Abstract:
BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices and prospectively assessed outcomes. METHODS:In this prospective multicenter international study Inflammatory activity was assessed with high definition and virtual chromoendoscopy in the rectum and sigmoid using Mayo Endoscopic Score (MES), UC Endoscopic Index of Severity (UCEIS) and PICaSSO. Targeted biopsies were taken for assessment using Robarts Histological Index (RHI), Nancy Histological index (NHI), ECAP, Geboes and Villanacci. Follow up data was obtained at 6 and 12 months after colonoscopy. RESULTS:307 patients were recruited. There was strong correlation between PICaSSO and histology scores, significantly superior to correlation coefficients of MES and UCEIS with histology scores. A PICaSSO score of ≤3 detected histologic remission by RHI (≤3 + absence of neutrophils) with AUROC 0.90 (95% CI 0.86-0.94) and NHI (≤1) AUROC 0.82 (95% CI 0.77-0.87). The inter-observer agreement for PICaSSO was 0.88 (95% CI 0.83-0.92). At 6- and 12-months follow-up PICaSSO score ≤3 predicted better outcomes than PICaSSO >3 {hazard ratio HR 0.19 (0.11-0.33) and 0.22 (0.13-0.34) respectively} as well as PICaSSO 4-8 {HR 0.25 (0.12,0.53) and 0.22 (0.12,0.39) respectively} and similar to histologic remission. CONCLUSION:In this first real-life multicenter study, the PICaSSO score correlated strongly with multiple histological indices. Furthemore, PICaSSO score predicted specified clinical outcomes at 6 and 12 months similar to histology. Thus, PICaSSO can be a useful endoscopic tool in the therapeutic management of UC.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontinidoi
10.1053/j.gastro.2020.12.024subject
Has Abstractpub_date
2020-12-18 00:00:00eissn
0016-5085issn
1528-0012pii
S0016-5085(20)35563-3pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90480-9
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND & AIMS:Patients with previous stomach and terminal ileum resections are often treated with intramuscular vitamin B12 injections. Disadvantages are, on a worldwide scale, the frequent need for medical personnel to administer injections and the sometimes painful way of application. This study was designed to i...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1053/gast.1997.v113.pm9247460
更新日期:1997-08-01 00:00:00
abstract::The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80079-2
更新日期:1985-05-01 00:00:00
abstract::Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90676-2
更新日期:1988-06-01 00:00:00
abstract::Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90152-0
更新日期:1985-03-01 00:00:00
abstract:BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v112.pm9178680
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70311-7
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.21170
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2015.05.043
更新日期:2015-09-01 00:00:00
abstract::In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::The diagnosis of inflammatory bowel disease (IBD) with its 2 main subforms, Crohn's disease and ulcerative colitis, is based on clinical, endoscopic, radiologic, and histologic criteria. This paradigm remains unchanged despite the advent of new molecular technologies for the examination of serum proteins and genetic s...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.09.001
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. M...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1053/j.gastro.2014.04.043
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.04.033
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90639-t
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.27997
更新日期:2001-10-01 00:00:00
abstract::Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91521-5
更新日期:1992-10-01 00:00:00
abstract::The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND & AIMS:Congenital tufting enteropathy (CTE) is a rare autosomal recessive diarrheal disorder presenting in the neonatal period. CTE is characterized by intestinal epithelial cell dysplasia leading to severe malabsorption and significant morbidity and mortality. The pathogenesis and genetics of this disorder ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.05.036
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND & AIMS:Cell stress signaling pathways result in phosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), which affects regulation of protein translation. Translation reprogramming mitigates stress by activating pathways that result in autophagy and cell death, to eli...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.12.016
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND/AIMS:The elevation of cytosolic free calcium concentration ([Ca2+]i) and intracellular pH mediate the growth factor-initiated proliferation of many cells, but it is not known if they trigger mitosis in resting hepatocytes. The maintenance of [Ca2+]i and intracellular pH depends partly on extracellular calciu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90077-2
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND & AIMS:Recent reports suggest that platelet-activating factor (PAF) plays a role in pancreatitis and pancreatitis-associated lung injury. In this study, the effects on these processes of termination of PAF action by recombinant PAF-acetylhydrolase (rPAF-AH) were investigated. METHODS:Rats were given rPAF-AH...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70096-4
更新日期:1998-11-01 00:00:00
abstract::The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2004.05.029
更新日期:2004-08-01 00:00:00
abstract::To study the peripheral effect of somatostatin in dogs a tiny Silastic catheter was implanted in an almost terminal branch of the mesenteric artery, providing blood supply to a jejunal segment of 5-10 cm. In 4 dogs one catheter was implanted, perfusing a small bowel segment about 60 cm below the angle of Treitz; in 3 ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(00)70430-6
更新日期:2000-01-01 00:00:00
abstract::In some patients with hiatus hernia, vomiting may propel a plug of redundant gastric mucosa into the distal esophagus, where it becomes incarcerated and engorged. Significant bleeding may result. Reduction of the hernia controls the hemorrhage. Endoscopy after the acute episode may demonstrate a gastric mucosal lesion...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-04-01 00:00:00
abstract:BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.01.043
更新日期:2006-05-01 00:00:00
abstract::We studied chronic intake of diets deficient in or supplemented with linoleic acid to determine whether it affects gastric acid secretion, release of prostaglandin E2, and stress-induced lesions. For 8-10 wk rats were fed three dietary regimens supplying 3.5% (control group), 0.3%, and 10% of total calories as linolei...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90285-5
更新日期:1988-07-01 00:00:00
abstract::Liver disease with inclusions of copper was recognized among 30 rural workers with "vineyard sprayer's lung." The pathological findings were varied: focal or diffuse swelling and proliferation of Kupffer cells; histiocytic and sarcoid-like granulomata; fibrosis of variable degree in the perisinusoidal, portal, and sub...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::Previous studies have suggested that Giardia infections are cleared immunologically, but have not defined the mechanism of clearance. The aim of the present work was to compare subpopulations of leukocytes harvested from the intestinal lumen of immunocompetent BALB/c mice, which clear Giardia muris infection rapidly, ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90656-0
更新日期:1985-12-01 00:00:00