Abstract:
:Cholylglycylhistamine, a derivative of cholic acid, has been synthesized and characterized. This derivative has been iodinated using Na125I and chloramine-T and purified free from unlabeled cholylglycylhistamine. Application of this iodinated bile salt derivative to radioimmunoassay of bile salts in human serum is reported. Antibody titers have uniformly increased over titers used in tritium-based assays; some antibodies are usable in dilutions of 1:80,000. The radioimmunoassay described here was found to measure predominantly the primary conjugated bile salts. Sensitivity has been maintained, with the least detectable amount being 0.5 pmoles per assay tube. Normal values in human serum are 3.47 +/- 2.16 (SD) nmoles per ml.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Spenney JG,Johnson BJ,Hirschowitz BI,Mihas AA,Gibson Rsubject
Has Abstractpub_date
1977-02-01 00:00:00pages
305-11issue
2eissn
0016-5085issn
1528-0012pii
S0016508577000535journal_volume
72pub_type
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