Primary hepatic actinomycosis.

abstract：BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

journal_title：Gastroenterology

authors： Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

更新日期：2010-06-01 00:00:00

abstract：:Celiac sprue and Crohn's disease have very rarely been documented in the same patient. We report a case involving an adolescent male with known Crohn's disease who had extreme wasting, growth retardation, intractable diarrhea, and delay in development of secondary sexual characteristics. Peroral jejunal biopsy showed ...

journal_title：Gastroenterology

authors： Euler AR,Ament ME

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Oral bile acid replacement has been shown to be an effective therapy in primary bile acid synthesis defects, but to date there have been no reports of the long-term effects of this therapy. The aim of the study was to evaluate the long-term effectiveness and safety of cholic acid (CA) therapy. METHOD...

journal_title：Gastroenterology

authors： Gonzales E,Gerhardt MF,Fabre M,Setchell KD,Davit-Spraul A,Vincent I,Heubi JE,Bernard O,Jacquemin E

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...

journal_title：Gastroenterology

authors： Peery AF,Barrett PR,Park D,Rogers AJ,Galanko JA,Martin CF,Sandler RS

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...

journal_title：Gastroenterology

authors： Apte MV,Phillips PA,Fahmy RG,Darby SJ,Rodgers SC,McCaughan GW,Korsten MA,Pirola RC,Naidoo D,Wilson JS

更新日期：2000-04-01 00:00:00

abstract：:Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

journal_title：Gastroenterology

authors： Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

更新日期：1989-07-01 00:00:00

abstract：:Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments...

journal_title：Gastroenterology

authors： Middleton HM 3rd

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND & AIMS:Germline mutations of DNA mismatch repair genes are responsible for cancer susceptibility in hereditary nonpolyposis colorectal cancer (HNPCC) kindreds. Transforming growth factor beta type II receptor (TGF-beta RII) has been found to be somatically altered in HNPCC. The aim of this study was to clari...

journal_title：Gastroenterology

authors： Akiyama Y,Iwanaga R,Saitoh K,Shiba K,Ushio K,Ikeda E,Iwama T,Nomizu T,Yuasa Y

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND & AIMS:Viral genotypes have been associated with different severity and outcome of hepatitis C virus (HCV)-related liver disease. The aim of this study was to determine whether HCV genotypes may influence the cirrhosis-related risk of the development of hepatocellular carcinoma (HCC). METHODS:Three groups o...

journal_title：Gastroenterology

authors： Silini E,Bottelli R,Asti M,Bruno S,Candusso ME,Brambilla S,Bono F,Iamoni G,Tinelli C,Mondelli MU,Ideo G

更新日期：1996-07-01 00:00:00

abstract：:A patient with the acquired immunodeficiency syndrome (AIDS) with a cytomegalovirus (CMV) infection localized in the area of an ileal Kaposi sarcoma resulting in perforation is described. Because only one case of such an association of Kaposi sarcoma with CMV leading to perforation has been reported, the presence and ...

journal_title：Gastroenterology

authors： Genta RM,Bleyzer I,Cate TR,Tandon AK,Yoffe B

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND & AIMS:Human primary liver cancer is classified into biologically distinct subgroups based on cellular origin. Liver cancer stem cells (CSCs) have been recently described. We investigated the ability of distinct lineages of hepatic cells to become liver CSCs and the phenotypic and genetic heterogeneity of pr...

journal_title：Gastroenterology

authors： Holczbauer Á,Factor VM,Andersen JB,Marquardt JU,Kleiner DE,Raggi C,Kitade M,Seo D,Akita H,Durkin ME,Thorgeirsson SS

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND & AIMS:The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cyt...

journal_title：Gastroenterology

authors： van der Zanden EP,Snoek SA,Heinsbroek SE,Stanisor OI,Verseijden C,Boeckxstaens GE,Peppelenbosch MP,Greaves DR,Gordon S,De Jonge WJ

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:Simvastatin improves liver generation of nitric oxide and hepatic endothelial dysfunction in patients with cirrhosis, so it could be an effective therapy for portal hypertension. This randomized controlled trial evaluated the effects of continuous simvastatin administration on the hepatic venous press...

journal_title：Gastroenterology

authors： Abraldes JG,Albillos A,Bañares R,Turnes J,González R,García-Pagán JC,Bosch J

更新日期：2009-05-01 00:00:00

abstract：:Colon motility and myoelectric slow wave activity were compared in 10 patients with progressive systemic sclerosis and 18 controls. Recordings were made in the rectosigmoid and rectum, 25-30 cm and 10-15 cm from the anal margin, respectively, during two 4-min baselines and in response to stepwise distention of the col...

journal_title：Gastroenterology

authors： Whitehead WE,Taitelbaum G,Wigley FM,Schuster MM

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an immunologically mediated inflammatory disease of the gastrointestinal tract. Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantat...

journal_title：Gastroenterology

authors： Oyama Y,Craig RM,Traynor AE,Quigley K,Statkute L,Halverson A,Brush M,Verda L,Kowalska B,Krosnjar N,Kletzel M,Whitington PF,Burt RK

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND & AIMS:Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated wi...

journal_title：Gastroenterology

authors： Ben Azzouz E,Boumaza A,Mezouar S,Bardou M,Carlini F,Picard C,Raoult D,Mège JL,Desnues B

更新日期：2018-11-01 00:00:00

abstract：:Twenty cirrhotic patients with esophageal varices and an episode of gastrointestinal bleeding within the previous week underwent hemodynamic studies which used an indicator dilution technique based on selective catheterization of the splanchnic arteries and hepatic vein. Portasystemic shunting of splenic arterial flow...

journal_title：Gastroenterology

authors： Lebrec D,Kotelanski B,Cohn JN

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND/AIMS:Spasmolytic polypeptide (SP) is a trefoil peptide expressed in the digestive tract. This study aimed to determine the structure and distribution of SP expression in the rat gastrointestinal tract. METHODS:The structure of rat SP was determined from the sequence of complementary DNAs isolated from antra...

journal_title：Gastroenterology

authors： Jeffrey GP,Oates PS,Wang TC,Babyatsky MW,Brand SJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND & AIMS:De novo lipogenesis is believed to be involved in oncogenesis. We investigated the role of aberrant lipid biosynthesis in the pathogenesis of human hepatocellular carcinoma (HCC). METHODS:We evaluated expression of enzymes that regulate lipogenesis in human normal liver tissues and HCC and surroundin...

journal_title：Gastroenterology

authors： Calvisi DF,Wang C,Ho C,Ladu S,Lee SA,Mattu S,Destefanis G,Delogu S,Zimmermann A,Ericsson J,Brozzetti S,Staniscia T,Chen X,Dombrowski F,Evert M

更新日期：2011-03-01 00:00:00

abstract：:The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...

journal_title：Gastroenterology

authors： Pawlotsky JM,Chevaliez S,McHutchison JG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND & AIMS:The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosus, and variants have been associated with Crohn disease (CD). Splice forms of CYLD that lack exons 7 and 8 regulate transcription factors and functions of immune cells. We examined ...

journal_title：Gastroenterology

authors： Tang Y,Reissig S,Glasmacher E,Regen T,Wanke F,Nikolaev A,Gerlach K,Popp V,Karram K,Fantini MC,Schattenberg JM,Galle PR,Neurath MF,Weigmann B,Kurschus FC,Hövelmeyer N,Waisman A

更新日期：2019-02-01 00:00:00

abstract：:Although nocturnal acid secretion has been emphasized in the pathophysiology and treatment of duodenal ulcer, its importance in gastric ulcer disease has been questioned. To explore this area, this multicenter U.S. trial compared the effect of a once-daily nighttime dose of H2-receptor antagonist with placebo on the h...

journal_title：Gastroenterology

authors： McCullough AJ,Graham DY,Knuff TE,Lanza FL,Levenson HL,Lyon DT,Munsell WP,Perozza J,Roufail WM,Sinar DR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...

journal_title：Gastroenterology

authors： Allez M,Tieng V,Nakazawa A,Treton X,Pacault V,Dulphy N,Caillat-Zucman S,Paul P,Gornet JM,Douay C,Ravet S,Tamouza R,Charron D,Lémann M,Mayer L,Toubert A

更新日期：2007-06-01 00:00:00

abstract：:Lamins have important roles in nuclear structure and cell signaling. Several diseases are associated with mutations in the lamin A/C gene (LMNA in humans). Patients with familial partial lipodystrophy caused by LMNA mutations develop pancreatitis, but lamin function in the pancreas and how these mutations affect pancr...

journal_title：Gastroenterology

authors： Elenbaas JS,Bragazzi Cunha J,Azuero-Dajud R,Nelson B,Oral EA,Williams JA,Stewart CL,Omary MB

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We assessed long-term outcomes and determinants of outcome in patients with AIH from a nontransplant cente...

journal_title：Gastroenterology

authors： Hoeroldt B,McFarlane E,Dube A,Basumani P,Karajeh M,Campbell MJ,Gleeson D

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:Photodynamic therapy (PDT) for high-grade dysplasia (HGD) in Barrett's esophagus is a Food and Drug Administration-approved alternative to esophagectomy. Critical information regarding overall survival of patients followed up long-term after these therapies is lacking. Our aim was to compare the long-...

journal_title：Gastroenterology

authors： Prasad GA,Wang KK,Buttar NS,Wongkeesong LM,Krishnadath KK,Nichols FC 3rd,Lutzke LS,Borkenhagen LS

更新日期：2007-04-01 00:00:00

abstract：:The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 m...

journal_title：Gastroenterology

authors： MacLellan DG,Upp JR Jr,Thompson JC

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...

journal_title：Gastroenterology

authors： Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

更新日期：2011-10-01 00:00:00

abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

journal_title：Gastroenterology

authors： Stopa EG,O'Brien R,Katz M

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND/AIMS:After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation. METHODS:Resected or tra...

journal_title：Gastroenterology

authors： Aghdassi E,Plapler H,Kurian R,Raina N,Royall D,Jeejeebhoy KN,Cohen Z,Allard JP

更新日期：1994-09-01 00:00:00