Abstract：
:A case of acute hypervitaminosis A complicating viral hepatitis is reported. Twenty days after presenting with hepatitis B, a 42-yr-old vegetarian developed acute hypervitaminosis A in the absence of recent, massive exposure to the vitamin. Findings included headache, confusion, skin desquamation, and hypercalcemia. Prior to developing hepatitis, he had ingested supplemental vitamin A without recognized ill effect. Liver and serum vitamin A without recognized ill effect. Liver and serum vitamin A levels were both elevated; the liver biopsy showed abundant, lipid-filled Ito cells and perisinusoidal fibrosis. This case demonstrates that patients with excessive hepatic stores of vitamin A may develop hypervitaminosis A during acute, intercurrent liver disease. Levels of retinol binding protein are reduced in hepatitis. This phenomenon may account for the findings in this case, since vitamin A is more toxic when not specifically bound to retinol binding protein. The size of the population at risk for this complication of hepatitis in unknown, but presumably it is growing with the widespread use of supplemental vitamin A.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JBsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
124-8issue
1eissn
0016-5085issn
1528-0012pii
S001650858200016Xjournal_volume
82pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:Obese subjects are prone to supersaturated bile, which is maintained or increased during weight loss. In this report, two related studies were carried out on obese subjects to investigate effects of bile acid feeding on biliary lipid metabolism before and during weight reduction. In one study, chenodeoxycholic acid (...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1979-03-01 00:00:00
abstract：BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(97)70236-1
更新日期：1997-01-01 00:00:00
abstract：:Pharmacologic and surgical procedures were used to define the neurohumoral pathways that mediate stress-induced changes in gastrointestinal transit in the rat. Physical restraint (a validated stressor) resulted in significant inhibition of gastric emptying and small bowel transit but in stimulation of large bowel tran...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)91439-x
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90686-x
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND & AIMS:Genetic variations in proinflammatory and anti-inflammatory cytokine genes influence individual response to carcinogenic exposures. Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer. The aim of this st...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)00157-4
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND & AIMS:There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigeneti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND & AIMS:Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended si...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.02.053
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND & AIMS:Treatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR)...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2013.07.051
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1053/gast.2002.35988
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND & AIMS:In intestinal inflammation the gut microbiota induces an innate immune response by activating epithelial and immune cells that initiate or maintain inflammation. We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis. METHODS:Human intestinal microv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.11.005
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2005.06.064
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND AND AIMS:We set out to test the hypothesis that irritable bowel syndrome (IBS) is characterized by an augmented cellular immune response with enhanced production of proinflammatory cytokines. We further aimed to explore whether symptoms and psychiatric comorbidity in IBS are linked to the release of proinfla...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.01.046
更新日期：2007-03-01 00:00:00
abstract：:We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.01.037
更新日期：2018-05-01 00:00:00
abstract：:A case of acute bacterial endocarditis is presented in which gallbladder infarction and areas of hepatic infarction were documented. Selective angiography showed findings consistent with emboli to the gallbladder and hepatic circulations. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:These studies were designed to better understand the effects of luminal nutrition on intestinal mass and function. Parenterally nourished rats received a midjejunal infusion of either 0.9% saline, 10% glucose, 10% 3-O-methyl glucose, or 30% glucose. A fifth group underwent sham operation. After 7 days, intestinal mass...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
abstract：:There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2014.12.036
更新日期：2015-05-01 00:00:00
abstract：:Twenty-one of 52 patients with regional enteritis had low serum zinc concentrations on initial testing. Fourteen of 31 patients followed longitudinally had low serum zinc concentrations. Two patients are presented as case reports who developed acrodermatitis skin lesions that responded to zinc therapy. Hypogonadism, g...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-02-01 00:00:00
abstract：BACKGROUND/AIMS:Heat-shock protein (Hsp) 60 is an immunodominant antigen of mycobacteria and other microorganisms that is highly homologous to its human counterpart. Hsp60 may provide a link between immunity to invading microorganisms and autoimmune diseases. METHODS:Expression of Hsp60 was studied by immunohistochemi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90010-1
更新日期：1995-01-01 00:00:00
abstract：:Endoscopic submucosal dissection was developed in Japan, early in this century, to provide a minimally invasive yet curative treatment for the large numbers of patients with early gastric cancer identified by the national screening program. Previously, the majority of these patients were treated surgically at substant...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2018.01.068
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND & AIMS:Intestinal epithelial cells release antigen-presenting vesicles (exosomes) bearing major histocompatibility complex class II/peptide complexes stimulating specific immune responses in vivo. To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load an...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.02.043
更新日期：2007-05-01 00:00:00
abstract：BACKGROUND & AIMS:The physiologic function of the efflux transporter Multidrug Resistance Protein 3 (MRP3) remains poorly defined. In vitro, MRP3 transports several glucuronidated compounds, but the compounds transported under physiologic conditions are unknown. Knowledge of the compounds transported by MRP3 in vivo wo...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.06.052
更新日期：2009-11-01 00:00:00
abstract：:The cells of the fundic portion of canine gastric mucosa were dispersed by collagenase digestion and separated into fractions by sequential use of velocity sedimentation in an elutriator rotor followed by a density gradient separation. There was a close correlation between histamine content and number of mast cells in...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-12-01 00:00:00
abstract：BACKGROUND AND AIMS:It is not clear what induction dose of mesalamine is optimal for treating patients with mildly and moderately active ulcerative colitis (UC). This study was conducted to determine the efficacy and safety of mesalamine 4.8 g/day compared with 2.4 g/day for the treatment of moderately active UC. METH...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2009.08.069
更新日期：2009-12-01 00:00:00
abstract：:The effect of magnesium on calcium- and pentagastrin-induced gastric acid secretion and on calcium-induced gastrin secretion were studied in healthy volunteers. Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output. Addition of mag...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：BACKGROUND & AIMS:Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during gemcitabine treatment. Signaling through sonic hedgehog and mammalian target of rapamycin (mTOR), respectively, may be essenti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2009.05.053
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.07.008
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND & AIMS:Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine. METHODS:We conducted a randomized, double-blind, pharmacogenetic study...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2008.07.009
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND & AIMS:In patients with chronic hepatitis C who failed to respond to standard therapy, high-dose pegylated interferon (IFN)-α and/or ribavirin could induce a stronger antiviral response and prevent treatment failure and HCV resistance when combined with direct-acting antivirals. The influence of genetic dete...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2011.03.039
更新日期：2011-07-01 00:00:00
abstract：:Hepatic cytochrome P450 levels in male rats fall after portal vein ligation, a procedure that produces total hepatic bypass of portal blood. The present study was undertaken to examine whether changes in sex hormone metabolism could account for these lowered cytochrome P450 levels. Portal vein ligation resulted in tes...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90924-8
更新日期：1986-02-01 00:00:00
abstract：:Most studies show that oral ingestion of iron does not cause a positive stool guaiac reaction. However, all in vitro studies show that iron does cause a positive guaiac reaction and some in vivo studies have shown a positive stool guaiac reaction in response to oral iron. This study examines this unresolved question. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90766-x
更新日期：1989-01-01 00:00:00
