Abstract:
BACKGROUND/AIMS:Helicobacter felis colonizes the gastric mucosa of rodents. Preliminary studies showed differences in the distribution of the organism in different parts of the stomach that seemed related to the secretory capacity of the mucosa. The aim of this study was to determine the localization of H. felis in the mouse stomach and to investigate the influence of acid-suppressive agents. METHODS:Specific-pathogen-free BALB/c mice were infected with H. felis. Colonization was assessed in longitudinal sections of gastric tissue from animals untreated or treated with omeprazole or ranitidine. RESULTS:In untreated H. felis-infected animals, the preferred ecological niche was the antrum and cardia equivalent. The density of colonization correlated with the number of parietal cells per gland. Partial acid suppression with ranitidine produced a slight increase in the colonization of the body but was restricted to the upper portions of the gastric gland. Omeprazole treatment produced a greater colonization of the body with bacteria traversing the entire gland. Some reduction in antral colonization occurred. CONCLUSIONS:These results are consistent with the hypothesis that local acid output is a crucial determinant in the distribution of Helicobacter species in the stomach. Differences in local acid output may explain the different patterns of Helicobacter pylori-induced gastric pathology.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Danon SJ,O'Rourke JL,Moss ND,Lee Adoi
10.1016/0016-5085(95)90686-xsubject
Has Abstractpub_date
1995-05-01 00:00:00pages
1386-95issue
5eissn
0016-5085issn
1528-0012pii
0016-5085(95)90686-Xjournal_volume
108pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)90027-v
更新日期:1992-09-01 00:00:00
abstract::Immunologic injury in the liver involves immigrant T and B lymphocytes and a resident lymphoid population that comprises distinct lymphocytic cells and accessory cells. The forerunner to autoimmunity is breaching of natural self-tolerance and hence the disruption of a fundamental property of the immune system. Such br...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/gast.2001.22441
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND & AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, have been implicated in diverticular complications. We examined the influence of aspirin and NSAID use on risk of diverticulitis and diverticular bleeding in a large prospective cohort. METHODS:We studied 47,210 US men in the Health Pr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.02.004
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND & AIMS:Liver graft dysfunction is related to hypothermic preservation and may implicate altered cell volume homeostasis. The aim of this study was to evaluate how cold preservation and rewarming affect hepatocellular volume regulation and concentrative amino acid uptake. METHODS:Rat hepatocytes suspended fo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70148-3
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND & AIMS:As life expectancy increases, there are greater numbers of patients with liver diseases who require surgery or transplantation. Livers of older patients have significantly less reparative capacity following ischemia and reperfusion (I/R) injury, which occurs during these operations. There are no strat...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.08.005
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND & AIMS:Aberrant activation of β-catenin and Yes-associated protein 1 (Yap1) signaling pathways have been associated with the development of multiple tumor types. Yap functions as a transcriptional coactivator by interacting with TEA domain DNA binding proteins. We investigated the interactions among these pa...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究
doi:10.1053/j.gastro.2014.05.004
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.8523
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND & AIMS:The function of microRNA (miRNA) in liver development is unknown. To address this issue, we characterized miRNA expression in the embryonic mouse liver, performed functional miRNA analysis in zebrafish larvae, and identified novel hepatic miRNA targets. METHODS:Hepatic RNA isolated from mice at embry...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2008.12.006
更新日期:2009-03-01 00:00:00
abstract::Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.09.016
更新日期:2013-01-01 00:00:00
abstract::The site and mechanism of alpha-[5-methyl-3-H]tocopherol absorption was investigated using everted rat small bowel sacs incubated in a micellar medium. Mean plus or minus SE absorption rates of the vitamin at 300 muM incubation solution concentration by proximal, medial, and distal small bowel segments were 2.2 plus o...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-06-01 00:00:00
abstract::The courses of 38 patients with severe, uncomplicated acute colitis (16 with Crohn's colitis and 22 with ulcerative colitis) were analyzed retrospectively. The patients were placed on total parenteral nutrition and treated concomitantly with corticosteroids, antibiotics (often metronidazole), sulfasalazine, and/or aza...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90470-l
更新日期:1990-12-01 00:00:00
abstract::The cells of the fundic portion of canine gastric mucosa were dispersed by collagenase digestion and separated into fractions by sequential use of velocity sedimentation in an elutriator rotor followed by a density gradient separation. There was a close correlation between histamine content and number of mast cells in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND/AIMS:Despite putative roles of calcium in biliary physiology and gallstone formation, quantitative aspects of calcium binding to bile salt (BS) monomers, simple micelles, mixed micelles, and vesicles, which constitute the lipid aggregates in bile, remain unexplored. METHODS:Calcium activity was measured usi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90134-1
更新日期:1994-09-01 00:00:00
abstract::In ilea of spontaneously infested guinea pigs, we examined the interface between the plasma membranes of cryptosporidia and absorptive cells using thin section and freeze fracture techniques. Initially, cryptosporidia invaginate microvilli, and the resulting redundant folds of membrane envelop the protozoan, thereby i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)91112-1
更新日期:1986-03-01 00:00:00
abstract::Two Crohn's disease tissue-specific proteins are identified and purified several thousand-fold from crude tissue extracts by different chromatographic procedures. The two proteins migrate in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as 200-210-kilodalton and 150-160-kilodalton species. They are glycopr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90564-0
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND & AIMS:It is unclear whether genomic derangement precedes the histological development of dysplasia in ulcerative colitis (UC)-related neoplastic progression. The primary aim of this study was to determine if chromosomal alterations occur early in the progression pathway of UC-related neoplasia. METHODS:Flu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70173-2
更新日期:1997-09-01 00:00:00
abstract::A monoclonal antibody to bromodeoxyuridine was used in tissue specimens previously incubated with bromodeoxyuridine to show S-phase cells by immunohistochemical technique. Biopsy specimens of normal mucosa (n = 10), hyperplastic polyps (n = 10), adenomas with low-grade dysplasia (n = 20), adenomas with high-grade dysp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90545-8
更新日期:1988-04-01 00:00:00
abstract::Treatment of eosinophilic esophagitis has progressed from elemental formula for children and esophageal dilation for adults to selective exclusion of food triggers and swallowed topical corticosteroids. Management guidelines are available from the American Gastroenterological Association and the Joint Task Force on Al...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2019.09.052
更新日期:2020-03-01 00:00:00
abstract::Using an in vivo canine chambered stomach preparation, the clearance of [14C]aminopyrine across mucosa when intravenously infused and the back-diffusion of this substance from gastric lumen to mucosa when topically applied to gastric epithelium were evaluated in aspirin-damaged gastric epithelium. In mucosa damaged by...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND/AIMS:Little is known about the evolution of morphological changes in pelvic ileal-pouch mucosa. This study evaluates prospectively the sequence of early morphological, histochemical, and phenotypic features in pouch mucosal biopsy specimens. METHODS:Twenty-two patients with pelvic ileal pouches constructed ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90169-4
更新日期:1994-08-01 00:00:00
abstract::The reason why hepatocellular carcinoma occurs less frequently in women than in men is unknown. The possibility that differences in the hepatitis B virus status between men and women with this tumor might be important in this regard was investigated in 75 black women and 75 age- and ethnically-matched men with hepatoc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND & AIMS:Genetic factors are believed to affect risk for irritable bowel syndrome (IBS), but there have been no sufficiently powered and adequately sized studies. To identify DNA variants associated with IBS risk, we performed a genome-wide association study (GWAS) of the large UK Biobank population-based coho...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.03.064
更新日期:2018-07-01 00:00:00
abstract::The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. Th...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2014.01.052
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND & AIMS:Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role of tuft cells in pancreatic tumorigenesis. METHODS:We performed studie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.07.037
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or unt...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0016-5085(98)70419-6
更新日期:1998-06-01 00:00:00
abstract::The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2007.03.116
更新日期:2007-05-01 00:00:00
abstract::We studied chronic intake of diets deficient in or supplemented with linoleic acid to determine whether it affects gastric acid secretion, release of prostaglandin E2, and stress-induced lesions. For 8-10 wk rats were fed three dietary regimens supplying 3.5% (control group), 0.3%, and 10% of total calories as linolei...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90285-5
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND & AIMS:Gastrin stimulation of the type 2 cholecystokinin (CCK(2)) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function. METHODS:The ECL cells in the oxyntic mucosa of CCK(2...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.34746
更新日期:2002-08-01 00:00:00
abstract::The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-08-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is one of the main chronic noncommunicable diseases in Westernized societies; its worldwide prevalence has doubled during the last 20 years. NAFLD has serious health implications not only for adults, but also for children. However, pediatric NAFLD is not only an important globa...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2016.03.009
更新日期:2016-06-01 00:00:00