当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Ontogenesis of the intestinal transport of biotin in the rat.

Ontogenesis of the intestinal transport of biotin in the rat.

Abstract：

:Developmental aspects of the intestinal transport of biotin were examined in suckling (16 day old) and weanling (24 day old) rats using the everted sac technique. The results were compared with those of adult rats previously reported by us using the same intestinal preparation. Transport of biotin was linear for 20 min of incubation in all age groups. Transport of biotin was significantly (p less than 0.05) lower in the jejunum than the ileum of suckling rats but was not significantly different in the jejunum and the ileum of weanling rats. In adult rats, biotin transport was significantly (p less than 0.01) higher in the jejunum than the ileum. In all age groups, transport of biotin in the jejunum was saturable at low concentrations (less than 10 microM) but linear at high concentrations. The apparent Km and Vmax of the saturable process showed a progressive increase from suckling to weanling to adult rats (apparent Km of 0.63, 2.49, and 3.37 microM; Vmax of 18.3, 44.7, and 124.4 pmol/g.min, respectively). On the other hand, the rate of transport by the nonsaturable process showed a progressive decrease with maturation (143.8, 111.6, and 87.5 pmol/g.min for suckling, weanling, and adult rats, respectively). Transport of biotin in suckling and weanling rats was similar to that of adult rats in that it was Na+-, energy-, and temperature-dependent and inhibited by structural analogues. These results demonstrate that biotin transport undergoes clear maturational changes. These changes include a decrease in the affinity and an increase in the activity (and/or the numbers) of the transport carrier, a decrease in the rate of transport by the nonsaturable process, and a change in the preferential site of transport.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Said HM,Redah R

doi

10.1016/0016-5085(88)90611-7

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

68-72

issue

1

eissn

0016-5085

issn

1528-0012

pii

0016-5085(88)90611-7

journal_volume

94

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • From Birth to Overweight and Atopic Disease: Multiple and Common Pathways of the Infant Gut Microbiome.

    abstract：BACKGROUND & AIMS:Few studies, even those with cohort designs, test the mediating effects of infant gut microbes and metabolites on the onset of disease. We undertook such a study. METHODS:Using structural equation modeling path analysis, we tested directional relationships between first pregnancy, birth mode, prolong...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.08.053

    authors： Vu K,Lou W,Tun HM,Konya TB,Morales-Lizcano N,Chari RS,Field CJ,Guttman DS,Mandal R,Wishart DS,Azad MB,Becker AB,Mandhane PJ,Moraes TJ,Lefebvre DL,Sears MR,Turvey SE,Subbarao P,Scott JA,Kozyrskyj AL

    更新日期：2021-01-01 00:00:00

  • Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis.

    abstract：:The normal surface anatomy of rat hepatocytes, sinusoids, and bile canaliculi was examined by scanning electron microscopy following finger fracture of tissues that were perfused via the portal vein and fixed with 2.5% glutaraldehyde. These normal findings were contrasted with several models of cholestasis, including ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Layden TJ,Schwarz,Boyer JL

    更新日期：1975-09-01 00:00:00

  • Antibodies against mitochondrial dehydrogenase complexes in primary biliary cirrhosis.

    abstract：:Antimitochondrial antibodies, serological hallmarks of primary biliary cirrhosis, recently were found to be directed against the E2 subunits of mitochondrial dehydrogenase complexes (pyruvate, branched-chain ketoacid, and alpha-ketoglutarate dehydrogenases). The objectives of this study were to extend these findings a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91247-4

    authors： Yoshida T,Bonkovsky H,Ansari A,Danner D

    更新日期：1990-07-01 00:00:00

  • Abnormal plasma lipoproteins and lecithin-cholesterol acyltransferase deficiency in alcoholic liver disease.

    abstract：:Serial studies of plasma lipids and lipoproteins were performed in 4 patients with acute alcoholic liver disease characterized by a massive fatty liver and laboratory evidence of intrahepatic cholestasis. There were striking alterations in the plasma lipoprotein electrophoretic patterns characterized by the absence of...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Sabesin SM,Hawkins HL,Kuiken L,Ragland JB

    更新日期：1977-03-01 00:00:00

  • Hypertrophic smooth muscle in the partially obstructed opossum esophagus. Excitability and electrophysiological properties.

    abstract：:Partial obstruction of the opossum esophagus leads to thickening of the circular muscle, hypertrophy of smooth muscle cells, and diminution of the extracellular space. The pharmacological and electrophysiological properties of this hypertrophied muscle were studied. Carbachol produced phasic and tonic contractions of ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90522-m

    authors： Conklin JL,Du CA,Schulze-Delrieu K,Shirazi S

    更新日期：1991-09-01 00:00:00

  • Hepatitis in children with acquired immune deficiency syndrome. Histopathologic and immunocytologic features.

    abstract：:Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(86)90090-9

    authors： Duffy LF,Daum F,Kahn E,Teichberg S,Pahwa R,Fagin J,Kenigsberg K,Kaplan M,Fisher SE,Pahwa S

    更新日期：1986-01-01 00:00:00

  • Somatostatin inhibits secretin-induced canine pancreatic response via a cholinergic mechanism.

    abstract：BACKGROUND:Somatostatin inhibits pancreatic exocrine secretion in intact animals but not in vitro, suggesting an indirect effect. The present study examined the influence of extrapancreatic nerves and intrapancreatic cholinergic activity on somatostatin-induced inhibition of pancreatic exocrine secretion in conscious d...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90732-r

    authors： Kuvshinoff BW,Brodish RJ,James L,McFadden DW,Fink AS

    更新日期：1993-08-01 00:00:00

  • Mechanisms underlying the protective effects of interleukin 1 in experimental nonsteroidal anti-inflammatory drug gastropathy.

    abstract：:Interleukin 1 (IL-1) has been shown to reduce the severity of experimental gastroduodenal ulceration, but the mechanism of action is unclear. The present study examined the possibility that the mechanism underlying the protective effects of IL-1 in experimental nonsteroidal anti-inflammatory drug (NSAID)-induced gastr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Wallace JL,Keenan CM,Cucala M,Mugridge KG,Parente L

    更新日期：1992-04-01 00:00:00

  • Erythropoietic protoporphyria: unusual skin and neurological problems after liver transplantation.

    abstract：:The case of a woman with protoporphyria who developed liver failure and underwent liver transplantation is described. During the pretransplant episode of liver failure she developed quadriparesis that rapidly progressed after transplantation to a severe polyneuropathy. Following transplantation she also developed a se...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90680-j

    authors： Herbert A,Corbin D,Williams A,Thompson D,Buckels J,Elias E

    更新日期：1991-06-01 00:00:00

  • Use of aspirin or nonsteroidal anti-inflammatory drugs increases risk for diverticulitis and diverticular bleeding.

    abstract：BACKGROUND & AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been implicated in diverticular complications. We examined the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. METHODS:We studied 47,210 US men in the Health Pr...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.02.004

    authors： Strate LL,Liu YL,Huang ES,Giovannucci EL,Chan AT

    更新日期：2011-05-01 00:00:00

  • The lymphoid liver: considerations on pathways to autoimmune injury.

    abstract：:Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and accessory cells. The forerunner to autoimmunity is breaching of natural self-tolerance and hence the disruption of a fundamental property of the immune system. Such br...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/gast.2001.22441

    authors： Kita H,Mackay IR,Van De Water J,Gershwin ME

    更新日期：2001-05-01 00:00:00

  • Large paraesophageal varices on endosonography predict recurrence of esophageal varices and rebleeding.

    abstract：BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9178670

    authors： Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

    更新日期：1997-06-01 00:00:00

  • Safety and efficacy of recombinant factor VIIa in patients with liver disease undergoing laparoscopic liver biopsy.

    abstract：BACKGROUND & AIMS:Activated recombinant factor VII (rFVIIa) has been shown to be effective in correcting prolonged prothrombin time (PT) in cirrhotic patients. The main objective of this study was to evaluate the effect of 4 (5, 20, 80, and 120 microg/kg) doses of rFVIIa on correction of PT and the time to achieve hemo...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1053/gast.2002.34164

    authors： Jeffers L,Chalasani N,Balart L,Pyrsopoulos N,Erhardtsen E

    更新日期：2002-07-01 00:00:00

  • High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases.

    abstract：BACKGROUND & AIMS:The interactions among pre-S deletion, precore (PC) mutation, and basal core promoter (BCP) mutation in various stages of chronic hepatitis B virus (HBV) infection remain unclear and were thus investigated in this study. METHODS:The sequences of the pre-S region and the BCP (A1762T, G1764A) and PC (G...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.01.011

    authors： Chen BF,Liu CJ,Jow GM,Chen PJ,Kao JH,Chen DS

    更新日期：2006-04-01 00:00:00

  • Intraarterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective, controlled clinical trial.

    abstract：:Intraarterial vasopressin has been reported to be effective in the treatment of massive upper gastrointestinal hemorrhage. A prospective, controlled clinical trial comparing conventional treatment with conventional therapy plus intraarterial vasopressin was undertaken. Sixty episodes of upper gastrointestinal hemorrha...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Conn HO,Ramsby GR,Storer EH,Mutchnick MG,Joshi PH,Phillips MM,Cohen GA,Fields GN,Petroski D

    更新日期：1975-02-01 00:00:00

  • Effect of aerobic exercise on mouth-to-cecum transit time.

    abstract：:To examine the premise that exercise reduces the gastrointestinal transit time, we evaluated the effect of walking 4.5 km in an hour on mouth-to-cecum transit time. Twenty-three healthy volunteers, 9 men and 14 women, with an age range of 19-28 yr, were studied. After an overnight fast, the subjects ingested 10 g of l...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Meshkinpour H,Kemp C,Fairshter R

    更新日期：1989-03-01 00:00:00

  • Comparison of clearance and metabolism of infused cholecystokinins 8 and 58 in dogs.

    abstract：BACKGROUND:Cholecystokinin (CCK) 58 is the predominant molecular form of CCK in canine and human intestine and circulating blood. There is no report on the metabolism and clearance rate of CCK-58. The aim of this study was to compare the in vivo half-life and metabolism of CCK-58 with that of synthetic CCK-8. METHODS:...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)91070-x

    authors： Hoffmann P,Eberlein GA,Reeve JR Jr,Bünte RH,Grandt D,Goebell H,Eysselein VE

    更新日期：1993-12-01 00:00:00

  • Gastrin induces proliferation in Barrett's metaplasia through activation of the CCK2 receptor.

    abstract：BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2003.50091

    authors： Haigh CR,Attwood SE,Thompson DG,Jankowski JA,Kirton CM,Pritchard DM,Varro A,Dimaline R

    更新日期：2003-03-01 00:00:00

  • Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma.

    abstract：BACKGROUND & AIMS:Outcomes of liver transplantation for hepatocellular carcinoma (HCC) are determined by cancer-related and non-related events. Treatments for hepatitis C virus infection have reduced non-cancer events among patients receiving liver transplants, so reducing HCC-related death might be an actionable end p...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.09.025

    authors： Mazzaferro V,Sposito C,Zhou J,Pinna AD,De Carlis L,Fan J,Cescon M,Di Sandro S,Yi-Feng H,Lauterio A,Bongini M,Cucchetti A

    更新日期：2018-01-01 00:00:00

  • Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models.

    abstract：:Two models of severe acute pancreatitis were chosen and pancreatitis induced by sodium taurocholate and by a choline-deficient ethionine-supplemented diet, to evaluate the effectiveness of FOY-305 (camostate), a new synthetic trypsin inhibitor. Prophylactic administration of FOY-305 had a significantly favorable effec...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90780-4

    authors： Lankisch PG,Pohl U,Göke B,Otto J,Wereszczynska-Siemiatkowska U,Gröne HJ,Rahlf G

    更新日期：1989-01-01 00:00:00

  • The genetically programmed down-regulation of lactase in children.

    abstract：BACKGROUND & AIMS:Intestinal lactase activity is high in all healthy human babies, but in adults a genetic polymorphism, which acts in cis to the lactase gene, determines high or low messenger RNA (mRNA) expression and activity (lactase persistence and nonpersistence, respectively). Our aim was to investigate the onset...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70429-9

    authors： Wang Y,Harvey CB,Hollox EJ,Phillips AD,Poulter M,Clay P,Walker-Smith JA,Swallow DM

    更新日期：1998-06-01 00:00:00

  • Neuropeptide Y inhibits excitatory enteric neurons supplying the circular muscle of the guinea pig small intestine.

    abstract：:The effect of neuropeptide Y on the motor activity of the circular and longitudinal muscle of the guinea pig small intestine was investigated. Neuropeptide Y (0.3-30 nM) inhibited, in a concentration-dependent manner, the ascending enteric reflex contraction of the circular muscle; both the cholinergic and noncholiner...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90628-7

    authors： Holzer P,Lippe IT,Barthó L,Saria A

    更新日期：1987-06-01 00:00:00

  • Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy.

    abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2019.01.251

    authors： Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

    更新日期：2019-05-01 00:00:00

  • Endoscopic papillotomy.

    abstract：:Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Koch H,Rösch W,Schaffner O,Demling L

    更新日期：1977-12-01 00:00:00

  • The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

    abstract：BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.12.030

    authors： Nanda SK,Herion D,Liang TJ

    更新日期：2006-03-01 00:00:00

  • Effect of cimetidine on net ion fluxes across the rat gastric mucosa during mucosal damage after gastric ischemia and after intravenous acetylsalicylic acid.

    abstract：:This study was performed to determine the relationship between net ion fluxes across the rat gastric mucosa and gastric mucosal damage after gastric ischemia and after intravenous administration of acetylsalicylic acid, and to determine the effect of cimetidine on these parameters. Gastric mucosal blood, albumin, and ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Pipkin G,Price CA,Parsons ME

    更新日期：1984-12-01 00:00:00

  • Epidemiologic evidence on the association between peptic ulceration and antiinflammatory drug use.

    abstract：:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of su...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/s0016-5085(89)80060-5

    authors： Langman MJ

    更新日期：1989-02-01 00:00:00

  • Hemosiderosis in cirrhosis: a study of 447 native livers.

    abstract：BACKGROUND & AIMS:Hemosiderosis may have a detrimental effect on some chronic liver diseases. The aim of this study was to determine the prevalence and diagnostic implications of hemosiderosis in cirrhosis. METHODS:Tissue iron in 447 cirrhotic livers was studied histologically and chemically. RESULTS:Positive iron st...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v112.pm9041250

    authors： Ludwig J,Hashimoto E,Porayko MK,Moyer TP,Baldus WP

    更新日期：1997-03-01 00:00:00

  • Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs.

    abstract：BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.11.041

    authors： Chan AT,Ogino S,Giovannucci EL,Fuchs CS

    更新日期：2011-03-01 00:00:00

  • Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis.

    abstract：BACKGROUND AND AIMS:The peptidyl prolyl isomerase Pin1 frequently is overexpressed in hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) is the most common etiologic agent in HCC, and its encoded X-protein (HBx) is oncogenic and possesses a serine-proline motif that may bind Pin1. The role of Pin1 in hepatocarcino...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.12.030

    authors： Pang R,Lee TK,Poon RT,Fan ST,Wong KB,Kwong YL,Tse E

    更新日期：2007-03-01 00:00:00