Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

abstract：:A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...

journal_title：Gastroenterology

authors： Guo YS,Narayan S,Yallampalli C,Singh P

更新日期：1992-04-01 00:00:00

abstract：:An enteroscopic method that uses a pediatric colonoscope provides an alternative approach to the diagnostic and management problems arising in the setting of a Roux-en-Y limb hepaticojejunostomy or biliary diversion. Three patients with Roux-en-Y limb reconstructions who experienced recurrent cholangitis, recurrent pa...

journal_title：Gastroenterology

authors： Gostout CJ,Bender CE

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy that invades surrounding structures and metastasizes rapidly. Although inflammation is associated with tumor formation and progression, little is known about the mechanisms of this connection. We investigate the effects of interleukin...

journal_title：Gastroenterology

authors： Perusina Lanfranca M,Zhang Y,Girgis A,Kasselman S,Lazarus J,Kryczek I,Delrosario L,Rhim A,Koneva L,Sartor M,Sun L,Halbrook C,Nathan H,Shi J,Crawford HC,Pasca di Magliano M,Zou W,Frankel TL

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND & AIMS:Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by...

journal_title：Gastroenterology

authors： Bertomeu A,Ros E,Zambón D,Vela M,Pérez-Ayuso RM,Targarona E,Trías M,Sanllehy C,Casals E,Ribó JM

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND & AIMS:Differences in genetic background may play a role in the development of ulcerative colitis (UC)-related neoplasia. Loss of heterozygosity (LOH) of APC has been reported in human UC-associated neoplasia. To investigate the role of genetic differences in UC-associated neoplasia, we compared differences ...

journal_title：Gastroenterology

authors： Cooper HS,Everley L,Chang WC,Pfeiffer G,Lee B,Murthy S,Clapper ML

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...

journal_title：Gastroenterology

authors： Zhuang Y,Peng LS,Zhao YL,Shi Y,Mao XH,Chen W,Pang KC,Liu XF,Liu T,Zhang JY,Zeng H,Liu KY,Guo G,Tong WD,Shi Y,Tang B,Li N,Yu S,Luo P,Zhang WJ,Lu DS,Yu PW,Zou QM

更新日期：2012-10-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

journal_title：Gastroenterology

authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND & AIMS:Endosonography-guided fine-needle aspiration biopsy (EUS-FNA) permits cytological confirmation of EUS findings. A multicenter prospective evaluation of EUS-FNA for primary diagnosis, staging, and/or follow-up purposes was undertaken. METHODS:EUS-FNA was performed in 457 patients with 554 lesions. Cli...

journal_title：Gastroenterology

authors： Wiersema MJ,Vilmann P,Giovannini M,Chang KJ,Wiersema LM

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND & AIMS:The risk of colorectal neoplasms among siblings of patients with advanced adenomas is not clear. We determined the prevalence of advanced adenomas in the siblings of patients with advanced adenomas and compared it with that of siblings of individuals without these lesions. METHODS:In a blinded, cross...

journal_title：Gastroenterology

authors： Ng SC,Lau JY,Chan FK,Suen BY,Tse YK,Hui AJ,Leung-Ki EL,Ching JY,Chan AW,Wong MC,Ng SS,To KF,Wu JC,Sung JJ

更新日期：2016-03-01 00:00:00

abstract：:The effect of thyroidectomy on the activity of liver alcohol dehydrogenase and on the rate of ethanol elimination was determined in the rat. Thyroidectomy resulted in a marked increase in liver alcohol dehydrogenase activity. Three isoenzymes of alcohol dehydrogenase activity were demonstrated in thyroidectomized anim...

journal_title：Gastroenterology

authors： Mezey E,Potter JJ

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic and epigenetic alterations contribute to the pathogenesis of colorectal cancer (CRC). There is considerable molecular heterogeneity among colorectal tumors, which appears to arise as polyps progress to cancer. This heterogeneity results in different pathways to tumorigenesis. Although epigenet...

journal_title：Gastroenterology

authors： Luo Y,Wong CJ,Kaz AM,Dzieciatkowski S,Carter KT,Morris SM,Wang J,Willis JE,Makar KW,Ulrich CM,Lutterbaugh JD,Shrubsole MJ,Zheng W,Markowitz SD,Grady WM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND & AIMS:Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression. METHODS:The dissemination potential of 10 human gastric cancer cell lines in mice with severe combined immun...

journal_title：Gastroenterology

authors： Ishii Y,Ochiai A,Yamada T,Akimoto S,Yanagihara K,Kitajima M,Hirohashi S

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND & AIMS:Chronic pancreatitis has been suggested as a causal risk factor for pancreatic cancer in a recent study. The aim of this study was to clarify the relationship between chronic pancreatitis and pancreatic cancer. METHODS:All patients in the Swedish inpatient Register with a discharge diagnosis of pancr...

journal_title：Gastroenterology

authors： Karlson BM,Ekbom A,Josefsson S,McLaughlin JK,Fraumeni JF Jr,Nyrén O

更新日期：1997-08-01 00:00:00

abstract：:Several studies suggest that bile salts are transported from the basolateral to the canalicular membrane of hepatocytes by a vesicular pathway, possibly in part via the Golgi complex. To test this hypothesis, the present study examined, in the perfused rat liver, the influence of the Na+ ionophore monensin on the bili...

journal_title：Gastroenterology

authors： Reynier MO,Abou Hashieh I,Crotte C,Carbuccia N,Richard B,Gérolami A

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND & AIMS:The ubiquitous cross-linking enzyme tissue transglutaminase (TG2) has been implicated in irreversible collagen stabilization in liver fibrosis, although functional evidence is lacking. We studied the contribution of TG2 to hepatic fibrotic matrix stability, as well as liver fibrosis progression and re...

journal_title：Gastroenterology

authors： Popov Y,Sverdlov DY,Sharma AK,Bhaskar KR,Li S,Freitag TL,Lee J,Dieterich W,Melino G,Schuppan D

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs. METHODS:We identified all patients with a hospital discharge ...

journal_title：Gastroenterology

authors： El-Serag HB,Everhart JE

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND & AIMS:AJM300 is an orally active small-molecule antagonist of the α4 integrin subunit. We performed a randomized trial to investigate the efficacy and safety of AJM300 in patients with active ulcerative colitis (UC). METHODS:In a double-blind, placebo-controlled, phase 2a study, 102 patients with moderatel...

journal_title：Gastroenterology

authors： Yoshimura N,Watanabe M,Motoya S,Tominaga K,Matsuoka K,Iwakiri R,Watanabe K,Hibi T,AJM300 Study Group.

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND & AIMS:Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS:Galectin 3 expression was examined immunohistochemically in 39 s...

journal_title：Gastroenterology

authors： Sanjuán X,Fernández PL,Castells A,Castronovo V,van den Brule F,Liu FT,Cardesa A,Campo E

更新日期：1997-12-01 00:00:00

abstract：:Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed chol...

journal_title：Gastroenterology

authors： Martins EB,Fleming KA,Garrido MC,Hine KR,Chapman RW

更新日期：1994-08-01 00:00:00

abstract：:We studied whether 16,16--dimethyl prostaglandin E2 (dmPGE2) may prevent acute liver damage induced by carbon tetrachloride (CCl4) in the rat. One hundred thirty male rats were divided into the following groups: (1) controls, (2) rats given CCl4 6670 mg/kg body wt subcutaneously, (3) rats pretreated with 5 micrograms/...

journal_title：Gastroenterology

authors： Stachura J,Tarnawski A,Ivey KJ,Mach T,Bogdal J,Szczudrawa J,klimczyk B

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND & AIMS:The transcription factor nuclear factor-κB (NF-κB) (a heterodimer of NF-κB1p50 and RelA) is activated rapidly in acute pancreatitis (AP). However, it is not clear whether NF-κB promotes or protects against AP. We used the NF-κB inhibitor protein, inhibitor of κB (IκB)α, to study the roles of NF-κB in ...

journal_title：Gastroenterology

authors： Neuhöfer P,Liang S,Einwächter H,Schwerdtfeger C,Wartmann T,Treiber M,Zhang H,Schulz HU,Dlubatz K,Lesina M,Diakopoulos KN,Wörmann S,Halangk W,Witt H,Schmid RM,Algül H

更新日期：2013-01-01 00:00:00

abstract：:Cell-mediated immunity is impaired during cholestasis, and there is evidence that bile acids play a role in this immune defect. Ursodeoxycholic acid (UDCA), which corrects the immunological abnormalities observed in primary biliary cirrhosis, could counter the detrimental effects of the endogenous bile acids. Accordin...

journal_title：Gastroenterology

authors： Calmus Y,Weill B,Ozier Y,Chéreau C,Houssin D,Poupon R

更新日期：1992-08-01 00:00:00

abstract：:The effects of calcium channel blockers on water transport in the rat ileum and distal colon were studied in vivo using the single-pass perfusion technique. Parenteral but not intraluminal verapamil, and parenteral nifedipine increased ileal water absorption, with effects lasting at least 60 min. In contrast, i.p. ver...

journal_title：Gastroenterology

authors： Donowitz M,Levin S,Powers G,Elta G,Cohen P,Cheng H

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...

journal_title：Gastroenterology

authors： Kumar A,Priyamvada S,Ge Y,Jayawardena D,Singhal M,Anbazhagan AN,Chatterjee I,Dayal A,Patel M,Zadeh K,Saksena S,Alrefai WA,Gill RK,Zadeh M,Zhao N,Mohamadzadeh M,Dudeja PK

更新日期：2020-11-13 00:00:00

abstract：:Median nerve somatosensory evoked potentials were recorded from 33 patients with various degrees of hepatic failure and from 10 age-matched controls. Within 20 ms poststimulation, one negative peak (N13) could be recorded from the middle of the back of the patient's neck at the C2 vertebral level. Within 150 ms, three...

journal_title：Gastroenterology

authors： Yang SS,Chu NS,Liaw YF

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND & AIMS:Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized. METHODS:We therefore compared the methylation profile and genetic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carci...

journal_title：Gastroenterology

authors： Kim SG,Chan AO,Wu TT,Issa JP,Hamilton SR,Rashid A

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND & AIMS:Screening for colorectal cancer (CRC) with sigmoidoscopy reduces CRC incidence by detecting and removing adenomas. The number needed to screen is a measure of screening efficiency, but is not directly associated with adenoma removal. We propose the following 2 new metrics for quantifying the relations...

journal_title：Gastroenterology

authors： Pinsky PF,Loberg M,Senore C,Wooldrage K,Atkin W,Bretthauer M,Cross AJ,Hoff G,Holme O,Kalager M,Segnan N,Schoen RE

更新日期：2018-10-01 00:00:00

abstract：:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

journal_title：Gastroenterology

authors： Chen GY,Núñez G

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND & AIMS:Mutations in the APC gene result in an increased propensity to develop intestinal neoplasia; however, a complete understanding of the mechanisms resulting in tumor formation has remained elusive. Min mice possess a mutation in the APC gene and display a neoplastic phenotype similar to that observed in...

journal_title：Gastroenterology

authors： Williams CS,Luongo C,Radhika A,Zhang T,Lamps LW,Nanney LB,Beauchamp RD,DuBois RN

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND & AIMS:Lactase is the intestinal disaccharidase responsible for digestion of lactose, the predominant carbohydrate in milk. Transcription of the lactase gene is activated during enterocyte differentiation. We have characterized the interaction between the lactase promoter and Cdx2, a homeodomain protein invo...

journal_title：Gastroenterology

authors： Fang R,Santiago NA,Olds LC,Sibley E

更新日期：2000-01-01 00:00:00