Abstract:
:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of such treatment. The risk appears to be related to increasing age, but no other associated factor has yet been identified. It is uncertain whether individuals with preexisting ulcer are at special risk or whether treatment predisposed equally to ulcer and ulcer complications, and there is no clear evidence that the nature of the disability leading to nonsteroidal antiinflammatory drug treatment influences the risk of gastrointestinal complications.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Langman MJdoi
10.1016/s0016-5085(89)80060-5subject
Has Abstractpub_date
1989-02-01 00:00:00pages
640-6issue
2 Pt 2 Suppleissn
0016-5085issn
1528-0012pii
S0016-5085(89)80060-5journal_volume
96pub_type
杂志文章,评审相关文献
GASTROENTEROLOGY文献大全abstract::The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90470-l
更新日期:1990-12-01 00:00:00
abstract::A technique for the direct measurement of portal vein pressure in fully conscious patients is described. This uses a percutaneous transhepatic approach with a thin Chiba needle and is shown to be simple and safe. The technique has been applied to 123 patients with a variety of liver disorders and the pressure measurem...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:The role of cytotoxicity mediated by peripheral blood mononuclear cells for colonic epithelial cells in inflammatory bowel disease (IBD) is still controversial. To clarify it, we studied major histocompatibility antigen (MHC)-restricted T cell-mediated cytotoxicity (CTL). METHODS:Cytotoxicity was measured b...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90405-2
更新日期:1993-02-01 00:00:00
abstract::The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90324-5
更新日期:1985-08-01 00:00:00
abstract::Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::A randomized, double-blind comparison of lactose enemas plus placebo tablets vs. starch enemas plus neomycin tablets was performed on 18 patients with acute portal systemic encephalopathy. Ten patients received starch enemas (10%; 1000 ml t.i.d.) plus neomycin tablets and 8 patients received lactose enemas (20%; 1000 ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1981-07-01 00:00:00
abstract::Several prostaglandins are cytoprotective for the stomach; they prevent mucosal necrosis and hemorrhages produced by noxious agents, such as absolute ethanol. One possible mechanism of cytoprotection would be that the prostaglandin may prevent penetration of the necrotizing agent into the gastric mucosa. To test this ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(85)80187-6
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.02.058
更新日期:2009-06-01 00:00:00
abstract::Human gastrointestinal cancer xenografts were established in the nude mouse. Grafts were accomplished with gastric adenocarcinomas, gastric leiomyosarcoma, histiocytic lymphoma of the stomach and gallbladder, pancreatic tumors, colonic cancers and cell lines of duodenal (HUTU-80) and pancreatic (HS-766-T) cancers, mel...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract:UNLABELLED:We investigated a patient (W.B.) with chronic symptomatic Giardiasis despite seven separate courses of either quinacrine or metronidazole who was cured by combined quinacrine and metronidazole. After isolating Giardia lamblia from W.B., we cultured the trophozoites to make the following observations. In vitr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND & AIMS:Patients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients with lower levels of hepatitis B surface antigen (HBsAg) have higher chances of losing HBsAg than those with high levels. However, little is known about whether higher level...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.02.007
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND & AIMS:Corticosteroids have been shown to significantly decrease short-term mortality in patients with severe alcoholic hepatitis. However, independent factors associated with a favorable outcome and long-term survival are unknown. The aim of this study was to examine prognostic factors and long-term surviva...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.1996.v110.pm8964410
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND & AIMS:The course of hereditary hemochromatosis may depend on the degree of iron overload and the time of therapeutic intervention. This analysis evaluates the impact of early diagnosis and iron removal on survival and complications in hereditary hemochromatosis. METHODS:A Cohort of 251 patients with hemoch...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8613000
更新日期:1996-04-01 00:00:00
abstract::Experiments were designed to test the hypothesis that alterations of intestinal motility accompany enteric helminth infections. Motility was measured in rats during the intestinal phase of infection with the nematode Trichinella spiralis by following the transit of radioactive chromium through the gut. Intraduodenal c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract:BACKGROUND & AIMS:Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate cells (HSCs) proliferate and acquire contractile properties. This study investigated the presence of receptors for ANGII and the ef...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70368-4
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND & AIMS:The natural history and management of pancreatic cysts, especially for branch duct intraductal papillary mucinous neoplasms (BD-IPMNs), remain uncertain. We developed evidence-based nomograms to assist with clinical decision making. METHODS:We used decision analysis with Markov modeling to compare co...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.10.001
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2011.08.036
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND & AIMS:Patients with cirrhosis are characterized by a reduced splanchnic vascular resistance and a hyporeactivity to adrenergic vasoconstrictors. So far, their adrenergic splanchnic vascular responsiveness has not been evaluated in vitro. We compared responses to alpha1- and beta2-adrenoceptor stimulation of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70136-8
更新日期:1999-02-01 00:00:00
abstract::Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty liver disease. A chronic, subacute state of inflammation often accompanies the accumulation of excess lipid in adipose tissue...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.03.059
更新日期:2007-05-01 00:00:00
abstract::CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2008.02.012
更新日期:2008-04-01 00:00:00
abstract::Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.11.009
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND & AIMS:Noninvasive methods are needed to identify clinically significant portal hypertension (CSPH) and esophageal varices (EVs) in patients with compensated cirrhosis. We looked for markers of the presence of CSPH and EVs in patients with cirrhosis. METHODS:We performed a cross-sectional study that include...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.10.001
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.02.031
更新日期:2020-06-01 00:00:00
abstract::Enriched populations of human intestinal and colonic intraepithelial lymphocytes were isolated separate from lamina propria lymphocytes. These populations, and peripheral blood mononuclear cells, were characterized for membrane features, lymphocyte subsets, and proliferative potential to the nonspecific mitogenic lect...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-11-01 00:00:00
abstract::The present study was undertaken to evaluate the ability of human hepatocytes to respond in culture to various mitotic agents including epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), or serum from patients with fulminant hepatitis. Human hepatocytes were maintained in culture on collagen-...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Two women, aged 19 and 28 yr, who had been on the contraceptive pill for at least 18 mo, developed abnormal levels of circulating liver enzymes, minimal hepatomegaly, and elevated erythrocyte sedimentation rate. Liver biopsy in both women showed a sinusoidal dilatation sparing the perihepatic venous regions. The liver...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND & AIMS:Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by heterozygous germline sequence mutations of DNA mismatch repair genes, most frequently MLH1 or MSH2. A novel molecular mechanism for HNPCC has recently been suggested by the finding of individuals with soma-wide monoallelic hypermethylatio...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.09.003
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND & AIMS:Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome, followed by compensatory anti-inflammatory response syndrome (CARS). We investigated the mechanisms of these processes in mice and human serum. METHODS:We induced severe acute pancreati...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2019.09.040
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.03.043
更新日期:2010-07-01 00:00:00
abstract::The noninvasive assessment of intestinal permeability in humans has a 20-year history. Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/0016-5085(95)90708-4
更新日期:1995-05-01 00:00:00