Abstract:
:Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Costea I,Mack DR,Lemaitre RN,Israel D,Marcil V,Ahmad A,Amre DKdoi
10.1053/j.gastro.2013.12.034subject
Has Abstractpub_date
2014-04-01 00:00:00pages
929-31issue
4eissn
0016-5085issn
1528-0012pii
S0016-5085(14)00002-Xjournal_volume
146pub_type
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