Abstract:
:Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed cholangiocarcinoma without jaundice and with no changes in their serum biochemistry. Both patients were taking ursodeoxycholic acid at the time of tumor diagnosis. Initial suspicion of malignancy was based on the development of superficial thrombophlebitis. Liver histology showed evidence of bile duct epithelial dysplasia in areas free from tumor in one patient, and in the other, bile duct epithelial dysplasia preceded the appearance of cholangiocarcinoma by at least 18 months. In one of the cases, the dysplastic epithelium stained positively for carcinoembryonic antigen. The histological finding of bile duct epithelial dysplasia in patients with primary sclerosing cholangitis may suggest either imminent or actual development of cholangiocarcinoma and may thus affect consideration of orthotopic liver transplantation. In addition, the development of superficial thrombophlebitis in patients with primary sclerosing cholangitis should arouse suspicion of the presence of cholangiocarcinoma even if there is no evidence of deterioration of the liver function or a dominant stricture on endoscopic retrograde cholangiography.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Martins EB,Fleming KA,Garrido MC,Hine KR,Chapman RWdoi
10.1016/0016-5085(94)90182-1subject
Has Abstractpub_date
1994-08-01 00:00:00pages
537-42issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(94)90182-1journal_volume
107pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.2000.19289
更新日期:2000-11-01 00:00:00
abstract::Medical and recreational cannabis use has increased dramatically over the last decade, resulting from mainstream cultural acceptance and legalization in several countries worldwide. Cannabis and its derivatives affect many gastrointestinal processes via the endocannabinoid system (ECS). The ECS influences gastrointest...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.03.087
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid pool. Experiments were performed to determine whether such transport is regulated by substrate load. METHODS:Using anesthetized biliary fistula guinea pigs or rats, the ileum was perfused with...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90833-x
更新日期:1993-01-01 00:00:00
abstract::Chloroquine and metronidazole were compared in a randomized trial for the treatment of amoebic liver abscess in 36 patients. An additional 30 patients were treated without randomization. Chloroquine was given according to the standard protocol at Los tangeles County-University of Southern California Medical Center, wh...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1975-07-01 00:00:00
abstract:BACKGROUND & AIMS:Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is due to an imbalance between intrahepatic triglyceride (IHTG) production and export. The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD. METHODS:Fatty acid, VLDL-TG, and VLDL-apolipoprotein...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.11.038
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.11.010
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.07.108
更新日期:2012-11-01 00:00:00
abstract::Increasing resistance to antibiotics worldwide has adverse effects on the effectiveness of standard therapies to eradicate Helicobacter pylori infection. We reviewed guidelines developed by expert groups in Europe, Canada, and the United States for the treatment of H pylori infection. We compared the recommendations o...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2019.04.011
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND & AIMS:Recent studies indicate that kringle 1-5 has a potent and specific antiangiogenic activity. Here, we investigated the antitumor effect of kringle 1-5 gene transfer on hepatocellular carcinoma in mice. METHODS:The inhibitory effect of kringle 1-5 protein on proliferation of bovine capillary endothelia...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.02.020
更新日期:2006-04-01 00:00:00
abstract::Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90567-6
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.01.043
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive and metastatic disease for which conventional treatments are of limited efficacy. A number of agents in development are potential anti-invasive and antimetastatic agents, including the Src kinase inhibitor dasatinib. The aim of this study wa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.03.034
更新日期:2010-07-01 00:00:00
abstract::The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::We constructed ileocolonic loops of distal ileum, ileocolonic sphincter, and proximal colon in 5 dogs; neuromuscular continuity was maintained between loop and intact bowel by a bridge of tunica muscularis. To study ileocolonic sphincter function, we recorded myoelectric activity from subserosal electrodes and intralu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::Patients with chronic nausea and vomiting frequently present challenging diagnostic and therapeutic problems. In such patients, gastroparesis of unknown cause, or "idiopathic" gastroparesis, may be the only objective finding. Two middle-aged women with nausea, vomiting, and weight loss of 10 and 26 kg over 6 and 18 mo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91255-5
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma. METHODS:We used in situ hybridization and quantitative reverse transcriptase polymerase chain reaction to measure expression of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.03.045
更新日期:2012-07-01 00:00:00
abstract::A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-10-01 00:00:00
abstract::There is considerable evidence that fluids are removed from the peritoneal cavity by drainage into lymphatics lining the surface of the diaphragm, but there is little quantitative information on the rate of reabsorption as affected by conditions which exist in cirrhotic ascites. In the present study a plethysmographic...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract::A 76-yr-old male presented with Guillain-Barré syndrome after acute hepatitis B virus infection. Main immunologic features were: (a) high levels of circulating hepatitis B surface antigen-containing immune complexes in serum and cerebrospinal fluid during the acute neurologic syndrome, and (b) clearance of immune-comp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-03-01 00:00:00
abstract::We tested methyl tertiary butyl ether both in vitro and in vivo to evaluate its efficacy as a potential cholesterol gallstone solvent for direct instillation into the human gallbladder or bile duct. Like diethyl ether, methyl tertiary butyl ether is an aliphatic ether with an excellent cholesterol-solubilizing capacit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80143-8
更新日期:1985-01-01 00:00:00
abstract::A newly recognized clinical and morphologic pattern of acute alcoholic liver disease is described. Twenty-one patients, having the hepatic morphologic features of alcoholic foamy degeneration, were retrospectively analyzed. All patients had a significant history of chronic alcoholism. Jaundice and hepatomegaly were us...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::Antimitochondrial antibodies, serological hallmarks of primary biliary cirrhosis, recently were found to be directed against the E2 subunits of mitochondrial dehydrogenase complexes (pyruvate, branched-chain ketoacid, and alpha-ketoglutarate dehydrogenases). The objectives of this study were to extend these findings a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)91247-4
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND & AIMS:Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel sy...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.03.046
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.12.049
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90861-6
更新日期:1993-01-01 00:00:00
abstract::Ileocecal sphincter pressure was studied in the cat, using an open-tipped perfused catheter system. Ileocecal sphincter pressure was measured under basal conditions and in response to bethanechol or direct vagal nerve electrical stimulation. The pressure was 26.1 +/- 5.0 mmHg basally, and was unaltered by section of e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::Gastric and esophageal emptying were assessed using scintigraphic techniques in 12 patients with progressive systemic sclerosis and 22 normal volunteers. Esophageal emptying was significantly delayed in the patient group, with 7 of the 12 patients beyond the normal range. Gastric emptying was slower in patients than i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract::The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND & AIMS:Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices (EV). METHODS:We performed a prospective cohort s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.03.036
更新日期:2016-07-01 00:00:00
abstract::We performed 92 computed tomography-guided percutaneous needle aspirations of pancreatic inflammatory masses in 60 patients suspected of harboring pancreatic infection. Thirty-six patients (60%) were found by Gram stain and culture to have a total of 41 separate episodes of pancreatic infection. Among 42 aspirates jud...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90261-7
更新日期:1987-12-01 00:00:00