当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications.

Growth rate of asymptomatic hepatocellular carcinoma and its clinical implications.

Abstract：

:The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with a median of 117 days, an arithmetic mean of 136 days, and a geometric mean of 110 days. In 17 tumors with more than two measurements, the growth rate remained exponential in nine, declined in growth in seven, and showed an initial lag period in one. Doubling time correlated with initial tumor diameter but was independent of the patient's age, sex, hepatitis B surface antigen status, tumor location, liver function tests, stage of liver cirrhosis, histologic type, or grade of malignancy. Although initial alpha-fetoprotein levels did not correlate well with growth rate, in 14 patients with an exponential increase of serum alpha-fetoprotein, the alpha-fetoprotein doubling time was closely related to the tumor doubling time. Based on the above data, the median detectable subclinical period of hepatocellular carcinoma was deduced to be 3.2 yr, and the suitable screening interval for its early detection in our area was 4-5 mo.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Sheu JC,Sung JL,Chen DS,Yang PM,Lai MY,Lee CS,Hsu HC,Chuang CN,Yang PC,Wang TH

doi

10.1016/0016-5085(85)90324-5

subject

Has Abstract,Author List Incomplete

pub_date

1985-08-01 00:00:00

pages

259-66

issue

2

eissn

0016-5085

issn

1528-0012

pii

0016-5085(85)90324-5

journal_volume

89

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Survival of patients identified as candidates for intestinal transplantation: a 3-year prospective follow-up.

    abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.03.043

    authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

    更新日期：2008-07-01 00:00:00

  • Use of macroaggregated albumin lung perfusion scan to diagnose hepatopulmonary syndrome: a new approach.

    abstract：BACKGROUND & AIMS:We have reported that contrast echocardiography is a sensitive screening test for the hepatopulmonary syndrome (HPS). However, contrast echocardiography lacks specificity because many cirrhotic patients have positive study results with normal arterial blood gases and therefore do not fulfill criteria ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70481-0

    authors： Abrams GA,Nanda NC,Dubovsky EV,Krowka MJ,Fallon MB

    更新日期：1998-02-01 00:00:00

  • Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury.

    abstract：BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90211-2

    authors： Neubauer K,Knittel T,Armbrust T,Ramadori G

    更新日期：1995-04-01 00:00:00

  • Portal and biliary phases of enterohepatic circulation of corrinoids in humans.

    abstract：:The assimilation of labeled cobalamin and the transport of corrinoids in portal blood, peripheral venous blood, and bile were studied in eight cholecystectomized patients, after ingestion of a dose of cyano[57Co]cobalamin (0.5 microCi). The radioactivity appeared in the portal vein after a delay of 1.5-2 hours and in ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90094-2

    authors： el Kholty S,Gueant JL,Bressler L,Djalali M,Boissel P,Gerard P,Nicolas JP

    更新日期：1991-11-01 00:00:00

  • Inhibition of rat methylbenzylnitrosamine metabolism by dietary zinc and zinc in vitro.

    abstract：:Methylbenzylnitrosamine is an esophageal-specific carcinogen in the rat, and the incidence of methylbenzylnitrosamine-induced esophageal carcinoma is increased by dietary zinc deficiency. Methylbenzylnitrosamine requires activation by cytochrome P-450 to be mutagenic; the present study examined the role of dietary zin...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90009-n

    authors： Barch DH,Fox CC,Rosche WA,Rundhaugen LM,Wrighton SA

    更新日期：1992-09-01 00:00:00

  • erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.

    abstract：BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2005.10.010

    authors： Lai GH,Zhang Z,Shen XN,Ward DJ,Dewitt JL,Holt SE,Rozich RA,Hixson DC,Sirica AE

    更新日期：2005-12-01 00:00:00

  • Cerebral electrical potentials evoked by balloon distention of the human esophagus.

    abstract：UNLABELLED:Cerebral evoked potentials provide a technique for evaluation of central nervous processing of information derived from a variety of sensory modalities. Evoked potentials associated with balloon distention of the smooth muscle esophagus were studied in 14 adult volunteers. Stimulation was applied via repeate...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90286-a

    authors： Castell DO,Wood JD,Frieling T,Wright FS,Vieth RF

    更新日期：1990-03-01 00:00:00

  • The "mirroring" of gallstones: description of a novel silvering method to determine the surface area of an irregular object. In vitro demonstration that multiple gallstones from the same gallbladder dissolve in unsaturated "bile" at the same rate.

    abstract：:We describe a novel "silvering" method to determine the surface area of nonspherical objects and have applied this method to human cholesterol gallstones. A standard curve is first constructed, using data obtained from the dissolution rates of silver-coated plastic spheres of known dimensions in unstirred thiosulfate-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Park YH,Igimi H,Carey MC

    更新日期：1982-11-01 00:00:00

  • Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer.

    abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2016.08.002

    authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

    更新日期：2016-12-01 00:00:00

  • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance.

    abstract：BACKGROUND & AIMS:Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS:A cohort of 417 HCC-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2003.12.049

    authors： Sangiovanni A,Del Ninno E,Fasani P,De Fazio C,Ronchi G,Romeo R,Morabito A,De Franchis R,Colombo M

    更新日期：2004-04-01 00:00:00

  • Cytomegalovirus infection of the appendix in patient with the acquired immunodeficiency syndrome.

    abstract：:Disseminated cytomegalovirus infection occurs predominantly in immunocompromised hosts. Involvement of the gastrointestinal tract in the acquired immunodeficiency syndrome is frequent, but to our knowledge there is only one report of involvement of the appendix. In this study, a patient with a history of the acquired ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90485-4

    authors： Valerdiz-Casasola S,Pardo-Mindan FJ

    更新日期：1991-07-01 00:00:00

  • Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease.

    abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90398-0

    authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

    更新日期：1994-06-01 00:00:00

  • Levels of Cytokines in Serum Associate With Development of Hepatocellular Carcinoma in Patients With HCV Infection Treated With Direct-Acting Antivirals.

    abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.10.035

    authors： Debes JD,van Tilborg M,Groothuismink ZMA,Hansen BE,Schulze Zur Wiesch J,von Felden J,de Knegt RJ,Boonstra A

    更新日期：2018-02-01 00:00:00

  • A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis.

    abstract：:We describe a 47-year-old patient who developed cholelithiasis in adolescence, followed by recurrent intrahepatic cholestasis of pregnancy, and finally biliary cirrhosis in adulthood. In our patient, the consecutive presentation of the 3 mentioned disorders raised the suspicion of a defect of MDR3, the canalicular pro...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2003.50144

    authors： Lucena JF,Herrero JI,Quiroga J,Sangro B,Garcia-Foncillas J,Zabalegui N,Sola J,Herraiz M,Medina JF,Prieto J

    更新日期：2003-04-01 00:00:00

  • Effect of chronic aspirin ingestion on epithelial proliferation in rat fundus, antrum, and duodenum.

    abstract：:We studied the effect of chronic aspirin ingestion on gastroduodenal epithelial proliferation by feeding rats aspirin in the drinking water. A control group of rats received plain water. At the end of 4 wk, [3H]-thymidine was given intravenously to label proliferating cells, and the rats were killed 1 h later. Section...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Eastwood GL,Quimby GF

    更新日期：1982-05-01 00:00:00

  • Interferon regulatory factor-2 regulates exocytosis mechanisms mediated by SNAREs in pancreatic acinar cells.

    abstract：BACKGROUND & AIMS:Pancreatic acinar cells are used to study regulated exocytosis. We investigated the role of interferon regulatory factor-2 (IRF2) in exocytosis in pancreatic acinar cells. METHODS:Pancreas tissues from Irf2⁺/⁺, Irf2⁺/⁻), and Irf2⁻/⁻ mice were examined by microscopy, immunohistochemical, and immunoblo...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.05.051

    authors： Mashima H,Sato T,Horie Y,Nakagawa Y,Kojima I,Ohteki T,Ohnishi H

    更新日期：2011-09-01 00:00:00

  • Metabolism of mixed human colonic bacteria in a continuous culture mimicking the human cecal contents.

    abstract：:The purpose of this study was to develop an in vitro model of the proximal colon that would permit investigation of the function of colonic bacteria. Five continuous cultures of fecal bacteria were maintained anaerobically in steady state for at least 21 days in a medium simulating ileostomy effluent. The pH was maint...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90017-4

    authors： Edwards CA,Duerden BI,Read NW

    更新日期：1985-06-01 00:00:00

  • Lack of effectiveness of the platelet-activating factor antagonist SR27417A in patients with active ulcerative colitis: a randomized controlled trial. The Platelet Activating Factor Antagonist Study Group in Ulcerative Colitis.

    abstract：BACKGROUND & AIMS:Platelet-activating factor (PAF) is increased during relapse of ulcerative colitis. In animal models of experimental colitis, specific inhibition of PAF has reduced inflammation. The aim of this study was to evaluate the efficacy and safety of the PAF antagonist SR27417A in moderately active UC. METH...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0016-5085(98)70011-3

    authors： Stack WA,Jenkins D,Vivet P,Hawkey CJ

    更新日期：1998-12-01 00:00:00

  • Hepatic sinusoidal endothelial cell G1/S arrest correlates with severity of alcoholic liver injury in the rat.

    abstract：BACKGROUND/AIMS:Capillarization of the hepatic sinusoid occurs in alcoholic liver disease. Because endothelial cell proliferation is relevant to capillarization, we used the intragastric feeding rat model to evaluate the relationship between pathological liver injury and endothelial cell proliferation. METHODS:Male Wi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90132-5

    authors： Nanji AA,Tahan SR,Wei Y,Sadrzadeh SM

    更新日期：1994-09-01 00:00:00

  • MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells.

    abstract：BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.10.029

    authors： Liu WH,Yeh SH,Lu CC,Yu SL,Chen HY,Lin CY,Chen DS,Chen PJ

    更新日期：2009-02-01 00:00:00

  • Platelets circulate in an activated state in inflammatory bowel disease.

    abstract：BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90741-2

    authors： Collins CE,Cahill MR,Newland AC,Rampton DS

    更新日期：1994-04-01 00:00:00

  • Hepatitis C virus attenuates interferon-induced major histocompatibility complex class I expression and decreases CD8+ T cell effector functions.

    abstract：BACKGROUND & AIMS:Major histocompatibility complex (MHC) class I-restricted CD8(+) T cells are required for clearance of hepatitis C virus (HCV) infection. MHC class I expression is up-regulated by type I and II interferons (IFNs). However, little is known about the effects of HCV infection on IFN-induced expression of...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.01.054

    authors： Kang W,Sung PS,Park SH,Yoon S,Chang DY,Kim S,Han KH,Kim JK,Rehermann B,Chwae YJ,Shin EC

    更新日期：2014-05-01 00:00:00

  • Prevalence of germline mutations in cancer predisposition genes in patients with pancreatic cancer.

    abstract：BACKGROUND & AIMS:We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. METHODS:The Ontario Pancreas Cancer Study enrolls consenting participants with pancreatic cancer from a province-wide elect...

    journal_title：Gastroenterology

    pub_type： 评论,杂志文章

    doi：10.1053/j.gastro.2014.11.042

    authors： Grant RC,Selander I,Connor AA,Selvarajah S,Borgida A,Briollais L,Petersen GM,Lerner-Ellis J,Holter S,Gallinger S

    更新日期：2015-03-01 00:00:00

  • Functional Anorectal Disorders.

    abstract：:This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2016.02.009

    authors： Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

    更新日期：2016-03-25 00:00:00

  • c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity.

    abstract：BACKGROUND & AIMS:In searching for effects of acetaminophen (APAP) on hepatocytes downstream of its metabolism that may participate in hepatotoxicity, we examined the role of stress kinases. METHODS:Mouse hepatocytes and C57BL/6 mice were administered a toxic dose of APAP with or without SP600125, a chemical c-jun N-t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.03.045

    authors： Gunawan BK,Liu ZX,Han D,Hanawa N,Gaarde WA,Kaplowitz N

    更新日期：2006-07-01 00:00:00

  • Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement.

    abstract：BACKGROUND & AIMS:Activation of Fas or tumor necrosis factor receptor 1 (TNF-R1) on hepatocytes leads to apoptosis, which requires mitochondria activation. The pro-death Bcl-2 family protein, Bid, mediates this pathway by inducing mitochondrial releases of cytochrome c and other apoptotic factors. How Bid activates mit...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(03)01066-7

    authors： Zhao Y,Ding WX,Qian T,Watkins S,Lemasters JJ,Yin XM

    更新日期：2003-09-01 00:00:00

  • Role of capsaicin-sensitive afferent neurons in alkaline secretory response to luminal acid in the rat duodenum.

    abstract：:The role of capsaicin-sensitive afferent neurons in acid-induced HCO3- secretion was investigated in the duodenum of anesthetized rats. The proximal duodenum was perfused with saline (pH 4.5), the pH of perfusate and the transmucosal potential differences were continuously monitored, and HCO3- output was determined by...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90721-v

    authors： Takeuchi K,Matsumoto J,Ueshima K,Okabe S

    更新日期：1991-10-01 00:00:00

  • JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

    abstract：BACKGROUND & AIMS:Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancrea...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.12.004

    authors： Song X,Zhu S,Xie Y,Liu J,Sun L,Zeng D,Wang P,Ma X,Kroemer G,Bartlett DL,Billiar TR,Lotze MT,Zeh HJ,Kang R,Tang D

    更新日期：2018-04-01 00:00:00

  • Lack of association between oral contraceptive use and Crohn's disease: a community-based matched case-control study.

    abstract：:Previous epidemiologic studies have suggested a weak association between oral contraceptive use and Crohn's disease, specifically Crohn's colitis. To measure a possible etiologic association, 51 women with Crohn's disease who were 18-50 yr old were studied and compared with peer-nominated age- and sex-matched controls...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)90388-0

    authors： Lashner BA,Kane SV,Hanauer SB

    更新日期：1989-12-01 00:00:00

  • Role of prostaglandins in the formation of aspirin-induced gastric ulcers.

    abstract：:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

    更新日期：1981-01-01 00:00:00