Prior colorectal neoplasia is associated with increased risk of ileoanal pouch neoplasia in patients with inflammatory bowel disease.


BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there is no consensus on the need for pouch surveillance. We aimed to determine the cumulative incidence of pouch neoplasia in patients with IBD and identify risk factors for developing pouch neoplasia. METHODS:We searched the Dutch Pathology Registry (PALGA) to identify all patients with IBD and IPAA in The Netherlands from January 1991 to May 2012. We calculated the cumulative incidence of pouch neoplasia and performed a case-control study to identify risk factors. Demographic and clinical variables were analyzed with univariable and multivariable Cox regression analyses. RESULTS:We identified 1200 patients with IBD and IPAA; 25 (1.83%) developed pouch neoplasia, including 16 adenocarcinomas. Respective cumulative incidences at 5, 10, 15, and 20 years were 1.0%, 2.0%, 3.7%, and 6.9% for pouch neoplasia and 0.6%, 1.4%, 2.1%, and 3.3% for pouch carcinoma. A history of colorectal neoplasia was the only risk factor associated with pouch neoplasia. Hazard ratios were 3.76 (95% confidence interval, 1.39-10.19) for prior dysplasia and 24.69 (95% confidence interval, 9.61-63.42) for prior carcinoma. CONCLUSIONS:The incidence of pouch neoplasia in patients with IBD without a history of colorectal neoplasia is relatively low. Prior dysplasia or colon cancer is associated with an approximate 4- and 25-fold increase in risk, respectively, of developing pouch neoplasia.






Derikx LA,Kievit W,Drenth JP,de Jong DJ,Ponsioen CY,Oldenburg B,van der Meulen-de Jong AE,Dijkstra G,Grubben MJ,van Laarhoven CJ,Nagtegaal ID,Hoentjen F,Dutch Initiative on Crohn and Colitis.




Has Abstract


2014-01-01 00:00:00














  • Effects of chlorpromazine on bilirubin metabolism and biliary secretion in the rat.

    abstract::Chlorpromazine (CPZ) is a long recognized cause of jaundice, but the mechanism by which this agent produces icteric liver disease is not well defined. This study examined some effects of CPZ administration on bilirubin metabolism and biliary secretion in the rat. Acute CPZ treatment (25 mg per kg intravenously) produc...


    pub_type: 杂志文章


    authors: Knodell RG

    更新日期:1975-10-01 00:00:00

  • Inhibitory effect of bile salts on gallbladder smooth muscle contractility in the guinea pig in vitro.

    abstract:BACKGROUND & AIMS:Impaired gallbladder emptying occurs in patients undergoing bile salt therapy for cholesterol gallstone dissolution and in patients with cirrhosis who have elevated serum bile salt concentrations. To determine if bile salts directly inhibit gallbladder contractility, isometric contraction of the guine...


    pub_type: 杂志文章


    authors: Xu QW,Freedman SM,Shaffer EA

    更新日期:1997-05-01 00:00:00

  • Degradative intracellular transport of antisecretory component in cultured hepatocytes. An alternate pathway for the immunoglobulin A receptor.

    abstract::The liver efficiently transports dimeric immunoglobulin A (dIgA) from blood to bile in a direct, nonlysosomal pathway involving smooth-surfaced vesicles. Secretory component (SC), the plasma membrane receptor for dIgA, is released into bile still bound to its ligand by disulfide bridges. Rabbit IgG antirat SC binds sp...


    pub_type: 杂志文章


    authors: Kim E,Hradek GT,Jones AL

    更新日期:1985-06-01 00:00:00

  • Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility.

    abstract::Ceftriaxone, a semisynthetic third-generation cephalosporin, has recently been associated with biliary sludge formation. Analysis of the biliary concretions induced by this agent shows a calcium salt of ceftriaxone. The present in vitro studies were undertaken to provide insight into the pathogenesis of ceftriaxone-as...


    pub_type: 杂志文章


    authors: Shiffman ML,Keith FB,Moore EW

    更新日期:1990-12-01 00:00:00

  • Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease.

    abstract:BACKGROUND & AIMS:Steatosis in patients with nonalcoholic fatty liver disease (NAFLD) is due to an imbalance between intrahepatic triglyceride (IHTG) production and export. The purpose of this study was to evaluate TG metabolism in adipose tissue and liver in NAFLD. METHODS:Fatty acid, VLDL-TG, and VLDL-apolipoprotein...


    pub_type: 杂志文章


    authors: Fabbrini E,Mohammed BS,Magkos F,Korenblat KM,Patterson BW,Klein S

    更新日期:2008-02-01 00:00:00

  • Effect of size and density on canine gastric emptying of nondigestible solids.

    abstract::Previous studies suggested that the food-containing canine stomach retains large, nondigestible spheres until all food has emptied; but it is not known whether there is a threshold size or a gradation of sizes that will empty along with food. Further, nothing is known of the effects of such parameters as density, shap...


    pub_type: 杂志文章


    authors: Meyer JH,Dressman J,Fink A,Amidon G

    更新日期:1985-10-01 00:00:00

  • Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients.

    abstract:BACKGROUND & AIMS:Biliary atresia (BA) is a rare disease in infants, with unknown mechanisms of pathogenesis. It is characterized by hepatobiliary inflammatory, progressive destruction of the biliary system leading to liver fibrosis, and deterioration of liver function. Interleukin (IL) 17A promotes inflammatory and au...


    pub_type: 杂志文章


    authors: Klemann C,Schröder A,Dreier A,Möhn N,Dippel S,Winterberg T,Wilde A,Yu Y,Thorenz A,Gueler F,Jörns A,Tolosa E,Leonhardt J,Haas JD,Prinz I,Vieten G,Petersen C,Kuebler JF

    更新日期:2016-01-01 00:00:00

  • Glycemic load, glycemic index, and carbohydrate intake in relation to risk of cholecystectomy in women.

    abstract:BACKGROUND & AIMS:High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear. METHODS:We examined the associations between high-carbohydrate diets with a high glycemic response and the...


    pub_type: 杂志文章


    authors: Tsai CJ,Leitzmann MF,Willett WC,Giovannucci EL

    更新日期:2005-07-01 00:00:00

  • Effect of chemical ablation of myenteric neurons on neurotransmitter levels in the rat jejunum.

    abstract::We have quantified neurotransmitter changes in the rat jejunum in which the myenteric neurons were ablated by serosal application of benzalkonium chloride. Within 2 days after benzalkonium chloride treatment, there was a 40% reduction in the activity of choline acetyltransferase, a specific marker for cholinergic neur...


    pub_type: 杂志文章


    authors: Dahl JL,Bloom DD,Epstein ML,Fox DA,Bass P

    更新日期:1987-02-01 00:00:00

  • HLA-linked hemochromatosis alleles in sporadic porphyria cutanea tarda.

    abstract::We tested the hypothesis that the hepatic siderosis that characterizes sporadic porphyria cutanea tarda is due to the presence of HLA-linked hemochromatosis alleles. We studied 21 probands with sporadic porphyria cutanea tarda and 135 of their relatives by determining HLA haplotypes and measuring transferrin saturatio...


    pub_type: 杂志文章


    authors: Edwards CQ,Griffen LM,Goldgar DE,Skolnick MH,Kushner JP

    更新日期:1989-10-01 00:00:00

  • Effects of somatostatin on gallbladder emptying.

    abstract::Because approximately 80% of reported patients with somatostatinomas have gallstones, this study was performed to determine the effects of exogenous somatostatin on gallbladder emptying responses to liquid and solid meals, direct cholinergic stimulation by bethanechol, indirect cholinergic stimulation by sham feeding,...


    pub_type: 杂志文章


    authors: Fisher RS,Rock E,Levin G,Malmud L

    更新日期:1987-04-01 00:00:00

  • IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial.

    abstract:BACKGROUND & AIMS:Refractory gastroesophageal reflux disease (GERD) reduces quality of life and creates significant financial burden on the health care system. Approximately 30% of patients with GERD who receive label-dose proton pump inhibitors (PPIs) still have symptoms. We performed a trial to evaluate the efficacy ...


    pub_type: 杂志文章


    authors: Vaezi MF,Fass R,Vakil N,Reasner DS,Mittleman RS,Hall M,Shao JZ,Chen Y,Lane L,Gates AM,Currie MG

    更新日期:2020-06-01 00:00:00

  • Relationship of abdominal bloating to distention in irritable bowel syndrome and effect of bowel habit.

    abstract:BACKGROUND & AIMS:The relationship between the sensation of bloating, often ranked as the most bothersome symptom by patients with irritable bowel syndrome (IBS), and actual distention manifest as an increase in abdominal girth is controversial. Investigation of this problem has been hampered by the lack of a reliable ...


    pub_type: 杂志文章


    authors: Houghton LA,Lea R,Agrawal A,Reilly B,Whorwell PJ

    更新日期:2006-10-01 00:00:00

  • Discharge of newly synthesized proteins in pure juice collected from the human pancreas. Indication of more than one pool of intracellular digestive enzymes.

    abstract::The pancreatic secretion of 6 normal human volunteers was collected by endoscopic cannulation of the main pancreatic duct. The appearance of newly synthesized proteins was monitored at 1-min intervals after labeling with [75Se]methionine. The minimum transit time of these proteins from their site of synthesis to the a...


    pub_type: 杂志文章


    authors: Robberecht P,Cremer M,Christophe J

    更新日期:1977-03-01 00:00:00

  • Enteric nerves and interstitial cells of Cajal are altered in patients with slow-transit constipation and megacolon.

    abstract:BACKGROUND & AIMS:A variety of gastrointestinal motility disorders have been attributed to alterations of interstitial cells of Cajal and malformations of the enteric nervous system. This study evaluates both the distribution of interstitial cells of Cajal and the pathohistology of the enteric nervous system in 2 sever...


    pub_type: 杂志文章


    authors: Wedel T,Spiegler J,Soellner S,Roblick UJ,Schiedeck TH,Bruch HP,Krammer HJ

    更新日期:2002-11-01 00:00:00

  • Macrophage turnover in Crohn's disease and ulcerative colitis.

    abstract::Monocytopoietic proliferation activity was determined in 8 patients during severe attacks of Crohn's disease and in 6 patients with ulcerative colitis. Similar results were obtained in both groups of patients. A moderate but significant hyperproliferation of monocytopoiesis was found to be present in about half of the...


    pub_type: 杂志文章


    authors: Meuret G,Bitzi A,Hammer B

    更新日期:1978-03-01 00:00:00

  • Duodenal volume and osmoreceptors in the stimulation of human pancreatic secretion.

    abstract::It is generally accepted that the intestinal phase of pancreatic secretion is initiated by the stimulation of chemoreceptors sensitive to fat and protein degradation products and hydrogen ions. The effect of the volume and osmolality of food emptied by the stomach into the duodenum has received less attention. We inve...


    pub_type: 杂志文章


    authors: Dooley CP,Valenzuela JE

    更新日期:1984-01-01 00:00:00

  • Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

    abstract:BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...


    pub_type: 杂志文章


    authors: Wallace DF,Summerville L,Subramaniam VN

    更新日期:2007-01-01 00:00:00

  • Membrane translocation and regulation of uridine diphosphate-glucuronic acid uptake in rat liver microsomal vesicles.

    abstract:BACKGROUND/AIMS:Hepatic glucuronidation is quantitatively the most important conjugation reaction by which an array of endogenous compounds and xenobiotics undergo biotransformation and detoxification. The active site of the uridine diphosphate (UDP) glucuronosyltransferases, which catalyze glucuronidation reactions, h...


    pub_type: 杂志文章


    authors: Berg CL,Radominska A,Lester R,Gollan JL

    更新日期:1995-01-01 00:00:00

  • Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.

    abstract:BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...


    pub_type: 杂志文章


    authors: Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

    更新日期:1998-07-01 00:00:00

  • American Gastroenterological Association Institute Technical Review on the Role of Elastography in Chronic Liver Diseases.

    abstract::Chronic liver diseases (CLDs), due to chronic hepatitis C; hepatitis B; nonalcoholic fatty liver diseases (NAFLD); and alcoholic liver disease, are a leading cause of morbidity and mortality globally. Early identification of patients with cirrhosis at high risk of progression to liver-related complications may facilit...


    pub_type: 杂志文章,评审


    authors: Singh S,Muir AJ,Dieterich DT,Falck-Ytter YT

    更新日期:2017-05-01 00:00:00

  • Plasma levels of gastrin, somatostatin, and cholecystokinin immunoreactivity during pregnancy and lactation in dogs.

    abstract::Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...


    pub_type: 杂志文章


    authors: Linden A,Eriksson M,Carlquist M,Uvnäs-Moberg K

    更新日期:1987-03-01 00:00:00

  • Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction.

    abstract::To understand the disorders of bowel motility, it is important to know the range of bowel patterns in the general population. We have devised a brief self-administered questionnaire which, when used among a group of 789 students and hospital employees, disclosed that 94.2% had stool frequencies between three per day a...


    pub_type: 杂志文章


    authors: Drossman DA,Sandler RS,McKee DC,Lovitz AJ

    更新日期:1982-09-01 00:00:00

  • Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

    abstract:BACKGROUND & AIMS:The rate of 12alpha-hydroxylation of bile acid intermediates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynthesis and the overall hydrophobicity of the bile acid pool. The aim of this study was to determine the effects of the level of expression of sterol...


    pub_type: 杂志文章


    authors: Pandak WM,Bohdan P,Franklund C,Mallonee DH,Eggertsen G,Björkhem I,Gil G,Vlahcevic ZR,Hylemon PB

    更新日期:2001-06-01 00:00:00

  • Initial endoscopy or empirical therapy with or without testing for Helicobacter pylori for dyspepsia: a decision analysis.

    abstract:BACKGROUND & AIMS:Empirical therapy has been proposed for initial management of dyspepsia. The aim of this study was to evaluate initial endoscopy, empirical therapy, and testing for Helicobacter pylori in the management of patients with a new onset of dyspepsia. METHODS:Decision analysis was used to compare the direc...


    pub_type: 杂志文章


    authors: Silverstein MD,Petterson T,Talley NJ

    更新日期:1996-01-01 00:00:00

  • HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

    abstract::We investigated whether intrapancreatic coagulation, with deposition of the fibrinogen-γ dimer (Fib-γD) and hypoxia, affect the severity of acute pancreatitis (AP) in mice. Pancreata of mice with AP induced by administration of cerulein or by L-arginine, or from patients with pancreatitis, had increased deposition of ...


    pub_type: 杂志文章


    authors: Park MJ,Iyer S,Xue X,Bragazzi Cunha J,Gu S,Moons D,Pipe SW,Williams JA,Simeone DM,Shah YM,Omary MB

    更新日期:2018-05-01 00:00:00

  • Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound.

    abstract::A number of minimally invasive methods have been tested for the thermal ablation of liver tumors as an alternative to surgical resection. The use of focused ultrasound transducers to ablate deep tumors offers the first completely noninvasive alternative to these techniques. By increasing the flexibility of this techno...


    pub_type: 杂志文章,评审


    authors: Jolesz FA,Hynynen K,McDannold N,Freundlich D,Kopelman D

    更新日期:2004-11-01 00:00:00

  • Binding of secretin to plastic surfaces.

    abstract::Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...


    pub_type: 杂志文章


    authors: Bitar KN,Zfass AM,Makhlouf GM

    更新日期:1978-12-01 00:00:00

  • Direct ex vivo analysis of hepatitis B virus-specific CD8(+) T cells associated with the control of infection.

    abstract:BACKGROUND & AIMS:Cytotoxic T cells have been suggested to be responsible for lysis of hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency, kinetics, phenotype, and capacity for clonal expansion of circulating HBV-specific CD8 cells were analyzed directly in patients with acute HB...


    pub_type: 杂志文章


    authors: Maini MK,Boni C,Ogg GS,King AS,Reignat S,Lee CK,Larrubia JR,Webster GJ,McMichael AJ,Ferrari C,Williams R,Vergani D,Bertoletti A

    更新日期:1999-12-01 00:00:00

  • Risk of colorectal neoplasia in patients with primary sclerosing cholangitis.

    abstract:BACKGROUND & AIMS:Studies implicating primary sclerosing cholangitis as a risk factor for colorectal neoplasia in patients with ulcerative colitis have been limited by small sample size and referral bias. The aim of this study was to determine the relative risk and cumulative incidence of colorectal neoplasia in a larg...


    pub_type: 杂志文章


    authors: Loftus EV Jr,Sandborn WJ,Tremaine WJ,Mahoney DW,Zinsmeister AR,Offord KP,Melton LJ 3rd

    更新日期:1996-02-01 00:00:00