Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis.

abstract：BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...

journal_title：Gastroenterology

authors： Park S,Zifan A,Kumar D,Mittal RK

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based coho...

journal_title：Gastroenterology

authors： Bonfiglio F,Zheng T,Garcia-Etxebarria K,Hadizadeh F,Bujanda L,Bresso F,Agreus L,Andreasson A,Dlugosz A,Lindberg G,Schmidt PT,Karling P,Ohlsson B,Simren M,Walter S,Nardone G,Cuomo R,Usai-Satta P,Galeazzi F,Neri M,P

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...

journal_title：Gastroenterology

authors： Haigh CR,Attwood SE,Thompson DG,Jankowski JA,Kirton CM,Pritchard DM,Varro A,Dimaline R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND & AIMS:Postcolonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cas...

journal_title：Gastroenterology

authors： Anderson R,Burr NE,Valori R

更新日期：2020-04-01 00:00:00

abstract：:Individual l-amino acids were instilled intragastrically to determine possible differences in stimulation of gastric acid secretion and gastrin and pancreatic polypeptide release. Phenylalanine and tryptophan were significantly more potent stimulants of gastric acid secretion and of pancreatic polypeptide and gastrin ...

journal_title：Gastroenterology

authors： Taylor IL,Byrne WJ,Christie DL,Ament ME,Walsh JH

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND & AIMS:Congenital diarrheal disorders are rare inherited intestinal disorders characterized by intractable, sometimes life-threatening, diarrhea and nutrient malabsorption; some have been associated with mutations in diacylglycerol-acyltransferase 1 (DGAT1), which catalyzes formation of triacylglycerol from ...

journal_title：Gastroenterology

authors： van Rijn JM,Ardy RC,Kuloğlu Z,Härter B,van Haaften-Visser DY,van der Doef HPJ,van Hoesel M,Kansu A,van Vugt AHM,Thian M,Kokke FTM,Krolo A,Başaran MK,Kaya NG,Aksu AÜ,Dalgıç B,Ozcay F,Baris Z,Kain R,Stigter ECA,Lich

更新日期：2018-07-01 00:00:00

abstract：:Heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (Saguinus oedipus, n = 18; Macaca mulatta, n = 2; Macaca fascicularis, n = 2; Aotus trivirgatus, n = 2; Saimiri sciureus, n = 2; and Callithrix jacchus, n = 2). After initial separation of radi...

journal_title：Gastroenterology

authors： Podolsky DK,Madara JL,King N,Sehgal P,Moore R,Winter HS

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Cirrhosis and portal hypertension due to chronic common bile duct ligation reproduce the features of human hepatopulmonary syndrome, whereas portal hypertension alone due to partial portal vein ligation does not. Nitric oxide contributes to experimental hepatopulmonary syndrome, but the nitric oxide s...

journal_title：Gastroenterology

authors： Zhang J,Ling Y,Luo B,Tang L,Ryter SW,Stockard CR,Grizzle WE,Fallon MB

更新日期：2003-11-01 00:00:00

abstract：:The nuclear lamina is a multi-protein lattice composed of A- and B-type lamins and their associated proteins. This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins, providing links among the genome, nucleoskeleton, and cytoskeleton. In the 1990s, mutations in EMD and LMNA we...

journal_title：Gastroenterology

authors： Brady GF,Kwan R,Bragazzi Cunha J,Elenbaas JS,Omary MB

更新日期：2018-05-01 00:00:00

abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...

journal_title：Gastroenterology

authors： Finklestein M,Goldman L,Grace ND,Foley M,Randall N

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:The prognosis of advanced cirrhosis due to chronic hepatitis B is poor, and results of therapies, including liver transplantation, have been unsatisfactory. Little is known about the effectiveness of interferon alfa in patients with cirrhosis. METHODS:Between 1984 and 1991, 18 patients with clinically-appar...

journal_title：Gastroenterology

authors： Hoofnagle JH,Di Bisceglie AM,Waggoner JG,Park Y

更新日期：1993-04-01 00:00:00

abstract：:The enterochromaffinlike cells in the rat stomach are rich in histamine and are thought to be under the influence of gastrin. The effect of sustained endogenous and exogenous hypergastrinemia on the activity and proliferation rate of the enterochromaffinlike cells was studied by determining the histidine decarboxylase...

journal_title：Gastroenterology

authors： Ryberg B,Tielemans Y,Axelson J,Carlsson E,Håkanson R,Mattson H,Sundler F,Willems G

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND & AIMS:The maintenance of the intestinal mucosal barrier may be energy dependent. Tacrolimus is a potent immunosuppressive drug that decreases mitochondrial adenosine triphosphate production and increases intestinal permeability in animals. METHODS:Twelve liver graft recipients receiving tacrolimus, 9 healt...

journal_title：Gastroenterology

authors： Gabe SM,Bjarnason I,Tolou-Ghamari Z,Tredger JM,Johnson PG,Barclay GR,Williams R,Silk DB

更新日期：1998-07-01 00:00:00

abstract：:Extracellular space and blood volume were measured using 82Br dilution and 51Cr-tagged erythrocytes in 24 tumor-free patients after total gastrectomy. Eleven of the patients suffered from early dumping. Age, blood volume, and extracellular space were significantly smaller in dumpers (P less than 0.05). The dumping sco...

journal_title：Gastroenterology

authors： Miholic J,Reilmann L,Meyer HJ,Körber H,Kotzerke J,Hecker H

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...

journal_title：Gastroenterology

authors： Ott SJ,Waetzig GH,Rehman A,Moltzau-Anderson J,Bharti R,Grasis JA,Cassidy L,Tholey A,Fickenscher H,Seegert D,Rosenstiel P,Schreiber S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND & AIMS:Unlike adult antral cells, feline newborn antral cells are unable to contract in response to agonists in the absence of extracellular calcium or in response to exogenous inositol 1,4,5-triphosphate (IP3) after permeabilization. Changes in intracellular pathways that are associated with these differenc...

journal_title：Gastroenterology

authors： Hillemeier AC,Deutsch DE,Bitar KN

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...

journal_title：Gastroenterology

authors： Yin J,Harpaz N,Tong Y,Huang Y,Laurin J,Greenwald BD,Hontanosas M,Newkirk C,Meltzer SJ

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND & AIMS:Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS:We used mass spectrometry...

journal_title：Gastroenterology

authors： Suda J,Zhu L,Okamoto CT,Karvar S

更新日期：2011-03-01 00:00:00

abstract：:A novel water-soluble dopamine-2 antagonist, N-[4-[2-(dimethylamino) ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) was synthesized and assayed for its gastrointestinal smooth muscle stimulating activity in vivo and in vitro. In the in vivo study, gastrointestinal contractile activity was measured by me...

journal_title：Gastroenterology

authors： Iwanaga Y,Miyashita N,Morikawa K,Mizumoto A,Kondo Y,Itoh Z

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND & AIMS:Entecavir demonstrated superior benefit to lamivudine at 48 weeks in nucleoside-naive patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB). We evaluated continued entecavir and lamivudine treatment through 96 weeks. METHODS:709 HBeAg-positive CHB patients were randomized to ...

journal_title：Gastroenterology

authors： Gish RG,Lok AS,Chang TT,de Man RA,Gadano A,Sollano J,Han KH,Chao YC,Lee SD,Harris M,Yang J,Colonno R,Brett-Smith H

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Sigmoidoscopy is an effective screening strategy for colorectal cancer that is not widely used by primary care providers. The aim of this study was to assess the impact of "academic detailing" in the form of an outreach educational seminar combined with implementation of on-site sigmoidoscopy services...

journal_title：Gastroenterology

authors： Schroy PC,Heeren T,Bliss CM,Pincus J,Wilson S,Prout M

更新日期：1999-08-01 00:00:00

abstract：:Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may be beneficial for bone strength. Fluoride toxicit...

journal_title：Gastroenterology

authors： Nielsen FH

更新日期：2009-11-01 00:00:00

abstract：:The cells of the fundic portion of canine gastric mucosa were dispersed by collagenase digestion and separated into fractions by sequential use of velocity sedimentation in an elutriator rotor followed by a density gradient separation. There was a close correlation between histamine content and number of mast cells in...

journal_title：Gastroenterology

authors： Soll AH,Lewin K,Beaven MA

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of trypsin on pancreatic ductal epithelial cells (PDECs) vary among species and depend on the localization of proteinase-activated receptor 2 (PAR-2). We compared PAR-2 localization in human and guinea-pig PDECs, and used isolated guinea pig ducts to study the effects of trypsin and a PAR-...

journal_title：Gastroenterology

authors： Pallagi P,Venglovecz V,Rakonczay Z Jr,Borka K,Korompay A,Ozsvári B,Judák L,Sahin-Tóth M,Geisz A,Schnúr A,Maléth J,Takács T,Gray MA,Argent BE,Mayerle J,Lerch MM,Wittmann T,Hegyi P

更新日期：2011-12-01 00:00:00

abstract：:A 62-year-old man with rheumatoid arthritis developed jaundice while taking piroxicam. A full evaluation including ultrasound, computerized tomography, endoscopic cholangiography, and liver biopsy confirmed the diagnosis of intrahepatic cholestasis. The patient's jaundice and all other liver function abnormalities nor...

journal_title：Gastroenterology

authors： Hepps KS,Maliha GM,Estrada R,Goodgame RW

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：:Basolateral, brush-border, and Golgi-enriched subcellular membrane fractions, prepared from homogenates of rat small intestinal mucosa obtained by scraping, had unusually high concentrations of nonesterified fatty acids. These fatty acids appear to be responsible for the large amount of calcium binding, an effect that...

journal_title：Gastroenterology

authors： Walters JR,Horvath PJ,Weiser MM

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The role of cytotoxicity mediated by peripheral blood mononuclear cells for colonic epithelial cells in inflammatory bowel disease (IBD) is still controversial. To clarify it, we studied major histocompatibility antigen (MHC)-restricted T cell-mediated cytotoxicity (CTL). METHODS:Cytotoxicity was measured b...

journal_title：Gastroenterology

authors： Okazaki K,Morita M,Nishimori I,Sano S,Toyonaga M,Nakazawa Y,Yamamoto Y,Yamamoto Y

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND & AIMS:Helicobacter pylori infection causes inflammation, accumulation of reactive oxygen species, and oxidative DNA damage in the gastric mucosa. Apurinic/apyrimidinic endonuclease-1 (APE-1)/redox factor-1 (Ref-1) repairs damaged DNA and reductively activates transcription factors, including activator prote...

journal_title：Gastroenterology

authors： Ding SZ,O'Hara AM,Denning TL,Dirden-Kramer B,Mifflin RC,Reyes VE,Ryan KA,Elliott SN,Izumi T,Boldogh I,Mitra S,Ernst PB,Crowe SE

更新日期：2004-09-01 00:00:00

abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...

journal_title：Gastroenterology

authors： Czaja MJ

更新日期：2011-06-01 00:00:00