Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study.

abstract：BACKGROUND & AIMS:We previously demonstrated that the 2 APC mutations in human colorectal tumors are coselected, because tumorigenesis requires an optimal level of Wnt signaling. We and others subsequently showed that the truncated APC proteins in colorectal tumors usually retain a total of 1-2 beta-catenin binding/deg...

journal_title：Gastroenterology

authors： Pollard P,Deheragoda M,Segditsas S,Lewis A,Rowan A,Howarth K,Willis L,Nye E,McCart A,Mandir N,Silver A,Goodlad R,Stamp G,Cockman M,East P,Spencer-Dene B,Poulsom R,Wright N,Tomlinson I

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

journal_title：Gastroenterology

authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...

journal_title：Gastroenterology

authors： Mizoguchi E,Xavier RJ,Reinecker HC,Uchino H,Bhan AK,Podolsky DK,Mizoguchi A

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies indicated that the peptide neurotensin (NT) stimulates Cl(-) secretion in animal small intestinal mucosa in vitro. In this study, we investigated whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this response. METHODS:Human mucosal preparations ...

journal_title：Gastroenterology

authors： Riegler M,Castagliuolo I,Wang C,Wlk M,Sogukoglu T,Wenzl E,Matthews JB,Pothoulakis C

更新日期：2000-08-01 00:00:00

abstract：:The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...

journal_title：Gastroenterology

authors： Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...

journal_title：Gastroenterology

authors： Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND & AIMS:Standardized instruments are needed to assess the activity of eosinophilic esophagitis (EoE) and to provide end points for clinical trials and observational studies. We aimed to develop and validate a patient-reported outcome (PRO) instrument and score, based on items that could account for variations...

journal_title：Gastroenterology

authors： Schoepfer AM,Straumann A,Panczak R,Coslovsky M,Kuehni CE,Maurer E,Haas NA,Romero Y,Hirano I,Alexander JA,Gonsalves N,Furuta GT,Dellon ES,Leung J,Collins MH,Bussmann C,Netzer P,Gupta SK,Aceves SS,Chehade M,Moawad F

更新日期：2014-12-01 00:00:00

abstract：:Phospholipases are enzymes that hydrolyze specific portions of phospholipid molecules. Their role in the digestion of exogenous phospholipids and as the active principle in snake and bee venoms has long been appreciated. Interest has increased in phospholipases recently because of new data implicating them in the infl...

journal_title：Gastroenterology

authors： Mansbach CM 2nd

更新日期：1990-05-01 00:00:00

abstract：:To evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, Fisher 344 rats. Specific activities of sucrase, maltase, lactase, and adenosine deaminase in...

journal_title：Gastroenterology

authors： Holt PR,Tierney AR,Kotler DP

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...

journal_title：Gastroenterology

authors： Delgiorno KE,Hall JC,Takeuchi KK,Pan FC,Halbrook CJ,Washington MK,Olive KP,Spence JR,Sipos B,Wright CV,Wells JM,Crawford HC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

journal_title：Gastroenterology

authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

更新日期：1995-01-01 00:00:00

abstract：:Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...

journal_title：Gastroenterology

authors： Pomeranz IS,Shaffer EA

更新日期：1985-03-01 00:00:00

abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...

journal_title：Gastroenterology

authors： Zargar SA,Kochhar R,Nagi B,Mehta S,Mehta SK

更新日期：1989-09-01 00:00:00

abstract：:Fever of 10 mo duration in a man of 35 yr was discovered at the time of a second laparatomy to be caused by actinomycotic infection of the liver. Actinomycosis of the liver usually presents as large single or as multiple abscesses. In this patient only nonspecific cellular infiltrates of the liver were found in liver ...

journal_title：Gastroenterology

authors： Meade RH 3rd

更新日期：1980-02-01 00:00:00

abstract：:Furosemide occasionally causes azotemia in patients with ascites, independently of induced volume depletion. To define this effect, we measured renal clearances in patients with chronic liver disease and ascites and in nonascitic controls. Furosemide (80 mg i.v.) transiently increased p-aminohippurate clearance in con...

journal_title：Gastroenterology

authors： Daskalopoulos G,Laffi G,Morgan T,Pinzani M,Harley H,Reynolds T,Zipser RD

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Paneth cells (PCs) secrete defensins and antimicrobial enzymes that contribute to innate immunity against pathogen infections within the mucosa of the small intestine. We examined the role of colony stimulating factor-1 (CSF-1) in PC development. METHODS:CSF-1-deficient and CSF-1 receptor (CSF-1R)-de...

journal_title：Gastroenterology

authors： Huynh D,Dai XM,Nandi S,Lightowler S,Trivett M,Chan CK,Bertoncello I,Ramsay RG,Stanley ER

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...

journal_title：Gastroenterology

authors： Yu L,Ioannou GN

更新日期：2007-08-01 00:00:00

abstract：:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

journal_title：Gastroenterology

authors： Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine ...

journal_title：Gastroenterology

authors： Doi K,Nagao T,Kawakubo K,Ibayashi S,Aoyagi K,Yano Y,Yamamoto C,Kanamoto K,Iida M,Sadoshima S,Fujishima M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND & AIMS:It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs. METHODS:We identified all patients with a hospital discharge ...

journal_title：Gastroenterology

authors： El-Serag HB,Everhart JE

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND/AIMS:K-ras-2 mutations and DNA content heterogeneity represent early events of human colorectal tumor progression. The aim of the study was to investigate if specific K-ras-2 mutations in 58 human sporadic adenomas were correlated with DNA aneuploidization and cell proliferation. METHODS:Multiparameter flow...

journal_title：Gastroenterology

authors： Giaretti W,Pujic N,Rapallo A,Nigro S,Di Vinci A,Geido E,Risio M

更新日期：1995-04-01 00:00:00

abstract：:Human intrinsic factor (IF) is found on the surface of parietal cells at the light microscopic level by immunofluorescence, but there is no direct evidence that IF is synthesized in and secreted from this cell. In order to provide this evidence, IF was localized at the ultrastructural level in human stomach, using an ...

journal_title：Gastroenterology

authors： Levine JS,Nakane PK,Allen RH

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. METHODS:The Ontario Pancreas Cancer Study enrolls consenting participants with pancreatic cancer from a province-wide elect...

journal_title：Gastroenterology

authors： Grant RC,Selander I,Connor AA,Selvarajah S,Borgida A,Briollais L,Petersen GM,Lerner-Ellis J,Holter S,Gallinger S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:Differences in genetic background may play a role in the development of ulcerative colitis (UC)-related neoplasia. Loss of heterozygosity (LOH) of APC has been reported in human UC-associated neoplasia. To investigate the role of genetic differences in UC-associated neoplasia, we compared differences ...

journal_title：Gastroenterology

authors： Cooper HS,Everley L,Chang WC,Pfeiffer G,Lee B,Murthy S,Clapper ML

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND & AIMS:We followed patients with ongoing hepatitis C virus (HCV) exposure following control of an initial HCV infection to determine whether primary control conferred protection against future persistent infections. METHODS:Twenty-two active injection drug users (IDU) who had cleared a primary hepatitis C v...

journal_title：Gastroenterology

authors： Osburn WO,Fisher BE,Dowd KA,Urban G,Liu L,Ray SC,Thomas DL,Cox AL

更新日期：2010-01-01 00:00:00

abstract：:Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotectiv...

journal_title：Gastroenterology

authors： Dickson RC,Bronk SF,Gores GJ

更新日期：1992-06-01 00:00:00

abstract：:Antibodies to a membrane-bound antigen, localized to the canalicular structures of the parietal cell, are found in most sera of patients with chronic atrophic gastritis and pernicious anemia. In the present study immunoglobulins containing parietal cell antibodies were found to inhibit the activity of H+,K+-adenosine ...

journal_title：Gastroenterology

authors： Burman P,Mårdh S,Norberg L,Karlsson FA

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase-phlorizin hydrolase (LPH) is an intestinal microvillus membrane glycoprotein that hydrolyzes lactose and phlorizin. These enzymatic activities have been assigned to glutamic acid (E) residues 1271 and 1747 in rabbit LPH. The aim of this study was to determine directly if this assignment was co...

journal_title：Gastroenterology

authors： Neele AM,Einerhand AW,Dekker J,Büller HA,Freund JN,Verhave M,Grand RJ,Montgomery RK

更新日期：1995-10-01 00:00:00