Uremia increases gastric mucosal permeability and acid back-diffusion injury in the rat.

abstract：:The effects of corticosteroid treatment on mucosal mast cells in rat jejunal mucosa were examined. Rats previously infected with Nippostrongylus brasiliensis received a single IP injection of 1 mg dexamethasone. Three hours later, one third of mucosal mast cells demonstrated minor granular changes (fusion or periphera...

journal_title：Gastroenterology

authors： Soda K,Kawabori S,Perdue MH,Bienenstock J

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND & AIMS:Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS:We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 ...

journal_title：Gastroenterology

authors： Wieten E,de Klerk CM,van der Steen A,Ramakers CR,Kuipers EJ,Hansen BE,Lansdorp-Vogelaar I,Bossuyt PM,Dekker E,Spaander MCW

更新日期：2018-11-01 00:00:00

abstract：:Receptor-dependent and -independent regulation of gastrin secretion from cultured human antral G cells was investigated. Human antral mucosal cell preparations that were enriched for G cells were obtained by sequential incubations with collagenase and ethylenediaminetetraacetic acid, centrifugal elutriation, and short...

journal_title：Gastroenterology

authors： Campos RV,Buchan AM,Meloche RM,Pederson RA,Kwok YN,Coy DH

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND & AIMS:In cirrhosis, increased amounts of circulating hormones such as angiotensin II may induce vascular tone changes and alter vascular smooth muscle cell (VSMC) function and growth. The aim of this study was to investigate the growth of aortic VSMCs from cirrhotic rats with or without the addition of angi...

journal_title：Gastroenterology

authors： Tazi KA,Moreau R,Cailmail S,Gadano A,Trombino C,Lebrec D

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND/AIMS:Both hemorrhagic and cardiogenic shock are associated with hepatic shock gene expression at resuscitation. This study investigated the potential role of intravascular superoxide anion as a proximal trigger of heat shock protein gene expression. METHODS:Preanesthetized pigs were subjected to 120 m of to...

journal_title：Gastroenterology

authors： Schoeniger LO,Andreoni KA,Ott GR,Risby TH,Bulkley GB,Udelsman R,Burdick JF,Buchman TG

更新日期：1994-01-01 00:00:00

abstract：:The effects of some newly developed tachykinin antagonists that are selective for the neurokinin (NK)-1 (L 668,169) or the NK-2 (MEN 10,207, L 659,877 and R 396) tachykinin receptor on the cholinergic and noncholinergic contraction and on the nonadrenergic noncholinergic relaxation produced by electrical field stimula...

journal_title：Gastroenterology

authors： Maggi CA,Giuliani S,Patacchini R,Santicioli P,Theodorsson E,Barbanti G,Turini D,Giachetti A

更新日期：1992-01-01 00:00:00

abstract：:Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated w...

journal_title：Gastroenterology

authors： Stampfl DA,Muñoz SJ,Moritz MJ,Rubin R,Armenti VT,Jarrell BE,Maddrey WC

更新日期：1990-12-01 00:00:00

abstract：:In rats injected with pentagastrin (2-500 micrograms/kg subcutaneously) in saline, peak gastric acid responses occurred after 31 (30-min output) or 63 micrograms/kg (60-min output). Rats were fed or fasted for 48 h and injected every 8 h with 63, 250, or 1000 micrograms/kg pentagastrin. Fasting decreased body weight (...

journal_title：Gastroenterology

authors： Solomon TE

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND AND AIMS:There has been much speculation about the potential impact on the use of conventional colonoscopy if "virtual" computed tomographic colonography (CTC) became a widely accepted modality for colorectal cancer (CRC) screening. However, no formal analysis of the impact of CTC on colonoscopy demand has b...

journal_title：Gastroenterology

authors： Hur C,Gazelle GS,Zalis ME,Podolsky DK

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) and hepatitis C virus (HCV) can be transmitted during administration of intravenous anesthesia when medication vials are used for multiple patients using incorrect technique. We investigated an outbreak of acute HBV and HCV infections among patients who received anesthesia duri...

journal_title：Gastroenterology

authors： Gutelius B,Perz JF,Parker MM,Hallack R,Stricof R,Clement EJ,Lin Y,Xia GL,Punsalang A,Eramo A,Layton M,Balter S

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIMS:The mechanisms of chemically induced injury are poorly understood. The purpose of this study was to develop a rapid method for isolation of gastric mucosal cells (GMCs) and sensitive tests for investigating cell damage and protection. METHODS:GMCs were prepared from rat glandular stomach with pronase a...

journal_title：Gastroenterology

authors： Nagy L,Szabo S,Morales RE,Plebani M,Jenkins JM

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：:The symptoms of urgency, diarrhea, and abdominal discomfort are exaggerated after a meal in inflammatory disorders of the colon, such as ulcerative colitis. The possible motor correlates of these symptoms were investigated in a model of acute colitis in six dogs. Each dog was instrumented with seven strain gauge trans...

journal_title：Gastroenterology

authors： Sethi AK,Sarna SK

更新日期：1991-12-01 00:00:00

abstract：:Serum amino acid levels were determined in 29 patients with severe chronic active liver disease before, during, and after administration of prednisone or placebo and in 22 healthy controls. The pretreatment molar ratio of amino acids was less in patients than in controls (p less than 0.001) and was lower in those with...

journal_title：Gastroenterology

authors： McCullough AJ,Czaja AJ,Jones JD,Go VL

更新日期：1981-10-01 00:00:00

abstract：:A 22-yr-old woman with a 7-yr history of systemic lupus erythematosus presented with anasarca and a serum albumin of 0.8 g/dl. Renal and hepatic function were near normal; the major route of protein loss appeared to be the intestine. A full-thickness section of jejunum obtained at laparotomy demonstrated a severe, dif...

journal_title：Gastroenterology

authors： Weiser MM,Andres GA,Brentjens JR,Evans JT,Reichlin M

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND & AIMS:Gastrin stimulation of the type 2 cholecystokinin (CCK(2)) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function. METHODS:The ECL cells in the oxyntic mucosa of CCK(2...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Al-Haider W,Håkanson R,Rehfeld JF,Kopin AS

更新日期：2002-08-01 00:00:00

abstract：:In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...

journal_title：Gastroenterology

authors： Uhlemann ER,Robberecht P,Gardner JD

更新日期：1979-05-01 00:00:00

abstract：:The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

journal_title：Gastroenterology

authors： Reppas C,Meyer JH,Sirois PJ,Dressman JB

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tiss...

journal_title：Gastroenterology

authors： Romano M,Lesch CA,Meise KS,Veljaca M,Sanchez B,Kraus ER,Boland CR,Guglietta A,Coffey RJ

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hydrogen sulfide is one of the main malodorous compounds in human flatus. This toxic gas also has been implicated in the pathogenesis of ulcerative colitis. Therefore, a treatment that reduces colonic H2S levels could be clinically useful in the treatment of flatus odor and of ulcerative colitis. In t...

journal_title：Gastroenterology

authors： Suarez FL,Furne JK,Springfield J,Levitt MD

更新日期：1998-05-01 00:00:00

abstract：:A case of acute hypervitaminosis A complicating viral hepatitis is reported. Twenty days after presenting with hepatitis B, a 42-yr-old vegetarian developed acute hypervitaminosis A in the absence of recent, massive exposure to the vitamin. Findings included headache, confusion, skin desquamation, and hypercalcemia. P...

journal_title：Gastroenterology

authors： Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JB

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fat-storing cells (FSCs) actively proliferate and secrete extracellular matrix during liver injury. Platelet-derived growth factor (PDGF) is a potent mitogen for cultured FSCs. In the present study, we investigated the regulation of PDGF gene expression and production in cultured human liver FSCs....

journal_title：Gastroenterology

authors： Marra F,Choudhury GG,Pinzani M,Abboud HE

更新日期：1994-10-01 00:00:00

abstract：:To find a possible explanation for the selective hepatic conjugation of bile acids with glycine or taurine, the N-acyl amidates of cholic acid and a number of amino acids and amino acid analogues were synthesized, and their susceptibility to hydrolysis by pancreatic juice, gastric juice, serum, or small intestinal muc...

journal_title：Gastroenterology

authors： Huijghebaert SM,Hofmann AF

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...

journal_title：Gastroenterology

authors： Takahashi I,Kiyono H,Hamada S

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Animal studies have shown that more than half of the dietary protein intake is used by the gut and that a large proportion of this utilization is devoted to (glyco-)protein synthesis. Recycling of these secretions may play a critical role in the regulation of overall dietary amino acid bioavailability...

journal_title：Gastroenterology

authors： Van Der Schoor SR,Reeds PJ,Stoll B,Henry JF,Rosenberger JR,Burrin DG,Van Goudoever JB

更新日期：2002-12-01 00:00:00

abstract：:The effects of IV injection of 5-hydroxytryptamine 3 receptor antagonists (BRL 43694 and GR38032F) on gastrointestinal contractile activity were studied in dogs with vagally denervated fundic pouch in the conscious state by means of chronically implanted force transducers in the gastrointestinal tract and the pouch. I...

journal_title：Gastroenterology

authors： Itoh Z,Mizumoto A,Iwanaga Y,Yoshida N,Torii K,Wakabayashi K

更新日期：1991-04-01 00:00:00

abstract：:Heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (Saguinus oedipus, n = 18; Macaca mulatta, n = 2; Macaca fascicularis, n = 2; Aotus trivirgatus, n = 2; Saimiri sciureus, n = 2; and Callithrix jacchus, n = 2). After initial separation of radi...

journal_title：Gastroenterology

authors： Podolsky DK,Madara JL,King N,Sehgal P,Moore R,Winter HS

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...

journal_title：Gastroenterology

authors： Ott SJ,Waetzig GH,Rehman A,Moltzau-Anderson J,Bharti R,Grasis JA,Cassidy L,Tholey A,Fickenscher H,Seegert D,Rosenstiel P,Schreiber S

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND & AIMS:Iron overload may cause or contribute to hepatic injury and fibrosis. Mutations in the HFE gene may influence development or progression of chronic liver disease by increasing iron stores or modulating immune responses. The aim of this work was to assess the influence of HFE mutations and serum and he...

journal_title：Gastroenterology

authors： Bonkovsky HL,Naishadham D,Lambrecht RW,Chung RT,Hoefs JC,Nash SR,Rogers TE,Banner BF,Sterling RK,Donovan JA,Fontana RJ,Di Bisceglie AM,Ghany MG,Morishima C,HALT-C Trial Group.

更新日期：2006-11-01 00:00:00