA,Sandler RS,Robertson DJ

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic myelopathy is a rare complication of chronic liver disease, causing progressive spastic paraparesis. Today, no therapy of this disorder has been established. Commonly used therapeutic strategies for hepatic encephalopathy aiming at the reduction of plasma ammonia levels such as protein restric...

journal_title：Gastroenterology

authors： Weissenborn K,Tietge UJ,Bokemeyer M,Mohammadi B,Bode U,Manns MP,Caselitz M

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...

journal_title：Gastroenterology

authors： Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

更新日期：2005-12-01 00:00:00

abstract：:Radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. Most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impair...

journal_title：Gastroenterology

authors： Gadacz TR,Allan RN,Mack E,Hofmann AF

更新日期：1976-06-01 00:00:00

abstract：:Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptami...

journal_title：Gastroenterology

authors： Crowe R,Kamm MA,Burnstock G,Lennard-Jones JE

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

journal_title：Gastroenterology

authors： Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...

journal_title：Gastroenterology

authors： Lala S,Ogura Y,Osborne C,Hor SY,Bromfield A,Davies S,Ogunbiyi O,Nuñez G,Keshav S

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...

journal_title：Gastroenterology

authors： Eckardt VF,Grace ND,Kantrowitz PA

更新日期：1976-08-01 00:00:00

abstract：:A rapid, sensitive, precise radioimmunoassay for conjugates of chenodeoxycholic (chenic) acid has been developed and validated. Immunogen was prepared with chenylglycine couples to bovine serum albumin, emulsified in Freund's complete adjuvant, and injected intracutaneously in rabbits. Antibodies of moderate titer (us...

journal_title：Gastroenterology

authors： Schalm SW,van Berge-Henegouwen GP,Hofmann AF,Cowen AE,Turcotte J

更新日期：1977-08-01 00:00:00

abstract：UNLABELLED:Cerebral evoked potentials provide a technique for evaluation of central nervous processing of information derived from a variety of sensory modalities. Evoked potentials associated with balloon distention of the smooth muscle esophagus were studied in 14 adult volunteers. Stimulation was applied via repeate...

journal_title：Gastroenterology

authors： Castell DO,Wood JD,Frieling T,Wright FS,Vieth RF

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...

journal_title：Gastroenterology

authors： Lau DT,Everhart J,Kleiner DE,Park Y,Vergalla J,Schmid P,Hoofnagle JH

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND & AIMS:Omeprazole is metabolized by cytochrome P450 (CYP2C19). The activity of this enzyme is polymorphic, with incidences of poor metabolizers (PMs), heterozygous extensive metabolizers (EMs), and homozygous EMs in white populations of 3%, 30%, and 67%, respectively. The importance of the CYP2C19 polymorphi...

journal_title：Gastroenterology

authors： Sagar M,Tybring G,Dahl ML,Bertilsson L,Seensalu R

更新日期：2000-09-01 00:00:00

abstract：:Effects of opiates on intestinal motor activity and transport of water and electrolytes have been studied separately in previous investigations. The aim of these experiments was to evaluate simultaneously the effects of a synthetic opiate, loperamide, on motor activity and transport in the human intestine. Jejunal, il...

journal_title：Gastroenterology

authors： Kachel G,Ruppin H,Hagel J,Barina W,Meinhardt M,Domschke W

更新日期：1986-01-01 00:00:00

abstract：:Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of H pylori infection. We compared the recommendations o...

journal_title：Gastroenterology

authors： Fallone CA,Moss SF,Malfertheiner P

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Integrity of the intestinal epithelium is required for nutrition absorption and defense against pathogens. Claudins are cell adhesion molecules that localize at tight junctions (TJs); many are expressed in the intestinal tract, but little is known about their functions. Claudin-7 is unique in that it ...

journal_title：Gastroenterology

authors： Ding L,Lu Z,Foreman O,Tatum R,Lu Q,Renegar R,Cao J,Chen YH

更新日期：2012-02-01 00:00:00