Inflammasomes in intestinal inflammation and cancer.


:Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and Nlrc4), the DNA sensor Aim2, the adaptor apoptosis-associated speck-like protein (ASC), and pro-caspase-1 are important components of inflammasomes. Stimulation with specific microbial and endogenous molecules leads to inflammasome assembly and caspase-1 activation. Inflammasomes are believed to mediate host defense against microbial pathogens and tissue homeostasis within the intestine, and their dysregulation might contribute to inflammatory diseases and intestinal cancer. Improving our understanding of inflammasome signaling pathways could provide insights into the pathogenesis of many gastrointestinal disorders and the development of therapeutic targets and approaches to treat diseases such as inflammatory bowel diseases and gastrointestinal cancers.






Chen GY,Núñez G




Has Abstract


2011-12-01 00:00:00














  • p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation.

    abstract:BACKGROUND & AIMS:p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that...


    pub_type: 杂志文章


    authors: Dai CY,Furth EE,Mick R,Koh J,Takayama T,Niitsu Y,Enders GH

    更新日期:2000-10-01 00:00:00

  • Biliary tree in cystic fibrosis. Biliary tract abnormalities in cystic fibrosis demonstrated by endoscopic retrograde cholangiography.

    abstract::Two female adolescents with cystic fibrosis were investigated by endoscopic retrograde cholangiography for recurrent abdominal pain. The cholangiogram of 1 patient demonstrated multiple irregular filling defects throughout the biliary tree representing thickened bile and mucus as well as stones. The cholangiogram of t...


    pub_type: 杂志文章


    authors: Bass S,Connon JJ,Ho CS

    更新日期:1983-06-01 00:00:00

  • Circulating Tumor DNA Analysis for Detection of Minimal Residual Disease After Chemoradiotherapy for Localized Esophageal Cancer.

    abstract:BACKGROUND & AIMS:Biomarkers are needed to risk stratify after chemoradiotherapy for localized esophageal cancer. These could improve identification of patients at risk for cancer progression and selection of additional therapy. METHODS:We performed deep sequencing (CAncer Personalized Profiling by deep Sequencing, [C...


    pub_type: 杂志文章


    authors: Azad TD,Chaudhuri AA,Fang P,Qiao Y,Esfahani MS,Chabon JJ,Hamilton EG,Yang YD,Lovejoy A,Newman AM,Kurtz DM,Jin M,Schroers-Martin J,Stehr H,Liu CL,Hui AB,Patel V,Maru D,Lin SH,Alizadeh AA,Diehn M

    更新日期:2020-02-01 00:00:00

  • Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.

    abstract::Acute liver injury was induced experimentally in rats by a single injection of a large amount of D-galactosamine. Hepatocellular damage was apparent from decrease of total serum proteins, marked release of transaminases into the circulation, precipitous decrease of total microsomal proteins, and intracellular enzymes ...


    pub_type: 杂志文章


    authors: Sawamura T,Kawasato S,Shiozaki Y,Sameshima Y,Nakada H,Tashiro Y

    更新日期:1981-09-01 00:00:00

  • Intestinal B-cell isotype response in relation to local bacterial load: evidence for immunoglobulin A subclass adaptation.

    abstract:BACKGROUND & AIMS:In experimental animals, the indigenous microbiota modulates mucosal immunity. In humans, such direct evidence is scarce. The aim of this study was to examine the effect of intestinal bacteria on the local immunoglobulin (Ig) response. METHODS:The numbers of IgA-, IgM-, and IgG-producing immunocytes ...


    pub_type: 杂志文章


    authors: Kett K,Baklien K,Bakken A,Kral JG,Fausa O,Brandtzaeg P

    更新日期:1995-09-01 00:00:00

  • Localization of gastrinomas by transhepatic portal catheterization and gastrin assay.

    abstract::Gastrinomas were localized by concurrent blood sampling in the hepatic vein and portal vein tributaries in 10 of 12 Zollinger-Ellison patients. In one patient, the portal vein could not be catheterized; in the other, a gastrin gradient could not be picked up in either of two examinations. Six of the patients were subs...


    pub_type: 杂志文章


    authors: Burcharth F,Stage JG,Stadil F,Jensen LI,Fischermann K

    更新日期:1979-09-01 00:00:00

  • Immunocytochemical localization of myosin in normal and phalloidin-treated rat hepatocytes.

    abstract::To clarify the intracellular distribution of myosin in normal rat hepatocytes and its alterations in phal-loidin-treated rat hepatocytes as a morphologic basis for the dysfunction of microfilaments, we performed indirect immunofluorescence using monospecific antibody raised against rat hepatocyte myosin. Cryostat rat ...


    pub_type: 杂志文章


    authors: Yasuura S,Ueno T,Watanabe S,Hirose M,Namihisa T

    更新日期:1989-10-01 00:00:00

  • Stimulation of gastric inhibitory polypeptide in normal and duodenal ulcer patients.

    abstract::To investigate the role of gastric inhibitory polypeptide (GIP), a potent inhibitor of gastric acid secretion, in the hypersecretion associated with duodenal ulcer, we compared the serum GIP concentrations in 11 healthy subjects and 16 duodenal ulcer patients after the stimulation of GIP release by a mixed meal. Fasti...


    pub_type: 杂志文章


    authors: Cataland S,O'Dorisio TM,Brooks R,Mekhjian HS

    更新日期:1977-07-01 00:00:00

  • Bone disease in cholestatic liver disease.

    abstract::Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...


    pub_type: 杂志文章,评审


    authors: Hay JE

    更新日期:1995-01-01 00:00:00

  • Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.

    abstract:BACKGROUND & AIMS:Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about the mechanism by which linaclotide reduces abdominal pain in patients with IBS-C. METHODS:We determined t...


    pub_type: 杂志文章,随机对照试验


    authors: Castro J,Harrington AM,Hughes PA,Martin CM,Ge P,Shea CM,Jin H,Jacobson S,Hannig G,Mann E,Cohen MB,MacDougall JE,Lavins BJ,Kurtz CB,Silos-Santiago I,Johnston JM,Currie MG,Blackshaw LA,Brierley SM

    更新日期:2013-12-01 00:00:00

  • Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.

    abstract:BACKGROUND & AIMS:Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hyperalgesia. METHODS:Male rats were subjected to 1-hour water avoidance (WA) stress or subcutaneous c...


    pub_type: 杂志文章


    authors: Hong S,Zheng G,Wu X,Snider NT,Owyang C,Wiley JW

    更新日期:2011-02-01 00:00:00

  • Bone metastases in malignant gastrinoma.

    abstract::Six patients (4 women, 2 men) with malignant gastrinoma developed multiple bone metastases; osteolytic as well as osteoblastic lesions occurred. All lesions involved the central skeleton, most caused symptoms, and, in 2 cases, there was associated hypercalcemia with normal serum parathormone levels. Poor responses wer...


    pub_type: 杂志文章


    authors: Barton JC,Hirschowitz BI,Maton PN,Jensen RT

    更新日期:1986-11-01 00:00:00

  • Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice.

    abstract:BACKGROUND & AIMS:The emergence of oxyntic atrophy and metaplastic cell lineages in response to chronic Helicobacter pylori infection predisposes to gastric neoplasia. We have described a trefoil factor family 2 (TFF2; spasmolytic polypeptide) expressing metaplasia (SPEM) associated with gastric neoplasia in both roden...


    pub_type: 杂志文章


    authors: Nomura S,Baxter T,Yamaguchi H,Leys C,Vartapetian AB,Fox JG,Lee JR,Wang TC,Goldenring JR

    更新日期:2004-08-01 00:00:00

  • Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection.

    abstract:BACKGROUND & AIMS:Fecal microbiota transplantation (FMT) is a highly effective therapy for recurrent Clostridium difficile infection (CDI). However, transferring undefined living bacteria entails uncontrollable risks for infectious and metabolic or malignant diseases, particularly in immunocompromised patients. We inve...


    pub_type: 杂志文章


    authors: Ott SJ,Waetzig GH,Rehman A,Moltzau-Anderson J,Bharti R,Grasis JA,Cassidy L,Tholey A,Fickenscher H,Seegert D,Rosenstiel P,Schreiber S

    更新日期:2017-03-01 00:00:00

  • Bile and stone analysis in two infants with brown pigment gallstones and infected bile.

    abstract::Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and...


    pub_type: 杂志文章


    authors: Treem WR,Malet PF,Gourley GR,Hyams JS

    更新日期:1989-02-01 00:00:00

  • Impairment of aminopyrine clearance in aspirin-damaged canine gastric mucosa.

    abstract::Using an in vivo canine chambered stomach preparation, the clearance of [14C]aminopyrine across mucosa when intravenously infused and the back-diffusion of this substance from gastric lumen to mucosa when topically applied to gastric epithelium were evaluated in aspirin-damaged gastric epithelium. In mucosa damaged by...


    pub_type: 杂志文章


    authors: Miller TA,Henagan JM,Loy TM

    更新日期:1983-09-01 00:00:00

  • REG Ialpha protein may function as a trophic and/or anti-apoptotic factor in the development of gastric cancer.

    abstract:BACKGROUND & AIMS:Although a significant amount of regenerating gene (REG) Ialpha protein is present not only in normal gastric mucosa but also in gastric cancer tissues, its pathophysiologic role in gastric cancer development remains unclear. We investigated REG Ialpha protein expression in early gastric cancers, and ...


    pub_type: 杂志文章


    authors: Sekikawa A,Fukui H,Fujii S,Takeda J,Nanakin A,Hisatsune H,Seno H,Takasawa S,Okamoto H,Fujimori T,Chiba T

    更新日期:2005-03-01 00:00:00

  • A novel enzyme immunoassay for serodiagnosis of Helicobacter pylori infection.

    abstract::Helicobacter pylori has recently been implicated as an etiologic agent of gastroduodenal disorders. Comparing the antibody to H. pylori in the sera of patients with that of normal controls by Western blot analysis, a unique antibody was detected in the sera of patients, which reacted with the 25-kilodalton antigen of ...


    pub_type: 杂志文章


    authors: Sugiyama T,Imai K,Yoshida H,Takayama Y,Yabana T,Yokota K,Oguma K,Yachi A

    更新日期:1991-07-01 00:00:00

  • Transient agranulocytosis associated with non-A, non-B hepatitis.

    abstract::A 44-yr-old woman with non-A, non-B hepatitis developed agranulocytosis and absence of marrow granulocyte precursor cells with only mild involvement of other blood elements. The agranulocytosis was complicated by gram-negative septicemia, successfully treated with antibiotic therapy. Marrow recovery followed 2 wk of s...


    pub_type: 杂志文章


    authors: Vande Stouwe RA,Attia AA,Karanas A,Ciavarella D,Grieco MH

    更新日期:1983-07-01 00:00:00

  • Enhanced hyperplasia of gastric enterochromaffinlike cells in response to omeprazole-evoked hypergastrinemia in rats with portacaval shunts. An immunocytochemical and chemical study.

    abstract::The histamine-storing enterochromaffinlike cells, which are numerous in the oxyntic mucosa of the rat stomach, are known to proliferate in response to long-lasting hypergastrinaemia. In addition, portacaval shunting, which is not associated with elevated serum gastrin, causes an increase in enterochromaffinlike cell d...


    pub_type: 杂志文章


    authors: Axelson J,Ekelund M,Sundler F,Håkanson R

    更新日期:1990-09-01 00:00:00

  • The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia.

    abstract:BACKGROUND & AIMS:Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population. METHODS:Adult participants of the Third National Health and Nutrition Examination Survey who did not consume alcohol (n = 8839) were compared w...


    pub_type: 杂志文章


    authors: Ioannou GN,Dominitz JA,Weiss NS,Heagerty PJ,Kowdley KV

    更新日期:2004-05-01 00:00:00

  • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.

    abstract:BACKGROUND & AIMS:In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on end...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Colombel JF,Rutgeerts P,Reinisch W,Esser D,Wang Y,Lang Y,Marano CW,Strauss R,Oddens BJ,Feagan BG,Hanauer SB,Lichtenstein GR,Present D,Sands BE,Sandborn WJ

    更新日期:2011-10-01 00:00:00

  • Protein kinase C isoforms in the chemopreventive effects of a novel vitamin D3 analogue in rat colonic tumorigenesis.

    abstract:BACKGROUND & AIMS:We recently showed that dietary supplementation with an analogue of 1alpha,25-dihydroxy-vitamin D3, 1alpha,25-dihydroxy-16-ene-23-yne-26,27 F6-vitamin D3 (RO24-5531), reduced the incidence of colonic tumors in rats treated with azoxymethane (AOM). The aim of this study was to determine whether alterat...


    pub_type: 杂志文章


    authors: Wali RK,Bissonnette M,Khare S,Aquino B,Niedziela S,Sitrin M,Brasitus TA

    更新日期:1996-07-01 00:00:00

  • Gastric mucosal alpha(4)beta(7)-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice.

    abstract:BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...


    pub_type: 杂志文章


    authors: Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

    更新日期:2000-07-01 00:00:00

  • The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.

    abstract::Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia. Significant improvement (P less than 0.002) of both the clinical grade of hepatic encephalopathy and t...


    pub_type: 杂志文章


    authors: Bosman DK,van den Buijs CA,de Haan JG,Maas MA,Chamuleau RA

    更新日期:1991-09-01 00:00:00

  • Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis.

    abstract:BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...


    pub_type: 杂志文章


    authors: Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

    更新日期:1996-05-01 00:00:00

  • Experimental ulceration of rabbit antral mucosa.

    abstract::The mechanism of acute ulceration and the nature of mucosal protective mechanisms were investigated in rabbit antrum, which is more resistant to injury than fundus of the same species, with particular reference to the relationship between H+ back diffusion, tissue acidification, and occurrence of ulceration. Exposure ...


    pub_type: 杂志文章


    authors: Kivilaakso E,Barzilai A,Schiessel R,Fromm D,Silen W

    更新日期:1981-01-01 00:00:00

  • Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics.

    abstract:BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...


    pub_type: 杂志文章


    authors: Halfvarson J,Bodin L,Tysk C,Lindberg E,Järnerot G

    更新日期:2003-06-01 00:00:00

  • Enteropathogenic Escherichia coli infection inhibits intestinal serotonin transporter function and expression.

    abstract:BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...


    pub_type: 杂志文章


    authors: Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

    更新日期:2009-12-01 00:00:00

  • Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis.

    abstract:BACKGROUND AND AIMS:To influence host and disease phenotype, compositional microbiome changes, which have been demonstrated in patients with primary sclerosing cholangitis (PSC), must be accompanied by functional changes. We therefore aimed to characterize the genetic potential of the gut microbiome in PSC compared to ...


    pub_type: 杂志文章


    authors: Kummen M,Thingholm LB,Rühlemann MC,Holm K,Hansen SH,Moitinho-Silva L,Liwinski T,Zenouzi R,Storm-Larsen C,Midttun Ø,McCann A,Ueland PM,Høivik ML,Vesterhus M,Trøseid M,Laudes M,Lieb W,Karlsen TH,Bang C,Schramm C,Fra

    更新日期:2020-12-30 00:00:00