Growth failure in children with inflammatory bowel disease: a prospective study.

Abstract:

BACKGROUND:Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS:We studied growth failure and its relationship to disease activity and steroid therapy in 69 children who have IBD by prospectively monitoring height for a maximum of 3 years. Disease activity and steroid use were recorded at entry into the study. RESULTS:The prevalence of growth failure was 24%, 23%, and 39% by height velocity, Z score, and height-for-age criteria, respectively; deficits were equally prevalent regardless of the stage of pubertal development. A delay in linear growth persisted throughout puberty and was not reversed after surgery. Patients who had Crohn's disease were twice as likely to have growth abnormalities than patients who had ulcerative colitis. We detected significant negative associations between linear growth and disease activity but not steroid therapy. CONCLUSIONS:In a unique group of children, growth failure is an early, "prepatterned" manifestation of IBD. The inflammatory process, rather than steroid use, has a predominant influence on the development of growth faltering.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Motil KJ,Grand RJ,Davis-Kraft L,Ferlic LL,Smith EO

doi

10.1016/0016-5085(93)90883-e

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

681-91

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(93)90883-E

journal_volume

105

pub_type

杂志文章
  • Tolerance to lactose among lactase-deficient American Indians.

    abstract::To determine the amount of lactose that could be tolerated in a meal, 59 lactase-deficient American Indians, ranging in age from 5 to 62, were given graded doses of lactose. The diagnosis of lactase deficiency had beeen documented previously by showing increased breath hydrogen after an oral lactose load (2 g per kg, ...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Newcomer AD,McGill DB,Thomas PJ,Hofmann AF

    更新日期:1978-01-01 00:00:00

  • Advances in Use of Endoscopy, Radiology, and Biomarkers to Monitor Inflammatory Bowel Diseases.

    abstract::Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel diseases, and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, therefore it is important that they are evaluated for the presence of active disease when symptoms a...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2016.10.005

    authors: Panes J,Jairath V,Levesque BG

    更新日期:2017-02-01 00:00:00

  • Ursodeoxycholic acid for the treatment of home parenteral nutrition-associated cholestasis. A case report.

    abstract::Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90486-5

    authors: Lindor KD,Burnes J

    更新日期:1991-07-01 00:00:00

  • Effects of streptozotocin-diabetes on rat intestinal mucin and goblet cells.

    abstract::Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)91417-0

    authors: Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

    更新日期:1989-07-01 00:00:00

  • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2000.8523

    authors: Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

    更新日期:2000-07-01 00:00:00

  • Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers.

    abstract:BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2010.04.009

    authors: Whiteman DC,Parmar P,Fahey P,Moore SP,Stark M,Zhao ZZ,Montgomery GW,Green AC,Hayward NK,Webb PM,Australian Cancer Study.

    更新日期:2010-07-01 00:00:00

  • Serum bile acid concentrations during pregnancy and their relationship to obstetric cholestasis.

    abstract::We have prospectively studied changes in serum postprandial cholylglycine (CG) concentration during 297 pregnancies. We found an increase in CG concentration from 0.3 mumol/L at 15 weeks' pregnancy to 0.6 mumol/L at 40 weeks' pregnancy. Although this increase was statistically significant (p less than 0.005), median c...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(86)90682-7

    authors: Lunzer M,Barnes P,Byth K,O'Halloran M

    更新日期:1986-10-01 00:00:00

  • Inflammatory bowel disease in all three members of one family.

    abstract::The occurrence of inflammatory bowel disease in all three members of one family is described. Studies of white blood cell chromosomes, histocompatibility antigens, and cellular and humoral immunity failed to explain this unusual phenomenon. However, the appearance of inflammatory bowel disease in an entire family reem...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Rosenberg JL,Kraft SC,Kirsner JB

    更新日期:1976-05-01 00:00:00

  • Hyperglycemia Increases Interstitial Cells of Cajal via MAPK1 and MAPK3 Signaling to ETV1 and KIT, Leading to Rapid Gastric Emptying.

    abstract:BACKGROUND & AIMS:Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis. However, in approximately 20% of patients with diabetes, gastric emptying (GE) is accelerated. GE also occurs faster in obese individuals, and is associated with increased blood levels of glucose in patients with type...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.04.020

    authors: Hayashi Y,Toyomasu Y,Saravanaperumal SA,Bardsley MR,Smestad JA,Lorincz A,Eisenman ST,Cipriani G,Nelson Holte MH,Al Khazal FJ,Syed SA,Gajdos GB,Choi KM,Stoltz GJ,Miller KE,Kendrick ML,Rubin BP,Gibbons SJ,Bharucha AE,

    更新日期:2017-08-01 00:00:00

  • The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

    abstract:BACKGROUND & AIMS:Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates tissue damage by promoting apoptosis of epithelial cells. However, little is known about the physiologic role of Dkk1 in normal intestinal homeostasis and during...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2011.03.043

    authors: Koch S,Nava P,Addis C,Kim W,Denning TL,Li L,Parkos CA,Nusrat A

    更新日期:2011-07-01 00:00:00

  • Effects of nonsteroidal anti-inflammatory drugs and misoprostol on gastroduodenal epithelial proliferation in arthritis.

    abstract::In this study, quantitation of the epithelial proliferation status of gastric glands and duodenal crypts was performed using endoscopic biopsy specimens from patients with rheumatological conditions requiring long-term anti-inflammatory and analgesic therapy, testing the hypothesis that long-term administration of non...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0016-5085(92)91720-o

    authors: Levi S,Goodlad RA,Lee CY,Walport MJ,Wright NA,Hodgson HJ

    更新日期:1992-05-01 00:00:00

  • Effects of liquid versus solid diet on colonic transit in humans. Evaluation by standard colonic transit scintigraphy.

    abstract::The effects of liquid versus solid diet on human colonic transit were investigated, and transit following cecal instillation of tracer was compared with transit following instillation in the proximal jejunum. In a randomized cross-over, single-blind fashion, 6 normal volunteers ingesting either normal solid foods or a...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0016-5085(90)91293-f

    authors: Kaufman PN,Richter JE,Chilton HM,Kerr RM,Cowan RC,Gelfand DW,Ott DJ

    更新日期:1990-01-01 00:00:00

  • A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up.

    abstract::The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(92)90027-v

    authors: Burman P,Kämpe O,Kraaz W,Lööf L,Smolka A,Karlsson A,Karlsson-Parra A

    更新日期:1992-09-01 00:00:00

  • Hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies.

    abstract::The long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. To study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and m...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Dyrszka H,Salen G,Zaki FG,Chen T,Mosbach EH

    更新日期:1976-01-01 00:00:00

  • Transient agranulocytosis associated with non-A, non-B hepatitis.

    abstract::A 44-yr-old woman with non-A, non-B hepatitis developed agranulocytosis and absence of marrow granulocyte precursor cells with only mild involvement of other blood elements. The agranulocytosis was complicated by gram-negative septicemia, successfully treated with antibiotic therapy. Marrow recovery followed 2 wk of s...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Vande Stouwe RA,Attia AA,Karanas A,Ciavarella D,Grieco MH

    更新日期:1983-07-01 00:00:00

  • Heptadecapeptide gastrin: measurement in blood by specific radioimmunoassay.

    abstract::The characteristics are described of an antibody (designated L6) which has virtually absolute specificity for heptadecapeptide gastrin. This antibody binds G17, but does not bind peptide fragments or molecular forms of gastrin comprising G17 with either amino acid deletions, or additions, at the carboxyl- and amino-te...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Dockray GJ,Taylor IL

    更新日期:1976-12-01 00:00:00

  • Protective effect of sucralfate against alcohol-induced gastric mucosal injury in the rat. Macroscopic, histologic, ultrastructural, and functional time sequence analysis.

    abstract::Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(85)80191-8

    authors: Hollander D,Tarnawski A,Krause WJ,Gergely H

    更新日期:1985-01-01 00:00:00

  • Spontaneous bacterial peritonitis caused by Neisseria gonorrhoeae. Evidence for a transfallopian route of infection.

    abstract::We describe the clinical and laboratory features of a case of spontaneous bacterial peritonitis caused by Neisseria gonorrhoeae in a sexually active woman with Laennec's cirrhosis, ascites, and asymptomatic cervical gonorrhea. Treatment of the infection with high-dose parenteral penicillin was associated with resoluti...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(85)90155-6

    authors: Stassen WN,McCullough AJ,Hilton PK

    更新日期:1985-03-01 00:00:00

  • Effect of substance P on somatostatin release from the isolated perfused rat stomach.

    abstract::The effect of substance P (SP) on the release of gastric somatostatinlike immunoreactivity (SLI) was studied. Substance P inhibited both basal SLI release and SLI release stimulated by gastric inhibitory polypeptide or 1-isoproterenol. This inhibitory action of SP was not blocked by atropine or hexamethonium, suggesti...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(85)80138-4

    authors: Kwok YN,McIntosh CH,Pederson RA,Brown JC

    更新日期:1985-01-01 00:00:00

  • Endosonographic TNM staging of extrahepatic bile duct cancer: comparison with pathological staging.

    abstract::Endosonography was performed preoperatively in 33 patients with common bile duct carcinoma and in 43 patients with carcinoma of the common hepatic duct and its bifurcation. The results were correlated with the histology of resected specimens according to the new (1987) TNM (tumor, node, metastasis) classification. End...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Tio TL,Cheng J,Wijers OB,Sars PR,Tytgat GN

    更新日期:1991-05-01 00:00:00

  • Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

    abstract::Microsatellite instability (MSI) caused by mismatch repair deficiency (dMMR) is detected in a small proportion of pancreatic ductal adenocarcinomas (PDACs). dMMR and MSI have been associated with responses of metastatic tumors, including PDACs, to immune checkpoint inhibitor therapy. We performed immunohistochemical a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.11.009

    authors: Lupinacci RM,Goloudina A,Buhard O,Bachet JB,Maréchal R,Demetter P,Cros J,Bardier-Dupas A,Collura A,Cervera P,Scriva A,Dumont S,Hammel P,Sauvanet A,Louvet C,Delpéro JR,Paye F,Vaillant JC,André T,Closset J,Emile JF

    更新日期:2018-03-01 00:00:00

  • Effect of hydroxypropylmethylcellulose on gastrointestinal transit and luminal viscosity in dogs.

    abstract::The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Reppas C,Meyer JH,Sirois PJ,Dressman JB

    更新日期:1991-05-01 00:00:00

  • Crohn's disease: influence of age at diagnosis on site and clinical type of disease.

    abstract:BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1996.v111.pm8780560

    authors: Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

    更新日期:1996-09-01 00:00:00

  • Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair.

    abstract:BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2006.05.051

    authors: Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

    更新日期:2006-09-01 00:00:00

  • K-ras-2 G-C and G-T transversions correlate with DNA aneuploidy in colorectal adenomas.

    abstract:BACKGROUND/AIMS:K-ras-2 mutations and DNA content heterogeneity represent early events of human colorectal tumor progression. The aim of the study was to investigate if specific K-ras-2 mutations in 58 human sporadic adenomas were correlated with DNA aneuploidization and cell proliferation. METHODS:Multiparameter flow...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90201-5

    authors: Giaretti W,Pujic N,Rapallo A,Nigro S,Di Vinci A,Geido E,Risio M

    更新日期:1995-04-01 00:00:00

  • Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study.

    abstract:BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

    journal_title:Gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1053/j.gastro.2007.05.023

    authors: Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

    更新日期:2007-08-01 00:00:00

  • Frequency of intrahepatic arteriovenous fistula as a sequela to percutaneous needle puncture of the liver.

    abstract::Incidence of intrahepatic arteriovenous fistula after needle biopsy of the liver, percutaneous transhepatic cholangiography, and transhepatic catheterization of an intrahepatic bile duct or portal vein, was determined by studying the hepatic arteriograms obtained within 1 month of the transhepatic procedure. An arteri...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Okuda K,Musha H,Nakajima Y,Takayasu K,Suzuki Y,Morita M,Yamasaki T

    更新日期:1978-06-01 00:00:00

  • What Is Needed to Eliminate Hepatitis B Virus and Hepatitis C Virus as Global Health Threats.

    abstract::Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause 1.3 million deaths annually. To prevent more than 7 million deaths by 2030, the World Health Organization set goals to eliminate HBV and HCV, defined as a 90% reduction in new infections and a 65% reduction in deaths, and prevent more than 7 million related dea...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2018.10.048

    authors: Ward JW,Hinman AR

    更新日期:2019-01-01 00:00:00

  • Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential.

    abstract::The origin and neoplastic potential of gastric epithelial polyps remains an area of great interest, and treatment choices are a topic of controversy. This report describes a patient diagnosed with three concurrent hyperplastic gastric polyps that were studied for genetic alterations. The polyps were investigated for a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1997.v112.pm9024310

    authors: Dijkhuizen SM,Entius MM,Clement MJ,Polak MM,Van den Berg FM,Craanen ME,Slebos RJ,Offerhaus GJ

    更新日期:1997-02-01 00:00:00

  • A magnetic resonance study of the effect of nutritional status on cold-preserved murine liver.

    abstract:BACKGROUND/AIMS:Clinical and experimental studies suggest a link between nutritional status and the recovery of hepatic function after hypoxic and hypothermic insults. This study aimed at determining the metabolic pathways involved in such recovery as a function of nutrition. METHODS:Livers from fed and fasted mice we...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90819-2

    authors: Dimicoli JL,Patry J,Adam R,Dennison A,Nedelec JF,Bismuth H

    更新日期:1994-12-01 00:00:00