The lymphoid liver: considerations on pathways to autoimmune injury.

abstract：:Characteristics of electrical activities, and the relationship between electrical and motor activities, were studied in circular and longitudinal (taenia) muscle of the human colon that was obtained from 21 individuals. Recordings were obtained with suction electrodes, the sucrose-gap method, and microelectrodes. The ...

journal_title：Gastroenterology

authors： Huizinga JD,Stern HS,Chow E,Diamant NE,El-Sharkawy TY

更新日期：1985-02-01 00:00:00

abstract：:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update was to rapidly review the emerging evidence and provide timely expert recommendations regarding the management of patients with inflammatory bowel disease during the coronavirus disease 2019 pandemic. This expert comm...

journal_title：Gastroenterology

authors： Rubin DT,Feuerstein JD,Wang AY,Cohen RD

更新日期：2020-07-01 00:00:00

abstract：:Ursodeoxycholic acid, the 7 beta-hydroxy epimer of chenodeoxycholic acid, is more hydrophilic and less hepatotoxic than chenodeoxycholic acid. Because "lagodeoxycholic acid," the 12 beta-hydroxy epimer of deoxycholic acid, is also more hydrophilic than deoxycholic acid, it was hypothesized that it should also be less ...

journal_title：Gastroenterology

authors： Schmassmann A,Angellotti MA,Clerici C,Hofmann AF,Ton-Nu HT,Schteingart CD,Marcus SN,Hagey LR,Rossi SS,Aigner A

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) usually recurs after intestinal resection; postoperative endoscopic monitoring and tailored treatment can reduce the chance of recurrence. We investigated whether monitoring levels of fecal calprotectin (FC) can substitute for endoscopic analysis of the mucosa. METHODS:We analyze...

journal_title：Gastroenterology

authors： Wright EK,Kamm MA,De Cruz P,Hamilton AL,Ritchie KJ,Krejany EO,Leach S,Gorelik A,Liew D,Prideaux L,Lawrance IC,Andrews JM,Bampton PA,Jakobovits SL,Florin TH,Gibson PR,Debinski H,Macrae FA,Samuel D,Kronborg I,Radfor

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Several aspects of the pathogenesis of osteopenia in celiac disease are still unclear. Therefore, bone mass and metabolism were evaluated in adults with celiac disease in a cross-sectional study. METHODS:Bone mineral density (BMD), assessed by total body dual-photon absorptiometry, and serum indices ...

journal_title：Gastroenterology

authors： Corazza GR,Di Sario A,Cecchetti L,Tarozzi C,Corrao G,Bernardi M,Gasbarrini G

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND & AIMS:In the intestines, Toll-like receptor 2 (TLR2) mediates immune responses to pathogens and regulates epithelial barrier function; polymorphisms in TLR2 have been associated with inflammatory bowel disease phenotype. We assessed the effects of TLR2 signaling on the enteric nervous system (ENS) in mice. ...

journal_title：Gastroenterology

authors： Brun P,Giron MC,Qesari M,Porzionato A,Caputi V,Zoppellaro C,Banzato S,Grillo AR,Spagnol L,De Caro R,Pizzuti D,Barbieri V,Rosato A,Sturniolo GC,Martines D,Zaninotto G,Palù G,Castagliuolo I

更新日期：2013-12-01 00:00:00

abstract：:The assimilation of labeled cobalamin and the transport of corrinoids in portal blood, peripheral venous blood, and bile were studied in eight cholecystectomized patients, after ingestion of a dose of cyano[57Co]cobalamin (0.5 microCi). The radioactivity appeared in the portal vein after a delay of 1.5-2 hours and in ...

journal_title：Gastroenterology

authors： el Kholty S,Gueant JL,Bressler L,Djalali M,Boissel P,Gerard P,Nicolas JP

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND & AIMS:Diets high in fructose have been proposed to contribute to nonalcoholic fatty liver disease. We compared the effects of high-fructose and matched glucose intake on hepatic triacylglycerol (TAG) concentration and other liver parameters. DESIGN:In a double-blind study, we randomly assigned 32 healthy b...

journal_title：Gastroenterology

authors： Johnston RD,Stephenson MC,Crossland H,Cordon SM,Palcidi E,Cox EF,Taylor MA,Aithal GP,Macdonald IA

更新日期：2013-11-01 00:00:00

abstract：:The effects of bile salts on energy metabolism and acid secretion were investigated in the amphibian gastric mucosa in vitro. Serosal exposure to deoxycholate (0.2-2 mM), cholate (2-8 mM), or taurocholate (4-80 mM), at pH 7.4, decreased acid secretion depending on the concentration and time of exposure. Mucosal applic...

journal_title：Gastroenterology

authors： Núñez D,Chacín J

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Although patients with inflammatory bowel disease (IBD) have reduced bone mass, there is controversy whether there is an increased risk of fracture. This study examines the risk of fracture and its predictors in patients with IBD. METHODS:In a primary care- based nested case-control study, 231,778 fr...

journal_title：Gastroenterology

authors： van Staa TP,Cooper C,Brusse LS,Leufkens H,Javaid MK,Arden NK

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Mutant hepatitis B virus is often associated with severe liver damage. The purpose of this study is to elucidate the relationship between mutations in hepatitis B precore/core gene and the severity of liver damage. METHODS:The hepatitis B precore/core gene from 20 patients with chronic hepatitis B virus inf...

journal_title：Gastroenterology

authors： Chuang WL,Omata M,Ehata T,Yokosuka O,Ito Y,Imazeki F,Lu SN,Chang WY,Ohto M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

journal_title：Gastroenterology

authors： Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

journal_title：Gastroenterology

authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

journal_title：Gastroenterology

authors： Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

更新日期：1996-03-01 00:00:00

abstract：:The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...

journal_title：Gastroenterology

authors： Terpstra OT,Dahl EP,Williamson RC,Ross JS,Malt RA

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...

journal_title：Gastroenterology

authors： Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND & AIMS:This randomized controlled trial compared variceal band ligation (VBL), propranolol (PPL), and isosorbide-5-mononitrate (ISMN) in the prevention of first esophageal variceal bleed. METHODS:Over a 6-year period, 172 patients with cirrhosis, grade II or III esophageal varices that had never bled, were ...

journal_title：Gastroenterology

authors： Lui HF,Stanley AJ,Forrest EH,Jalan R,Hislop WS,Mills PR,Finlayson ND,Macgilchrist AJ,Hayes PC

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:The clonality of hepatocellular carcinoma is still controversial. To evaluate the clonality of this cancer, mostly small multiple hepatocellular carcinomas of 18 patients were analyzed by DNA fingerprinting. METHODS:DNA from the liver tissues was digested with HinfI. After gel electrophoresis, in gel-hybrid...

journal_title：Gastroenterology

authors： Sheu JC,Huang GT,Chou HC,Lee PH,Wang JT,Lee HS,Chen DS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:Proliferating cholangiocytes secrete and respond to neuroendocrine hormones, including secretin. We investigated whether secretin secreted by S cells and cholangiocytes stimulates biliary proliferation in mice. METHODS:Cholestasis was induced in secretin knockout (Sct(-/-)) and wild-type (control) mi...

journal_title：Gastroenterology

authors： Glaser S,Meng F,Han Y,Onori P,Chow BK,Francis H,Venter J,McDaniel K,Marzioni M,Invernizzi P,Ueno Y,Lai JM,Huang L,Standeford H,Alvaro D,Gaudio E,Franchitto A,Alpini G

更新日期：2014-06-01 00:00:00

abstract：:The liver efficiently transports dimeric immunoglobulin A (dIgA) from blood to bile in a direct, nonlysosomal pathway involving smooth-surfaced vesicles. Secretory component (SC), the plasma membrane receptor for dIgA, is released into bile still bound to its ligand by disulfide bridges. Rabbit IgG antirat SC binds sp...

journal_title：Gastroenterology

authors： Kim E,Hradek GT,Jones AL

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND & AIMS:Exposure to biologic and immunosuppressant agents during breastfeeding is controversial, and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBDs) and whether breastfeeding while receiving...

journal_title：Gastroenterology

authors： Matro R,Martin CF,Wolf D,Shah SA,Mahadevan U

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...

journal_title：Gastroenterology

authors： Ono Y,Kanai T,Sujino T,Nemoto Y,Kanai Y,Mikami Y,Hayashi A,Matsumoto A,Takaishi H,Ogata H,Matsuoka K,Hisamatsu T,Watanabe M,Hibi T

更新日期：2012-11-01 00:00:00

abstract：:We have developed an isolated intestinal cell system to study the regulation of cholecystokinin release. Enzymatically dispersed canine jejunal mucosal cells were separated by counterflow elutriation to enrich cholecystokinin content 20-fold. Release of cholecystokinin from freshly isolated cells was determined by rad...

journal_title：Gastroenterology

authors： Barber DL,Walsh JH,Soll AH

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Mutations in HFE are the most common cause of the iron-overload disorder hereditary hemochromatosis. Levels of the main iron regulatory hormone, hepcidin, are inappropriately low in hereditary hemochromatosis mouse models and patients with HFE mutations, indicating that HFE regulates hepcidin. The b...

journal_title：Gastroenterology

authors： Corradini E,Garuti C,Montosi G,Ventura P,Andriopoulos B Jr,Lin HY,Pietrangelo A,Babitt JL

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:Triage of patients with acute upper gastrointestinal hemorrhage (UGIH) has traditionally required urgent upper endoscopy. The aim of this study is to evaluate the use of artificial neural network for nonendoscopic triage. METHODS:A cohort of 387 patients was used to train (n = 194) and internally val...

journal_title：Gastroenterology

authors： Das A,Ben-Menachem T,Farooq FT,Cooper GS,Chak A,Sivak MV Jr,Wong RC

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND/AIMS:Reflex relaxation is a mechanism whereby the colon can show short-term dilatation in the absence of mechanical obstruction. This study investigated the tonic response of the canine colon to ileal distention and its pharmacological control. METHODS:In four dogs, the tone of the proximal colon was record...

journal_title：Gastroenterology

authors： Basilisco G,Phillips SF

更新日期：1994-03-01 00:00:00

abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

journal_title：Gastroenterology

authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND & AIMS:Feeding intolerance because of functional gastrointestinal dysmotility and parenteral nutrition-associated cholestasis (PNAC) are common problems in preterm, very-low-birth-weight (VLBW) infants. This double-blind, randomized, placebo-controlled study aimed to assess the effectiveness of "high-dose" o...

journal_title：Gastroenterology

authors： Ng PC,Lee CH,Wong SP,Lam HS,Liu FY,So KW,Lee CY,Fok TF

更新日期：2007-05-01 00:00:00

abstract：:In the search for novel therapeutic approaches to treat patients with colorectal carcinoma, anticancer vaccination holds promise. A large body of preclinical and clinical evidence has demonstrated that the immune system can be polarized against malignant cells by means of several active specific immunotherapy strategi...

journal_title：Gastroenterology

authors： Mocellin S,Rossi CR,Lise M,Nitti D

更新日期：2004-12-01 00:00:00