Mucosal expression by B7-positive cells of the 60-kilodalton heat-shock protein in inflammatory bowel disease.

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：:Reduction in caloric intake was associated with a greater absolute rise in the serum bilirubin concentration in patients with Gilbert's syndrome and partial hepatic bilirubin uridine diphosphate glucuronyltransferase (UDPG-T) dysfunction compared to patients with hemolytic unconjugated hyperbilirubinemia and normal su...

journal_title：Gastroenterology

authors： Felsher BF,Carpio NM

更新日期：1975-07-01 00:00:00

abstract：BACKGROUND & AIMS:Colorectal cancers (CRC) associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome display high-level microsatellite instability (MSI-H) as a consequence of mismatch repair deficiency. HNPCC-associated CRC frequently show features of a pronounced immune response, most likely resul...

journal_title：Gastroenterology

authors： Schwitalle Y,Kloor M,Eiermann S,Linnebacher M,Kienle P,Knaebel HP,Tariverdian M,Benner A,von Knebel Doeberitz M

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND/AIMS:Spasmolytic polypeptide (SP) is a trefoil peptide expressed in the digestive tract. This study aimed to determine the structure and distribution of SP expression in the rat gastrointestinal tract. METHODS:The structure of rat SP was determined from the sequence of complementary DNAs isolated from antra...

journal_title：Gastroenterology

authors： Jeffrey GP,Oates PS,Wang TC,Babyatsky MW,Brand SJ

更新日期：1994-02-01 00:00:00

abstract：:The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense dis...

journal_title：Gastroenterology

authors： Roman F,Pascaud X,Chomette G,Bueno L,Junien JL

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:No controlled trial has examined the clinical efficacy of antibiotics in small bowel bacterial overgrowth. METHODS:Ten patients with bacterial overgrowth-related diarrhea underwent the following five 7-day treatment periods: untreated (control period), then placebo, and subsequently, in random order ...

journal_title：Gastroenterology

authors： Attar A,Flourié B,Rambaud JC,Franchisseur C,Ruszniewski P,Bouhnik Y

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS:We studied growth failure and its relationship to disease activi...

journal_title：Gastroenterology

authors： Motil KJ,Grand RJ,Davis-Kraft L,Ferlic LL,Smith EO

更新日期：1993-09-01 00:00:00

abstract：:This study presents normal values of bowel habits, colonic transit times of radioopaque markers, and anorectal pressure obtained from 114 normal subjects. Their stool frequency ranged from 3 to 11 per 7 days, whereas their diet contained an average of 14.4 g of crude fibers. Radioopaque markers progressed regularly al...

journal_title：Gastroenterology

authors： Martelli H,Devroede G,Arhan P,Duguay C,Dornic C,Faverdin C

更新日期：1978-10-01 00:00:00

abstract：:The effects of cisapride on jejunal interdigestive motor activity were studied in 12 healthy men participating in three experiments each. Five minutes after an activity front (phase III) they received, in random double-blind fashion, 10 mg of cisapride, 4 mg of cisapride, or saline placebo by intravenous injection. Mo...

journal_title：Gastroenterology

authors： Stacher G,Steinringer H,Schneider C,Winklehner S,Mittelbach G,Gaupmann G

更新日期：1986-05-01 00:00:00

abstract：BACKGROUND & AIMS:Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS:Mutations and deletions involved in colorectal carcinoma were studied in sporadic and Crohn's-associated intestinal carcinomas and precur...

journal_title：Gastroenterology

authors： Rashid A,Hamilton SR

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND & AIMS:Agents designed to block or alter cytokinesis can kill or stop proliferation of cancer cells. We aimed to identify cytokinesis-related proteins that are overexpressed in hepatocellular carcinoma (HCC) cells and might be targeted to slow liver tumor growth. METHODS:Using the Oncomine database, we comp...

journal_title：Gastroenterology

authors： Yang XM,Cao XY,He P,Li J,Feng MX,Zhang YL,Zhang XL,Wang YH,Yang Q,Zhu L,Nie HZ,Jiang SH,Tian GA,Zhang XX,Liu Q,Ji J,Zhu X,Xia Q,Zhang ZG

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with chronic hepatitis C who failed to respond to standard therapy, high-dose pegylated interferon (IFN)-α and/or ribavirin could induce a stronger antiviral response and prevent treatment failure and HCV resistance when combined with direct-acting antivirals. The influence of genetic dete...

journal_title：Gastroenterology

authors： Chevaliez S,Hézode C,Soulier A,Costes B,Bouvier-Alias M,Rouanet S,Foucher J,Bronowicki JP,Tran A,Rosa I,Mathurin P,Alric L,Leroy V,Couzigou P,Mallat A,Charaf-Eddine M,Babany G,Pawlotsky JM

更新日期：2011-07-01 00:00:00

abstract：:Gastrointestinal symptoms occur in a large number of patients with food allergies. Immediate hypersensitivity mechanisms may give rise to the nausea, vomiting, abdominal pain, and diarrhea experienced by these patients. However, there are limited human data about the pathophysiological basis for these symptoms. Most o...

journal_title：Gastroenterology

authors： Crowe SE,Perdue MH

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

journal_title：Gastroenterology

authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Fecal incontinence (FI) is characterized by uncontrolled passage of solid or liquid stool. We aimed to determine the prevalence and severity of FI in a large sample of US residents. METHODS:We recruited a representative sample of patients in October 2015 to complete the National Gastrointestinal (GI)...

journal_title：Gastroenterology

authors： Menees SB,Almario CV,Spiegel BMR,Chey WD

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND & AIMS:It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue th...

journal_title：Gastroenterology

authors： Schoellhammer CM,Lauwers GY,Goettel JA,Oberli MA,Cleveland C,Park JY,Minahan D,Chen Y,Anderson DG,Jaklenec A,Snapper SB,Langer R,Traverso G

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND & AIMS:We evaluated etanercept, a human soluble tumor necrosis factor receptor: Fc fusion protein, for the treatment of active Crohn's disease. METHODS:Forty-three patients with moderate to severe Crohn's disease were enrolled in an 8-week placebo-controlled trial. Patients were randomized to subcutaneous e...

journal_title：Gastroenterology

authors： Sandborn WJ,Hanauer SB,Katz S,Safdi M,Wolf DG,Baerg RD,Tremaine WJ,Johnson T,Diehl NN,Zinsmeister AR

更新日期：2001-11-01 00:00:00

abstract：:Pancreatic blood flow and its relationship to pancreatic interstitial pressure were investigated in a model of chronic pancreatitis in cats using a hydrogen gas-clearance technique with an intraductal electrode. The intraductal technique correlated well with blood flow measurements made using gamma-labeled microsphere...

journal_title：Gastroenterology

authors： Reber HA,Karanjia ND,Alvarez C,Widdison AL,Leung FW,Ashley SW,Lutrin FJ

更新日期：1992-08-01 00:00:00

abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

journal_title：Gastroenterology

authors： Dubnansky E,Omary MB

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:Endosonography-guided fine-needle aspiration biopsy (EUS-FNA) permits cytological confirmation of EUS findings. A multicenter prospective evaluation of EUS-FNA for primary diagnosis, staging, and/or follow-up purposes was undertaken. METHODS:EUS-FNA was performed in 457 patients with 554 lesions. Cli...

journal_title：Gastroenterology

authors： Wiersema MJ,Vilmann P,Giovannini M,Chang KJ,Wiersema LM

更新日期：1997-04-01 00:00:00

abstract：:Intestinal mucosal biopsy immunoglobulin content in a patient with eosinophilia, allergic gastroenteropathy (atopy, food sensitivities, protein-losing enteropathy, iron deficiency anemia, and growth retardation), and hyperimmunoglobulinemia E (68,000 units) was compared with that of a control group and a group with eo...

journal_title：Gastroenterology

authors： Caldwell JH,Sharma HM,Hurtubise PE,Colwell DL

更新日期：1979-09-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux disease on the basis of histology and lack of responsiveness to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to proton pump inhibitors. Genetic and environmental factors contribute...

journal_title：Gastroenterology

authors： Rothenberg ME

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...

journal_title：Gastroenterology

authors： Direnzo D,Hess DA,Damsz B,Hallett JE,Marshall B,Goswami C,Liu Y,Deering T,Macdonald RJ,Konieczny SF

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

journal_title：Gastroenterology

authors： Wallace DF,Summerville L,Subramaniam VN

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND & AIMS:Lifestyle factors have been shown to influence prognosis in Crohn's disease. The purpose of this study was to prospectively assess the effects of smoking and oral contraceptive use on clinical relapse rates. METHODS:Placebo-treated patients formed a prospective cohort, followed up for 48 weeks or unt...

journal_title：Gastroenterology

authors： Timmer A,Sutherland LR,Martin F

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...

journal_title：Gastroenterology

authors： Musso A,Condon TP,West GA,De La Motte C,Strong SA,Levine AD,Bennett CF,Fiocchi C

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND & AIMS:Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by...

journal_title：Gastroenterology

authors： Sun X,Wu Y,Gao W,Enjyoji K,Csizmadia E,Müller CE,Murakami T,Robson SC

更新日期：2010-09-01 00:00:00

abstract：:The amount of bile acid excreted via an ileostomy at the end of the ileum should give an estimate of the amount of bile acid transported to the colon. In the present study, 8 patients with ileostomies at the end of the ileum but without disease or resection of the small intestine excreted 1690 +/- 205 mumol/day (mean ...

journal_title：Gastroenterology

authors： Stiehl A,Raedsch R,Rudolph G

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND & AIMS:Foxp3-expressing regulatory T cells (Tregs) play a key role in the maintenance of the gut immune homeostasis, and an intact transforming growth factor (TGF)-beta signaling is required for their function. In inflammatory bowel disease (IBD), the TGF-beta signaling is impaired because of high expression...

journal_title：Gastroenterology

authors： Fantini MC,Rizzo A,Fina D,Caruso R,Sarra M,Stolfi C,Becker C,Macdonald TT,Pallone F,Neurath MF,Monteleone G

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...

journal_title：Gastroenterology

authors： Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

更新日期：2019-12-01 00:00:00