Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice.

abstract：BACKGROUND & AIMS:Metaplasias often have characteristics of developmentally related tissues. Pancreatic metaplastic ducts are usually associated with pancreatitis and pancreatic ductal adenocarcinoma. The tuft cell is a chemosensory cell that responds to signals in the extracellular environment via effector molecules. ...

journal_title：Gastroenterology

authors： Delgiorno KE,Hall JC,Takeuchi KK,Pan FC,Halbrook CJ,Washington MK,Olive KP,Spence JR,Sipos B,Wright CV,Wells JM,Crawford HC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:To define signaling events initiating healing after intestinal epithelial injury, activation of mitogen-activated protein kinase (MAPK) pathways was assessed after wounding using an in vitro model. METHODS:Proteins isolated from wounded monolayers of nontransformed intestinal epithelial cells (IEC-6)...

journal_title：Gastroenterology

authors： Göke M,Kanai M,Lynch-Devaney K,Podolsky DK

更新日期：1998-04-01 00:00:00

abstract：:To study directly the functions of the cells that line the bile ducts inside the liver, we developed a new technique for isolating intrahepatic bile duct epithelial cells (IBDECs) from normal rat liver. Parenchymal and nonparenchymal cells were separated from whole liver by enzymatic digestion and mechanical disruptio...

journal_title：Gastroenterology

authors： Ishii M,Vroman B,LaRusso NF

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND & AIMS:In patients with Wilson's disease presenting with liver involvement, the correct diagnosis is often missed or delayed. The aim of this study was to find an algorithm for diagnosis of this difficult patient group. METHODS:Clinical and laboratory findings of 55 patients with Wilson's disease were evalu...

journal_title：Gastroenterology

authors： Steindl P,Ferenci P,Dienes HP,Grimm G,Pabinger I,Madl C,Maier-Dobersberger T,Herneth A,Dragosics B,Meryn S,Knoflach P,Granditsch G,Gangl A

更新日期：1997-07-01 00:00:00

abstract：:Thyrotropin-releasing hormone transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine, and blocked by atropine and tetrodotoxin; this excitation was, the...

journal_title：Gastroenterology

authors： Oouchi M,Ichikawa S

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

journal_title：Gastroenterology

authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND & AIMS:Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS:We studied fecal specimens pros...

journal_title：Gastroenterology

authors： Chua HH,Chou HC,Tung YL,Chiang BL,Liao CC,Liu HH,Ni YH

更新日期：2018-01-01 00:00:00

abstract：:In dispersed acini prepared from guinea pig pancreas, ethanol inhibited the increase in amylase secretion caused by cholecystokinin, carbachol, secretin, or vasoactive intestinal peptide. Ethanol did not alter binding of [125I] vasoactive intestinal peptide to pancreatic acinar cells or the inhibition of binding cause...

journal_title：Gastroenterology

authors： Uhlemann ER,Robberecht P,Gardner JD

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored. METHODS:RA(+), RO(+) PBT, and LPT were activated with CD3, CD2, and CD28 antibodi...

journal_title：Gastroenterology

authors： Sturm A,Mohr S,Fiocchi C

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND/AIMS:The elevation of cytosolic free calcium concentration ([Ca2+]i) and intracellular pH mediate the growth factor-initiated proliferation of many cells, but it is not known if they trigger mitosis in resting hepatocytes. The maintenance of [Ca2+]i and intracellular pH depends partly on extracellular calciu...

journal_title：Gastroenterology

authors： Zhang BH,Farrell GC

更新日期：1995-02-01 00:00:00

abstract：:A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...

journal_title：Gastroenterology

authors： Conrad ME,Barton JC

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...

journal_title：Gastroenterology

authors： van Bodegraven AA,Curley CR,Hunt KA,Monsuur AJ,Linskens RK,Onnie CM,Crusius JB,Annese V,Latiano A,Silverberg MS,Bitton A,Fisher SA,Steinhart AH,Forbes A,Sanderson J,Prescott NJ,Strachan DP,Playford RJ,Mathew CG,Wijm

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic cancers contain exclusively tumorigenic cancer stem cells (CSCs), which are highly resistant to chemotherapy, resulting in a relative increase in CSC numbers during gemcitabine treatment. Signaling through sonic hedgehog and mammalian target of rapamycin (mTOR), respectively, may be essenti...

journal_title：Gastroenterology

authors： Mueller MT,Hermann PC,Witthauer J,Rubio-Viqueira B,Leicht SF,Huber S,Ellwart JW,Mustafa M,Bartenstein P,D'Haese JG,Schoenberg MH,Berger F,Jauch KW,Hidalgo M,Heeschen C

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...

journal_title：Gastroenterology

authors： Vanwolleghem T,Meuleman P,Libbrecht L,Roskams T,De Vos R,Leroux-Roels G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The mucosal response to intestinal resection has been extensively studied; little is known of the motor response. Our aim was to evaluate motility in the intestinal remnant following distal resection. METHODS:Motor activity, duodenocecal transit, nutrition, and absorption were studied over a 3-month period ...

journal_title：Gastroenterology

authors： Quigley EM,Thompson JS

更新日期：1993-09-01 00:00:00

abstract：:The short-term effects of rat pancreatic duct obstruction were evaluated and compared with those recently reported to follow obstruction of the rabbit pancreatic duct. In both species pancreatic edema and hyperamylasemia are noted, and the lysosomal hydrolase cathepsin B is redistributed from the lysosome-enriched to ...

journal_title：Gastroenterology

authors： Ohshio G,Saluja A,Steer ML

更新日期：1991-01-01 00:00:00

abstract：:The fibrinolytic activity of blood draining from the stomachs of patients with gastroduodenal disease has been compared with the fibrinolytic activity of blood in the systemic venous circulation and with the blood draining from normal stomachs. Gastric venous blood from normal and diseased stomachs contains greater am...

journal_title：Gastroenterology

authors： O'Brien TE,Hadley H,Irving MH

更新日期：1979-03-01 00:00:00

abstract：BACKGROUND & AIMS:Impaired gallbladder emptying occurs in patients undergoing bile salt therapy for cholesterol gallstone dissolution and in patients with cirrhosis who have elevated serum bile salt concentrations. To determine if bile salts directly inhibit gallbladder contractility, isometric contraction of the guine...

journal_title：Gastroenterology

authors： Xu QW,Freedman SM,Shaffer EA

更新日期：1997-05-01 00:00:00

abstract：:Intragastric titration, introduced in 1973, has become more popular than in the past and is being applied to the study of gastric secretion under a variety of conditions using NaHCO3 and NaOH as titrant. Physical chemical and technical considerations point to limitations on the conditions under which quantitative resu...

journal_title：Gastroenterology

authors： Spenney JG

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND & AIMS:Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular i...

journal_title：Gastroenterology

authors： Comarmond C,Garrido M,Pol S,Desbois AC,Costopoulos M,Le Garff-Tavernier M,Si Ahmed SN,Alric L,Fontaine H,Bellier B,Maciejewski A,Rosenzwajg M,Klatzmann D,Musset L,Poynard T,Cacoub P,Saadoun D

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling. METHODS:Stellate cells (HSC) were incubated with pure ONOO- or SIN-1 (a ONOO- donor)....

journal_title：Gastroenterology

authors： Urtasun R,Cubero FJ,Vera M,Nieto N

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...

journal_title：Gastroenterology

authors： Luckey A,Wang L,Jamieson PM,Basa NR,Million M,Czimmer J,Vale W,Taché Y

更新日期：2003-09-01 00:00:00

abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...

journal_title：Gastroenterology

authors： Czaja MJ

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:The US Medicare indications for intestinal transplantation are based on failure of home parenteral nutrition. The American Society of Transplantation also includes patients at high risk of death from their primary disease or with high morbidity intestinal failure. A 3-year prospective study evaluated ...

journal_title：Gastroenterology

authors： Pironi L,Forbes A,Joly F,Colomb V,Lyszkowska M,Van Gossum A,Baxter J,Thul P,Hébuterne X,Gambarara M,Gottrand F,Moreno Villares JM,Messing B,Goulet O,Staun M,Home Artificial Nutrition Working Group of the European Society fo

更新日期：2008-07-01 00:00:00

abstract：:We studied intestinal function and hepatic microsomal phase I monooxygenase function in healthy, free-living subjects, aged 19-91 yr. In subjects (n = 114) given a diet including 100 g/day of fat, fecal fat in a 72-h collection did not increase with advancing age. D-Xylose excretion (n = 54) following a 25-g oral load...

journal_title：Gastroenterology

authors： Arora S,Kassarjian Z,Krasinski SD,Croffey B,Kaplan MM,Russell RM

更新日期：1989-06-01 00:00:00

abstract：:A 22-yr-old woman with a 7-yr history of systemic lupus erythematosus presented with anasarca and a serum albumin of 0.8 g/dl. Renal and hepatic function were near normal; the major route of protein loss appeared to be the intestine. A full-thickness section of jejunum obtained at laparotomy demonstrated a severe, dif...

journal_title：Gastroenterology

authors： Weiser MM,Andres GA,Brentjens JR,Evans JT,Reichlin M

更新日期：1981-09-01 00:00:00

abstract：:Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors that develop most frequently in women without cirrhosis. Genomic approaches have identified signaling pathways related to these benign hepatocyte proliferations. FNH, a polyclonal lesion, is characterized by local vascula...

journal_title：Gastroenterology

authors： Nault JC,Bioulac-Sage P,Zucman-Rossi J

更新日期：2013-05-01 00:00:00

abstract：:Recent data seem to support a tubular defect as the mechanism of the elevated renal clearance of amylase relative to creatinine in acute pancreatitis. Glucagon has been proposed by some to be an important factor in this phenomenon. To examine the role of glucagon as this "tubular dysfunction factor", we investigated t...

journal_title：Gastroenterology

authors： Tedesco FJ,Davila E,Gardner LB

更新日期：1978-10-01 00:00:00

abstract：:In contrast to the "toxigenic diarrheas" caused by Vibrio cholerae and Escherichia coli, the site and mechanism of fluid loss in shigellosis are unknown. The occurrence of watery diarrhea in shigellosis suggests involvement of the small bowel. Therefore, jejunal, ileal, and colonic water and electrolyte transport was ...

journal_title：Gastroenterology

authors： Rout WR,Formal SB,Giannella RA,Dammin GJ

更新日期：1975-02-01 00:00:00