Inflammasomes in intestinal inflammation and cancer.

abstract：:Treatment options for inflammatory bowel disease (IBD) reflect a continuing shift from empiricism to strategies based on improved understanding of the pathophysiology of disease. In susceptible individuals, IBD appears to be the result of defective regulation of mucosal immune interactions with the enteric microflora....

journal_title：Gastroenterology

authors： Shanahan F

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND & AIMS:We investigated the prevalence of germline mutations in APC, ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, PALB2, PMS2, PRSS1, STK11, and TP53 in patients with pancreatic cancer. METHODS:The Ontario Pancreas Cancer Study enrolls consenting participants with pancreatic cancer from a province-wide elect...

journal_title：Gastroenterology

authors： Grant RC,Selander I,Connor AA,Selvarajah S,Borgida A,Briollais L,Petersen GM,Lerner-Ellis J,Holter S,Gallinger S

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs via promoter hypermethylation (epigenetic modification), and less frequently via CDH1 mutations and l...

journal_title：Gastroenterology

authors： Oliveira C,Sousa S,Pinheiro H,Karam R,Bordeira-Carriço R,Senz J,Kaurah P,Carvalho J,Pereira R,Gusmão L,Wen X,Cipriano MA,Yokota J,Carneiro F,Huntsman D,Seruca R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIMS:The neuropeptide somatostatin exerts multiple functions in the gastrointestinal tract and may also play a regulatory role in inflammatory bowel disease, as several other neuropeptides do, e.g., substance P or calcitonin gene-related peptide. Therefore, the expression of somatostatin receptors was evalua...

journal_title：Gastroenterology

authors： Reubi JC,Mazzucchelli L,Laissue JA

更新日期：1994-04-01 00:00:00

abstract：:We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis. Jaundice and pruritus lasted 19 and 20 mo, respectively. Three liver biopsies were performed at different stages of the disease showing the course of liver lesions. Cholestasis initially located in the ...

journal_title：Gastroenterology

authors： Larrey D,Amouyal G,Pessayre D,Degott C,Danne O,Machayekhi JP,Feldmann G,Benhamou JP

更新日期：1988-01-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

journal_title：Gastroenterology

authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

更新日期：2013-01-01 00:00:00

abstract：:S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...

journal_title：Gastroenterology

authors： Everson GT,Ahnen D,Harper PC,Krawitt EL

更新日期：1989-05-01 00:00:00

abstract：:Helicobacter pylori infects the stomach of half of the human population worldwide and causes chronic active gastritis, which can lead to peptic ulcer disease, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. The host immune response to the infection is ineffective, because the bacterium persists...

journal_title：Gastroenterology

authors： Wilson KT,Crabtree JE

更新日期：2007-07-01 00:00:00

abstract：:Most studies show that oral ingestion of iron does not cause a positive stool guaiac reaction. However, all in vitro studies show that iron does cause a positive guaiac reaction and some in vivo studies have shown a positive stool guaiac reaction in response to oral iron. This study examines this unresolved question. ...

journal_title：Gastroenterology

authors： McDonnell WM,Ryan JA,Seeger DM,Elta GH

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...

journal_title：Gastroenterology

authors： Wong P,Verselis SJ,Garber JE,Schneider K,DiGianni L,Stockwell DH,Li FP,Syngal S

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND & AIMS:In colorectal adenoma and carcinoma, glutathione S-transferase-pi (GSTP1-1) is highly expressed. K-ras mutation is also known to occur frequently in colorectal adenoma and carcinoma, as well as in the putative precursor of adenoma, aberrant crypt foci (ACF). Further, forced expression of v-H-ras in ra...

journal_title：Gastroenterology

authors： Miyanishi K,Takayama T,Ohi M,Hayashi T,Nobuoka A,Nakajima T,Takimoto R,Kogawa K,Kato J,Sakamaki S,Niitsu Y

更新日期：2001-10-01 00:00:00

abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...

journal_title：Gastroenterology

authors： Eckardt VF,Grace ND,Kantrowitz PA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND & AIMS:Practice guidelines recommend that endoscopists spend at least 7 minutes examining the colonic mucosa during colonoscopy withdrawal to optimize polyp yield. The aim of this study was to determine if the implementation of an institution-wide policy of colonoscopy withdrawal time > or = 7 minutes was as...

journal_title：Gastroenterology

authors： Sawhney MS,Cury MS,Neeman N,Ngo LH,Lewis JM,Chuttani R,Pleskow DK,Aronson MD

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND & AIMS:Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to galectin-3. METHODS:...

journal_title：Gastroenterology

authors： Bresalier RS,Byrd JC,Tessler D,Lebel J,Koomen J,Hawke D,Half E,Liu KF,Mazurek N,Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network.

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND & AIMS:CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. We investigated their role in the pathogenesis of gastric cancer. METHODS:We used flow cytometry analyses to determine levels and phenotype of Tc17 cells in blood and tumor samples fr...

journal_title：Gastroenterology

authors： Zhuang Y,Peng LS,Zhao YL,Shi Y,Mao XH,Chen W,Pang KC,Liu XF,Liu T,Zhang JY,Zeng H,Liu KY,Guo G,Tong WD,Shi Y,Tang B,Li N,Yu S,Luo P,Zhang WJ,Lu DS,Yu PW,Zou QM

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND & AIMS:The effect of hepatitis C viral (HCV) infection on patient and allograft survival after orthotopic liver transplantation is controversial. Hepatitis C recurrence after transplant is inevitable, but studies to date have not found a survival difference between recipients with and without HCV. METHODS:U...

journal_title：Gastroenterology

authors： Forman LM,Lewis JD,Berlin JA,Feldman HI,Lucey MR

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND & AIMS:Diets high in fructose have been proposed to contribute to nonalcoholic fatty liver disease. We compared the effects of high-fructose and matched glucose intake on hepatic triacylglycerol (TAG) concentration and other liver parameters. DESIGN:In a double-blind study, we randomly assigned 32 healthy b...

journal_title：Gastroenterology

authors： Johnston RD,Stephenson MC,Crossland H,Cordon SM,Palcidi E,Cox EF,Taylor MA,Aithal GP,Macdonald IA

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND & AIMS:Although a number of epidemiologic studies have found dietary fiber and whole grains to be inversely associated with colorectal cancer incidence, studies of dietary and other risk factors for small intestinal cancer have been sparse and all of a case-control design. We conducted a prospective cohort s...

journal_title：Gastroenterology

authors： Schatzkin A,Park Y,Leitzmann MF,Hollenbeck AR,Cross AJ

更新日期：2008-10-01 00:00:00

abstract：:Approximately 10% of persons 70 years old or older are now diagnosed with pancreatic cysts, but it is not clear which ones require additional analysis, interventions, or follow-up. Primary care doctors rely on gastroenterologists for direction because no one wants to miss a diagnosis of pancreatic cancer, but meanwhil...

journal_title：Gastroenterology

authors： Farrell JJ,Fernández-del Castillo C

更新日期：2013-06-01 00:00:00

abstract：:In spite of the widespread use of the Garren-Edwards gastric bubble as an adjuvant device in weight reduction, its efficacy has not been established. Therefore, our purpose was to conduct a randomized, double-blind, crossover study of this device in the management of exogenous obesity. The study group consisted of 23 ...

journal_title：Gastroenterology

authors： Meshkinpour H,Hsu D,Farivar S

更新日期：1988-09-01 00:00:00

abstract：:The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...

journal_title：Gastroenterology

authors： Makhlouf GM,Bodanszky M,Fink ML,Schebalin M

更新日期：1978-08-01 00:00:00

abstract：:A prospective and randomized study was performed comparing pneumatic forceful dilatation and surgical esophagomyotomy as primary treatment of patients with achalasia of the esophagus. Eighteen dilated and 20 operated patients were studied before and after treatment with 1 patient lost. Clinical, radiologic, and manome...

journal_title：Gastroenterology

authors： Csendes A,Velasco N,Braghetto I,Henriquez A

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND & AIMS:Math1 (Atoh1) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adul...

journal_title：Gastroenterology

authors： Shroyer NF,Helmrath MA,Wang VY,Antalffy B,Henning SJ,Zoghbi HY

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：:Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...

journal_title：Gastroenterology

authors： Whitehead WE,Cheskin LJ,Heller BR,Robinson JC,Crowell MD,Benjamin C,Schuster MM

更新日期：1990-06-01 00:00:00

abstract：:The effect of experimental bypass on the intestinal epithelium of the rat was investigated from 2 to 360 days after creating a Thiry-Vella fistula. Within 7 to 14 days the number of cells per villus column and, to a lesser degree, the number of cells per crypt column decreased and subsequently these values remained co...

journal_title：Gastroenterology

authors： Rijke RP,Plaisier HM,de Ruiter H,Galjaard H

更新日期：1977-05-01 00:00:00

abstract：:The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...

journal_title：Gastroenterology

authors： Wesdorp E,Bartelsman J,Pape K,Dekker W,Tytgat GN

更新日期：1978-05-01 00:00:00

abstract：:Fifty-nine studies of gastrointestinal transit time were performed in 27 healthy women during pregnancy and postpartum. Gastrointestinal transit time was defined as the time of the first sustained rise in breath hydrogen concentration after ingestion of 10 g of lactulose. Gastrointestinal transit time was significantl...

journal_title：Gastroenterology

authors： Lawson M,Kern F Jr,Everson GT

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND & AIMS:A Th1 clone, II-6, established from an autoimmune gastritis BALB/c mouse that underwent thymectomy 3 days after birth, recognized a 15 mer peptide constructing the alpha subunit of H+, K(+)-adenosine triphosphatase as antigen and induced gastritis in nu/nu mice by adoptive transfer. The aim of this st...

journal_title：Gastroenterology

authors： Nishio A,Katakai T,Oshima C,Kasakura S,Sakai M,Yonehara S,Suda T,Nagata S,Masuda T

更新日期：1996-10-01 00:00:00

abstract：:The burden of disease consequent to hepatitis C virus (HCV) infection has been well described and is expected to increase dramatically over the next decade. Current approved antiviral therapies are effective in eradicating the virus in approximately 50% of infected patients. However, pegylated interferon and ribavirin...

journal_title：Gastroenterology

authors： Pawlotsky JM,Chevaliez S,McHutchison JG

更新日期：2007-05-01 00:00:00