Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine.

abstract：BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...

journal_title：Gastroenterology

authors： de la Concha EG,Fernandez-Arquero M,Lopez-Nava G,Martin E,Allcock RJ,Conejero L,Paredes JG,Diaz-Rubio M

更新日期：2000-12-01 00:00:00

abstract：:To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...

journal_title：Gastroenterology

authors： Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

更新日期：1989-10-01 00:00:00

abstract：:The possibility that chronic uremia renders the gastric mucosa more susceptible to acid injury was investigated. A rat model of chronic renal failure was induced by subtotal nephrectomy. [H+] back-diffusion across the mucosa, following intragastric perfusion of 0.15N HCl or 15% ethanol in 0.15N HCl, was significantly ...

journal_title：Gastroenterology

authors： Quintero E,Kaunitz J,Nishizaki Y,De Giorgio R,Sternini C,Guth PH

更新日期：1992-12-01 00:00:00

abstract：:We examined whether patients with irritable bowel syndrome have increased airway responsiveness by measuring forced expiratory volumes in 1 second (FEV1) after inhalation of increasing concentrations of methacholine. Responses obtained in 11 IBS patients were compared with those obtained in 11 normal subjects and in 1...

journal_title：Gastroenterology

authors： White AM,Stevens WH,Upton AR,O'Byrne PM,Collins SM

更新日期：1991-01-01 00:00:00

abstract：:An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...

journal_title：Gastroenterology

authors： Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...

journal_title：Gastroenterology

authors： Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Ground-glass (GG) inclusions within hepatocytes are an important histopathologic marker of chronic hepatitis B virus (HBV) infection but may also be seen in Lafora's disease (myoclonus epilepsy), cyanamide alcohol aversion therapy, and type IV glycogenosis. We have noted a recent increased incidence o...

journal_title：Gastroenterology

authors： Lefkowitch JH,Lobritto SJ,Brown RS Jr,Emond JC,Schilsky ML,Rosenthal LA,George DM,Cairo MS

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...

journal_title：Gastroenterology

authors： Vaezi MF,Fass R,Vakil N,Reasner DS,Mittleman RS,Hall M,Shao JZ,Chen Y,Lane L,Gates AM,Currie MG

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there i...

journal_title：Gastroenterology

authors： Derikx LA,Kievit W,Drenth JP,de Jong DJ,Ponsioen CY,Oldenburg B,van der Meulen-de Jong AE,Dijkstra G,Grubben MJ,van Laarhoven CJ,Nagtegaal ID,Hoentjen F,Dutch Initiative on Crohn and Colitis.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Although bacterial bowel flora may be one of the contributing factors in the pathogenesis of chronic mucosal inflammation, antibiotic treatment has no established role in ulcerative colitis. The aim of the study was to evaluate the role of ciprofloxacin in the induction and maintenance of remission in...

journal_title：Gastroenterology

authors： Turunen UM,Färkkilä MA,Hakala K,Seppälä K,Sivonen A,Ogren M,Vuoristo M,Valtonen VV,Miettinen TA

更新日期：1998-11-01 00:00:00

abstract：:The onset, course, and regression of the biochemical and structural alterations associated with pancreatitis induced by various doses of caerulein were studied in the mouse. In addition, the protective effect of secretin was compared with that of the cholecystokinin-receptor antagonists proglumide and benzotript. Subc...

journal_title：Gastroenterology

authors： Niederau C,Ferrell LD,Grendell JH

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...

journal_title：Gastroenterology

authors： Polito JM 2nd,Childs B,Mellits ED,Tokayer AZ,Harris ML,Bayless TM

更新日期：1996-09-01 00:00:00

abstract：:A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...

journal_title：Gastroenterology

authors： Ahlquist DA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND & AIMS:Recent reports suggest that platelet-activating factor (PAF) plays a role in pancreatitis and pancreatitis-associated lung injury. In this study, the effects on these processes of termination of PAF action by recombinant PAF-acetylhydrolase (rPAF-AH) were investigated. METHODS:Rats were given rPAF-AH...

journal_title：Gastroenterology

authors： Hofbauer B,Saluja AK,Bhatia M,Frossard JL,Lee HS,Bhagat L,Steer ML

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

journal_title：Gastroenterology

authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND & AIMS:Despite many advances in our understanding of Crohn's disease, the course of the disease in any given patient remains unpredictable. There is little agreement as to which factors increase a patient's risk of early postoperative recurrence. We have attempted to identify predictors of early recurrence a...

journal_title：Gastroenterology

authors： Lautenbach E,Berlin JA,Lichtenstein GR

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:There is controversy over the optimal management strategy for patients with acute pancreatitis (AP). Studies have shown a hospital volume benefit for in-hospital mortality after surgery, and we examined whether a similar mortality benefit exists for patients admitted with AP. METHODS:Using the Nation...

journal_title：Gastroenterology

authors： Singla A,Simons J,Li Y,Csikesz NG,Ng SC,Tseng JF,Shah SA

更新日期：2009-12-01 00:00:00

abstract：:A patient with the acquired immunodeficiency syndrome (AIDS) with a cytomegalovirus (CMV) infection localized in the area of an ileal Kaposi sarcoma resulting in perforation is described. Because only one case of such an association of Kaposi sarcoma with CMV leading to perforation has been reported, the presence and ...

journal_title：Gastroenterology

authors： Genta RM,Bleyzer I,Cate TR,Tandon AK,Yoffe B

更新日期：1993-06-01 00:00:00

abstract：:In humans and most other species, a decline in pH of gallbladder contents occurs during the concentration of bile. Recent in vitro studies in rabbit, guinea pig, and Necturus gallbladders have strongly suggested mucosal H+ secretion during sodium reabsorption, presumably representing a Na+/H+ exchange. The present in ...

journal_title：Gastroenterology

authors： Rege RV,Moore EW

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND & AIMS:Screening colonoscopy is an effective method to reduce the incidence of and mortality from colorectal cancer (CRC). There is little empirical evidence available about the optimal interval for screening, making this a subject of debate. We associated the prevalence of advanced colorectal neoplasms with...

journal_title：Gastroenterology

authors： Brenner H,Haug U,Arndt V,Stegmaier C,Altenhofen L,Hoffmeister M

更新日期：2010-03-01 00:00:00

abstract：:In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 ind...

journal_title：Gastroenterology

authors： Iida M,Yao T,Itoh H,Watanabe H,Kohrogi N,Shigematsu A,Iwashita A,Fujishima M

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study in...

journal_title：Gastroenterology

authors： Hutfless SM,Weng X,Liu L,Allison J,Herrinton LJ

更新日期：2007-12-01 00:00:00

abstract：:An in vitro fecal incubation system was used to demonstrate how lactulose influences ammonia metabolism in the colon. Lactulose and other fermentable substrates (glucose, mannitol, and sorbitol), pH and organic acid were varied independently so that their different effects could be determined. Fermentable substrate ca...

journal_title：Gastroenterology

authors： Vince A,Killingley M,Wrong OM

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which antimicrobial therapy against Helicobacter pylori is enhanced by acid suppression is unknown. The aim of this study was to investigate the effect of omeprazole on gastric juice, plasma, and saliva concentrations of metronidazole, amoxicillin, and clarithromycin. METHODS:Single ...

journal_title：Gastroenterology

authors： Goddard AF,Jessa MJ,Barrett DA,Shaw PN,Idström JP,Cederberg C,Spiller RC

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms for tissue regeneration and renewal after acute pancreatitis are not well understood but may involve activation of Notch signaling. To study the effect of Notch signaling ablation during acute experimental pancreatitis, we used a chemical and genetic approach to ablate Notch signaling i...

journal_title：Gastroenterology

authors： Siveke JT,Lubeseder-Martellato C,Lee M,Mazur PK,Nakhai H,Radtke F,Schmid RM

更新日期：2008-02-01 00:00:00

abstract：:Histologic or ultrastructural evidence of the ability of sucralfate to protect the gastric mucosa against ethanol injury is lacking. Therefore we analyzed morphologic and functional changes in the mucosa of 120 rats receiving, intragastrically, 2 ml of either sucralfate 500 mg/kg body wt or a control solution and 1 h ...

journal_title：Gastroenterology

authors： Hollander D,Tarnawski A,Krause WJ,Gergely H

更新日期：1985-01-01 00:00:00

abstract：:We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower ...

journal_title：Gastroenterology

authors： Fujita YK,Kamata K,Kameda H,Isselbacher KJ,Wands JR

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND & AIMS:Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine ...

journal_title：Gastroenterology

authors： Doi K,Nagao T,Kawakubo K,Ibayashi S,Aoyagi K,Yano Y,Yamamoto C,Kanamoto K,Iida M,Sadoshima S,Fujishima M

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND & AIMS:Activating transcription factor 4 (ATF4) regulates genes involved in the inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum stress. We investigated whether its activity is altered in patients with inflammatory bowel diseases (IBDs) and mice with enterocolitis. METHODS:...

journal_title：Gastroenterology

authors： Hu X,Deng J,Yu T,Chen S,Ge Y,Zhou Z,Guo Y,Ying H,Zhai Q,Chen Y,Yuan F,Niu Y,Shu W,Chen H,Ma C,Liu Z,Guo F

更新日期：2019-03-01 00:00:00

abstract：:We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...

journal_title：Gastroenterology

authors： Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

更新日期：2016-05-01 00:00:00