Abstract:
:Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments. Pyridoxal 5'-phosphate binding to albumin was pH-, PLP concentration-, and albumin concentration-dependent. Binding occurred at higher pH levels (5-7.4) and markedly inhibited hydrolysis of 2 microM PLP both in vitro and in vivo. At low pH (3-4), alkaline phosphatase was still active with PLP as substrate; binding of PLP to albumin was negligible; and PLP hydrolysis was unaffected by even a high concentration of albumin. The pH required to prevent binding and thus in turn prevent inhibition of hydrolysis was a function of albumin concentration: the higher the concentration, the lower the pH necessary. The present studies suggest an important role for the low pH values resulting from gastric acid secretion in the normal absorption of dietary PLP, and raise questions about the implications of widespread use of acid-lowering therapeutic modalities on vitamin B6 nutritional status.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Middleton HM 3rddoi
10.1016/0016-5085(86)90567-6subject
Has Abstractpub_date
1986-08-01 00:00:00pages
343-50issue
2eissn
0016-5085issn
1528-0012pii
0016-5085(86)90567-6journal_volume
91pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::A case of a 41-year-old man with diarrhea, hypoalbuminemia, and cryptogenic cirrhosis with features of portal hypertension is described. Protein-losing enteropathy was confirmed by analysis of whole-gut lavage fluid, and intestinal inflammation and infection were excluded. Distal duodenal biopsy specimens showed evide...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(96)70033-1
更新日期:1996-12-01 00:00:00
abstract::Developmental aspects of the intestinal transport of biotin were examined in suckling (16 day old) and weanling (24 day old) rats using the everted sac technique. The results were compared with those of adult rats previously reported by us using the same intestinal preparation. Transport of biotin was linear for 20 mi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90611-7
更新日期:1988-01-01 00:00:00
abstract::Serum gastrin and gastric endocrine cell numerical densities were examined in 22 patients with long-standing Zollinger-Ellison syndrome who were receiving either ranitidine, omeprazole, or other antisecretory drugs (SMS 201-995 or pirenzepine with or without ranitidine) for long periods of time. Fifteen patients had i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(89)91620-x
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.02.018
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND & AIMS:The absence of grade A supporting evidence for surveillance colonoscopy in patients with ulcerative colitis (UC) has led to controversy regarding its benefit, yet it is routinely recommended in practice guidelines. Limited data are available on rates of colonoscopy surveillance and factors associated ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.07.039
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND & AIMS:The adenoma detection rate (ADR) is an important quality indicator of screening colonoscopy; it is inversely associated with risk of interval cancers and colorectal cancer mortality. We assessed trends in the ADR in the first 10 years of the German screening colonoscopy program. METHODS:We calculated...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2015.04.012
更新日期:2015-08-01 00:00:00
abstract::This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.02.009
更新日期:2016-03-25 00:00:00
abstract::Noninvasive imaging modalities may suggest the diagnosis of Budd-Chiari syndrome but they are rarely diagnostic. Inferior vena cavography, hepatic venography, and liver biopsy, alone or in combination, are usually necessary for definitive diagnosis. Because of its excellent depiction of blood vessels as regions of abs...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(86)80029-4
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND & AIMS:Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized. METHODS:We therefore compared the methylation profile and genetic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carci...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00278-6
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.07.008
更新日期:2017-10-01 00:00:00
abstract::The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90948-z
更新日期:1990-09-01 00:00:00
abstract::The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-07-01 00:00:00
abstract:BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. M...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1053/j.gastro.2014.04.043
更新日期:2014-08-01 00:00:00
abstract::To study the peripheral effect of somatostatin in dogs a tiny Silastic catheter was implanted in an almost terminal branch of the mesenteric artery, providing blood supply to a jejunal segment of 5-10 cm. In 4 dogs one catheter was implanted, perfusing a small bowel segment about 60 cm below the angle of Treitz; in 3 ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract::Using an in vivo canine chambered stomach preparation, the clearance of [14C]aminopyrine across mucosa when intravenously infused and the back-diffusion of this substance from gastric lumen to mucosa when topically applied to gastric epithelium were evaluated in aspirin-damaged gastric epithelium. In mucosa damaged by...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract::The assessment of disease activity in Crohn's disease involves determination of either clinical indexes (e.g., Crohn's disease activity index) or laboratory measurements (e.g., C-reactive protein and erythrocyte sedimentation rate). These have the disadvantage of being indirect and nonspecific correlates of gut inflam...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-12-01 00:00:00
abstract::Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.01.024
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70481-0
更新日期:1998-02-01 00:00:00
abstract::Spontaneous remission of gastric acid hypersecretion in the Zollinger-Ellison syndrome occurs rarely. This study shows the development of gastric secretory mucosal atrophy resulting in achlorhydria and loss of pepsin secretion in a 63-year-old woman with the Zollinger-Ellison syndrome. Reduced secretion began soon aft...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90484-3
更新日期:1991-07-01 00:00:00
abstract::This literature review and the recommendations therein were prepared for the American Gastroenterological Association Clinical Practice and Practice Economics committee. The paper was approved by the committee on May 16, 1999, and by the AGA governing board on July 18, 1999. ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(00)70430-6
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or unt...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0016-5085(98)70419-6
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND & AIMS:Intestinal microbes induce homeostatic mucosal immune responses, but can also cause inappropriate immune activation in genetically susceptible hosts. Although immune responses to bacterial products have been studied extensively, little is known about how intestinal inflammation affects functions of co...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.06.064
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.10.018
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Liver injury in many patients with chronic hepatitis B is sporadic and is often characterized by acute exacerbations alternating with relatively normal liver function. The aim of this study was to perform detailed serological and biochemical analysis during periods of active liver disease to better understan...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90960-k
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND & AIMS:To screen the genetic variants in cyclooxygenase-2 (COX-2), and evaluate their effects on COX-2 expression and risk of gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, Shangdong Province, an area of China, a high-risk area of GC. METHODS:Genotypes were d...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2006.03.021
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/j.gastro.2005.05.059
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2007.11.003
更新日期:2008-02-01 00:00:00
abstract::Specific radioimmunoassay were used to measure somatostatin and vasoactive peptide in portal and peripheral plasma from conscious dogs prepared with indwelling portal catheters. In six animals with intact stomachs, a test meal induced a significant rise of portal and peripheral somatostatin, while the significant resp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract:BACKGROUND & AIMS:Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The specific role of epithelial barrier function remains undefined, although increased activity of intestinal epithelial myosin...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.10.081
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND & AIMS:Long-term ursodeoxycholic acid (UDCA) therapy slows the progression of primary biliary cirrhosis. This study examined the effect of UDCA therapy on survival free of liver transplantation in a large group of patients. METHODS:Data from three clinical trials were combined in which patients with primary...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70183-5
更新日期:1997-09-01 00:00:00