Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone.

abstract：BACKGROUND & AIMS:Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8+ reg...

journal_title：Gastroenterology

authors： Ménager-Marcq I,Pomié C,Romagnoli P,van Meerwijk JP

更新日期：2006-12-01 00:00:00

abstract：:In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 ind...

journal_title：Gastroenterology

authors： Iida M,Yao T,Itoh H,Watanabe H,Kohrogi N,Shigematsu A,Iwashita A,Fujishima M

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of Barrett's esophagus and esophageal adenocarcinoma has increased despite surveillance of patients with Barrett's esophagus. Limited data indicate that nonsteroidal anti-inflammatory drug (NSAID) and statin use reduce the risk for esophageal adenocarcinoma. We investigated whether NSAID...

journal_title：Gastroenterology

authors： Kastelein F,Spaander MC,Biermann K,Steyerberg EW,Kuipers EJ,Bruno MJ,Probar-study Group.

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...

journal_title：Gastroenterology

authors： Lehwald N,Tao GZ,Jang KY,Sorkin M,Knoefel WT,Sylvester KG

更新日期：2011-08-01 00:00:00

abstract：:An in vitro fecal incubation system was used to demonstrate how lactulose influences ammonia metabolism in the colon. Lactulose and other fermentable substrates (glucose, mannitol, and sorbitol), pH and organic acid were varied independently so that their different effects could be determined. Fermentable substrate ca...

journal_title：Gastroenterology

authors： Vince A,Killingley M,Wrong OM

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND & AIMS:Electroneutral NaCl absorption across small intestine contributes importantly to systemic fluid balance. Disturbances in this process occur in both obstructive and diarrheal diseases, eg, cystic fibrosis, secretory diarrhea. NaCl absorption involves coupling of Cl(-)/HCO(3)(-) exchanger(s) primarily w...

journal_title：Gastroenterology

authors： Walker NM,Simpson JE,Yen PF,Gill RK,Rigsby EV,Brazill JM,Dudeja PK,Schweinfest CW,Clarke LL

更新日期：2008-11-01 00:00:00

abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

journal_title：Gastroenterology

authors： Dubois A,Walker RI

更新日期：1988-08-01 00:00:00

abstract：:The target appearance of grey scale ultrasound is thought to be a characteristic sign of gastrointestinal wall thickening. It consists of a strong echogenic center surrounded by a sonolucent rim. In a prospective controlled study, the sensitivity and specificity of the ultrasonic B-scan for Crohn's disease were invest...

journal_title：Gastroenterology

authors： Sonnenberg A,Erckenbrecht J,Peter P,Niederau C

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND/AIMS:Approximately 50% of patients with functional dyspepsia have Helicobacter pylori infection; it remains controversial whether this infection causes chronic symptoms, but rigorously conducted therapeutic trials should establish whether H. pylori plays a role in functional dyspepsia. The aim here was to de...

journal_title：Gastroenterology

authors： Talley NJ

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...

journal_title：Gastroenterology

authors： Anderson R,Burr NE,Valori R

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Intrahepatic bile ducts express a range of lymphocyte adhesion molecules during episodes of inflammation. This may contribute to the susceptibility of biliary epithelium to immunologic damage during liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis. However, no previo...

journal_title：Gastroenterology

authors： Leon MP,Bassendine MF,Gibbs P,Thick M,Kirby JA

更新日期：1997-03-01 00:00:00

abstract：:Data collected by nine population-based tumor registries participating in the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute were analyzed to characterize the epidemiology of noncarcinoid adenocarcinomas of the colon and rectum in young adults. Tumors diagnosed in persons under 40...

journal_title：Gastroenterology

authors： Griffin PM,Liff JM,Greenberg RS,Clark WS

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms by which hepatitis C virus (HCV) induces liver fibrosis are unknown. Hepatocytes secrete HCV proteins, which may interact with hepatic stellate cells (HSCs). Our aims were to investigate whether HCV proteins induce fibrogenic effects on HSCs. METHODS & RESULTS:Human-activated HSCs expr...

journal_title：Gastroenterology

authors： Bataller R,Paik YH,Lindquist JN,Lemasters JJ,Brenner DA

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND & AIMS:Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancrea...

journal_title：Gastroenterology

authors： Song X,Zhu S,Xie Y,Liu J,Sun L,Zeng D,Wang P,Ma X,Kroemer G,Bartlett DL,Billiar TR,Lotze MT,Zeh HJ,Kang R,Tang D

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND & AIMS:There is no clear and point for the response to treatment of gastrointestinal human cytomegalovirus (HCMV) disease. HCMV-DNA quantitation on gastrointestinal biopsy specimens has proven its value for the diagnosis of gastrointestinal HCMV disease in patients with acquired immunodeficiency syndrome (AI...

journal_title：Gastroenterology

authors： Cotte L,Drouet E,Bailly F,Vitozzi S,Denoyel G,Trepo C

更新日期：1996-08-01 00:00:00

abstract：:A strict gluten-free diet (GFD) for life is the only treatment for celiac disease (CD). This article reviews (1) the impact of the GFD on the quality of life of individuals with CD and their families; (2) the causes of poorly controlled CD; (3) the access to and source and quality of information provided by health pro...

journal_title：Gastroenterology

authors： Case S

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:It was recently reported that ventromedial hypothalamic (VMH) lesions produced an increase in gastrointestinal DNA content in rats. In the present study, the mechanism of this alteration was examined. METHODS:The DNA content and synthesis after VMH lesioning in rat gastrointestinal tracts were determined. ...

journal_title：Gastroenterology

authors： Kiba T,Tanaka K,Endo O,Inoue S

更新日期：1993-02-01 00:00:00

abstract：:2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...

journal_title：Gastroenterology

authors： Xie JM,Greenberg SS,Longenecker G

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND & AIMS:HCV nonstructural protein 5A (NS5A) has been implicated in regulating cell growth and interferon response. The NS5A protein contains proline-rich regions that are highly conserved among HCV genotypes and match Src homology 3 (SH3)-binding motifs (PxxP) found in various cellular signaling molecules. M...

journal_title：Gastroenterology

authors： Nanda SK,Herion D,Liang TJ

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND & AIMS:Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethnic groups. We evaluated the impact of race on respon...

journal_title：Gastroenterology

authors： McHutchison JG,Poynard T,Pianko S,Gordon SC,Reid AE,Dienstag J,Morgan T,Yao R,Albrecht J

更新日期：2000-11-01 00:00:00

abstract：:Previously, we reported that two glycoproteins, carcinoembryonic antigen and secretory component, are preferentially expressed on the apical or laterobasal surfaces, respectively, of normal human colonic epithelial cells, whereas these antigens may be expressed over the entire cell surface of colonic cancer cells. The...

journal_title：Gastroenterology

authors： Sugiyama T,Brown WR,Ahnen DJ

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

journal_title：Gastroenterology

authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) uses several host factors to infect and replicate in human hepatocytes. Cyclophilin A (CypA) is required for viral replication, and CypA inhibitors are in development. We investigated the effects of nonsynonymous single nucleotide polymorphisms (SNPs) in the region of peptidyl-...

journal_title：Gastroenterology

authors： von Hahn T,Schiene-Fischer C,Van ND,Pfaender S,Karavul B,Steinmann E,Potthoff A,Strassburg C,Hamdi N,Abdelaziz AI,Sarrazin C,Müller T,Berg T,Trépo E,Wedemeyer H,Manns MP,Pietschmann T,Ciesek S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation...

journal_title：Gastroenterology

authors： Henn MR,O'Brien EJ,Diao L,Feagan BG,Sandborn WJ,Huttenhower C,Wortman JR,McGovern BH,Wang-Weigand S,Lichter DI,Chafee M,Ford CB,Bernardo P,Zhao P,Simmons S,Tomlinson AD,Cook DN,Pomerantz RJ,Misra BK,Auninš JG,Truc

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

journal_title：Gastroenterology

authors： Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：:Hepatic morphology and immunocytology were evaluated in 4 children with clinical and immunologic characteristics of the acquired immune deficiency syndrome or acquired immune deficiency syndrome related complex. All 4 children had hepatomegaly and increased serum alanine and aspartate aminotransferase activity. Both l...

journal_title：Gastroenterology

authors： Duffy LF,Daum F,Kahn E,Teichberg S,Pahwa R,Fagin J,Kenigsberg K,Kaplan M,Fisher SE,Pahwa S

更新日期：1986-01-01 00:00:00

abstract：:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...

journal_title：Gastroenterology

authors： Gukovskaya AS,Gukovsky I,Algül H,Habtezion A

更新日期：2017-11-01 00:00:00

abstract：:In Japan, approximately 30,000 patients died of hepatocellular carcinoma (HCC) in 2003. Ten percent had hepatitis B virus infection and 80% had hepatitis C virus (HCV) infection, indicating that viral hepatitis accounted for >90% of cases of HCC. In comparison, only 3% (1.5%, hepatitis B virus; 1.5%, HCV) of the gener...

journal_title：Gastroenterology

authors： Omata M,Tateishi R,Yoshida H,Shiina S

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:We have few population-level data on the performance of endoscopic retrograde cholangiopancreatography (ERCP) in the United States. We investigated the numbers of unplanned hospital encounters (UHEs), patient and facility factors associated with UHEs, and variation in quality and outcomes in the perfo...

journal_title：Gastroenterology

authors： Huang RJ,Barakat MT,Girotra M,Lee JS,Banerjee S

更新日期：2019-01-01 00:00:00