当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Detection of hepatitis B virus infection in hepatitis B surface antigen-negative hemodialysis patients by monoclonal radioimmunoassays.

Detection of hepatitis B virus infection in hepatitis B surface antigen-negative hemodialysis patients by monoclonal radioimmunoassays.

Abstract：

:We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower limit of detection for hepatitis B surface antigen-associated determinants in serum of approximately 55 and 15 pg/ml, respectively. We found that 14 of 375 chronic hemodialysis patients were positive for hepatitis B surface antigen by both polyclonal and monoclonal radioimmunoassay. However, an additional 17, some of whom had chronic hepatitis and hepatocellular carcinoma, were identified as harboring hepatitis B virus infection only by the monoclonal radioimmunoassays. Thus the monoclonal radioimmunoassays improved the hepatitis B virus detection rate by 120% (3.7% vs. 8.3%). More importantly, 6 of the 17 monoclonal radioimmunoassay-reactive patients had no serologic evidence of recent or past hepatitis B virus exposure as shown by the absence of antibodies to the hepatitis B core and surface antigens in the blood. We conclude that there are hemodialysis patients with hepatitis B virus infection undetectable by conventional polyclonal radioimmunoassays.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Fujita YK,Kamata K,Kameda H,Isselbacher KJ,Wands JR

doi

10.1016/0016-5085(86)90187-3

subject

Has Abstract

pub_date

1986-12-01 00:00:00

pages

1357-63

issue

6

eissn

0016-5085

issn

1528-0012

pii

0016-5085(86)90187-3

journal_volume

91

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Comparison of endogenous and radiolabeled bile acid excretion in patients with idiopathic chronic diarrhea.

    abstract：:Fecal recovery of radioactivity after ingestion of a bolus of radiolabeled bile acid is abnormally high in most patients with idiopathic chronic diarrhea. To evaluate the significance of this malabsorption, concurrent fecal excretion of both exogenous radiolabeled bile acid and endogenous (unlabeled) bile acid were me...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90031-u

    authors： Schiller LR,Bilhartz LE,Santa Ana CA,Fordtran JS

    更新日期：1990-04-01 00:00:00

  • Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

    abstract：BACKGROUND & AIMS:Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice. METHODS:Food intake and body weight were measured after intraperiton...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(99)70491-9

    authors： Asakawa A,Inui A,Ueno N,Makino S,Fujino MA,Kasuga M

    更新日期：1999-06-01 00:00:00

  • A study of autoimmune gastritis in the postpartum period and at a 5-year follow-up.

    abstract：:The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90027-v

    authors： Burman P,Kämpe O,Kraaz W,Lööf L,Smolka A,Karlsson A,Karlsson-Parra A

    更新日期：1992-09-01 00:00:00

  • Gut macromolecular permeability in pancreatitis correlates with severity of disease in rats.

    abstract：BACKGROUND:Increased intestinal macromolecular permeability could allow absorption of substances from the bowel into the systemic circulation and contribute to multiple organ system failure. METHODS:Mild, intermediate, and severe grades of pancreatitis were induced in rats using intravenous caerulein and intraductal g...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)91027-f

    authors： Ryan CM,Schmidt J,Lewandrowski K,Compton CC,Rattner DW,Warshaw AL,Tompkins RG

    更新日期：1993-03-01 00:00:00

  • Hepcidin expression does not rescue the iron-poor phenotype of Kupffer cells in Hfe-null mice after liver transplantation.

    abstract：BACKGROUND & AIMS:Hemochromatosis is a common hereditary disease caused by mutations in HFE and characterized by increased absorption of iron in the intestine. However, the intestine does not appear to be the site of mutant HFE activity in the disease; we investigated the role of the liver-the source of the iron regula...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.03.043

    authors： Garuti C,Tian Y,Montosi G,Sabelli M,Corradini E,Graf R,Ventura P,Vegetti A,Clavien PA,Pietrangelo A

    更新日期：2010-07-01 00:00:00

  • Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

    abstract：:Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Stopa EG,O'Brien R,Katz M

    更新日期：1979-02-01 00:00:00

  • Management Strategies to Improve Outcomes of Patients With Inflammatory Bowel Diseases.

    abstract：:Strategies for management of inflammatory bowel diseases are shifting from simple control of symptoms toward full control of these diseases (clinical and endoscopic remission), with the final aim of blocking their progression and preventing bowel damage and disability. New goals have been proposed for treatment, such ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2016.09.046

    authors： Colombel JF,Narula N,Peyrin-Biroulet L

    更新日期：2017-02-01 00:00:00

  • Gene targeting demonstrates additive detrimental effects of interleukin 1 and tumor necrosis factor during pancreatitis.

    abstract：BACKGROUND & AIMS:During severe pancreatitis, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are produced in large quantities. The aim of this study was to determine whether either one plays a more dominant role and if their detrimental effects are additive. METHODS:Necrotizing pancreatitis was induced i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v113.pm9352880

    authors： Denham W,Yang J,Fink G,Denham D,Carter G,Ward K,Norman J

    更新日期：1997-11-01 00:00:00

  • Restricted V(H) gene usage in lamina propria B cells producing anticolon antibody from patients with ulcerative colitis.

    abstract：BACKGROUND AND AIMS:Autoimmune responses against colonic epithelium may play a role in the development of colonic inflammation associated with ulcerative colitis (UC). In this study, we established and characterized B-cell lines and clones that produced anticolon antibody from inflamed colonic mucosa of UC subjects. M...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.25477

    authors： Inoue N,Watanabe M,Sato T,Okazawa A,Yamazaki M,Kanai T,Ogata H,Iwao Y,Ishii H,Hibi T

    更新日期：2001-07-01 00:00:00

  • Long-term follow-up of patients with chronic hepatitis B treated with interferon alfa.

    abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1053/gast.1997.v113.pm9352870

    authors： Lau DT,Everhart J,Kleiner DE,Park Y,Vergalla J,Schmid P,Hoofnagle JH

    更新日期：1997-11-01 00:00:00

  • Selective blockade of DCAMKL-1 results in tumor growth arrest by a Let-7a MicroRNA-dependent mechanism.

    abstract：BACKGROUND & AIMS:MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression. The tumor suppressor miRNA let-7a has been reported to be inhibited posttranscriptionally in embryonic stem cells and in human cancers. Microtubule-associated kinase DCAMKL-1 is a putative intestinal stem cell marker that is express...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2009.05.004

    authors： Sureban SM,May R,Ramalingam S,Subramaniam D,Natarajan G,Anant S,Houchen CW

    更新日期：2009-08-01 00:00:00

  • A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.

    abstract：BACKGROUND & AIMS:Due to the phenotypic and molecular diversity of hepatocellular carcinomas (HCC), it is a challenge to determine a patient's prognosis. We aimed to identify new prognostic markers of patients with HCC treated by liver resection. METHODS:We collected 314 HCC samples from patients at Bordeaux (1998-200...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.03.051

    authors： Nault JC,De Reyniès A,Villanueva A,Calderaro J,Rebouissou S,Couchy G,Decaens T,Franco D,Imbeaud S,Rousseau F,Azoulay D,Saric J,Blanc JF,Balabaud C,Bioulac-Sage P,Laurent A,Laurent-Puig P,Llovet JM,Zucman-Rossi J

    更新日期：2013-07-01 00:00:00

  • Methemoglobinemia as a complication of 20% benzocaine spray for endoscopy.

    abstract：:Topical 20% benzocaine (Hurricaine, Beutlich, Inc., Niles, Ill.) spray is frequently used for oral anesthesia before upper endoscopy. Side effects attributed to this agent are exceedingly rare. The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91312-t

    authors： Collins JF

    更新日期：1990-01-01 00:00:00

  • Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal.

    abstract：BACKGROUND & AIMS:Gastroesophageal reflux typically occurs after meals. During dual gastric and esophageal pH monitoring, we observed that postprandial refluxate was often more acidic than the gastric contents. This study aimed to investigate this phenomenon. METHODS:Dual gastric and esophageal pH tracings were analyz...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.27997

    authors： Fletcher J,Wirz A,Young J,Vallance R,McColl KE

    更新日期：2001-10-01 00:00:00

  • Human intestinal intraepithelial lymphocytes have potent chemotactic activity.

    abstract：BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90573-1

    authors： Ebert EC

    更新日期：1995-10-01 00:00:00

  • Magnetic resonance imaging diagnosis of Budd-Chiari syndrome.

    abstract：:Noninvasive imaging modalities may suggest the diagnosis of Budd-Chiari syndrome but they are rarely diagnostic. Inferior vena cavography, hepatic venography, and liver biopsy, alone or in combination, are usually necessary for definitive diagnosis. Because of its excellent depiction of blood vessels as regions of abs...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(86)80029-4

    authors： Friedman AC,Ramchandani P,Black M,Caroline DF,Radecki PD,Heeger P

    更新日期：1986-11-01 00:00:00

  • Acute relapsing pancreatitis as a complication of papillary stenosis after endoscopic sphincterotomy.

    abstract：:Endoscopic sphincterotomy has proven to be a safe alternative to surgery for selected types of biliary disease. Despite a relatively low morbidity, postprocedure complications are well described. This report presents an experience with three patients in whom acute relapsing pancreatitis developed as a possible complic...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90663-w

    authors： Asbun HJ,Rossi RL,Heiss FW,Shea JA

    更新日期：1993-06-01 00:00:00

  • Cerebral electrical potentials evoked by balloon distention of the human esophagus.

    abstract：UNLABELLED:Cerebral evoked potentials provide a technique for evaluation of central nervous processing of information derived from a variety of sensory modalities. Evoked potentials associated with balloon distention of the smooth muscle esophagus were studied in 14 adult volunteers. Stimulation was applied via repeate...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)90286-a

    authors： Castell DO,Wood JD,Frieling T,Wright FS,Vieth RF

    更新日期：1990-03-01 00:00:00

  • Radioimmunoassay of bile acids: development, validation, and preliminary application of an assay for conjugates of chenodeoxycholic acid.

    abstract：:A rapid, sensitive, precise radioimmunoassay for conjugates of chenodeoxycholic (chenic) acid has been developed and validated. Immunogen was prepared with chenylglycine couples to bovine serum albumin, emulsified in Freund's complete adjuvant, and injected intracutaneously in rabbits. Antibodies of moderate titer (us...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Schalm SW,van Berge-Henegouwen GP,Hofmann AF,Cowen AE,Turcotte J

    更新日期：1977-08-01 00:00:00

  • Helicobacter pylori infection in Swedish school children: lack of evidence of child-to-child transmission outside the family.

    abstract：BACKGROUND & AIMS:Helicobacter pylori infection is mainly acquired in early childhood, but the exact routes of transmission remain elusive. To distinguish between risks of intrafamilial and extraneous child-to-child transmission, we studied H. pylori seroprevalence among Swedish school children with varying family back...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.26282

    authors： Tindberg Y,Bengtsson C,Granath F,Blennow M,Nyrén O,Granström M

    更新日期：2001-08-01 00:00:00

  • Risk of colorectal cancer in patients prescribed statins, nonsteroidal anti-inflammatory drugs, and cyclooxygenase-2 inhibitors: nested case-control study.

    abstract：BACKGROUND AND AIMS:Several studies suggest that statins prevent some cancers, with one study finding a 47% reduction in colorectal cancer risk after >or=5 years of regular use. METHODS:A nested case-control study was conducted within 454 general practices in the United Kingdom using the QRESEARCH database. Cases with...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2007.05.023

    authors： Vinogradova Y,Hippisley-Cox J,Coupland C,Logan RF

    更新日期：2007-08-01 00:00:00

  • Natural killer activity of human lymphocytes against colon cancer cells.

    abstract：:A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Helms RA,Bull DM

    更新日期：1980-04-01 00:00:00

  • Ontogeny of the receptor for polymeric immunoglobulins in rat hepatocytes.

    abstract：:Based on in vitro experiments measuring daily secretion rates in the culture media of rat hepatocytes and in vivo experiments using pulse labeling of intracellular precursors, the present study examines the ontogenic expression of the polymeric immunoglobulin receptor and secretory component by hepatocytes during grow...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(92)90181-w

    authors： Buts JP,Vaerman JP,Lescoat G

    更新日期：1992-03-01 00:00:00

  • Antroduodenal resistance to flow in the control of duodenogastric bile reflux during fasting.

    abstract：:Our objectives in this study were (a) to determine the role of antroduodenal resistance in the control of fasting duodenogastric bile reflux in the dog and (b) to elucidate the contribution of the pylorus both to resistance and to reflux. Thus, we measured simultaneously throughout the interdigestive motor cycle (a) a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90566-x

    authors： Mearin F,Azpiroz F,Malagelada JR,Zinsmeister AR

    更新日期：1987-11-01 00:00:00

  • Association of Helicobacter pylori infection with reduced risk for esophageal cancer is independent of environmental and genetic modifiers.

    abstract：BACKGROUND & AIMS:Infection with Helicobacter pylori is associated with reduced risk of esophageal adenocarcinoma (EAC), but it is not clear whether this reduction is modified by genotype, other host characteristics, or environmental factors. Furthermore, little is known about the association between H pylori and adeno...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2010.04.009

    authors： Whiteman DC,Parmar P,Fahey P,Moore SP,Stark M,Zhao ZZ,Montgomery GW,Green AC,Hayward NK,Webb PM,Australian Cancer Study.

    更新日期：2010-07-01 00:00:00

  • Sex steroid metabolism and receptor status in hepatic hyperplasia and cancer in rats.

    abstract：BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1996.v110.pm8613010

    authors： Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

    更新日期：1996-04-01 00:00:00

  • Proton Pump Inhibitors Decrease Phlebotomy Need in HFE Hemochromatosis: Double-Blind Randomized Placebo-Controlled Trial.

    abstract：:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...

    journal_title：Gastroenterology

    pub_type： 杂志文章,随机对照试验

    doi：10.1053/j.gastro.2017.06.006

    authors： Vanclooster A,van Deursen C,Jaspers R,Cassiman D,Koek G

    更新日期：2017-09-01 00:00:00

  • Enterohepatic circulation in the rat.

    abstract：:Several compounds, in particular bile acids, undergo enterohepatic circulation (EHC). Limited data are available on the pathophysiologic aspects of this circulation. In the present study we describe a surgical technique in rats that allows a long-term, reversible interruption of the EHC and monitoring of peripheral bl...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90499-8

    authors： Kuipers F,Havinga R,Bosschieter H,Toorop GP,Hindriks FR,Vonk RJ

    更新日期：1985-02-01 00:00:00

  • Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.

    abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.11.029

    authors： Mormone E,Lu Y,Ge X,Fiel MI,Nieto N

    更新日期：2012-03-01 00:00:00

  • Cell wall-defective variants of pseudomonas-like (group Va) bacteria in Crohn's disease.

    abstract：:Several animal transmission studies have indicated that Crohn's disease may be caused by a filterable agent. Filtrates of homogenized tissues were prepared from 8 patients with Crohn's disease, 9 patients with chronic ulcerative colitis, and 20 control patients without inflammatory bowel disease. Conventional bacterio...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Parent K,Mitchell P

    更新日期：1978-09-01 00:00:00