Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells.

abstract：BACKGROUND AND AIMS:Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an im...

journal_title：Gastroenterology

authors： Nocito A,Dahm F,Jochum W,Jang JH,Georgiev P,Bader M,Renner EL,Clavien PA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...

journal_title：Gastroenterology

authors： Sawada N,Inoue M,Iwasaki M,Sasazuki S,Shimazu T,Yamaji T,Takachi R,Tanaka Y,Mizokami M,Tsugane S,Japan Public Health Center-Based Prospective Study Group.

更新日期：2012-06-01 00:00:00

abstract：:A patient with recurrent gastrointestinal bleeding caused by hereditary hemorrhagic telangiectasia localized to the small intestine is described. The diagnosis was made by combining two recognized investigational tools-fiberoptic endoscopy and laparotomy. ...

journal_title：Gastroenterology

authors： Greenberg GR,Phillips MJ,Tovee EB,Jeejeebhoy KN

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...

journal_title：Gastroenterology

authors： Kumar A,Priyamvada S,Ge Y,Jayawardena D,Singhal M,Anbazhagan AN,Chatterjee I,Dayal A,Patel M,Zadeh K,Saksena S,Alrefai WA,Gill RK,Zadeh M,Zhao N,Mohamadzadeh M,Dudeja PK

更新日期：2020-11-13 00:00:00

abstract：:Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Levin G,Malmud L

更新日期：1987-04-01 00:00:00

abstract：:Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...

journal_title：Gastroenterology

authors： Singaram C,Sweet MA,Gaumnitz EA,Cameron AJ,Camilleri M

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...

journal_title：Gastroenterology

authors： Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...

journal_title：Gastroenterology

authors： Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

更新日期：2008-02-01 00:00:00

abstract：:Low residue, chemically defined diets containing all essential nutrients in a readily assimilated form, require minimal digestion and are almost entirely absorbed in the upper gastrointestinal tract. Within the past decade, these diets have been reported to provide nutritional support in a variety of clinical situatio...

journal_title：Gastroenterology

authors： Young EA,Heuler N,Russell P,Weser E

更新日期：1975-12-01 00:00:00

abstract：:The possibility that chronic uremia renders the gastric mucosa more susceptible to acid injury was investigated. A rat model of chronic renal failure was induced by subtotal nephrectomy. [H+] back-diffusion across the mucosa, following intragastric perfusion of 0.15N HCl or 15% ethanol in 0.15N HCl, was significantly ...

journal_title：Gastroenterology

authors： Quintero E,Kaunitz J,Nishizaki Y,De Giorgio R,Sternini C,Guth PH

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

journal_title：Gastroenterology

authors： Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

更新日期：2006-09-01 00:00:00

abstract：:Sixty chronically alcoholic men who were impotent and known to have abstained from alcohol were followed prospectively to determine (a) the frequency of spontaneous recovery of normal sexual functioning, (b) indicators of spontaneous recovery, and (c) the response of those who did not achieve a spontaneous recovery to...

journal_title：Gastroenterology

authors： Van Thiel DH,Gavaler JS,Sanghvi A

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:Practice guidelines recommend that endoscopists spend at least 7 minutes examining the colonic mucosa during colonoscopy withdrawal to optimize polyp yield. The aim of this study was to determine if the implementation of an institution-wide policy of colonoscopy withdrawal time > or = 7 minutes was as...

journal_title：Gastroenterology

authors： Sawhney MS,Cury MS,Neeman N,Ngo LH,Lewis JM,Chuttani R,Pleskow DK,Aronson MD

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocellular carcinoma (HCC) is often associated with hepatitis B virus (HBV) infection. Cells of most HBV-related HCCs contain HBV-DNA fragments that do not encode entire HBV antigens. We investigated whether these integrated HBV-DNA fragments encode epitopes that are recognized by T cells and whet...

journal_title：Gastroenterology

authors： Tan AT,Yang N,Lee Krishnamoorthy T,Oei V,Chua A,Zhao X,Tan HS,Chia A,Le Bert N,Low D,Tan HK,Kumar R,Irani FG,Ho ZZ,Zhang Q,Guccione E,Wai LE,Koh S,Hwang W,Chow WC,Bertoletti A

更新日期：2019-05-01 00:00:00

abstract：:Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...

journal_title：Gastroenterology

authors： Meyer JH,Dressman J,Fink A,Amidon G

更新日期：1985-10-01 00:00:00

abstract：:A patient with ulcerative ileojejunitis was studied by determination of HL-A phenotype, by measurement of jejunal IgA synthesis using a labeled amino acid incorporation technique, and by in vitro organ culture. The patient carried the HL-A8 phenotype in common with 87.5% of patients with gluten-sensitive enteropathy. ...

journal_title：Gastroenterology

authors： Klaeveman HL,Gebhard RL,Sessoms C,Strober W

更新日期：1975-03-01 00:00:00

abstract：:Concern has arisen about the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection treated with direct-acting antivirals (DAAs). To identify patients at risk for HCC, we evaluated serum levels of immune mediators before, during, and after DAA treatment of HCV infection. Our s...

journal_title：Gastroenterology

authors： Debes JD,van Tilborg M,Groothuismink ZMA,Hansen BE,Schulze Zur Wiesch J,von Felden J,de Knegt RJ,Boonstra A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND & AIMS:Small epithelial wounds heal by purse-string contraction of an actomyosin ring that is regulated by myosin light chain (MLC) kinase (MLCK) and rho kinase (ROCK). These studies aimed to define the roles of these kinases in purse-string wound closure. METHODS:Oligocellular and single-cell wounds were c...

journal_title：Gastroenterology

authors： Russo JM,Florian P,Shen L,Graham WV,Tretiakova MS,Gitter AH,Mrsny RJ,Turner JR

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:No enzyme replacement therapy exists for patients with congenital sucrase-isomaltase deficiency (CSID). A by-product of the manufacture of baker's yeast is a liquid preparation containing high sucrase activity. The aim of the present study was to investigate the activity and stability of this preparation and...

journal_title：Gastroenterology

authors： Treem WR,Ahsan N,Sullivan B,Rossi T,Holmes R,Fitzgerald J,Proujansky R,Hyams J

更新日期：1993-10-01 00:00:00

abstract：:This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

journal_title：Gastroenterology

authors： Mahadevan U,Kane S

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

journal_title：Gastroenterology

authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:The Raf kinase inhibitor protein (RKIP) has been identified as a suppressor of the mitogen-activated protein kinase (MAPK) pathway. Loss of RKIP function promotes tumor metastasis in prostate cancer and melanoma. The insulin-like growth factor I (IGF-I)-mediated MAPK cascade is often activated in hepa...

journal_title：Gastroenterology

authors： Lee HC,Tian B,Sedivy JM,Wands JR,Kim M

更新日期：2006-10-01 00:00:00

abstract：:In ilea of spontaneously infested guinea pigs, we examined the interface between the plasma membranes of cryptosporidia and absorptive cells using thin section and freeze fracture techniques. Initially, cryptosporidia invaginate microvilli, and the resulting redundant folds of membrane envelop the protozoan, thereby i...

journal_title：Gastroenterology

authors： Marcial MA,Madara JL

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...

journal_title：Gastroenterology

authors： Joosten SPJ,Zeilstra J,van Andel H,Mijnals RC,Zaunbrecher J,Duivenvoorden AAM,van de Wetering M,Clevers H,Spaargaren M,Pals ST

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND & AIMS:In several rat infection experiments, we have shown that dietary calcium inhibits intestinal colonization and translocation of invasive salmonella. The aim of the present study was to find out whether calcium is also protective against enterotoxigenic Escherichia coli (ETEC) infection. This was first ...

journal_title：Gastroenterology

authors： Bovee-Oudenhoven IM,Lettink-Wissink ML,Van Doesburg W,Witteman BJ,Van Der Meer R

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...

journal_title：Gastroenterology

authors： Neubauer K,Knittel T,Armbrust T,Ramadori G

更新日期：1995-04-01 00:00:00

abstract：:The asialoglycoprotein receptor is present on the plasma membrane of rat hepatocytes and mediates the endocytosis of exogenous asialoglycoproteins. The intracellular locations of the receptor are incompletely defined, and whether the receptor is present on the canalicular membrane is controversial. To investigate thes...

journal_title：Gastroenterology

authors： Mizuno M,Brown WR,Vierling JM

更新日期：1984-10-01 00:00:00

abstract：DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...

journal_title：Gastroenterology

authors： Quigley EMM,Murray JA,Pimentel M

更新日期：2020-10-01 00:00:00