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Pathological findings of lymphangiectasia of the large intestine in a patient with protein-losing enteropathy.

Abstract：

:Lymphangiectasia of the large intestine associated with protein-losing enteropathy is reported. A 33-yr-old man suffered from diarrhea, sometimes mixed with blood. Colonoscopic study revealed reddish and edematous mucosa with multiple flat elevated lesions and giant folds in the localized segment of the rectosigmoid. An intestinal clearance test of alpha 1-antitrypsin revealed the association of protein-losing enteropathy. Operation was performed successfully, resulting in a marked improvement of symptoms and laboratory data, especially serum total protein, albumin, IgG, and Leu-2a-positive cells (suppressor/cytotoxic T cells). Giant folds consisted of the submucosal edema and hyperplasia of the epithelial glands with cystic dilatation of glands, and flat elevated lesions consisted of mucosal and submucosal edema associated with intestinal lymphangiectasia, adipose tissue, and blood capillaries. The population of the Leu-2a-positive cells in the lamina propria and intraepithelial layer was decreased and that of the Leu-3a-positive cells (helper/inducer T cells) in the lamina propria was increased.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Asakura H,Tsuchiya M,Katoh S,Kobayashi K,Yonei Y,Yoshida T,Hamada Y,Miura S,Morita A,Kuramochi S

doi

10.1016/0016-5085(86)90644-x

subject

Has Abstract,Author List Incomplete

pub_date

1986-09-01 00:00:00

pages

719-24

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(86)90644-X

journal_volume

91

pub_type

杂志文章

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